Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen

Vaccine

Volumn 25, Issue 2, 2007, Pages 346-355

  Duc, Le H ^a   Hong, Huynh A ^a   Atkins, Helen S ^b   Flick Smith, Helen C ^b   Durrani, Zarmina ^c   Rijpkema, Sjoerd ^c   Titball, Richard W ^b,d   Cutting, Simon M ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Anthrax; Anthrax vaccine; Endospores; Heat stable vaccine

Indexed keywords

ANTHRAX VACCINE; BACTERIAL ANTIGEN; PROTECTIVE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ANTIGEN EXPRESSION; ARTICLE; BACILLUS ANTHRACIS; BACILLUS SUBTILIS; BACTERIAL SPORE; CONTROLLED STUDY; FEMALE; IMMUNITY; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPORANGIUM; SPORE GERMINATION;

ANIMALS; ANTHRAX; ANTHRAX VACCINES; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; SPORES, BACTERIAL; VACCINES, SYNTHETIC;

EID: 33845209467     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.07.037     Document Type: Article

References (40)

1. Mock M., and Fouet A. Anthrax. Annu Rev Microbiol 55 (2001) 647-671
2. Baillie L. The development of new vaccines against Bacillus anthracis. J Appl Microbiol 91 (2001) 609-613
3. McBride B.W., Mogg A., Telfer J.L., Lever M.S., Miller J., Turnbull P.C., et al. Protective efficacy of a recombinant protective antigen against Bacillus anthracis challenge and assessment of immunological markers. Vaccine 16 8 (1998) 810-817
4. Leppla S.H., Robbins J.B., Schneerson R., and Shiloach J. Development of an improved vaccine for anthrax. J Clin Invest 110 (2002) 141-144
5. Muniz A.E. Lymphocytic vasculitis associated with the anthrax vaccine: case report and review of anthrax vaccination. J Emerg Med 25 3 (2003) 271-276
6. Brey R.N. Molecular basis for improved anthrax vaccines. Adv Drug Deliv Rev 57 9 (2005) 1266-1292
7. Green B.D., Battisti L., Koehler T.M., Thorne C.B., and Ivins B.E. Demonstration of a capsule plasmid in Bacillus anthracis. Infect Immun 49 2 (1985) 291-297
8. Klimpel K.R., Molloy S.S., Thomas G., and Leppla S.H. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc Natl Acad Sci USA 89 21 (1992) 10277-10281
9. Petosa C., Collier R.J., Klimpel K.R., Leppla S.H., and Liddington R.C. Crystal structure of the anthrax toxin protective antigen. Nature 385 6619 (1997) 833-838
10. Flick-Smith H.C., Walker N.J., Gibson P., Bullifent H., Hayward S., Miller J., et al. A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection. Infect Immun 70 3 (2002) 1653-1656
11. Flick-Smith H.C., Eyles J.E., Hebdon R., Waters E.L., Beedham R.J., Stagg T.J., et al. Mucosal or parenteral administration of microsphere-associated Bacillus anthracis protective antigen protects against anthrax infection in mice. Infect Immun 70 4 (2002) 2022-2028
12. Duc L.H., Hong H.A., Fairweather N., Ricca E., and Cutting S.M. Bacterial spores as vaccine vehicles. Infect Immun 71 (2003) 2810-2818
13. Casula G., and Cutting S.M. Bacillus probiotics: spore germination in the gastrointestinal tract. Appl Environ Microbiol 68 (2002) 2344-2352
14. Duc L.H., Hong H.A., and Cutting S.M. Germination of the spore in the gastrointestinal tract provides a novel route for heterologous antigen presentation. Vaccine 21 (2003) 4215-4224
15. Rhee K.J., Sethupathi P., Driks A., Lanning D.K., and Knight K.L. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J Immunol 172 (2004) 1118-1124
16. Duc L.H., Hong H.A., Uyen N.Q., and Cutting S.M. Intracellular fate and immunogenicity of B. subtilis spores. Vaccine 22 (2004) 1873-1885
17. Hong H.A., Duc L.H., and Cutting S.M. The use of bacterial spore formers as probiotics. FEMS Microbiol Rev 29 (2005) 813-835
18. Beedham R.J., Turnbull P.C., and Williamson E.D. Passive transfer of protection against Bacillus anthracis infection in a murine model. Vaccine 19 31 (2001) 4409-4416
19. Youngman P., Perkins J., and Losick R. Construction of a cloning site near one end of Tn917 into which foreign DNA may be inserted without affecting transposition in Bacillus subtilis or expression of the transposon-borne erm gene. Plasmid 12 (1984) 1-9
20. Sambrook J., and Russell D.W. Molecular Cloning: A Laboratory Manual. 3rd ed (2001), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
21. Harwood C.R., and Cutting S.M. Molecular Biological Methods for Bacillus (1990), John Wiley & Sons Ltd., Chichester, England
22. Guerout-Fleury A.M., Frandsen N., and Stragier P. Plasmids for ectopic integration in Bacillus subtilis. Gene 180 1-2 (1996) 57-61
23. Nicholson W.L., and Setlow P. Sporulation, germination and outgrowth. In: Harwood C.R., and Cutting S.M. (Eds). Molecular Biological Methods for Bacillus (1990), John Wiley & Sons Ltd., Chichester, UK 391-450
24. Hering D., Thompson W., Hewetson J., Little S., Norris S., and Pace-Templeton J. Validation of the anthrax lethal toxin neutralization assay. Biologicals 32 1 (2004) 17-27
25. Brossier F., Levy M., and Mock M. Anthrax spores make an essential contribution to vaccine efficacy. Infect Immun 70 (2002) 661-664
26. Isticato R., Cangiano G., Tran H.T., Ciabattini A., Medaglini D., Oggioni M.R., et al. Surface display of recombinant proteins on Bacillus subtilis spores. J Bacteriol 183 (2001) 6294-6301
27. Mauriello E.M.F., Duc L.H., Isticato R., Cangiano G., Hong H.A., De Felice M., et al. Display of heterologous antigens on the Bacillus subtilis spore coat using CotC as a fusion partner. Vaccine 22 (2004) 1177-1187
28. Welkos S.L., Keener T.J., and Gibbs P.H. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect Immun 51 3 (1986) 795-800
29. Flick-Smith H.C., Waters E.L., Walker N.J., Miller J., Stagg A.J., Green M., et al. Mouse model characterisation for anthrax vaccine development: comparison of one inbred and one outbred mouse strain. Microb Pathog 38 1 (2005) 33-40
30. Williamson E.D., Hodgson I., Walker N.J., Topping A.W., Duchars M.G., Mott J.M., et al. Immunogenicity of recombinant protective antigen and efficacy against aerosol challenge with anthrax. Infect Immun 73 9 (2005) 5978-5987
31. Ivins B.E., Welkos S.L., Knudson G.B., and Little S.F. Immunization against anthrax with aromatic compound-dependent (Aro-) mutants of Bacillus anthracis and with recombinant strains of Bacillus subtilis that produce anthrax protective antigen. Infect Immun 58 2 (1990) 303-308
32. Ivins B.E., and Welkos S.L. Cloning and expression of the Bacillus anthracis protective antigen gene in Bacillus subtilis. Infect Immun 54 2 (1986) 537-542
33. VanCott J.L., Staats H.F., Pascual D.W., Roberts M., Chatfield S.N., Yamamoto A., et al. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunisation with live recombinant Salmonella. J Immunol 156 (1996) 1504-1514
34. Isaka M., Yasuda Y., Mizokami M., Kozuka S., Taniguchi T., Matano K., et al. Mucosal immunization against hepatitis B virus by intranasal co-administration of recombinant hepatitis B surface antigen and recombinant cholera toxin B subunit as an adjuvant. Vaccine 19 (2001) 1460-1466
35. Roberts M., Li J., Bacon A., and Chatfield S. Oral vaccination against tetanus: comparison of the immunogenicities of Salmonella strains expressing fragment C from the nirA and htrA promoters. Infect Immun 66 (1998) 3080-3087
36. Garmory H.S., Titball R.W., Griffin K.F., Hahn U., Bohm R., and Beyer W. Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge. Infect Immun 71 7 (2003) 3831-3836
37. Williamson E.D., Beedham R.J., Bennett A.M., Perkins S.D., Miller J., and Baillie L.W. Presentation of protective antigen to the mouse immune system: immune sequelae. J Appl Microbiol 87 2 (1999) 315-317
38. Cote C.K., Rossi C.A., Kang A.S., Morrow P.R., Lee J.S., and Welkos S.L. The detection of protective antigen (PA) associated with spores of Bacillus anthracis and the effects of anti-PA antibodies on spore germination and macrophage interactions. Microb Pathog 38 5-6 (2005) 209-225
39. Guidi-Rontani C., Weber-Levy M., Labruyere E., and Mock M. Germination of Bacillus anthracis spores within alveolar macrophages. Mol Microbiol 31 (1999) 9-17
40. Moir A., and Smith D.A. The genetics of bacterial spore germination. Annu Rev Microbiol 44 (1990) 531-553