메뉴 건너뛰기




Volumn 26, Issue 28, 2008, Pages 4539-4541

Molecular classification of acute myeloid leukemia: Are we there yet?

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; TRANSCRIPTION FACTOR; WT1 PROTEIN;

EID: 53749102779     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2008.16.4293     Document Type: Editorial
Times cited : (8)

References (28)
  • 1
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrozek K, Dodge RK, et al: Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461). Blood 100:4325-4336, 2002
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrozek, K.2    Dodge, R.K.3
  • 2
    • 0041737454 scopus 로고    scopus 로고
    • Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia
    • Meshinchi S, Stirewalt DL, Alonzo TA, et al: Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood 102:1474-1479, 2003
    • (2003) Blood , vol.102 , pp. 1474-1479
    • Meshinchi, S.1    Stirewalt, D.L.2    Alonzo, T.A.3
  • 3
    • 0035383768 scopus 로고    scopus 로고
    • FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al: FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 97:3589-3595, 2001
    • (2001) Blood , vol.97 , pp. 3589-3595
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 4
    • 0028214608 scopus 로고
    • Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
    • Neubauer A, Dodge RK, George SL, et al: Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood 83:1603-1611, 1994
    • (1994) Blood , vol.83 , pp. 1603-1611
    • Neubauer, A.1    Dodge, R.K.2    George, S.L.3
  • 5
    • 0024990090 scopus 로고
    • N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance
    • Radich JP, Kopecky KJ, Willman CL, et al: N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance. Blood 76:801-807, 1990
    • (1990) Blood , vol.76 , pp. 801-807
    • Radich, J.P.1    Kopecky, K.J.2    Willman, C.L.3
  • 6
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al: The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98:1752-1759, 2001
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 7
    • 33845254595 scopus 로고    scopus 로고
    • Clinical implications of FLT3 mutations in pediatric AML
    • Meshinchi S, Alonzo TA, Stirewalt DL, et al: Clinical implications of FLT3 mutations in pediatric AML. Blood 108:3654-3661, 2006
    • (2006) Blood , vol.108 , pp. 3654-3661
    • Meshinchi, S.1    Alonzo, T.A.2    Stirewalt, D.L.3
  • 8
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al: Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 97:2434-2439, 2001
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 9
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, et al: The impact of FLT3 internal tandem duplication mutant level, number, size and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 111:2776-2784, 2008
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 10
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al: Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis. Blood 99:4326-4335, 2002
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 11
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
    • Whitman SP, Archer KJ, Feng L, et al: Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study. Cancer Res 61:7233-7239, 2001
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 12
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations
    • Döhner K, Schlenk RF, Habdank M, et al: Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: Interaction with other gene mutations. Blood 106:3740-3746, 2005
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Döhner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 13
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B, Mecucci C, Tiacci E, et al: Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 352:254-266, 2005
    • (2005) N Engl J Med , vol.352 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 14
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger S, Schoch C, Kern W, et al: Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 106:3733-3739, 2005
    • (2005) Blood , vol.106 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 15
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede C, Koch S, Creutzig E, et al: Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 107:4011-4020, 2006
    • (2006) Blood , vol.107 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3
  • 16
    • 16544369516 scopus 로고    scopus 로고
    • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L, Dohner K, Bair E, et al: Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med 350:1605-1616, 2004
    • (2004) N Engl J Med , vol.350 , pp. 1605-1616
    • Bullinger, L.1    Dohner, K.2    Bair, E.3
  • 17
    • 33745957993 scopus 로고    scopus 로고
    • Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction
    • Wilson CS, Davidson GS, Martin SB, et al: Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood 108:685-696, 2006
    • (2006) Blood , vol.108 , pp. 685-696
    • Wilson, C.S.1    Davidson, G.S.2    Martin, S.B.3
  • 18
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B Study
    • Paschka P, Marcucci G, Ruppert AS, et al: Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B Study. J Clin Oncol 26:4595-4602, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 19
    • 34247579714 scopus 로고    scopus 로고
    • A tumor suppressor and oncogene: The WT1 story
    • Yang L, Han Y, Suarez Saiz F, et al: A tumor suppressor and oncogene: The WT1 story. Leukemia 21:868-876, 2007
    • (2007) Leukemia , vol.21 , pp. 868-876
    • Yang, L.1    Han, Y.2    Suarez Saiz, F.3
  • 20
    • 0030737629 scopus 로고    scopus 로고
    • High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome
    • Bergmann L, Miething C, Maurer U, et al: High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome. Blood 90:1217-1225, 1997
    • (1997) Blood , vol.90 , pp. 1217-1225
    • Bergmann, L.1    Miething, C.2    Maurer, U.3
  • 21
    • 0032522974 scopus 로고    scopus 로고
    • Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance
    • King-Underwood L, Pritchard-Jones K: Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 91:2961-2968, 1998
    • (1998) Blood , vol.91 , pp. 2961-2968
    • King-Underwood, L.1    Pritchard-Jones, K.2
  • 22
    • 23844458023 scopus 로고    scopus 로고
    • Prognostic impact of RT-PCR-based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukemia
    • Weisser M, Kern W, Rauhut S, et al: Prognostic impact of RT-PCR-based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukemia. Leukemia 19:1416-1423, 2005
    • (2005) Leukemia , vol.19 , pp. 1416-1423
    • Weisser, M.1    Kern, W.2    Rauhut, S.3
  • 23
    • 33847238455 scopus 로고    scopus 로고
    • Wilms' tumor 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML
    • aut
    • Summers K, Stevens J, Kakkas I, et al: Wilms' tumor 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML. Leukemia 21:550-551; aut, 2007
    • (2007) Leukemia , vol.21 , pp. 550-551
    • Summers, K.1    Stevens, J.2    Kakkas, I.3
  • 24
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Fröhling S, Schlenk RF, Stolze I, et al: CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations. J Clin Oncol 22:624-633, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 624-633
    • Fröhling, S.1    Schlenk, R.F.2    Stolze, I.3
  • 25
    • 33644830601 scopus 로고    scopus 로고
    • Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
    • Marcucci G, Baldus CD, Ruppert AS, et al: Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study. J Clin Oncol 23:9234-9242, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 9234-9242
    • Marcucci, G.1    Baldus, C.D.2    Ruppert, A.S.3
  • 26
    • 24944464648 scopus 로고    scopus 로고
    • Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): A Cancer and Leukemia Group B study
    • Marcucci G, Mrózek K, Ruppert AS, et al: Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): A Cancer and Leukemia Group B study. J Clin Oncol 23:5705-5717, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 5705-5717
    • Marcucci, G.1    Mrózek, K.2    Ruppert, A.S.3
  • 27
    • 53749099948 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and RAS mutations benefit most from postremission treatment with high-dose cytarabine: A Cancer and Leukemia Group B study
    • Neubauer A, Maharry K, Mrózek K, et al: Patients with acute myeloid leukemia and RAS mutations benefit most from postremission treatment with high-dose cytarabine: A Cancer and Leukemia Group B study. J Clin Oncol 26:4603-4609, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 4603-4609
    • Neubauer, A.1    Maharry, K.2    Mrózek, K.3
  • 28
    • 1842614240 scopus 로고    scopus 로고
    • Repetitive cycles of high-dose cytarabine benefit patients with acute myeloid leukemia and inv(16)(p13q22) or t(16;16)(p13;q22): Results from CALGB 8461
    • Byrd JC, Ruppert AS, Mrozek K, et al: Repetitive cycles of high-dose cytarabine benefit patients with acute myeloid leukemia and inv(16)(p13q22) or t(16;16)(p13;q22): Results from CALGB 8461. J Clin Oncol 22:1087-1094, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 1087-1094
    • Byrd, J.C.1    Ruppert, A.S.2    Mrozek, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.