메뉴 건너뛰기




Volumn 7, Issue 8, 2008, Pages 1257-1276

Mucosal vaccination against bacterial respiratory infections

Author keywords

Adjuvant; Bordetella pertussis; Haemophilus influenzae; Moraxella catarrhalis; Mucosa associated lymphoid tissue; Mucosal vaccination; Mycobacterium tuberculosis; Nasal vaccination; Oral vaccination; Pseudomonas aeroginosa; Respiratory infection

Indexed keywords

ADHESIN; BACTERIUM LYSATE; BCG VACCINE; CHITOSAN; CHOLERA TOXIN; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLUENZA VACCINE; MENINGITIS VACCINE; ORAL POLIOMYELITIS VACCINE; PERTUSSIS VACCINE; PNEUMOCOCCUS VACCINE; POLIOMYELITIS VACCINE; PSEUDOMONAS VACCINE; SALMONELLOSIS VACCINE;

EID: 53849087185     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.7.8.1257     Document Type: Review
Times cited : (28)

References (149)
  • 1
    • 33646470569 scopus 로고    scopus 로고
    • CDC. Vaccine preventable deaths and the Global Immunization Vision and Strategy, 2006-2015. MMWR Morb. Mortal. Wkly Rep. 55(18), 511-515 (2006). •• Provides data on the global burden of infectious diseases and expresses the WHO strategy for vaccine development.
    • CDC. Vaccine preventable deaths and the Global Immunization Vision and Strategy, 2006-2015. MMWR Morb. Mortal. Wkly Rep. 55(18), 511-515 (2006). •• Provides data on the global burden of infectious diseases and expresses the WHO strategy for vaccine development.
  • 2
    • 0035978034 scopus 로고    scopus 로고
    • Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in adults aged 65 years or older: A prospective study
    • Christenson B, Lundbergh P, Hedlund J, Ortqvist A. Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in adults aged 65 years or older: a prospective study. Lancet 357(9261), 1008-1011 (2001).
    • (2001) Lancet , vol.357 , Issue.9261 , pp. 1008-1011
    • Christenson, B.1    Lundbergh, P.2    Hedlund, J.3    Ortqvist, A.4
  • 3
    • 53849100598 scopus 로고    scopus 로고
    • CDC. Pneumococcal disease. In: Epidemiology and Prevention of Vaccine Preventable Diseases: The Pink Book. CDC (Ed.). GA, USA 257-270 (2007).
    • CDC. Pneumococcal disease. In: Epidemiology and Prevention of Vaccine Preventable Diseases: The Pink Book. CDC (Ed.). GA, USA 257-270 (2007).
  • 4
    • 24944542396 scopus 로고    scopus 로고
    • Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease - United States, 1998-2003
    • Describes the effects of herd immunity achieved by the antipneumococcal routine vaccination of children. CDC, •
    • CDC. Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease - United States, 1998-2003. MMWR Morb. Mortal. Wkly Rep. 54(36), 893-897 (2005). • Describes the effects of herd immunity achieved by the antipneumococcal routine vaccination of children.
    • (2005) MMWR Morb. Mortal. Wkly Rep , vol.54 , Issue.36 , pp. 893-897
  • 5
    • 85136388823 scopus 로고    scopus 로고
    • Singleton RJ, Hennessy TW, Bulkow LR et al. Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. JAMA 297(16), 1784-1792 (2007). • Reports serotype replacement following introduction of antipneumococcal routine vaccination of children.
    • Singleton RJ, Hennessy TW, Bulkow LR et al. Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. JAMA 297(16), 1784-1792 (2007). • Reports serotype replacement following introduction of antipneumococcal routine vaccination of children.
  • 6
    • 36749044437 scopus 로고    scopus 로고
    • Novel approaches to fight Streptococcus pneumoniae. Recent Patents Anti-Infect
    • Maestro B, Sanz JM. Novel approaches to fight Streptococcus pneumoniae. Recent Patents Anti-Infect. Drug Disc. 2(3), 188-196 (2007).
    • (2007) Drug Disc , vol.2 , Issue.3 , pp. 188-196
    • Maestro, B.1    Sanz, J.M.2
  • 7
    • 0035825720 scopus 로고    scopus 로고
    • Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    • Eskola J, Kilpi T, Palmu A et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N. Engl. J. Med. 344(6), 403-409 (2001).
    • (2001) N. Engl. J. Med , vol.344 , Issue.6 , pp. 403-409
    • Eskola, J.1    Kilpi, T.2    Palmu, A.3
  • 8
    • 33644695618 scopus 로고    scopus 로고
    • Efficacy of Haemophilus influenzae type b vaccination of children: A meta-analysis
    • Obonyo CO, Lau J. Efficacy of Haemophilus influenzae type b vaccination of children: a meta-analysis. Eur. J. Clin. Microbiol. Infect. Dis. 25(2), 90-97 (2006).
    • (2006) Eur. J. Clin. Microbiol. Infect. Dis , vol.25 , Issue.2 , pp. 90-97
    • Obonyo, C.O.1    Lau, J.2
  • 9
    • 33750595507 scopus 로고    scopus 로고
    • Group C meningococcal polysaccharidetetanus toxoid conjugate vaccine: A meta-analysis of immunogenicity, safety and posology
    • Comprehensive meta-analysis of clinical trials with a meningitus C vaccine, •
    • Pollabauer EM, Petermann R, Ehrlich HJ. Group C meningococcal polysaccharidetetanus toxoid conjugate vaccine: a meta-analysis of immunogenicity, safety and posology. Hum. Vaccin. 1(4), 131-139 (2005). • Comprehensive meta-analysis of clinical trials with a meningitus C vaccine.
    • (2005) Hum. Vaccin , vol.1 , Issue.4 , pp. 131-139
    • Pollabauer, E.M.1    Petermann, R.2    Ehrlich, H.J.3
  • 10
    • 53849137229 scopus 로고    scopus 로고
    • CDC. Meningococcal disease. In: Epidemiology and Prevention of Vaccine Preventable Diseases: The Pink Book. CDC (Ed.), GA, USA 271-281 (2007)
    • CDC. Meningococcal disease. In: Epidemiology and Prevention of Vaccine Preventable Diseases: The Pink Book. CDC (Ed.), GA, USA 271-281 (2007)
  • 11
    • 0026334477 scopus 로고
    • Vaccine against group B Neisseria meningitidis: Protection trial and mass vaccination results in Cuba
    • Sierra GV, Campa HC, Varcacel NM et al. Vaccine against group B Neisseria meningitidis: protection trial and mass vaccination results in Cuba. NIPH Ann. 14(2), 195-207 (1991).
    • (1991) NIPH Ann , vol.14 , Issue.2 , pp. 195-207
    • Sierra, G.V.1    Campa, H.C.2    Varcacel, N.M.3
  • 12
    • 0025989151 scopus 로고
    • Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway
    • Bjune G, Hoiby EA, Gronnesby JK et al. Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. Lancet 338(8775), 1093-1096 (1991).
    • (1991) Lancet , vol.338 , Issue.8775 , pp. 1093-1096
    • Bjune, G.1    Hoiby, E.A.2    Gronnesby, J.K.3
  • 13
    • 0026730501 scopus 로고
    • Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil
    • de Moraes JC, Perkins BA, Camargo MC et al. Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil. Lancet 340(8827), 1074-1078 (1992).
    • (1992) Lancet , vol.340 , Issue.8827 , pp. 1074-1078
    • de Moraes, J.C.1    Perkins, B.A.2    Camargo, M.C.3
  • 14
    • 0033611936 scopus 로고    scopus 로고
    • Immunogenicity of 2 serogroup B outer-membrane protein meningococcal vaccines: A randomized controlled trial in Chile
    • Tappero JW, Lagos R, Ballesteros AM et al. Immunogenicity of 2 serogroup B outer-membrane protein meningococcal vaccines: a randomized controlled trial in Chile. JAMA 281(16), 1520-1527 (1999).
    • (1999) JAMA , vol.281 , Issue.16 , pp. 1520-1527
    • Tappero, J.W.1    Lagos, R.2    Ballesteros, A.M.3
  • 15
    • 34250365388 scopus 로고    scopus 로고
    • Identification by genomic immunization of a pool of DNA vaccine candidates that confer protective immunity in mice against Neisseria meningitidis serogroup B
    • Yero D, Pajon R, Perez Y et al. Identification by genomic immunization of a pool of DNA vaccine candidates that confer protective immunity in mice against Neisseria meningitidis serogroup B. Vaccine 25(28), 5175-5188 (2007).
    • (2007) Vaccine , vol.25 , Issue.28 , pp. 5175-5188
    • Yero, D.1    Pajon, R.2    Perez, Y.3
  • 16
    • 37349011119 scopus 로고    scopus 로고
    • Pulsed-field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains
    • Bottero D, Gaillard ME, Fingermann M et al. Pulsed-field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains. Clin. Vaccine Immunol. 14(11), 1490-1498 (2007).
    • (2007) Clin. Vaccine Immunol , vol.14 , Issue.11 , pp. 1490-1498
    • Bottero, D.1    Gaillard, M.E.2    Fingermann, M.3
  • 17
    • 33746856385 scopus 로고    scopus 로고
    • Pertussis outbreak in an Amish community - Kent County, Delaware, September 2004-February 2005
    • CDC
    • CDC. Pertussis outbreak in an Amish community - Kent County, Delaware, September 2004-February 2005. MMWR Morb. Mortal. Wkly Rep. 55(30), 817-821 (2006).
    • (2006) MMWR Morb. Mortal. Wkly Rep , vol.55 , Issue.30 , pp. 817-821
  • 18
    • 34247533752 scopus 로고    scopus 로고
    • Pathogens in early-onset and late-onset intensive care unit-acquired pneumonia
    • Verhamme KM, De Coster W, De Roo L et al. Pathogens in early-onset and late-onset intensive care unit-acquired pneumonia. Infect. Control Hosp. Epidemiol. 28(4), 389-397 (2007).
    • (2007) Infect. Control Hosp. Epidemiol , vol.28 , Issue.4 , pp. 389-397
    • Verhamme, K.M.1    De Coster, W.2    De Roo, L.3
  • 19
    • 33750707549 scopus 로고    scopus 로고
    • Implications of COPD in patients admitted to the intensive care unit by community-acquired pneumonia
    • Rello J, Rodriguez A, Torres A et al. Implications of COPD in patients admitted to the intensive care unit by community-acquired pneumonia. Eur. Respir. J. 27(6), 1210-1216 (2006).
    • (2006) Eur. Respir. J , vol.27 , Issue.6 , pp. 1210-1216
    • Rello, J.1    Rodriguez, A.2    Torres, A.3
  • 20
    • 33750302487 scopus 로고    scopus 로고
    • Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis
    • Ratjen F. Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis. Curr. Opin. Pulm. Med. 12(6), 428-432 (2006).
    • (2006) Curr. Opin. Pulm. Med , vol.12 , Issue.6 , pp. 428-432
    • Ratjen, F.1
  • 21
    • 42049115532 scopus 로고    scopus 로고
    • The neglected intrinsic resistome of bacterial pathogens
    • Fajardo A, Martinez-Martin N, Mercadillo M et al. The neglected intrinsic resistome of bacterial pathogens. PLoS ONE 3(2), e1619 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.2
    • Fajardo, A.1    Martinez-Martin, N.2    Mercadillo, M.3
  • 22
    • 34547432470 scopus 로고    scopus 로고
    • Doring G, Meisner C, Stern M. A double-blind randomized placebo-controlled Phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients. Proc. Natl Acad. Sci. USA 104(26), 11020-11025 (2007). •• First randomized controlled clinical trial with an antipseudomonal vaccine in cystic fibrosis. Demonstrates that antipseudomonal vaccination can be effective in this patient group.
    • Doring G, Meisner C, Stern M. A double-blind randomized placebo-controlled Phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients. Proc. Natl Acad. Sci. USA 104(26), 11020-11025 (2007). •• First randomized controlled clinical trial with an antipseudomonal vaccine in cystic fibrosis. Demonstrates that antipseudomonal vaccination can be effective in this patient group.
  • 23
    • 3042638668 scopus 로고    scopus 로고
    • Vaccination of cystic fibrosis patients against Pseudomonas aeruginosa reduces the proportion of patients infected and delays time to infection
    • Lang AB, Rudeberg A, Schoni MH et al. Vaccination of cystic fibrosis patients against Pseudomonas aeruginosa reduces the proportion of patients infected and delays time to infection. Pediatr. Infect. Dis. J. 23(6), 504-510 (2004).
    • (2004) Pediatr. Infect. Dis. J , vol.23 , Issue.6 , pp. 504-510
    • Lang, A.B.1    Rudeberg, A.2    Schoni, M.H.3
  • 24
    • 33645989166 scopus 로고    scopus 로고
    • Trunz BB, Fine P, Dye C. Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367(9517), 1173-1180 (2006). • Analyzes the huge amount of data on the clinical use of bacillus Calmette-Guerin (BCG) vaccination.
    • Trunz BB, Fine P, Dye C. Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367(9517), 1173-1180 (2006). • Analyzes the huge amount of data on the clinical use of bacillus Calmette-Guerin (BCG) vaccination.
  • 25
    • 33846941602 scopus 로고    scopus 로고
    • Revaccination with Bacillus Calmette-Guerin (BCG) vaccine does not reduce morbidity from malaria in African children
    • Rodrigues A, Schellenberg JA, Roth A et al. Revaccination with Bacillus Calmette-Guerin (BCG) vaccine does not reduce morbidity from malaria in African children. Trop. Med. Int. Health 12(2), 224-229 (2007).
    • (2007) Trop. Med. Int. Health , vol.12 , Issue.2 , pp. 224-229
    • Rodrigues, A.1    Schellenberg, J.A.2    Roth, A.3
  • 26
    • 34548409687 scopus 로고    scopus 로고
    • Development of new tuberculosis vaccines: A global perspective on regulatory issues
    • Brennan MJ, Fruth U, Milstien J et al. Development of new tuberculosis vaccines: a global perspective on regulatory issues. PLoS Med. 4(8), e252 (2007).
    • (2007) PLoS Med , vol.4 , Issue.8
    • Brennan, M.J.1    Fruth, U.2    Milstien, J.3
  • 28
    • 0036750697 scopus 로고    scopus 로고
    • Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: An Italian multicenter study
    • Plebani A, Soresina A, Rondelli R et al. Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: an Italian multicenter study. Clin. Immunol. 104(3), 221-230 (2002).
    • (2002) Clin. Immunol , vol.104 , Issue.3 , pp. 221-230
    • Plebani, A.1    Soresina, A.2    Rondelli, R.3
  • 29
    • 0034108060 scopus 로고    scopus 로고
    • Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)
    • Hammarstrom L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin. Exp. Immunol. 120(2), 225-231 (2000).
    • (2000) Clin. Exp. Immunol , vol.120 , Issue.2 , pp. 225-231
    • Hammarstrom, L.1    Vorechovsky, I.2    Webster, D.3
  • 30
    • 13444278991 scopus 로고    scopus 로고
    • The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency
    • Carsetti R, Rosado MM, Donnanno S et al. The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency. J. Allergy Clin. Immunol. 115(2), 412-417 (2005).
    • (2005) J. Allergy Clin. Immunol , vol.115 , Issue.2 , pp. 412-417
    • Carsetti, R.1    Rosado, M.M.2    Donnanno, S.3
  • 31
    • 0021848960 scopus 로고
    • Immunoglobulin G subclass proteins in serum and lavage fluid of normal subjects. Quantitation and comparison with immunoglobulins A and E
    • Merrill WW, Naegel GP, Olchowski JJ, Reynolds HY. Immunoglobulin G subclass proteins in serum and lavage fluid of normal subjects. Quantitation and comparison with immunoglobulins A and E. Am. Rev. Respir. Dis. 131(4), 584-587 (1985).
    • (1985) Am. Rev. Respir. Dis , vol.131 , Issue.4 , pp. 584-587
    • Merrill, W.W.1    Naegel, G.P.2    Olchowski, J.J.3    Reynolds, H.Y.4
  • 32
    • 34548797131 scopus 로고    scopus 로고
    • Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: A clinical Phase I/II study
    • Demonstrates the formation of mucosal antibodies in human lower airways following nasal protein vaccination without the use of adjuvants, •
    • Baumann U, Gocke K, Gewecke B, Freihorst J, von Specht BU. Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical Phase I/II study. Respir. Res. 8, 57 (2007). • Demonstrates the formation of mucosal antibodies in human lower airways following nasal protein vaccination without the use of adjuvants.
    • (2007) Respir. Res , vol.8 , pp. 57
    • Baumann, U.1    Gocke, K.2    Gewecke, B.3    Freihorst, J.4    von Specht, B.U.5
  • 33
    • 0346099419 scopus 로고    scopus 로고
    • New insights into the pathophysiology and in vivo function of IgG Fc receptors through gene deletion studies
    • Baumann U, Schmidt RE, Gessner JE. New insights into the pathophysiology and in vivo function of IgG Fc receptors through gene deletion studies. Arch. Immunol. Ther. Exp. (Warsz.) 51(6), 399-406 (2003).
    • (2003) Arch. Immunol. Ther. Exp. (Warsz.) , vol.51 , Issue.6 , pp. 399-406
    • Baumann, U.1    Schmidt, R.E.2    Gessner, J.E.3
  • 35
    • 21744458071 scopus 로고    scopus 로고
    • A quantitative analysis of cedar pollen-specific immunoglobulins in nasal lavage supported the local production of specific IgE, not of specific IgG
    • Yoshida T, Usui A, Kusumi T et al. A quantitative analysis of cedar pollen-specific immunoglobulins in nasal lavage supported the local production of specific IgE, not of specific IgG. Microbiol. Immunol. 49(6), 529-534 (2005).
    • (2005) Microbiol. Immunol , vol.49 , Issue.6 , pp. 529-534
    • Yoshida, T.1    Usui, A.2    Kusumi, T.3
  • 36
    • 10744231864 scopus 로고    scopus 로고
    • Immunologic studies of specific mucosal and systemic immune responses in Mexican school children after booster aerosol or subcutaneous immunization with measles vaccine
    • Bellanti JA, Zeligs BJ, Mendez-Inocencio J et al. Immunologic studies of specific mucosal and systemic immune responses in Mexican school children after booster aerosol or subcutaneous immunization with measles vaccine. Vaccine 22(9-10), 1214-1220 (2004).
    • (2004) Vaccine , vol.22 , Issue.9-10 , pp. 1214-1220
    • Bellanti, J.A.1    Zeligs, B.J.2    Mendez-Inocencio, J.3
  • 37
    • 0037622187 scopus 로고    scopus 로고
    • Role of secretory antibodies in the defence against infections
    • Brandtzaeg P. Role of secretory antibodies in the defence against infections. Int. J. Med. Microbiol. 293(1), 3-15 (2003).
    • (2003) Int. J. Med. Microbiol , vol.293 , Issue.1 , pp. 3-15
    • Brandtzaeg, P.1
  • 38
    • 33645521806 scopus 로고    scopus 로고
    • Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide
    • Provides experimental data suggesting that host defense against extracellular bacterial pathogens can rely solely on a cellular response, •
    • Malley R, Srivastava A, Lipsitch M et al. Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect. Immun. 74(4), 2187-2195 (2006). • Provides experimental data suggesting that host defense against extracellular bacterial pathogens can rely solely on a cellular response.
    • (2006) Infect. Immun , vol.74 , Issue.4 , pp. 2187-2195
    • Malley, R.1    Srivastava, A.2    Lipsitch, M.3
  • 40
    • 0142197629 scopus 로고    scopus 로고
    • Plasma-cell homing
    • Summarizes the evidence of mechanisms of mucosal homing, •
    • Kunkel EJ, Butcher EC. Plasma-cell homing. Nat. Rev. Immunol. 3(10), 822-829 (2003). • Summarizes the evidence of mechanisms of mucosal homing.
    • (2003) Nat. Rev. Immunol , vol.3 , Issue.10 , pp. 822-829
    • Kunkel, E.J.1    Butcher, E.C.2
  • 41
    • 23344453236 scopus 로고    scopus 로고
    • Mucosal B cells: Phenotypic characteristics, transcriptional regulation, and homing properties
    • Brandtzaeg P, Johansen FE. Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunol. Rev. 206, 32-63 (2005).
    • (2005) Immunol. Rev , vol.206 , pp. 32-63
    • Brandtzaeg, P.1    Johansen, F.E.2
  • 42
    • 49149092490 scopus 로고    scopus 로고
    • Bronchial response pattern of antigen presenting cells and regulatory T cells in children below two years of age
    • Heier I, Malmstrom K, Pelkonen AS et al. Bronchial response pattern of antigen presenting cells and regulatory T cells in children below two years of age. Thorax 63(8), 703-709 (2008).
    • (2008) Thorax , vol.63 , Issue.8 , pp. 703-709
    • Heier, I.1    Malmstrom, K.2    Pelkonen, A.S.3
  • 43
    • 0344061225 scopus 로고    scopus 로고
    • Quiding-Jabrink M, Nordstrom I, Granstrom G et al. Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses. J. Clin. Invest. 99(6), 1281-1286 (1997). •• First study to demonstrate the differential expression of mucosal homing receptors following various mucosal and the systemic route in humans.
    • Quiding-Jabrink M, Nordstrom I, Granstrom G et al. Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses. J. Clin. Invest. 99(6), 1281-1286 (1997). •• First study to demonstrate the differential expression of mucosal homing receptors following various mucosal and the systemic route in humans.
  • 44
    • 2942516894 scopus 로고    scopus 로고
    • Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    • Yoshida M, Claypool SM, Wagner JS et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20(6), 769-783 (2004).
    • (2004) Immunity , vol.20 , Issue.6 , pp. 769-783
    • Yoshida, M.1    Claypool, S.M.2    Wagner, J.S.3
  • 45
    • 0024389095 scopus 로고
    • Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes
    • Brandtzaeg P, Halstensen TS, Kett K et al. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology 97(6), 1562-1584 (1989).
    • (1989) Gastroenterology , vol.97 , Issue.6 , pp. 1562-1584
    • Brandtzaeg, P.1    Halstensen, T.S.2    Kett, K.3
  • 46
    • 0346751944 scopus 로고    scopus 로고
    • Nasal-associated lymphoid tissue (NALT): Frequency and localization in young children
    • Debertin AS, Tschernig T, Tonjes H et al. Nasal-associated lymphoid tissue (NALT): frequency and localization in young children. Clin. Exp. Immunol. 134(3), 503-507 (2003).
    • (2003) Clin. Exp. Immunol , vol.134 , Issue.3 , pp. 503-507
    • Debertin, A.S.1    Tschernig, T.2    Tonjes, H.3
  • 47
    • 0017259286 scopus 로고
    • Distribution of immunoglobulin-containing cells in human bone marrow and lymphoid tissues
    • Turesson I. Distribution of immunoglobulin-containing cells in human bone marrow and lymphoid tissues. Acta Med. Scand. 199(4), 293-304 (1976).
    • (1976) Acta Med. Scand , vol.199 , Issue.4 , pp. 293-304
    • Turesson, I.1
  • 48
    • 0141724603 scopus 로고    scopus 로고
    • Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults
    • Gordon SB, Miller DE, Day RB et al. Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. J. Infect. Dis. 188(5), 666-670 (2003).
    • (2003) J. Infect. Dis , vol.188 , Issue.5 , pp. 666-670
    • Gordon, S.B.1    Miller, D.E.2    Day, R.B.3
  • 49
    • 14744287233 scopus 로고    scopus 로고
    • Immune response versus mucosal tolerance to mucosally administered antigens
    • Mestecky J, Moldoveanu Z, Elson CO. Immune response versus mucosal tolerance to mucosally administered antigens. Vaccine 23(15), 1800-1803 (2005).
    • (2005) Vaccine , vol.23 , Issue.15 , pp. 1800-1803
    • Mestecky, J.1    Moldoveanu, Z.2    Elson, C.O.3
  • 50
    • 34250319272 scopus 로고    scopus 로고
    • Intranasal vaccines for protection against respiratory and systemic bacterial infections
    • Oliveira ML, Areas AP, Ho PL. Intranasal vaccines for protection against respiratory and systemic bacterial infections. Expert Rev. Vaccines 6(3), 419-429 (2007).
    • (2007) Expert Rev. Vaccines , vol.6 , Issue.3 , pp. 419-429
    • Oliveira, M.L.1    Areas, A.P.2    Ho, P.L.3
  • 51
    • 30344457304 scopus 로고    scopus 로고
    • Sullivan VJ, Mikszta JA, Laurent P, Huang J, Ford B. Noninvasive delivery technologies: respiratory delivery of vaccines. Expert Opin. Drug Deliv. 3(1), 87-95 (2006). • Reviews nasal delivery systems.
    • Sullivan VJ, Mikszta JA, Laurent P, Huang J, Ford B. Noninvasive delivery technologies: respiratory delivery of vaccines. Expert Opin. Drug Deliv. 3(1), 87-95 (2006). • Reviews nasal delivery systems.
  • 52
    • 0032516267 scopus 로고    scopus 로고
    • The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children
    • Belshe RB, Mendelman PM, Treanor J et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children. N. Engl. J. Med. 338(20), 1405-1412 (1998).
    • (1998) N. Engl. J. Med , vol.338 , Issue.20 , pp. 1405-1412
    • Belshe, R.B.1    Mendelman, P.M.2    Treanor, J.3
  • 53
    • 33846995457 scopus 로고    scopus 로고
    • Live attenuated versus inactivated influenza vaccine in infants and young children
    • Randomized clinical trial that shows the superiority of a nasal live vaccine versus a systemic vaccine in children, ••
    • Belshe RB, Edwards KM, Vesikari T et al. Live attenuated versus inactivated influenza vaccine in infants and young children. N. Engl. J. Med. 356(7), 685-696 (2007). •• Randomized clinical trial that shows the superiority of a nasal live vaccine versus a systemic vaccine in children.
    • (2007) N. Engl. J. Med , vol.356 , Issue.7 , pp. 685-696
    • Belshe, R.B.1    Edwards, K.M.2    Vesikari, T.3
  • 54
    • 0348078299 scopus 로고    scopus 로고
    • Mucosal antibody response induced with a nasal virosome-based influenza vaccine
    • Durrer P, Gluck U, Spyr C et al. Mucosal antibody response induced with a nasal virosome-based influenza vaccine. Vaccine 21(27-28), 4328-4334 (2003).
    • (2003) Vaccine , vol.21 , Issue.27-28 , pp. 4328-4334
    • Durrer, P.1    Gluck, U.2    Spyr, C.3
  • 55
    • 1342268100 scopus 로고    scopus 로고
    • Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
    • Mutsch M, Zhou W, Rhodes P et al. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N. Engl. J. Med. 350(9), 896-903 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.9 , pp. 896-903
    • Mutsch, M.1    Zhou, W.2    Rhodes, P.3
  • 56
    • 7044222885 scopus 로고    scopus 로고
    • Enhanced immunogenicity in the murine airway mucosa with an attenuated Salmonella live vaccine expressing OprF-OprI from Pseudomonas aeruginosa
    • Arnold H, Bumann D, Felies M et al. Enhanced immunogenicity in the murine airway mucosa with an attenuated Salmonella live vaccine expressing OprF-OprI from Pseudomonas aeruginosa. Infect. Immun. 72(11), 6546-6553 (2004).
    • (2004) Infect. Immun , vol.72 , Issue.11 , pp. 6546-6553
    • Arnold, H.1    Bumann, D.2    Felies, M.3
  • 57
    • 40349114404 scopus 로고    scopus 로고
    • Sublingual vaccination with influenza virus protects mice against lethal viral infection
    • Song JH, Nguyen HH, Cuburu N et al. Sublingual vaccination with influenza virus protects mice against lethal viral infection. Proc. Natl Acad. Sci. USA 105(5), 1644-1649 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.5 , pp. 1644-1649
    • Song, J.H.1    Nguyen, H.H.2    Cuburu, N.3
  • 58
    • 33749511016 scopus 로고    scopus 로고
    • Protective efficacy of intranasal vaccination with Mycobacterium bovis BCG against airway Mycobacterium tuberculosis challenge in mice
    • One of the few experimental studies on sublingual vaccination, •
    • Giri PK, Verma I, Khuller GK. Protective efficacy of intranasal vaccination with Mycobacterium bovis BCG against airway Mycobacterium tuberculosis challenge in mice. J. Infect. 53(5), 350-356 (2006). • One of the few experimental studies on sublingual vaccination.
    • (2006) J. Infect , vol.53 , Issue.5 , pp. 350-356
    • Giri, P.K.1    Verma, I.2    Khuller, G.K.3
  • 59
    • 33746622593 scopus 로고    scopus 로고
    • Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough
    • Mielcarek N, Debrie AS, Raze D et al. Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough. PLoS Pathog. 2(7), e65 (2006).
    • (2006) PLoS Pathog , vol.2 , Issue.7
    • Mielcarek, N.1    Debrie, A.S.2    Raze, D.3
  • 60
    • 2442661589 scopus 로고    scopus 로고
    • Bordetella pertussis from functional genomics to intranasal vaccination
    • Locht C, Antoine R, Raze D et al. Bordetella pertussis from functional genomics to intranasal vaccination. Int. J. Med. Microbiol. 293(7-8), 583-588 (2004).
    • (2004) Int. J. Med. Microbiol , vol.293 , Issue.7-8 , pp. 583-588
    • Locht, C.1    Antoine, R.2    Raze, D.3
  • 61
    • 33646151139 scopus 로고    scopus 로고
    • Oliveira ML, Areas AP, Campos IB et al. Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A. Microbes Infect. 8(4), 1016-1024 (2006). • Demonstrates the potential of nasal vaccination with recombinant live attenuated bacteria expressing heterologous antigens.
    • Oliveira ML, Areas AP, Campos IB et al. Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A. Microbes Infect. 8(4), 1016-1024 (2006). • Demonstrates the potential of nasal vaccination with recombinant live attenuated bacteria expressing heterologous antigens.
  • 62
    • 0034730695 scopus 로고    scopus 로고
    • Improved protection against lung colonization by Actinobacillus pleuropneumoniae ghosts: Characterization of a genetically inactivated vaccine
    • Huter V, Hensel A, Brand E, Lubitz W. Improved protection against lung colonization by Actinobacillus pleuropneumoniae ghosts: characterization of a genetically inactivated vaccine. J. Biotechnol. 83(1-2), 161-172 (2000).
    • (2000) J. Biotechnol , vol.83 , Issue.1-2 , pp. 161-172
    • Huter, V.1    Hensel, A.2    Brand, E.3    Lubitz, W.4
  • 64
    • 31544467844 scopus 로고    scopus 로고
    • Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria
    • van Roosmalen ML, Kanninga R, El Khattabi M et al. Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria. Methods 38(2), 144-149 (2006).
    • (2006) Methods , vol.38 , Issue.2 , pp. 144-149
    • van Roosmalen, M.L.1    Kanninga, R.2    El Khattabi, M.3
  • 65
    • 33845209467 scopus 로고    scopus 로고
    • Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen
    • • Demonstrates the potential of spores expressing heterologous antigens
    • Duc le H, Hong HA, Atkins HS et al. Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen. Vaccine 25(2), 346-355 (2007). • Demonstrates the potential of spores expressing heterologous antigens.
    • (2007) Vaccine , vol.25 , Issue.2 , pp. 346-355
    • Duc le, H.1    Hong, H.A.2    Atkins, H.S.3
  • 66
    • 0042346025 scopus 로고    scopus 로고
    • Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara
    • Goonetilleke NP, McShane H, Hannan CM et al. Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara. J. Immunol. 171(3), 1602-1609 (2003).
    • (2003) J. Immunol , vol.171 , Issue.3 , pp. 1602-1609
    • Goonetilleke, N.P.1    McShane, H.2    Hannan, C.M.3
  • 67
    • 8444222278 scopus 로고    scopus 로고
    • Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis
    • Wang J, Thorson L, Stokes RW et al. Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis. J. Immunol. 173(10), 6357-6365 (2004).
    • (2004) J. Immunol , vol.173 , Issue.10 , pp. 6357-6365
    • Wang, J.1    Thorson, L.2    Stokes, R.W.3
  • 68
    • 33845730816 scopus 로고    scopus 로고
    • Uptake of microparticles into the epithelium of human nasopharyngeal lymphoid tissue
    • Fujimura Y, Akisada T, Harada T, Haruma K. Uptake of microparticles into the epithelium of human nasopharyngeal lymphoid tissue. Med. Mol. Morphol. 39(4), 181-186 (2006).
    • (2006) Med. Mol. Morphol , vol.39 , Issue.4 , pp. 181-186
    • Fujimura, Y.1    Akisada, T.2    Harada, T.3    Haruma, K.4
  • 69
    • 4444304990 scopus 로고    scopus 로고
    • Intranasal immunisation of mice with liposomes containing recombinant meningococcal OpaB and OpaJ proteins
    • de Jonge MI, Hamstra HJ, Jiskoot W et al. Intranasal immunisation of mice with liposomes containing recombinant meningococcal OpaB and OpaJ proteins. Vaccine 22(29-30), 4021-4028 (2004).
    • (2004) Vaccine , vol.22 , Issue.29-30 , pp. 4021-4028
    • de Jonge, M.I.1    Hamstra, H.J.2    Jiskoot, W.3
  • 70
    • 34248324878 scopus 로고    scopus 로고
    • Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin
    • Kang ML, Jiang HL, Kang SG et al. Pluronic F127 enhances the effect as an adjuvant of chitosan microspheres in the intranasal delivery of Bordetella bronchiseptica antigens containing dermonecrotoxin. Vaccine 25(23), 4602-4610 (2007).
    • (2007) Vaccine , vol.25 , Issue.23 , pp. 4602-4610
    • Kang, M.L.1    Jiang, H.L.2    Kang, S.G.3
  • 71
    • 33644789168 scopus 로고    scopus 로고
    • Baudner BC, Verhoef JC, Giuliani MM et al. Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform. J. Drug Target 13(8-9), 489-498 (2005). • Compares different adjuvants for nasal vaccination.
    • Baudner BC, Verhoef JC, Giuliani MM et al. Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform. J. Drug Target 13(8-9), 489-498 (2005). • Compares different adjuvants for nasal vaccination.
  • 72
    • 0037157246 scopus 로고    scopus 로고
    • A new intra-NALT route elicits mucosal and systemic immunity against Moraxella catarrhalis in a mouse challenge model
    • Hou Y, Hu WG, Hirano T, Gu XX. A new intra-NALT route elicits mucosal and systemic immunity against Moraxella catarrhalis in a mouse challenge model. Vaccine 20(17-18), 2375-2381 (2002).
    • (2002) Vaccine , vol.20 , Issue.17-18 , pp. 2375-2381
    • Hou, Y.1    Hu, W.G.2    Hirano, T.3    Gu, X.X.4
  • 73
    • 0035925682 scopus 로고    scopus 로고
    • Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers
    • Larbig M, Mansouri E, Freihorst J et al. Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. Vaccine 19(17-19), 2291-2297 (2001).
    • (2001) Vaccine , vol.19 , Issue.17-19 , pp. 2291-2297
    • Larbig, M.1    Mansouri, E.2    Freihorst, J.3
  • 74
    • 9244265539 scopus 로고    scopus 로고
    • Oral vaccination of BALB/c mice with Salmonella enterica serovar Typhimurium expressing Pseudomonas aeruginosa O antigen promotes increased survival in an acute fatal pneumonia model
    • DiGiandomenico A, Rao J, Goldberg JB. Oral vaccination of BALB/c mice with Salmonella enterica serovar Typhimurium expressing Pseudomonas aeruginosa O antigen promotes increased survival in an acute fatal pneumonia model. Infect. Immun. 72(12), 7012-7021 (2004).
    • (2004) Infect. Immun , vol.72 , Issue.12 , pp. 7012-7021
    • DiGiandomenico, A.1    Rao, J.2    Goldberg, J.B.3
  • 75
    • 0027934655 scopus 로고
    • Protection of immunosuppressed mice against translocation of Pseudomonas aeruginosa from the gut by oral immunization with recombinant Pseudomonas aeruginosa outer membrane protein I expressing Salmonella Dublin
    • Toth A, Schodel F, Duchene M et al. Protection of immunosuppressed mice against translocation of Pseudomonas aeruginosa from the gut by oral immunization with recombinant Pseudomonas aeruginosa outer membrane protein I expressing Salmonella Dublin. Vaccine 12(13), 1215-1221 (1994).
    • (1994) Vaccine , vol.12 , Issue.13 , pp. 1215-1221
    • Toth, A.1    Schodel, F.2    Duchene, M.3
  • 76
    • 46449130050 scopus 로고    scopus 로고
    • Analysis of Type II secretion of recombinant pneumococcal PspA and PspC in a Salmonella enterica serovar Typhimurium vaccine with regulated delayed antigen synthesis
    • Xin W, Wanda SY, Li Y et al. Analysis of Type II secretion of recombinant pneumococcal PspA and PspC in a Salmonella enterica serovar Typhimurium vaccine with regulated delayed antigen synthesis. Infect. Immun. 76(7), 3241-3254 (2008).
    • (2008) Infect. Immun , vol.76 , Issue.7 , pp. 3241-3254
    • Xin, W.1    Wanda, S.Y.2    Li, Y.3
  • 77
    • 36849008174 scopus 로고    scopus 로고
    • Rational design of Salmonella recombinant vaccines
    • Cheminay C, Hensel M. Rational design of Salmonella recombinant vaccines. Int. J. Med. Microbiol. 298(1-2), 87-98 (2008).
    • (2008) Int. J. Med. Microbiol , vol.298 , Issue.1-2 , pp. 87-98
    • Cheminay, C.1    Hensel, M.2
  • 78
    • 14744303986 scopus 로고    scopus 로고
    • Mucosal adjuvants
    • Freytag LC, Clements JD. Mucosal adjuvants. Vaccine 23(15), 1804-1813 (2005).
    • (2005) Vaccine , vol.23 , Issue.15 , pp. 1804-1813
    • Freytag, L.C.1    Clements, J.D.2
  • 79
    • 34548019707 scopus 로고    scopus 로고
    • Fraser CK, Diener KR, Brown MP, Hayball JD. Improving vaccines by incorporating immunological coadjuvants. Expert Rev. Vaccines 6(4), 559-578 (2007). •• Comprehensive review on adjuvants, including mucosal application.
    • Fraser CK, Diener KR, Brown MP, Hayball JD. Improving vaccines by incorporating immunological coadjuvants. Expert Rev. Vaccines 6(4), 559-578 (2007). •• Comprehensive review on adjuvants, including mucosal application.
  • 80
    • 33744974789 scopus 로고    scopus 로고
    • Intranasal vaccination of neonatal mice with polysaccharide conjugate vaccine for protection against pneumococcal otitis media
    • Sabirov A, Metzger DW. Intranasal vaccination of neonatal mice with polysaccharide conjugate vaccine for protection against pneumococcal otitis media. Vaccine 24(27-28), 5584-5592 (2006).
    • (2006) Vaccine , vol.24 , Issue.27-28 , pp. 5584-5592
    • Sabirov, A.1    Metzger, D.W.2
  • 81
    • 40049101622 scopus 로고    scopus 로고
    • Intranasal vaccination of infant mice induces protective immunity in the absence of nasal-associated lymphoid tissue
    • Sabirov A, Metzger DW. Intranasal vaccination of infant mice induces protective immunity in the absence of nasal-associated lymphoid tissue. Vaccine 26(12), 1566-1576 (2008).
    • (2008) Vaccine , vol.26 , Issue.12 , pp. 1566-1576
    • Sabirov, A.1    Metzger, D.W.2
  • 82
    • 0043246700 scopus 로고    scopus 로고
    • Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12
    • Lynch JM, Briles DE, Metzger DW. Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12. Infect. Immun. 71(8), 4780-4788 (2003).
    • (2003) Infect. Immun , vol.71 , Issue.8 , pp. 4780-4788
    • Lynch, J.M.1    Briles, D.E.2    Metzger, D.W.3
  • 83
    • 0030934988 scopus 로고    scopus 로고
    • Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae
    • One of the first studies to demonstrate superiority of nasal compared with systemic vaccination, •
    • Wu HY, Nahm MH, Guo Y, Russell MW, Briles DE. Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae. J. Infect. Dis. 175(4), 839-846 (1997). • One of the first studies to demonstrate superiority of nasal compared with systemic vaccination.
    • (1997) J. Infect. Dis , vol.175 , Issue.4 , pp. 839-846
    • Wu, H.Y.1    Nahm, M.H.2    Guo, Y.3    Russell, M.W.4    Briles, D.E.5
  • 84
    • 33947163349 scopus 로고    scopus 로고
    • Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice
    • Tanaka N, Fukuyama S, Fukuiwa T et al. Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine 25(14), 2680-2687 (2007).
    • (2007) Vaccine , vol.25 , Issue.14 , pp. 2680-2687
    • Tanaka, N.1    Fukuyama, S.2    Fukuiwa, T.3
  • 85
    • 33751188270 scopus 로고    scopus 로고
    • Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine
    • Hirano T, Jiao X, Chen Z, Van Waes C, Gu XX. Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine. Immunol. Lett. 107(2), 131-139 (2006).
    • (2006) Immunol. Lett , vol.107 , Issue.2 , pp. 131-139
    • Hirano, T.1    Jiao, X.2    Chen, Z.3    Van Waes, C.4    Gu, X.X.5
  • 86
    • 33645528950 scopus 로고    scopus 로고
    • Nasal vaccination with CpG oligodeoxynucleotide induces protective immunity against non-typeable Haemophilus influenzae in the nasopharynx
    • Abe N, Kodama S, Hirano T, Eto M, Suzuki M. Nasal vaccination with CpG oligodeoxynucleotide induces protective immunity against non-typeable Haemophilus influenzae in the nasopharynx. Laryngoscope 116(3), 407-412 (2006).
    • (2006) Laryngoscope , vol.116 , Issue.3 , pp. 407-412
    • Abe, N.1    Kodama, S.2    Hirano, T.3    Eto, M.4    Suzuki, M.5
  • 87
    • 19944430291 scopus 로고    scopus 로고
    • A recombinant P4 protein of Haemophilus influenzae induces specific immune responses biologically active against nasopharyngeal colonization in mice after intranasal immunization
    • Hotomi M, Ikeda Y, Suzumoto M et al. A recombinant P4 protein of Haemophilus influenzae induces specific immune responses biologically active against nasopharyngeal colonization in mice after intranasal immunization. Vaccine 23(10), 1294-1300 (2005).
    • (2005) Vaccine , vol.23 , Issue.10 , pp. 1294-1300
    • Hotomi, M.1    Ikeda, Y.2    Suzumoto, M.3
  • 88
    • 34548355236 scopus 로고    scopus 로고
    • Local application of CpG oligodeoxynucleotide enhances nontypeable Haemophilus influenzae-specific mucosal IgA responses in the middle ear
    • Kodama S, Hirano T, Abe N, Suzuki M. Local application of CpG oligodeoxynucleotide enhances nontypeable Haemophilus influenzae-specific mucosal IgA responses in the middle ear. Acta Otolaryngol. 127(8), 809-815 (2007).
    • (2007) Acta Otolaryngol , vol.127 , Issue.8 , pp. 809-815
    • Kodama, S.1    Hirano, T.2    Abe, N.3    Suzuki, M.4
  • 89
    • 4043093490 scopus 로고    scopus 로고
    • Reduction of nasal colonization of nontypeable Haemophilus influenzae following intranasal immunization with rLP4/rLP6/UspA2 proteins combined with aqueous formulation of RC529
    • Mason KW, Zhu D, Scheuer CA et al. Reduction of nasal colonization of nontypeable Haemophilus influenzae following intranasal immunization with rLP4/rLP6/UspA2 proteins combined with aqueous formulation of RC529. Vaccine 22(25-26), 3449-3456 (2004).
    • (2004) Vaccine , vol.22 , Issue.25-26 , pp. 3449-3456
    • Mason, K.W.1    Zhu, D.2    Scheuer, C.A.3
  • 90
    • 0036840446 scopus 로고    scopus 로고
    • Specific immune responses and enhancement of murine pulmonary clearance of Moraxella catarrhalis by intranasal immunization with a detoxified lipooligosaccharide conjugate vaccine
    • Jiao X, Hirano T, Hou Y, Gu XX. Specific immune responses and enhancement of murine pulmonary clearance of Moraxella catarrhalis by intranasal immunization with a detoxified lipooligosaccharide conjugate vaccine. Infect. Immun. 70(11), 5982-5989 (2002).
    • (2002) Infect. Immun , vol.70 , Issue.11 , pp. 5982-5989
    • Jiao, X.1    Hirano, T.2    Hou, Y.3    Gu, X.X.4
  • 91
    • 0020676237 scopus 로고
    • Specific immune response in the respiratory tract after administration of an oral polyvalent bacterial vaccine
    • Clancy RL, Cripps AW, Husband AJ, Buckley D. Specific immune response in the respiratory tract after administration of an oral polyvalent bacterial vaccine. Infect. Immun. 39(2), 491-496 (1983).
    • (1983) Infect. Immun , vol.39 , Issue.2 , pp. 491-496
    • Clancy, R.L.1    Cripps, A.W.2    Husband, A.J.3    Buckley, D.4
  • 92
    • 0026210902 scopus 로고
    • A controlled trial of a killed Haemophilus influenzae vaccine for prevention of acute exacerbations of chronic bronchitis
    • Tandon MK, Gebski V. A controlled trial of a killed Haemophilus influenzae vaccine for prevention of acute exacerbations of chronic bronchitis. Aust. NZ J. Med. 21(4), 427-432 (1991).
    • (1991) Aust. NZ J. Med , vol.21 , Issue.4 , pp. 427-432
    • Tandon, M.K.1    Gebski, V.2
  • 93
    • 33847148399 scopus 로고    scopus 로고
    • Oral purified bacterial extracts in acute respiratory tract infections in childhood: A systematic quantitative review
    • Steurer-Stey C, Lagler L, Straub DA, Steurer J, Bachmann LM. Oral purified bacterial extracts in acute respiratory tract infections in childhood: a systematic quantitative review. Eur. J. Pediatr. 166(4), 365-376 (2007).
    • (2007) Eur. J. Pediatr , vol.166 , Issue.4 , pp. 365-376
    • Steurer-Stey, C.1    Lagler, L.2    Straub, D.A.3    Steurer, J.4    Bachmann, L.M.5
  • 94
    • 33744789184 scopus 로고    scopus 로고
    • Intranasal immunization of mice with recombinant lipidated P2086 protein reduces nasal colonization of group B Neisseria meningitidis
    • Zhu D, Barniak V, Zhang Y, Green B, Zlotnick G. Intranasal immunization of mice with recombinant lipidated P2086 protein reduces nasal colonization of group B Neisseria meningitidis. Vaccine 24(26), 5420-5425 (2006).
    • (2006) Vaccine , vol.24 , Issue.26 , pp. 5420-5425
    • Zhu, D.1    Barniak, V.2    Zhang, Y.3    Green, B.4    Zlotnick, G.5
  • 95
    • 23344443129 scopus 로고    scopus 로고
    • Intranasal delivery of group B meningococcal native outer membrane vesicle vaccine induces local mucosal and serum bactericidal antibody responses in rabbits
    • Shoemaker DR, Saunders NB, Brandt BL et al. Intranasal delivery of group B meningococcal native outer membrane vesicle vaccine induces local mucosal and serum bactericidal antibody responses in rabbits. Infect. Immun. 73(8), 5031-5038 (2005).
    • (2005) Infect. Immun , vol.73 , Issue.8 , pp. 5031-5038
    • Shoemaker, D.R.1    Saunders, N.B.2    Brandt, B.L.3
  • 97
    • 3042681606 scopus 로고    scopus 로고
    • Mucosal vaccination against serogroup B meningococci: Induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin
    • Bowe F, Lavelle EC, McNeela EA et al. Mucosal vaccination against serogroup B meningococci: induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin. Infect. Immun. 72(7), 4052-4060 (2004).
    • (2004) Infect. Immun , vol.72 , Issue.7 , pp. 4052-4060
    • Bowe, F.1    Lavelle, E.C.2    McNeela, E.A.3
  • 98
    • 28444471597 scopus 로고    scopus 로고
    • Induction of protective serum meningococcal bactericidal and diphtherianeutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan
    • Huo Z, Sinha R, McNeela EA et al. Induction of protective serum meningococcal bactericidal and diphtherianeutralizing antibodies and mucosal immunoglobulin A in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan. Infect. Immun. 73(12), 8256-8265 (2005).
    • (2005) Infect. Immun , vol.73 , Issue.12 , pp. 8256-8265
    • Huo, Z.1    Sinha, R.2    McNeela, E.A.3
  • 99
    • 21544441180 scopus 로고    scopus 로고
    • Production of nontypeable Haemophilus influenzae HtrA by recombinant Bordetella pertussis with the use of filamentous hemagglutinin as a carrier
    • Alonso S, Willery E, Renauld-Mongenie G, Locht C. Production of nontypeable Haemophilus influenzae HtrA by recombinant Bordetella pertussis with the use of filamentous hemagglutinin as a carrier. Infect. Immun. 73(7), 4295-4301 (2005).
    • (2005) Infect. Immun , vol.73 , Issue.7 , pp. 4295-4301
    • Alonso, S.1    Willery, E.2    Renauld-Mongenie, G.3    Locht, C.4
  • 100
    • 0037381690 scopus 로고    scopus 로고
    • Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein
    • Lee SF, Halperin SA, Salloum DF, MacMillan A, Morris A. Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein. Infect. Immun. 71(4), 2272-2275 (2003).
    • (2003) Infect. Immun , vol.71 , Issue.4 , pp. 2272-2275
    • Lee, S.F.1    Halperin, S.A.2    Salloum, D.F.3    MacMillan, A.4    Morris, A.5
  • 101
    • 4143123345 scopus 로고    scopus 로고
    • Mucosal immunisation of murine neonates using whole cell and acellular pertussis vaccines
    • Hale C, Humphreys IR, Hussell T et al. Mucosal immunisation of murine neonates using whole cell and acellular pertussis vaccines. Vaccine 22(27-28), 3595-3602 (2004).
    • (2004) Vaccine , vol.22 , Issue.27-28 , pp. 3595-3602
    • Hale, C.1    Humphreys, I.R.2    Hussell, T.3
  • 102
    • 0033952739 scopus 로고    scopus 로고
    • A nasal whole-cell pertussis vaccine induces specific systemic and cross-reactive mucosal antibody responses in human volunteers
    • Berstad AK, Holst J, Froholm LO et al. A nasal whole-cell pertussis vaccine induces specific systemic and cross-reactive mucosal antibody responses in human volunteers. J. Med. Microbiol. 49(2), 157-163 (2000).
    • (2000) J. Med. Microbiol , vol.49 , Issue.2 , pp. 157-163
    • Berstad, A.K.1    Holst, J.2    Froholm, L.O.3
  • 103
    • 0037371506 scopus 로고    scopus 로고
    • Protection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutant
    • Priebe GP, Meluleni GJ, Coleman FT, Goldberg JB, Pier GB. Protection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutant. Infect. Immun. 71(3), 1453-1461 (2003).
    • (2003) Infect. Immun , vol.71 , Issue.3 , pp. 1453-1461
    • Priebe, G.P.1    Meluleni, G.J.2    Coleman, F.T.3    Goldberg, J.B.4    Pier, G.B.5
  • 104
    • 17344376679 scopus 로고    scopus 로고
    • Mucosal vaccination with a recombinant OprF-I vaccine of Pseudomonas aeruginosa in healthy volunteers: Comparison of a systemic vs. a mucosal booster schedule
    • Gocke K, Baumann U, Hagemann H et al. Mucosal vaccination with a recombinant OprF-I vaccine of Pseudomonas aeruginosa in healthy volunteers: comparison of a systemic vs. a mucosal booster schedule. FEMS Immunol. Med. Microbiol. 37(2-3), 167-171 (2003).
    • (2003) FEMS Immunol. Med. Microbiol , vol.37 , Issue.2-3 , pp. 167-171
    • Gocke, K.1    Baumann, U.2    Hagemann, H.3
  • 105
    • 27744517295 scopus 로고    scopus 로고
    • Recent findings in immunology give tuberculosis vaccines a new boost
    • Kaufmann SH. Recent findings in immunology give tuberculosis vaccines a new boost. Trends Immunol. 26(12), 660-667 (2005).
    • (2005) Trends Immunol , vol.26 , Issue.12 , pp. 660-667
    • Kaufmann, S.H.1
  • 106
    • 33646894153 scopus 로고    scopus 로고
    • Polymeric IgR knockout mice are more susceptible to mycobacterial infections in the respiratory tract than wild-type mice
    • Tjarnlund A, Rodriguez A, Cardona PJ et al. Polymeric IgR knockout mice are more susceptible to mycobacterial infections in the respiratory tract than wild-type mice. Int. Immunol. 18(5), 807-816 (2006).
    • (2006) Int. Immunol , vol.18 , Issue.5 , pp. 807-816
    • Tjarnlund, A.1    Rodriguez, A.2    Cardona, P.J.3
  • 107
    • 4644312486 scopus 로고    scopus 로고
    • A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab′) fragment prolong survival of mice infected with Mycobacterium tuberculosis
    • Hamasur B, Haile M, Pawlowski A et al. A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab′) fragment prolong survival of mice infected with Mycobacterium tuberculosis. Clin. Exp. Immunol. 138(1), 30-38 (2004).
    • (2004) Clin. Exp. Immunol , vol.138 , Issue.1 , pp. 30-38
    • Hamasur, B.1    Haile, M.2    Pawlowski, A.3
  • 109
    • 0348141905 scopus 로고    scopus 로고
    • Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared with subcutaneous vaccination against pulmonary tuberculosis
    • Chen L, Wang J, Zganiacz A, Xing Z. Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared with subcutaneous vaccination against pulmonary tuberculosis. Infect. Immun. 72(1), 238-246 (2004).
    • (2004) Infect. Immun , vol.72 , Issue.1 , pp. 238-246
    • Chen, L.1    Wang, J.2    Zganiacz, A.3    Xing, Z.4
  • 110
    • 33645219336 scopus 로고    scopus 로고
    • + T cells to nasal killed-bacillus Calmette-Guerin in mice
    • + T cells to nasal killed-bacillus Calmette-Guerin in mice. Vaccine 24(17), 3591-3598 (2006).
    • (2006) Vaccine , vol.24 , Issue.17 , pp. 3591-3598
    • Takahashi, H.1    Sasaki, K.2    Takahashi, M.3
  • 111
    • 20144387363 scopus 로고    scopus 로고
    • Nasal boost with adjuvanted heat-killed BCG or arabinomannan-protein conjugate improves primary BCG-induced protection in C57BL/6 mice
    • Haile M, Hamasur B, Jaxmar T et al. Nasal boost with adjuvanted heat-killed BCG or arabinomannan-protein conjugate improves primary BCG-induced protection in C57BL/6 mice. Tuberculosis (Edinb.) 85(1-2), 107-114 (2005).
    • (2005) Tuberculosis (Edinb.) , vol.85 , Issue.1-2 , pp. 107-114
    • Haile, M.1    Hamasur, B.2    Jaxmar, T.3
  • 112
    • 33746632535 scopus 로고    scopus 로고
    • Intranasal boosting with an adenovirus-vectored vaccine markedly enhances protection by parenteral Mycobacterium bovis BCG immunization against pulmonary tuberculosis
    • Santosuosso M, McCormick S, Zhang X, Zganiacz A, Xing Z. Intranasal boosting with an adenovirus-vectored vaccine markedly enhances protection by parenteral Mycobacterium bovis BCG immunization against pulmonary tuberculosis. Infect. Immun. 74(8), 4634-4643 (2006).
    • (2006) Infect. Immun , vol.74 , Issue.8 , pp. 4634-4643
    • Santosuosso, M.1    McCormick, S.2    Zhang, X.3    Zganiacz, A.4    Xing, Z.5
  • 113
    • 33750319222 scopus 로고    scopus 로고
    • Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity
    • One of a series of studies demonstrating improved protection with a nasal booster following BCG primary vaccination, •
    • Dietrich J, Andersen C, Rappuoli R et al. Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity. J. Immunol. 177(9), 6353-6360 (2006). • One of a series of studies demonstrating improved protection with a nasal booster following BCG primary vaccination.
    • (2006) J. Immunol , vol.177 , Issue.9 , pp. 6353-6360
    • Dietrich, J.1    Andersen, C.2    Rappuoli, R.3
  • 114
    • 0033023394 scopus 로고    scopus 로고
    • Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit
    • One of the few studies systematically assessing mucosal antibody induction following nasal and oral immunization, ••
    • Rudin A, Riise GC, Holmgren J. Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit. Infect. Immun. 67(6), 2884-2890 (1999). •• One of the few studies systematically assessing mucosal antibody induction following nasal and oral immunization.
    • (1999) Infect. Immun , vol.67 , Issue.6 , pp. 2884-2890
    • Rudin, A.1    Riise, G.C.2    Holmgren, J.3
  • 115
    • 34948813217 scopus 로고    scopus 로고
    • The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant
    • Ebensen T, Schulze K, Riese P, Morr M, Guzman CA. The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant. Clin. Vaccine Immunol. 14(8), 952-958 (2007).
    • (2007) Clin. Vaccine Immunol , vol.14 , Issue.8 , pp. 952-958
    • Ebensen, T.1    Schulze, K.2    Riese, P.3    Morr, M.4    Guzman, C.A.5
  • 116
    • 2142704355 scopus 로고    scopus 로고
    • Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infections
    • Hall MA, Stroop SD, Hu MC et al. Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infections. Infect. Immun. 72(5), 2507-2512 (2004).
    • (2004) Infect. Immun , vol.72 , Issue.5 , pp. 2507-2512
    • Hall, M.A.1    Stroop, S.D.2    Hu, M.C.3
  • 117
    • 34147127485 scopus 로고    scopus 로고
    • Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis in an experimental murine model
    • Becker PD, Bertot GM, Souss D et al. Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis in an experimental murine model. Infect. Immun. 75(4), 1778-1784 (2007).
    • (2007) Infect. Immun , vol.75 , Issue.4 , pp. 1778-1784
    • Becker, P.D.1    Bertot, G.M.2    Souss, D.3
  • 118
    • 34848874475 scopus 로고    scopus 로고
    • A pegylated derivative of a-galactosylceramide exhibits improved biological properties
    • Ebensen T, Link C, Riese P et al. A pegylated derivative of a-galactosylceramide exhibits improved biological properties. J. Immunol. 179(4), 2065-2073 (2007).
    • (2007) J. Immunol , vol.179 , Issue.4 , pp. 2065-2073
    • Ebensen, T.1    Link, C.2    Riese, P.3
  • 119
    • 33846055330 scopus 로고    scopus 로고
    • The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties
    • Ebensen T, Schulze K, Riese P et al. The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties. Vaccine 25(8), 1464-1469 (2007).
    • (2007) Vaccine , vol.25 , Issue.8 , pp. 1464-1469
    • Ebensen, T.1    Schulze, K.2    Riese, P.3
  • 120
    • 1642272442 scopus 로고    scopus 로고
    • The Toll-like receptor ligand MALP-2 stimulates dendritic cell maturation and modulates proteasome composition and activity
    • Link C, Gavioli R, Ebensen T et al. The Toll-like receptor ligand MALP-2 stimulates dendritic cell maturation and modulates proteasome composition and activity. Eur. J. Immunol. 34(3), 899-907 (2004).
    • (2004) Eur. J. Immunol , vol.34 , Issue.3 , pp. 899-907
    • Link, C.1    Gavioli, R.2    Ebensen, T.3
  • 121
    • 0035925682 scopus 로고    scopus 로고
    • Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers
    • Larbig M, Mansouri E, Freihorst J et al. Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. Vaccine 19(17-19), 2291-2297 (2001).
    • (2001) Vaccine , vol.19 , Issue.17-19 , pp. 2291-2297
    • Larbig, M.1    Mansouri, E.2    Freihorst, J.3
  • 122
    • 33744825193 scopus 로고    scopus 로고
    • Lactococcus lactis GEM particles displaying pneumococcal antigens induce local and systemic immune responses following intranasal immunization
    • Audouy SA, van Roosmalen ML, Neef J et al. Lactococcus lactis GEM particles displaying pneumococcal antigens induce local and systemic immune responses following intranasal immunization. Vaccine 24(26), 5434-5441 (2006).
    • (2006) Vaccine , vol.24 , Issue.26 , pp. 5434-5441
    • Audouy, S.A.1    van Roosmalen, M.L.2    Neef, J.3
  • 123
    • 0034924220 scopus 로고    scopus 로고
    • Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci
    • Malley R, Lipsitch M, Stack A et al. Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci. Infect. Immun. 69(8), 4870-4873 (2001).
    • (2001) Infect. Immun , vol.69 , Issue.8 , pp. 4870-4873
    • Malley, R.1    Lipsitch, M.2    Stack, A.3
  • 124
    • 33845989506 scopus 로고    scopus 로고
    • The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis
    • Andersen CS, Dietrich J, Agger EM et al. The combined CTA1-DD/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis. Infect. Immun. 75(1), 408-416 (2007).
    • (2007) Infect. Immun , vol.75 , Issue.1 , pp. 408-416
    • Andersen, C.S.1    Dietrich, J.2    Agger, E.M.3
  • 125
    • 33846786635 scopus 로고    scopus 로고
    • Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants
    • Nawar HF, Arce S, Russell MW, Connell TD. Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants. Infect. Immun. 75(2), 621-633 (2007).
    • (2007) Infect. Immun , vol.75 , Issue.2 , pp. 621-633
    • Nawar, H.F.1    Arce, S.2    Russell, M.W.3    Connell, T.D.4
  • 126
    • 0043246700 scopus 로고    scopus 로고
    • Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12
    • Lynch JM, Briles DE, Metzger DW. Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12. Infect. Immun. 71(8), 4780-4788 (2003).
    • (2003) Infect. Immun , vol.71 , Issue.8 , pp. 4780-4788
    • Lynch, J.M.1    Briles, D.E.2    Metzger, D.W.3
  • 127
    • 8444222278 scopus 로고    scopus 로고
    • Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis
    • Wang J, Thorson L, Stokes RW et al. Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis. J. Immunol. 173(10), 6357-6365 (2004).
    • (2004) J. Immunol , vol.173 , Issue.10 , pp. 6357-6365
    • Wang, J.1    Thorson, L.2    Stokes, R.W.3
  • 128
    • 33847655124 scopus 로고    scopus 로고
    • Development of lactococcal GEM-based pneumococcal vaccines
    • Audouy SA, van Selm S, van Roosmalen ML et al. Development of lactococcal GEM-based pneumococcal vaccines. Vaccine 25(13), 2497-2506 (2007).
    • (2007) Vaccine , vol.25 , Issue.13 , pp. 2497-2506
    • Audouy, S.A.1    van Selm, S.2    van Roosmalen, M.L.3
  • 129
    • 0033984377 scopus 로고    scopus 로고
    • Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae
    • Briles DE, Ades E, Paton JC et al. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect. Immun. 68(2), 796-800 (2000).
    • (2000) Infect. Immun , vol.68 , Issue.2 , pp. 796-800
    • Briles, D.E.1    Ades, E.2    Paton, J.C.3
  • 130
    • 3543037586 scopus 로고    scopus 로고
    • Expression and characterization of cholera toxin B-pneumococcal surface adhesin A fusion protein in Escherichia coli: Ability of CTB-PsaA to induce humoral immune response in mice
    • Areas AP, Oliveira ML, Miyaji EN et al. Expression and characterization of cholera toxin B-pneumococcal surface adhesin A fusion protein in Escherichia coli: ability of CTB-PsaA to induce humoral immune response in mice. Biochem. Biophys. Res. Commun. 321(1), 192-196 (2004).
    • (2004) Biochem. Biophys. Res. Commun , vol.321 , Issue.1 , pp. 192-196
    • Areas, A.P.1    Oliveira, M.L.2    Miyaji, E.N.3
  • 131
    • 33746632534 scopus 로고    scopus 로고
    • Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice
    • Pimenta FC, Miyaji EN, Areas AP et al. Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice. Infect. Immun. 74(8), 4939-4944 (2006).
    • (2006) Infect. Immun , vol.74 , Issue.8 , pp. 4939-4944
    • Pimenta, F.C.1    Miyaji, E.N.2    Areas, A.P.3
  • 132
    • 0036176042 scopus 로고    scopus 로고
    • Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin a encapsulated in microspheres
    • Seo JY, Seong SY, Ahn BY et al. Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin a encapsulated in microspheres. Infect. Immun. 70(3), 1143-1149 (2002).
    • (2002) Infect. Immun , vol.70 , Issue.3 , pp. 1143-1149
    • Seo, J.Y.1    Seong, S.Y.2    Ahn, B.Y.3
  • 133
    • 0036716434 scopus 로고    scopus 로고
    • Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles
    • Baudner BC, Balland O, Giuliani MM et al. Enhancement of protective efficacy following intranasal immunization with vaccine plus a nontoxic LTK63 mutant delivered with nanoparticles. Infect. Immun. 70(9), 4785-4790 (2002).
    • (2002) Infect. Immun , vol.70 , Issue.9 , pp. 4785-4790
    • Baudner, B.C.1    Balland, O.2    Giuliani, M.M.3
  • 134
    • 3843066751 scopus 로고    scopus 로고
    • Recombinant cholera toxin B subunit (rCTB) as a mucosal adjuvant enhances induction of diphtheria and tetanus antitoxin antibodies in mice by intranasal administration with diphtheria-pertussis-tetanus (DPT) combination vaccine
    • Isaka M, Komiya T, Takahashi M et al. Recombinant cholera toxin B subunit (rCTB) as a mucosal adjuvant enhances induction of diphtheria and tetanus antitoxin antibodies in mice by intranasal administration with diphtheria-pertussis-tetanus (DPT) combination vaccine. Vaccine 22(23-24), 3061-3068 (2004).
    • (2004) Vaccine , vol.22 , Issue.23-24 , pp. 3061-3068
    • Isaka, M.1    Komiya, T.2    Takahashi, M.3
  • 135
    • 0032374351 scopus 로고    scopus 로고
    • Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice
    • Jabbal-Gill I, Fisher AN, Rappuoli R, Davis SS, Illum L. Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice. Vaccine 16(20), 2039-2046 (1998).
    • (1998) Vaccine , vol.16 , Issue.20 , pp. 2039-2046
    • Jabbal-Gill, I.1    Fisher, A.N.2    Rappuoli, R.3    Davis, S.S.4    Illum, L.5
  • 136
    • 0026674953 scopus 로고
    • Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit
    • Walker MJ, Rohde M, Timmis KN, Guzman CA. Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit. Infect. Immun. 60(10), 4260-4268 (1992).
    • (1992) Infect. Immun , vol.60 , Issue.10 , pp. 4260-4268
    • Walker, M.J.1    Rohde, M.2    Timmis, K.N.3    Guzman, C.A.4
  • 137
    • 33745112513 scopus 로고    scopus 로고
    • Antibody responses induced by long-term vaccination with an octovalent conjugate Pseudomonas aeruginosa vaccine in children with cystic fibrosis
    • Zuercher AW, Horn MP, Que JU et al. Antibody responses induced by long-term vaccination with an octovalent conjugate Pseudomonas aeruginosa vaccine in children with cystic fibrosis. FEMS Immunol. Med. Microbiol. 47(2), 302-308 (2006).
    • (2006) FEMS Immunol. Med. Microbiol , vol.47 , Issue.2 , pp. 302-308
    • Zuercher, A.W.1    Horn, M.P.2    Que, J.U.3
  • 138
    • 0038771232 scopus 로고    scopus 로고
    • Immunisation with non-integral OMPs promotes pulmonary clearance of Pseudomonas aeruginosa
    • Thomas LD, Kyd JM, Bastin DA, Dunkley ML, Cripps AW. Immunisation with non-integral OMPs promotes pulmonary clearance of Pseudomonas aeruginosa. FEMS Immunol. Med. Microbiol. 37(2-3), 155-160 (2003).
    • (2003) FEMS Immunol. Med. Microbiol , vol.37 , Issue.2-3 , pp. 155-160
    • Thomas, L.D.1    Kyd, J.M.2    Bastin, D.A.3    Dunkley, M.L.4    Cripps, A.W.5
  • 139
    • 0027970037 scopus 로고
    • Pulmonary immunity to Pseudomonas aeruginosa in intestinally immunized rats roles of alveolar macrophages, tumor necrosis factor a, and interleukin-1 a
    • Buret A, Dunkley ML, Pang G, Clancy RL, Cripps AW. Pulmonary immunity to Pseudomonas aeruginosa in intestinally immunized rats roles of alveolar macrophages, tumor necrosis factor a, and interleukin-1 a. Infect. Immun. 62(12), 5335-5343 (1994).
    • (1994) Infect. Immun , vol.62 , Issue.12 , pp. 5335-5343
    • Buret, A.1    Dunkley, M.L.2    Pang, G.3    Clancy, R.L.4    Cripps, A.W.5
  • 140
    • 0026600219 scopus 로고
    • Intranasal immunization with bacterial polysaccharide containing liposomes enhances antigen-specific pulmonary secretory antibody response
    • Abraham E. Intranasal immunization with bacterial polysaccharide containing liposomes enhances antigen-specific pulmonary secretory antibody response. Vaccine 10(7), 461-468 (1992).
    • (1992) Vaccine , vol.10 , Issue.7 , pp. 461-468
    • Abraham, E.1
  • 141
    • 33646447036 scopus 로고    scopus 로고
    • Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers
    • Stephenson I, Zambon MC, Rudin A et al. Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers. J. Virol. 80(10), 4962-4970 (2006).
    • (2006) J. Virol , vol.80 , Issue.10 , pp. 4962-4970
    • Stephenson, I.1    Zambon, M.C.2    Rudin, A.3
  • 142
    • 33645079448 scopus 로고    scopus 로고
    • Phase I, randomized, controlled trial to study the reactogenicity and immunogenicity of a nasal, inactivated trivalent influenza virus vaccine in healthy adults
    • Halperin SA, Smith B, Clarke K et al. Phase I, randomized, controlled trial to study the reactogenicity and immunogenicity of a nasal, inactivated trivalent influenza virus vaccine in healthy adults. Hum. Vaccin. 1(1), 37-42 (2005).
    • (2005) Hum. Vaccin , vol.1 , Issue.1 , pp. 37-42
    • Halperin, S.A.1    Smith, B.2    Clarke, K.3
  • 143
    • 32544440903 scopus 로고    scopus 로고
    • Safety and immunogenicity of a proteosome-trivalent inactivated influenza vaccine, given nasally to healthy adults
    • Langley JM, Halperin SA, McNeil S et al. Safety and immunogenicity of a proteosome-trivalent inactivated influenza vaccine, given nasally to healthy adults. Vaccine 24(10), 1601-1608 (2006).
    • (2006) Vaccine , vol.24 , Issue.10 , pp. 1601-1608
    • Langley, J.M.1    Halperin, S.A.2    McNeil, S.3
  • 144
    • 29044438039 scopus 로고    scopus 로고
    • Intranasal administration of a proteosome-influenza vaccine is well-tolerated and induces serum and nasal secretion influenza antibodies in healthy human subjects
    • Treanor J, Nolan C, O'Brien D et al. Intranasal administration of a proteosome-influenza vaccine is well-tolerated and induces serum and nasal secretion influenza antibodies in healthy human subjects. Vaccine 24(3), 254-262 (2006).
    • (2006) Vaccine , vol.24 , Issue.3 , pp. 254-262
    • Treanor, J.1    Nolan, C.2    O'Brien, D.3
  • 145
    • 0034967546 scopus 로고    scopus 로고
    • Safety and immunogenicity of a proteosome-Shigella flexneri 2a lipopolysaccharide vaccine administered intranasally to healthy adults
    • Fries LF, Montemarano AD, Mallett CP et al. Safety and immunogenicity of a proteosome-Shigella flexneri 2a lipopolysaccharide vaccine administered intranasally to healthy adults. Infect. Immun. 69(7), 4545-4553 (2001).
    • (2001) Infect. Immun , vol.69 , Issue.7 , pp. 4545-4553
    • Fries, L.F.1    Montemarano, A.D.2    Mallett, C.P.3
  • 146
    • 11144258882 scopus 로고    scopus 로고
    • Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans
    • Van Kampen KR, Shi Z, Gao P et al. Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans. Vaccine 23(8), 1029-1036 (2005).
    • (2005) Vaccine , vol.23 , Issue.8 , pp. 1029-1036
    • Van Kampen, K.R.1    Shi, Z.2    Gao, P.3
  • 147
    • 1242270653 scopus 로고    scopus 로고
    • Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: Enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan
    • McNeela EA, Jabbal-Gill I, Illum L et al. Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan. Vaccine 22(8), 909-914 (2004).
    • (2004) Vaccine , vol.22 , Issue.8 , pp. 909-914
    • McNeela, E.A.1    Jabbal-Gill, I.2    Illum, L.3
  • 148
    • 53849100268 scopus 로고    scopus 로고
    • WHO. 2004 global immunization data www.who.int/immunization_monitoring/ data/globalimmunizationdata.pdf
    • WHO. 2004 global immunization data www.who.int/immunization_monitoring/ data/globalimmunizationdata.pdf


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.