Carbonic anhydrase inhibitors: Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides-in vitro and in vivo studies

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5466-5471

  Krungkrai, Jerapan ^a   Krungkrai, Sudaratana R ^b   Supuran, Claudiu T ^c  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b Faculty of Science   (Thailand)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase; Enzyme inhibitor; In vivo study; Malaria; Plasmodium berghei; Plasmodium falciparum; Sulfonamide

Indexed keywords

1,3,4 THIADIAZOLE SULFONAMIDE; 1,3,4 THIADIAZOLINE 2 SULFONAMIDE; 4 (3,4 DICHLOROPHENYLUREIDO)THIOUREIDO BENZENESULFONAMIDE DERIVATIVE; ANTIMALARIAL AGENT; CARBAMOYL PHOSPHATE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; CHLOROQUINE; ENZYME INHIBITOR; PYRIMIDINE NUCLEOTIDE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SYNTHESIS; EX VIVO STUDY; GROWTH INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MALARIA; MICE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PYRIMIDINES; SULFONAMIDES;

ANIMALIA; MUS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 53549094659     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.030     Document Type: Article

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