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Volumn 18, Issue 20, 2008, Pages 5643-5647

Corrigendum to "synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor" [Bioorg. Med. Chem. Lett. 18 (2008) 5643-5647] (DOI:10.1016/j.bmcl.2008.08.092);Synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor

Author keywords

Carbamates; Nicotinic acetylcholine receptors; Potentiators

Indexed keywords

CARBAMIC ACID DERIVATIVE; ETHER DERIVATIVE; NICOTINIC ACETYLCHOLINE ALPHA4BETA2 RECEPTOR STIMULATING AGENT; NICOTINIC RECEPTOR; PYRAZOLE CARBAMATE DERIVATIVE; PYRAZOLE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; VARENICLINE;

EID: 53349165560     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.115     Document Type: Erratum
Times cited : (13)

References (26)
  • 1
    • 34548012169 scopus 로고    scopus 로고
    • For reviews of nicotinic acetylcholine receptors and their therapeutic potential, see:
    • For reviews of nicotinic acetylcholine receptors and their therapeutic potential, see:. Moaddel R., Jozwiak K., and Wainer I.W. Med. Res. Rev. 27 (2007) 723
    • (2007) Med. Res. Rev. , vol.27 , pp. 723
    • Moaddel, R.1    Jozwiak, K.2    Wainer, I.W.3
  • 23
    • 33747597579 scopus 로고    scopus 로고
    • Measurement of test compound to potentiate a submaximal response to nicotine (1/8 EC50, or EC12) based on an average of n ≥ 2. For a recent report of nAChR potentiators, and assay conditions, see:
    • Measurement of test compound to potentiate a submaximal response to nicotine (1/8 EC50, or EC12) based on an average of n ≥ 2. For a recent report of nAChR potentiators, and assay conditions, see:. Broad L.M., Zwart R., Pearson K.H., Lee M., Wallace L., McPhie G.I., Emkey R., Hollinshead S.P., Dell C.P., Baker S.R., and Sher E. J. Pharmacol. Exp. Ther. 318 (2006) 1108
    • (2006) J. Pharmacol. Exp. Ther. , vol.318 , pp. 1108
    • Broad, L.M.1    Zwart, R.2    Pearson, K.H.3    Lee, M.4    Wallace, L.5    McPhie, G.I.6    Emkey, R.7    Hollinshead, S.P.8    Dell, C.P.9    Baker, S.R.10    Sher, E.11
  • 24
    • 53349145155 scopus 로고    scopus 로고
    • note
    • Transport across MDR1-LLC-PK1 cells (pig kidney cells transfected with human MDR1 gene) was carried out as described (Yamazaki et al., J. Pharmacol. Exp. Ther. 2001, 296, 723) with some modifications. Briefly, MDR1-LLC-PK1 cells were plated at a density of 200,000 cells/well on membrane filters (24-well Transwells, Millipore, Cambridge, MA). Transport was performed manually in basolateral to apical (B to A) and apical to basolateral (A to B) directions in the presence of 0.1% bovine serum albumin on the fifth day after plating. Efflux ratio was determined as the transport ratio of B to A versus A to B at 5 μM after a 2-h incubation.
  • 25
    • 53349164372 scopus 로고    scopus 로고
    • note
    • 1H NMR. Additional NMR studies were employed as necessary.
  • 26
    • 53349162092 scopus 로고    scopus 로고
    • note
    • Enantiomerically enriched epoxide obtained from HKR.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.