Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats

International Immunopharmacology

Volumn 4, Issue 13, 2004, Pages 1625-1632

  Wei, Yao Hong ^a   Li, Yue ^b   Qiang, Chen Ji ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ANHUI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Adjuvant arthritis; FR167653; IL 1; IL 10; Synoviocytes; TNF

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIINFLAMMATORY AGENT; FREUND ADJUVANT; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; LEFLUNOMIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; MALE; NONHUMAN; ORGAN WEIGHT; PATHOGENESIS; PAW EDEMA; POLYARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SPLEEN WEIGHT; STATISTICAL SIGNIFICANCE; SYNOVIOCYTE; THYMUS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BODY WEIGHT; CELL PROLIFERATION; CHINA; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FREUND'S ADJUVANT; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-1; INTERLEUKIN-10; ISOXAZOLES; KNEE JOINT; MALE; ORGAN SIZE; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPLEEN; SYNOVIAL FLUID; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 5344241219     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2004.07.022     Document Type: Article

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