Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit

Infection and Immunity

Volumn 67, Issue 6, 1999, Pages 2884-2890

  Rudin, Anna ^a   Riise, Gerdt C ^a   Holmgren, Jan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN B SUBUNIT; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ADHERENCE; CLINICAL ARTICLE; HUMAN; INTRANASAL DRUG ADMINISTRATION; LOWER RESPIRATORY TRACT; LUNG LAVAGE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; UPPER RESPIRATORY TRACT; URINALYSIS; UROGENITAL SYSTEM; VACCINATION;

EID: 0033023394     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.6.2884-2890.1999     Document Type: Article

References (38)

1. Abitorabi, M. A., C. R. Mackay, E. H. Jerome, O. Osorio, E. C. Butcher, and D. J. Erle. 1996. Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph. J. Immunol. 156: 3111-3117.
2. Banks, D. E., J. E. Morgan, R. D. Deshazo, D. Weissman, F. H. Rodriguez, H. W. Barkman, and J. E. Salvaggio. 1990. Reliability of cell counts and protein determinations in serial bronchoalveolar lavage procedures performed on healthy volunteers. Am. J. Med. Sci. 300:275-282.
3. Belshe, R. B., P. M. Mendelman, J. Treanor, J. King, W. C. Gruber, P. Piedra, D. I. Bernstein, F. G. Hayden, K. Kotloff, K. Zangwill, D. Iacuzio, and M. Wolff. 1998. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children. N. Engl. J. Med. 338:1405-1412.
4. Bergquist, C., E.-L. Johansson, T. Lagergård, J. Holmgren, and A. Rudin. 1997. Intranasal vaccinatino of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina. Infect. Immun. 65:2676-2684.
5. Bergquist, C., T. Lagergård, M. Lindblad, and J. Holmgren. 1995. Local and systemic responses to dextran-cholera toxin B subunit conjugates. Infect. Immun. 63:2021-2025.
6. Craig, S. W., and J. J. Cebra. 1975. Rabbit Peyer's patches, appendix, and popliteal lymph node B lymphocytes: a comparative analysis of their membrane immunoglobulin components and plasma cell precursor potential. J. Immunol. 114:492-502.
7. Cripps, A. W., M. L. Dunkley, and R. L. Clancy. 1994. Mucosal and systemic immunizations with killed Pseudomonas aeruginosa protect against acute respiratory infection in rats. Infect. Immun. 62:1427-1436.
8. Czerkinsky, C., L. Å. Nilsson, H. Nygren, Ö. Ouchterlony, and A. Tarkowski. 1983. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J. Immunol. Methods 65:109-121.
9. Daniele, R. P. 1990. Immunoglobulin secretion in the airways. Annu. Rev. Physiol. 52:177-195.
10. Garlepp, M. J., A. H. Rose, R. V. Bowman, N. Mavaddat, J. Dench, B. J. Holt, M. Baron-Hay, P. G. Holt, and B. W. S. Robinson. 1992. A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals. Immunology 77:31-37.
11. Hachen, H. J. 1992. Oral immunotherapy in paraplegic patients with chronic urinary tract infections: a double-blind, placebocontrolled trial. J. Urol. 143:759-763.
12. Hiller, A. S., T. Tschernig, W. J. Kleemann, and R. Pabst. 1998. Bronchus-associated lymphoid tissue (BALT) and larynx-associated lymphoid tissue (LALT) are found in different frequencies in children, adolescents and adults. Scand. J. Immunol. 47:159-162.
13. Holmgren, J., C. Czerkinsky, N. Lycke, and A.-M. Svennerholm. 1994. Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen carrier and adjuvant. Am. J. Trop. Med. Hyg. 50(Suppl.):42-54.
14. Holmgren, J. 1981. Actions of cholera toxin and the prevention and treatment of cholera. Nature 292:413-417.
15. Jertborn, M., A.-M. Svennerholm, and J. Holmgren. 1994. Immunological memory after immunization with oral cholera B subunit-whole-cell vaccine in Swedish volunteers. Vaccine 12:1078-1081.
16. Joel, D. D., and A. D. Chanana. 1985. Comparison of pulmonary and intestinal lymphocyte migration patterns in sheep. Ann. N. Y. Acad. Sci. 459:56-66.
17. Johansson, E.-L., C. Rask, M. Fredriksson, K. Eriksson, C. Czerkinsky, and J. Holmgren. 1998. Antibodies and antibody-secreting cells in the female genital tract after vaginal and intranasal immunization with cholera toxin B subunit or conjugates. Infect. Immun. 66:514-520.
18. Kaltreider, H. B., P. K. Byrd, T. W. Daughety, and M. R. Shalaby. 1983. The mechanism of appearance of specific antibody-forming cells in lungs of inbred mice after intratracheal immunization with sheep erythrocytes. Am. Rev. Respir. Dis. 127:316-321.
19. Mattsby-Baltzer, I., L.-A. Hanson, S. Olling, and B. Kaijser. 1982. Experimental Escherichia coli ascending pyelonephritis in rats: active peroral immunization with live Escherichia coli. Infect. Immun. 35:647-653.
20. Mattsson, A., H. Lönroth, M. Quiding-Järbrink, and A.-M. Svennerholm. 1998. Induction of B-cell responses in the stomach of Helicobacter pylori-infected subjects after oral cholera vaccination. J. Clin. Investig. 102:51-56.
21. McWilliam, A. S., A. M. Marsh, and P. G. Holt. 1997. Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells. J. Virol. 71:226-236.
22. Mestecky, J. 1987. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7:265-276.
23. Pierce, N. F., and W. C. Cray, Jr. 1981. Cellular dissemination of priming for a mucosal immune response to cholera toxin in rats. J. Immunol. 127:2461-2464.
24. Polly, S. M., R. H. Waldman, P. High, M. K. Winner, A. Dorfman, and E. N. Fox. 1975. Protective studies with a group A streptococcal M protein vaccine. II. Challenge of volunteers after local immunization in the upper respiratory tract. J. Infect. Dis. 131:217-224.
25. Prince, G. A., R. L. Horswood, and R. M. Chanock. 1985. Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats. J. Virol. 55:517-520.
26. Pudney, J., and D. J. Anderson. 1995. Immunobiology of the human penile urethra. Am. J. Pathol. 147:155-165.
27. Quiding-Järbrink, M., G. Granström. I. Nordström, J. Holmgren, and C. Czerkinsky. 1995. Induction of compartmentalized B-cell responses in human tonsils. Infect. Immun. 63:853-857.
28. Rankin, J. A., G. P. Naefel, C. E. Schrader, R. A. Matthay, and H. Y. Reynolds. 1983. Air-space immunoglobulin production and levels in bronchoalveolar lavage fluid of normal subjects and patients with sarcoidosis. Am. Rev. Respir. Dis. 127:442-448.
29. Rudin, A., E.-L. Johansson, C. Bergquist, and J. Holmgren. 1998. Differential kinetics and distribution of antibodies in serum, and nasal and vaginal secretions after nasal and oral vaccination of humans. Infect. Immun. 66: 3390-3396.
30. Russell, M. W., Z. Moldoveanu, P. L. White, G. J. Silbert, J. Mestecky, and S. Michalek. 1996. Salivary, nasal, genital and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1272-1283.
31. Sanchez, J., and J. Holmgren. 1989. Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development. Proc. Natl. Acad. Sci. USA 86:481-486.
32. Schuyler, M., C. R. Lyons, B. Masten, and D. Bice. 1997. Immunoglobulin response to intrapulmonary immunization of asthmatics. Immunology 91: 167-175.
33. Svanborg-Eden, C., and A.-M. Svennerholm. 1978. Secretory immunoglobulin A and G antibodies prevent adhesion of Escherichia coli to human urinary tract epithelial cells. Infect. Immun. 22:790-797.
34. Svennerholm, A.-M., and J. Holmgren. 1978. Identification of Escherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure. Curr. Microbiol. 1:19-23.
35. Thepen, T., C. McMenamin, J. Oliver, G. Kraal, and P. G. Holt. 1991. Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs immunity. Eur. J. Immunol. 21:2845-2850.
36. Waldman, R. H., P. F. Jurgensen, G. N. Olsen, R. Ganguly, and J. E. Johnson. 1973. Immune response of the human respiratory tract. I. Immunoglobulin levels and influenza virus vaccine antibody response. J. Immunol. 111:38-41.
37. Weisz-Carrington, P., S. R. Grimes, and M. E. Lamm. 1987. Gut-associated lymphoid tissue as source of an IgA immune response in the respiratory tract after oral immunization and intrabronchial challenge. Cell. Immunol. 106: 132-138.
38. Williams, R. C., and R. J. Gibbons. 1972. Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal. Science 177:697-699.