Synthesis, DNA-binding ability and biological activity of C8 linked G1 dendrimer-pyrrolobenzodiazepine conjugates as anticancer agents

Letters in Drug Design and Discovery

Volumn 5, Issue 7, 2008, Pages 424-432

  Kamal, Ahmed ^a   Balakishan, G ^a   Rajender, ^a   Sreekanth, K ^a   Reddy, D Rajasekhar ^a   Reddy, M Kashi ^a   Sen, Subrata ^b   Kurian, Nisha ^b   Juvekar, Aarti S ^b   Zingde, Surekha M ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b TATA MEMORIAL HOSPITAL   (India)

Author keywords

DNA binding affinity and cytotoxicity; G1 Poly (aryl ether) dendrimer; Lipophilicity; Piperazine; Pyrrolobenzodiazepine

Indexed keywords

7 METHOXY 8 [3 [METHYL 4 [3 [4 (METHOXYCARBONYL)BENZYL]OXY 5 (PIPERAZINOMETHYL)PHENOXY]METHYLBENZOATE]PROPYL]OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEP IN 5 ONE; 7 METHOXY 8 [4 [METHYL 4 [3 [4 (METHOXYCARBONYL)BENZYL]OXY 5 (PIPERAZINOMETHYL)PHENOXY]METHYLBENZOATE]BUTYL]OXY 1,2,3,4,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEP IN 5 ONE; 7 METHOXY 8 [5 [METHYL 4 [3 [4 (METHOXYCARBONYL)BENZYL]OXY 5 (PIPERAZINOMETHYL)PHENOXY]METHYLBENZOATE]PENTYL]OXY 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEP IN 5 ONE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; DENDRIMER; DOXORUBICIN; DRUG CARRIER; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRROLE DERIVATIVE; PYRROLOBENZODIAZEPINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONJUGATE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYBRID; LIPOPHILICITY; PRIORITY JOURNAL;

EID: 53549130980     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018008785909859     Document Type: Article

References (34)

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