β-cell development: The role of intercellular signals

Diabetes, Obesity and Metabolism

Volumn 10, Issue SUPPL. 4, 2008, Pages 195-200

  Scharfmann, R ^a   Duvillie, V ^a   Stetsyuk, M ^a   Attali, G ^a   Filhoulaud, G ^a   Guillemain, G ^a  

^a INSERM   (France)

Author keywords

Development; Differentiation; Epithelium; Glucose; Mesenchyme; Pancreas

Indexed keywords

CARBOXYPEPTIDASE A; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 2; GLUCAGON; INSULIN; KERATINOCYTE GROWTH FACTOR; MYELOPID; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 3; TRANSCRIPTION FACTOR PDX 1; TYROSINE KINASE RECEPTOR;

ACINAR CELL; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL GROWTH; CELL LINEAGE; CELL MATURATION; CONFERENCE PAPER; DIABETES MELLITUS; DOWN REGULATION; ENDOCRINE CELL; ENDODERM; ENDOTHELIUM CELL; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; HUMAN; IN SITU HYBRIDIZATION; MESENCHYME CELL; MORPHOGENESIS; NONHUMAN; NOTOCHORD; ORGANOGENESIS; PANCREAS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL;

EID: 53549106902     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.00953.x     Document Type: Conference Paper

References (47)

1. Madsen OD, Serup P. Towards cell therapy for diabetes. Nat Biotechnol 2006; 24: 1481-1483.
2. Dor Y, Brown J, Martinez OI et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004; 429: 41-46.
3. Xu X, D'Hoker J, Stange G et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008; 132: 197-207.
4. Edlund H. Pancreas: How to get there from the gut? Curr Opin Cell Biol 1999; 11: 663-668.
5. Edlund H. Organogenesis: Pancreatic organogenesis developmental mechanisms and implications for therapy. Nat Rev Genet 2002; 3: 524-532.
6. Collombat P, Hecksher-Sorensen J, Serup P et al. Specifying pancreatic endocrine cell fates. Mech Dev 2006; 123: 501-512.
7. Murtaugh LC, Melton DA. Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol 2003; 19: 71-89.
8. Murtaugh LC. Pancreas and beta-cell development: From the actual to the possible. Development 2007; 134: 427-438.
9. Wilson ME, Scheel D, German MS. Gene expression cascades in pancreatic development. Mech Dev 2003; 120: 65-80.
10. Ohlsson H, Karlsson K, Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 1993; 12: 4251-4259.
11. Jensen J, Heller RS, Funder-Nielsen T et al. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 2000; 49: 163-176.
12. Piper K, Brickwood S, Turnpenny LW et al. Beta cell differentiation during early human pancreas development. J Endocrinol 2004; 181: 11-23.
13. Ahlgren U, Jonsson J, Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/ PDX1-deficient mice. Development 1996; 122: 1409-1416.
14. Offield M, Jetton T, Laborsky P et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996; 122: 983-995.
15. Stoffers DA, Zinkin NT, Stanojevic V et al. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 1997; 15: 106-110.
16. Herrera PL. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 2000; 127: 2317-2322.
17. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002; 129: 2447-2457.
18. Apelqvist A, Li H, Sommer L et al. Notch signalling controls pancreatic cell differentiation. Nature 1999; 400: 877-881.
19. Sarkar SA, Kobberup S, Wong R et al. Global gene expression profiling and histochemical analysis of the developing human fetal pancreas. Diabetologia 2008; 51: 285-297.
20. Gradwohl G, Dierich A, LeMeur M et al. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 2000; 97: 1607-1611.
21. Wang J, Cortina G, Wu SV et al. Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med 2006; 355: 270-280.
22. Jenny M, Uhl C, Roche C et al. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J 2002; 21: 6338-6347.
23. Jensen JN, Rosenberg LC, Hecksher-Sorensen J et al. Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med 2007; 356: 1781-1782; author reply 1782.
24. Slack J. Developmental biology of the pancreas. Development 1995; 121: 1569-1580.
25. Kim S, Hebrok M, Melton D. Notochord to endoderm signaling is required for pancreas development. Development 1997; 124: 4243-4252.
26. Hebrok M, Kim S, Melton D. Notochord repression of endodermal sonic hedgehog permits pancreas development. Genes Dev 1998; 12: 1705-1713.
27. Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001; 294: 564-567.
28. Yoshitomi H, Zaret KS. Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 2004; 131: 807-817.
29. Pictet R, Rutter W. Development of the embryonic pancreas. In: Steiner DF, Freinkel N eds. Handbook in Physiology. Baltimore: Williams & Wilkins, 1972; 25-66.
30. Golosow N, Grobstein C. Epitheliomesenchymal interaction in pancreatic morphogenesis. Dev Biol 1962; 4: 242-255.
31. Wessels N, Cohen J. Early pancreas organogenesis: Morphogenesis, tissue interactions, and mass effects. Dev Biol 1967; 15: 237-270.
32. Miralles F, Czernichow P, Scharfmann R. Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 1998; 125: 1017-1024.
33. Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol 2001; 2: 3005.1-3005.12.
34. Ornitz D, Xu J, Colvin J et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem 1996; 271: 15292-15297.
35. Zhang X, Ibrahimi OA, Olsen SK et al. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem 2006; 281: 15694-15700.
36. Miralles F, Czernichow P, Ozaki K et al. Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A 1999; 96: 6267-6272.
37. Elghazi L, Cras-Meneur C, Czernichow P et al. Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation. Proc Natl Acad Sci U S A 2002; 99: 3884-3889.
38. Bhushan A, Itoh N, Kato S et al. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 2001; 128: 5109-5117.
39. Hart A, Papadopoulou S, Edlund H. Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev Dyn 2003; 228: 185-193.
40. Norgaard GA, Jensen JN, Jensen J. FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol 2003; 264: 323-338.
41. Miralles F, Serup P, Cluzeaud F et al. Characterization of β cells developed in vitro from rat embryonic pancreatic epithelium. Dev Dyn 1999; 214: 116-126.
42. Duvillie B, Attali M, Bounacer A et al. The mesenchyme controls the timing of pancreatic β-cell differentiation. Diabetes 2006; 55: 582-589.
43. Attali M, Stetsyuk V, Basmaciogullari A et al. Control of β-cell differentiation by the pancreatic mesenchyme. Diabetes 2007; 56: 1248-1258.
44. Ye F, Duvillie B, Scharfmann R. Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells. Diabetologia 2005; 48: 277-281.
45. Rutter WJ, Pictet RL, Harding JD et al. An analysis of pancreatic development: Role of mesenchymal factor and other extracellular factors. Symp Soc Dev Biol 1978; 35: 205-227.
46. Guillemain G, Filhoulaud G, Da Silva-Xavier G et al. Glucose is necessary for embryonic pancreatic endocrine cell differentiation. J Biol Chem 2007; 282: 15228-15237.
47. D'Amour KA, Bang AG, Eliazer S et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006; 24: 1392-1401.