FR167653, a cytokine synthesis inhibitor, exhibits anti-inflammatory effects early in rat carrageenin-induced pleurisy but no effect later

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 2, 2001, Pages 519-527

  Hatanaka, K O ^a   Kawamura, Michiko ^a   Murai, Naoki ^b   Ogino, Michiko ^a   Majima, Masataka ^a   Ogino, Keiko ^c   Harada, Yoshiteru ^b  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; 6 OXOPROSTAGLANDIN F1 ALPHA; CARRAGEENAN; CYCLOOXYGENASE 2; DEXAMETHASONE; INTERLEUKIN 1BETA; MESSENGER RNA; PROSTANOID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXUDATE; MALE; MESOTHELIUM CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PLEURISY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CARRAGEENAN; CYCLOOXYGENASE 2; CYTOKINES; DEXAMETHASONE; EXUDATES AND TRANSUDATES; INTERLEUKIN-1; ISOENZYMES; MALE; PLEURISY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034756675     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. The expression of IL-8 mRNA and infiltration of neutrophils with FR167653 administration on extended liver resection with ischemia in dogs
2. Anti-inflammatory actions of glucocorticoids: Molecular mechanisms
3. The production of cytokines by polymorphonuclear neutrophils
4. Expression of cyclooxygenase-2 in rat vascular smooth muscle cells is unrelated to nuclear-κB activation
5. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
6. The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin
7. Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493
8. SK&F 86002: A structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid
9. 2 formation in rat carrageenin-induced pleurisy
10. Detection of inducible prostaglandin H synthase-2 in cells in the exudate of rat carrageenin-induced pleurisy
11. Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat
12. Cell types expressing COX-2 in rat carrageenin-induced pleurisy
13. Expression and function of cyclooxygenase-2 in mesothelial cells during late phase of rat carrageenin-induced pleurisy
14. Immunocytochemical localization of prostaglandin endoperoxide synthase in the bovine intestine
15. A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea pigs and rats
16. A site of action of dexamethasone on leukocyte extravasation in microcirculation
17. Are the anti-inflammatory effects of dexamethasone responsible for inhibition of the induction of enzymes involved in prostanoid formation in rat carrageenin-induced pleurisy?
18. Comparison of suppressive effects of a new anti-inflammatory compound, FR167653, on production of PGE2 and inflammatory cytokines, human monocytes, and alveolar macrophages in response to endotoxin
19. Quantitative analysis of cyclooxygenase-2 gene expression on acute gastric injury induced by ischemia-reperfusion in rats
20. Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors
21. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
22. Detection of the degradation products of bradykinin by enzyme immunoassays as markers for the release of kinin in vivo
23. Molecular control of immune/inflammatory responses: Interactions between nuclear factor-κB and steroid receptor-signaling pathways
24. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
25. Regulatory functions of phospholipase A2
26. The effect of FR167653 on pulmonary ischemia-reperfusion injury in rats
27. Regulation of nitric oxide and prostaglandin E2 production by CSAIDS (SB203580) in murine macrophages and bovine chondrocytes stimulated with LPS
28. Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase
29. Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha
30. Role of cyclooxygenase-2 in the healing of gastric ulcers in rats
31. Glucocorticoids
32. Infiltration of neutrophils by intrapleural injection of tumour necrosis factor, interleukin-1, and interleukin-8 in rats, and its modification by actinomycin D
33. Prostaglandins as potentiators of increased vascular permeability in inflammation
34. Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation
35. FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor-α, ameliorates endotoxin-induced shock
36. Effects of a dual inhibitor of tumor necrosis factor-α and interleukin-1 on lipopolysaccharide-induced lung injury in rats: Involvement of the p38 mitogen-activated protein kinase pathway
37. Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level