Bronchial response pattern of antigen presenting cells and regulatory T cells in children less than 2 years of age

Thorax

Volumn 63, Issue 8, 2008, Pages 703-709

  Heier, I ^a   Malmstrom K ^b   Pelkonen, A S ^b   Malmberg, L P ^b   Kajosaari, M ^c   Turpeinen, M ^b   Lindahl, H ^c   Brandtzaeg, P ^a   Jahnsen, F L ^a,d   Makela M J ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; HLA DR ANTIGEN; T6 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ANTIGEN PRESENTING CELL; ARTICLE; ASTHMA; ATOPY; BRONCHUS ASSOCIATED LYMPHOID TISSUE; BRONCHUS BIOPSY; BRONCHUS REACTIVITY; CELL TYPE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CLINICAL FEATURE; DENDRITIC CELL; FEMALE; HUMAN; HUMAN RHINOVIRUS; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INFANT; LOWER RESPIRATORY TRACT; LUNG FUNCTION; LYMPH FOLLICLE; MALE; PLASMA CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFECTION; T LYMPHOCYTE SUBPOPULATION;

EID: 49149092490     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2007.082974     Document Type: Article

References (44)

1. Holt PG, Upham JW, Sly PD. Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies. J Allergy Clin Immunol 2005;116:16-24.
2. Marchant A, Goldman M. T cell-mediated immune responses in human newborns: ready to learn? Clin Exp Immunol 2005;141:10-18.
3. Holt PG. Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period. Environ Health Perspect 1998;106(Suppl 3):795-800.
4. Upham JW, Lee PT, Holt BJ, et al. Development of interleukin-12-producing capacity throughout childhood. Infect Immun 2002;70:6583-8.
5. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
6. Hunt DW, Huppertz HI, Jiang HJ, et al. Studies of human cord blood dendritic cells: evidence for functional immaturity. Blood 1994;84:4333-43.
7. Jahnsen FL, Gran E, Haye R, et al. Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. Am J Respir Cell Mol Biol 2004;30:31-7.
8. Holt PG, Haining S, Nelson DJ, et al. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol 1994;153:256-61.
9. Holt PG, Stumbles PA, McWilliam AS. Functional studies on dendritic cells in the respiratory tract and related mucosal tissues. J Leukoc Biol 1999;66:272-5.
10. Nelson DJ, Holt PG. Defective regional immunity in the respiratory tract of neonates is attributable to hyporesponsiveness of local dendritic cells to activation signals. J Immunol 1995;155:3517-24.
11. Kvale EO, Floisand Y, Lund-Johansen F, et al. Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells. Blood 2007;109:3369-76.
12. Ito T, Yang M, Wang YH, et al. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med 2007;204:105-15.
13. Borras FE, Matthews NC, Lowdell MW, et al. Identification of both myeloid CD11c+ and lymphoid CD11c- dendritic cell subsets in cord blood. Br J Haematol 2001;113:925-31.
14. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-62.
15. Sakaguchi S, Ono M, Setoguchi R, et al. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27.
16. Umetsu DT, DeKruyff RH. The regulation of allergy and asthma. Immunol Rev 2006;212:238-55.
17. Michaelsson J, Mold JE, McCune JM, et al. Regulation of T cell responses in the developing human fetus. J Immunol 2006;176:5741-8.
18. Saglani S, Malmstrom K, Pelkonen AS, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005;171:722-7.
19. Lindahl H, Rintala R, Malinen L, et al. Bronchoscopy during the first month of life. J Pediatr Surg 1992;27:548-50.
20. Malmstrom K, Pitkaranta A, Carpen O, et al. Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. J Allergy Clin Immunol 2006;118:591-6.
21. Soler P, Moreau A, Basset F, et al. Cigarette smoking-induced changes in the number and differentiated state of pulmonary dendritic cells/Langerhans cells. Am Rev Respir Dis 1989;139:1112- 17.
22. Moller GM, Overbeek SE, Van Helden-Meeuwsen CG, et al. Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin Exp Allergy 1996;26:517-24.
23. Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-{beta} dependent but does not confer a regulatory phenotype. Blood 2007;110:2983-90.
24. Pillai V, Karandikar NJ. Attack on the clones? Human FOXP3 detection by PCH101, 236A/E7, 206D, and 259D reveals 259D as the outlier with lower sensitivity. Blood 2008;111:463-4.
25. Tschernig T, Debertin AS, Paulsen F, et al. Dendritic cells in the mucosa of the human trachea are not regularly found in the first year of life. Thorax 2001;56:427-31.
26. Tschernig T, De Vries VC, Debertin AS, et al. Density of dendritic cells in the human tracheal mucosa is age dependent and site specific. Thorax 2006;61:986-91.
27. Debertin AS, Tschernig T, Schurmann A, et al. Coincidence of different structures of mucosa-associated lymphoid tissue (MALT) in the respiratory tract of children: no indications for enhanced mucosal immunostimulation in sudden infant death syndrome (SIDS). Clin Exp Immunol 2006;146:54-9.
28. Hiller AS, Kracke A, Tschernig T, et al. Comparison of the immunohistology of mucosa-associated lymphoid tissue in the larynx and lungs in cases of sudden infant death and controls. Int J Legal Med 1997;110:316-22.
29. Pabst R. Is BALT a major component of the human lung immune system? Immunol Today 1992;13:119-22.
30. Hiller AS, Tschernig T, Kleemann WJ, et al. Bronchus-associated lymphoid tissue (BALT) and larynx-associated lymphoid tissue (LALT) are found at different frequencies in children, adolescents and adults. Scand J Immunol 1998;47:159-62.
31. Sue-Chu M, Karjalainen E, Altraja A, et al. Lymphoid aggregates in endobronchial biopsies from young elite cross-country skiers. Am J Respir Crit Care Med 1998;158:597-601.
32. Tschernig T, Pabst R. Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases. Pathobiology 2000;68:1-8.
33. Tschernig T, Kleemann WJ, Pabst R. Bronchus-associated lymphoid tissue (BALT) in the lungs of children who had died from sudden infant death syndrome and other causes. Thorax 1995;50:658-60.
34. Moyron-Quiroz JE, Rangel-Moreno J, Kusser K, et al. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med 2004;10:927-34.
35. Rangel-Moreno J, Hartson L, Navarro C, et al. Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest 2006;116: 3183-94.
36. Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005;23:275-306.
37. de Heer HJ, Hammad H, Soullie T, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004;200:89-98.
38. Moseman EA, Liang X, Dawson AJ, et al. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol 2004;173:4433-42.
39. Gilliet M, Liu YJ. Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum Immunol 2002;63:1149-55.
40. Jahnsen FL, Strickland DH, Thomas JA, et al. Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus. J Immunol 2006;177:5861-7.
41. Chieppa M, Rescigno M, Huang AYC, et al. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 2006;203:2841-52.
42. Rescigno M, Urbano M, Valzasina B, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001;2:361-7.
43. Steinman RM, Hawiger D, Liu K, et al. Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann N Y Acad Sci 2003;987:15-25.
44. Martinez FD. Development of wheezing disorders and asthma in preschool children 1. Pediatrics 2002;109:362-7.