Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine

Molecular Cancer Therapeutics

Volumn 7, Issue 8, 2008, Pages 2556-2565

  Ross, James ^a   Najjar, Amer M ^a   Sankaranarayanapillai, Madhuri ^a   Tong, William P ^a   Kaluarachchi, Kumaralal ^a   Ronen, Sabrina M ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERULENIN; CHOLINE KINASE; FATTY ACID SYNTHASE; PHOSPHATIDYLCHOLINE; PHOSPHORYLCHOLINE; TETRAHYDROLIPSTATIN;

ARTICLE; BREAST CANCER; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OVARY CANCER; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA PRIMERS; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; HUMANS; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLCHOLINE;

EID: 53349175014     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0015     Document Type: Article

References (42)

1. Wakil SJ. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 1989;28:4523-30.
2. Weiss L, Hoffmann GE, Schreiber R, et al. Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution off atty-acid synthase. Biol Chem Hoppe Seyler 1986;367:905-12.
3. Rashid A, Pizer ES, Moga M, et al. Elevated expression off atty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol 1997;150:201-8.
4. Swinnen JV, Vanderhoydonc F, Elgamal AA, et al. Selective activation of the fatty acid synthesis pathway in human prostate cancer. Int J Cancer 2000;88:176-9.
5. Alò PL, Visca P, Botti C, et al. Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue. Am J Clin Pathol 2001;116:129-34.
6. Wang YY, Kuhajda FP, Sokoll LJ, Chan DW. Two-site ELISA for the quantitative determination off atty acid synthase. Clin Chim Acta 2001;304:107-15.
7. Shah US, Dhir R, Gollin SM, et al. Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma. Hum Pathol 2006;37:401-9.
8. Milgraum LZ, Witters LA, Pasternack GR, Kuhajda FP. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 1997;3:2115-20.
9. Kuhajda FP. Fatty acid synthase and cancer: new applications of an old pathway. Cancer Res 2006;66:5977-80.
10. Lupu R, Menendez JA. Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr Pharm Biotechnol 2006;7:483-93.
11. Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007;7:763-77.
12. Kridel SJ, Axelrod F, Rozenkrantz N, Smith JW. Orlistat is a novel inhibitor off atty acid synthase with antitumor activity. Cancer Res 2004;64:2070-5.
13. Knowles LM, Axelrod F, Browne CD, Smith JW. A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. J Biol Chem 2004;279:30540-5.
14. Kuhajda FP, Pizer ES, Li JN, et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci U S A 2000;97:3450-4.
15. De Schrijver E, Brusselmans K, Heyns W, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res 2003;63:3799-804.
16. Brusselmans K, Schrijver ED, Heyns W, Verhoeven G, Swinnen JV. Epigallocatechin-3-gallate is a potent natural inhibitor off atty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. Int J Cancer 2003;106:856-62.
17. Menendez JA, Vellon L, Lupu R. Antitumoral actions of the anti-obesity drug orlistat (Xenical) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erb B-2) oncogene. Ann Oncol 2005;16:1253-67.
18. Hatzivassiliou G, Zhao F, Bauer DE, et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005;8:311-21.
19. Brusselmans K, Schrijver ED, Verhoeven G, Swinnen JV. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-α gene induces growth inhibition and apoptosis ofprostate cancer cells. Cancer Res 2005;65:6719-25.
20. Chajes V, Cambot M, Moreau K, Lenoir GM, Joulin V. Acetyl-CoA carboxylase a is essential to breast cancer cell survival. Cancer Res 2006;66:5287-94.
21. Jackowski S, Wang J, Baburina I. Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution off atty acids into glycerolipids in proliferating cells. Biochim Biophys Acta 2000;1483:301-15.
22. 13C-NMR studies of choline and ethanolamine uptake. Biochim Biophys Acta 1992;1138:203-12.
23. Podo F. Tumour phospholipid metabolism. NMR Biomed 1999;12:413-39.
24. Evelhoch JL, Gillies RJ, Karczmar GS, et al. Applications of magnetic resonance in model systems: cancer therapeutics. Neoplasia 2000;2:152-65.
25. Chung Y-L, Troy H, Banerji U, et al. Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino, 17-demethoxygeldanamycin (17AAG) in human colon cancer models. J Natl Cancer Inst 2003;95:1624-33.
26. Beloueche-Babari M, Jackson LE, Al-Saffar NMS, et al. Magnetic resonance spectroscopy monitoring of mitogen-activated protein kinase signaling inhibition. Cancer Res 2005;65:3356-63.
27. Gillies RJ, Morse DL. In vivo magnetic resonance spectroscopy in cancer. Annu Rev Biochem Eng 2005;7:287-326.
28. Sankaranarayanapillai M, Tong WP, Maxwell DS, et al. Detection of histone deacetylase inhibition by noninvasive magnetic resonance spectroscopy. Mol Cancer Ther 2006;5:1325-34.
29. KIP1, BRCA1, and NF-κB. Int J Oncol 2004;24:591-608.
30. Tyagi RK, Azrad A, Dagani H, Salomon Y. Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magn Reson Med 1996;35:194-200.
31. Iorio E, Mezzanzanica D, Paola A, et al. Alterations of choline phospholipid metabolism in ovarian tumor progression. Cancer Res 2005;65:9369-76.
32. Van de Sande T, Roskams T, Lerut E, et al. High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. J Pathol 2005;206:214-9.
33. Bandyopadhyay S, Pai SK, Watabe M, et al. FAS expression inversely correlates with PTEN level in prostate cancer and a PI3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene 2005;24:5389-95.
34. Kumar-Sinha C, Ignatoski KW, Lippman ME, Ethier SP, Chinnaiyan AM. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res 2003;63:132-9.
35. Menendez JA, Vellon L, Mehmi I, et al. Inhibition off atty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci U S A 2004;101:10715-20.
36. Beloueche-Babari M, Jackson LE, Al-Saffar NMS, et al. Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cells. Mol Cancer Ther 2006;5:187-96.
37. Ramirez de Molina A, Penalva V, Lucas L, Lacal JC. Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. Oncogene 2002;21:937-46.
38. Li J-N, Gorospe M, Chrest FJ, et al. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res 2001;61:1493-9.
39. Thangapazham RL, Singh AK, Sharma A, et al. Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo. Cancer Lett 2007;245:232-41.
40. Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ. Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res 2007;67:1262-9.
41. Thupari JN, Landree LE, Ronnett GV, Kuhajda FP. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A 2002;99:9498-502.
42. Ridgway ND, Lagace TA. Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms. Biochem J 2003;372:811-9.