Synthesis and antimalarial activity of sixteen dispiro- 1,2,4,5-tetraoxanes: Alkyl-substituted 7,8,15,16- tetraoxadispiro[5.2.5.2]hexadecanes

Journal of Medicinal Chemistry

Volumn 43, Issue 14, 2000, Pages 2753-2758

  Vennerstrom, Jonathan L ^a   Dong, Yuxiang ^a   Andersen, Steven L ^b   Ager Jr , Arba L ^c   Fu, Hong Ning ^a   Miller, Robert E ^b   Wesche, David L ^b   Kyle, Dennis E ^b   Gerena, Lucia ^b   Walters, Sheri M ^d   Wood, James K ^d   Edwards, Geoffrey ^e,f   Holme, Alexandra D ^e   McLean, W Graham ^e   Milhous, Wilbur K ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

^f LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 DIMETHYL 7,8,15,16 TETRAOXADISPIRO[5.2.5.2]HEXADECANE; ANTIMALARIAL AGENT; ARTEMISIN; CHLOROQUINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NEUROTOXICITY; NONHUMAN; PEROXIDATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ALKANES; ANIMALS; ANTIMALARIALS; MALARIA; MICE; NEURITES; NEUROBLASTOMA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 18744417592     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0000766     Document Type: Article

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