An Elmo-like Protein Associated with Myosin II Restricts Spurious F-Actin Events to Coordinate Phagocytosis and Chemotaxis

Developmental Cell

Volumn 15, Issue 4, 2008, Pages 590-602

  Isik, Nilgun ^a   Brzostowski, Joseph A ^a   Jin, Tian ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

CELLBIO

Indexed keywords

F ACTIN; GREEN FLUORESCENT PROTEIN; MYOSIN II; PROTEIN ELMOA; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; CELL SHAPE; CELLULAR DISTRIBUTION; CHEMOTAXIS; CONTROLLED STUDY; CORRELATION FUNCTION; DICTYOSTELIUM DISCOIDEUM; FLUORESCENCE MICROSCOPY; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PSEUDOPODIUM;

ACTINS; ANIMALS; CELL POLARITY; CELL SHAPE; CHEMOTAXIS; DICTYOSTELIUM; GREEN FLUORESCENT PROTEINS; MICROFILAMENT PROTEINS; MYOSIN TYPE II; PHAGOCYTOSIS; PROTOZOAN PROTEINS; RAC GTP-BINDING PROTEINS;

DICTYOSTELIUM DISCOIDEUM; PSEUDOPODA;

EID: 53449096043     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2008.08.006     Document Type: Article

References (40)

1. Andrew N., and Insall R.H. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat. Cell Biol. 9 (2007) 193-200
2. Axelrod D. Total internal reflection fluorescence microscopy in cell biology. Traffic 2 (2001) 764-774
3. Blagg S.L., Stewart M., Sambles C., and Insall R.H. PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium. Curr. Biol. 13 (2003) 1480-1487
4. Bianco A., Poukkula M., Cliffe A., Mathieu J., Luque C.M., Fulga T.A., and Rorth P. Two distinct modes of guidance signalling during collective migration of border cells. Nature 448 (2007) 362-365
5. Bosgraaf L., and van Haastert P.J. The regulation of myosin II in Dictyostelium. Eur. J. Cell Biol. 85 (2006) 969-979
6. Bowzard J.B., Cheng D., Peng J., and Kahn R.A. ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs. J. Biol. Chem. 282 (2007) 17568-17580
7. Brugnera E., Haney L., Grimsley C., Lu M., Walk S.F., Tosello-Trampont A.C., Macara I.G., Madhani H., Fink G.R., and Ravichandran K.S. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat. Cell Biol. 4 (2002) 574-582
8. Chen L., Janetopoulos C., Huang Y.E., Iijima M., Borleis J., and Devreotes P.N. Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol. Biol. Cell 14 (2003) 5028-5037
9. Chung C.Y., Funamoto S., and Firtel R.A. Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 26 (2001) 557-566
10. Comer F.I., Lippincott C.K., Masbad J.J., and Parent C.A. The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr. Biol. 15 (2005) 134-139
11. Cote J.F., and Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol. 17 (2007) 383-393
12. Dalous J., Burghardt E., Muller-Taubenberger A., Bruckert F., Gerisch G., and Bretschneider T. Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation. Biophys. J. 94 (2008) 1063-1074
13. Devreotes P.N. G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron 12 (1994) 235-241
14. Devreotes P.N., and Zigmond S.H. Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annu. Rev. Cell Biol. 4 (1988) 649-686
15. Egelhoff T.T., Lee R.J., and Spudich J.A. Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo. Cell 75 (1993) 363-371
16. Fang J., Brzostowski J.A., Ou S., Isik N., Nair V., and Jin T. A vesicle surface tyrosine kinase regulates phagosome maturation. J. Cell Biol. 178 (2007) 411-423
17. Gerisch G., Bretschneider T., Muller-Taubenberger A., Simmeth E., Ecke M., Diez S., and Anderson K. Mobile actin clusters and traveling waves in cells recovering from actin depolymerization. Biophys. J. 87 (2004) 3493-3503
18. Iijima M., Huang Y.E., and Devreotes P. Temporal and spatial regulation of chemotaxis. Dev. Cell 3 (2002) 469-478
19. Insall R.H., Borleis J., and Devreotes P.N. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr. Biol. 6 (1996) 719-729
20. Jarzynka M.J., Hu B., Hui K.M., Bar-Joseph I., Gu W., Hirose T., Haney L.B., Ravichandran K.S., Nishikawa R., and Cheng S.Y. ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer Res. 67 (2007) 7203-7211
21. Jin T., and Hereld D. Moving toward understanding eukaryotic chemotaxis. Eur. J. Cell Biol. 85 (2006) 905-913
22. Jung G., Remmert K., Wu X., Volosky J.M., and Hammer III J.A. The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains. J. Cell Biol. 153 (2001) 1479-1497
23. Laevsky G., and Knecht D.A. Cross-linking of actin filaments by myosin II is a major contributor to cortical integrity and cell motility in restrictive environments. J. Cell Sci. 116 (2003) 3761-3770
24. Li Z., Dong X., Wang Z., Liu W., Deng N., Ding Y., Tang L., Hla T., Zeng R., Li L., et al. Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7 (2005) 399-404
25. Maniak M., Rauchenberger R., Albrecht R., Murphy J., and Gerisch G. Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag. Cell 83 (1995) 915-924
26. Nombela-Arrieta C., Lacalle R.A., Montoya M.C., Kunisaki Y., Megias D., Marques M., Carrera A.C., Manes S., Fukui Y., Martinez A.C., et al. Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. Immunity 21 (2004) 429-441
27. Norwood F.L., Sutherland-Smith A.J., Keep N.H., and Kendrick-Jones J. The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy. Structure 8 (2000) 481-491
28. Parent C.A., and Devreotes P.N. A cell's sense of direction. Science 284 (1999) 765-770
29. Parent C.A., Blacklock B.J., Froehlich W.M., Murphy D.B., and Devreotes P.N. G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95 (1998) 81-91
30. Pollard T.D., and Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112 (2003) 453-465
31. Ravichandran K.S., and Lorenz U. Engulfment of apoptotic cells: signals for a good meal. Nat. Rev. Immunol. 7 (2007) 964-974
32. Reddien P.W., and Horvitz H.R. The engulfment process of programmed cell death in caenorhabditis elegans. Annu. Rev. Cell Dev. Biol. 20 (2004) 193-221
33. Servant G., Weiner O.D., Herzmark P., Balla T., Sedat J.W., and Bourne H.R. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287 (2000) 1037-1040
34. Vartiainen M.K., and Machesky L.M. The WASP-Arp2/3 pathway: genetic insights. Curr. Opin. Cell Biol. 16 (2004) 174-181
35. Weiner O.D., Marganski W.A., Wu L.F., Altschuler S.J., and Kirschner M.W. An actin-based wave generator organizes cell motility. PLoS Biol. 5 (2007) e221
36. Wessels D., Lusche D.F., Kuhl S., Heid P., and Soll D.R. PTEN plays a role in the suppression of lateral pseudopod formation during Dictyostelium motility and chemotaxis. J. Cell Sci. 120 (2007) 2517-2531
37. Xu X.S., Lee E., Chen T., Kuczmarski E., Chisholm R.L., and Knecht D.A. During multicellular migration, myosin ii serves a structural role independent of its motor function. Dev. Biol. 232 (2001) 255-264
38. Xu X., Meier-Schellersheim M., Jiao X., Nelson L.E., and Jin T. Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol. Biol. Cell 16 (2005) 676-688
39. Xu X., Meier-Schellersheim M., Yan J., and Jin T. Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing. J. Cell Biol. 178 (2007) 141-153
40. Yam P.T., Wilson C.A., Ji L., Hebert B., Barnhart E.L., Dye N.A., Wiseman P.W., Danuser G., and Theriot J.A. Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility. J. Cell Biol. 178 (2007) 1207-1221