A recombinant P4 protein of Haemophilus influenzae induces specific immune responses biologically active against nasopharyngeal colonization in mice after intranasal immunization

Vaccine

Volumn 23, Issue 10, 2005, Pages 1294-1300

  Hotomi, Muneki ^a   Ikeda, Yorihiko ^a   Suzumoto, Masaki ^a   Yamauchi, Kazuma ^a   Green, Bruce A ^b   Zlotnick, Gary ^b   Billal, Dewan S ^a   Shimada, Jun ^a   Fujihara, Keiji ^a   Yamanaka, Noboru ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b PFIZER INC   (United States)

Author keywords

Intranasal immunization; Nontypeable Haemophilus influenzae; Outer membrane protein; P4; P6

Indexed keywords

CHOLERA TOXIN; IMMUNOGLOBULIN A ANTIBODY; OUTER MEMBRANE PROTEIN; RECOMBINANT P4 PROTEIN; RECOMBINANT P6 PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; HAEMOPHILUS INFLUENZAE; IMMUNE RESPONSE; IMMUNIZATION; MALE; MOUSE; MUCOSAL IMMUNITY; NASOPHARYNX; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; BACTERIAL OUTER MEMBRANE PROTEINS; BLOOD BACTERICIDAL ACTIVITY; CHOLERA TOXIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTERASES; FATTY ACIDS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS VACCINES; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LIPOPROTEINS; MALE; MICE; MICE, INBRED BALB C; NASAL MUCOSA; VACCINES, SYNTHETIC;

EID: 19944430291     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2004.08.042     Document Type: Article

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