Helioxanthin inhibits interleukin-1β-induced MIP-1β production by reduction of c-jun expression and binding of the c-jun/CREB1 complex to the AP-1/CRE site of the MIP-1β promoter in Huh7 cells

Biochemical Pharmacology

Volumn 76, Issue 9, 2008, Pages 1121-1133

  Tseng, Pei Chi ^a   Hsu, Hsing Chih ^a   Janmanchi, Damodar ^a   Lin, Chih Hsiu ^b   Kuo, Yueh Hsiung ^c,d   Chou, Chen Kung ^e   Yeh, Sheau Farn ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF CHEMISTRY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^e CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

AP 1 CRE site; c jun; Helioxanthin (HE 145); IL 1 induced MIP 1 expression; JNK

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HELIOXANTHIN; INTERLEUKIN 1BETA; LIGNAN DERIVATIVE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; DNA BINDING; DRUG MECHANISM; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS;

CELL LINE, TUMOR; CHEMOKINE CCL4; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIGNANS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; TRANSCRIPTION FACTOR AP-1;

EID: 53649095301     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.08.023     Document Type: Article

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