Inhibition of prostaglandin E2 production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action

Biochemical Pharmacology

Volumn 64, Issue 9, 2002, Pages 1345-1354

  Ban, Hyun Seung ^a   Lee, Sanghyun ^b   Kim, Yong Pil ^a   Yamaki, Kouya ^a   Shin, Kuk Hyun ^b   Ohuchi, Kazuo ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Seoul National University   (South Korea)

Author keywords

Cyclooxygenase activity; Lignans; Macrophage; Prostaglandin E2; Taiwanin C

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DEXAMETHASONE; DIBENZYLBUTYROLACTONE; HELIOXANTHIN; INDOMETACIN; LIGNAN DERIVATIVE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; SAVININ; SESAMIN; STAUROSPORINE; TAIWANIN C; THAPSIGARGIN; TRITIUM; UNCLASSIFIED DRUG;

ACANTHOPANAX CHIISANENSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; ISOTOPE LABELING; MALE; MEDICINAL PLANT; NONHUMAN; PERITONEUM MACROPHAGE; PLANT ROOT; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; RADIOACTIVITY; RAT; TAIWAN;

ANIMALS; ARACHIDONIC ACID; ARALIACEAE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; DRUG INTERACTIONS; ENZYME INHIBITORS; ISOENZYMES; LACTONES; LIGNANS; MACROPHAGES, PERITONEAL; MALE; MEMBRANE PROTEINS; PLANT ROOTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; STAUROSPORINE; TETRADECANOYLPHORBOL ACETATE; THAPSIGARGIN; TRITIUM;

EID: 0036829009     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01348-5     Document Type: Article

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