Ginseng extract inhibits lipolysis in rat adipocytes in vitro by activating phosphodiesterase 4

Journal of Nutrition

Volumn 136, Issue 2, 2006, Pages 337-342

  Wang, Hong ^a   Reaves, Lisa A ^b   Edens, Neilé K ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

cAMP; Diabetes; Glycerol; Panax; Phosphodiesterase

Indexed keywords

FATTY ACID; GINSENG EXTRACT; GLYCEROL; PHOSPHATIDYLINOSITOL KINASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV; ROLIPRAM; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; LIPOLYSIS; MALE; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

ANIMALIA; PANAX; PANAX GINSENG;

EID: 32444445645     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.2.337     Document Type: Conference Paper

References (39)

1. Bergman RN, Finegood DT, Kahn SE. The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes. Eur J Clin Invest. 2002;32:Suppl 3:35-45.
2. DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care. 1992;15:318-68.
3. Summers SA, Whiteman EL, Birnbaum MJ. Insulin signaling in the adipocyte. Int J Obes Relat Metab Disord. 2000;24:Suppl 4:S67-70.
4. Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev. 2002;23:201-29.
5. Golay A, Swislocki AL, Chen YD, Jaspan JB, Reaven GM. Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations. J Clin Endocrinol Metab. 1986;63:481-4.
6. Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes. 1988;37:1020-4.
7. Campbell PJ, Carlson MG, Nurjhan N. Fat metabolism in human obesity. Am J Physiol. 1994;266:E600-5.
8. Del Prato S, Enzi G, Vigili de Kreutzenberg S, Lisato G, Riccio A, Maifreni L, Iori E, Zurlo F, Sergi G, Tiengo A. Insulin regulation of glucose and lipid metabolism in massive obesity. Diabetologia. 1990;33:228-36.
9. Bergman RN, Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab. 2000;11:351-6.
10. 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 1999;48:1600-6.
11. Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A. 1998;95:2498-502.
12. m cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990;87:533-7.
13. Smith CJ, Vasta V, Degerman E, Belfrage P, Manganiello VC. Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation. J Biol Chem. 1991;266:13385-90.
14. Degerman E, Landström TR, Wijkander J, Holst LS, Ahmad F, Belfrage P, Manganiello V. Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B. Methods. 1998;14:43-53.
15. Rahn T, Ridderstrale M, Tornqvist H, Manganiello V, Fredrikson G, Belfrage P, Degerman E. Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin. FEBS Lett. 1994;350:314-8.
16. Wijkander J, Landstrom TR, Manganiello V, Belfrage P, Degerman E. Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase. Endocrinology. 1998;139:219-27.
17. Kimura M, Waki I, Chujo T, Kikuchi T, Hiyama C, Yamazaki K, Tanaka O. Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas. J Pharmacobiodyn. 1981;4:410-7.
18. Yokozawa T, Kobayashi T, Oura H, Kawashima Y. Hyperlipemia-improving effects of ginsenoside-Rb2 in streptozotocin-diabetic rats. Chem Pharm Bull (Tokyo). 1985;33:3893-8.
19. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes. 2002;51:1851-8.
20. Vuksan V, Sievenpiper JL, Koo VY, Francis T, Beljan-Zdravkovic U, Xu Z, Vidgen E. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med. 2000;160:1009-13.
21. Vuksan V, Xu Z, Jenkins AL, Beljan-Zdravkovic U, Sievenpiper JL, Leiter LA, Josse RG, Stavro MP. American ginseng improves long term glycemic control in Type 2 diabetes: double-blind placebo controlled crossover trial [abstract]. Diabetes. 2000;49:Suppl 1:A95.
22. Vuksan V, Sievenpiper J, Sung MK, Buono MD, Jenkins A, Stavro P, Leiter L. Nam, KY Safety and efficacy of Korean red ginseng intervention (SAEKI): results of a randomized, double-blind, placebo-controlled crossover trial in type 2 diabetes [abstract]. Diabetes. 2003;52:Suppl 1:A137.
23. Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in noninsulin-dependent diabetic patients. Diabetes Care. 1995;18:1373-5.
24. Hasegawa H, Matsumiya S, Murakami C, Kurokawa T, Kasai R, Ishibashi S, Yamasaki K. Interactions of ginseng extract, ginseng separated fractions, and some triterpenoid saponins with glucose transporters in sheep erythrocytes. Planta Med. 1994;60:153-7.
25. Waki I, Kyo H, Yasuda M, Kimura M. Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals. J Pharmacobiodyn. 1982;5:547-54.
26. Onomura M, Tsukada H, Fukuda K, Hosokawa M, Nakamura H, Kodama M, Ohya M, Seino Y. Effects of ginseng radix on sugar absorption in the small intestine. Am J Chin Med. 1999;27:347-54.
27. Takaku T, Kameda K, Matsuura Y, Sekiya K, Okuda H. Studies on insulin-like substances in Korean red ginseng. Planta Med. 1990;56:27-30.
28. Edens NK, Reaves LA, Bergana MS, Reyzer IL, O'Mara P, Baxter JH, Snowden MK. Yeast extract stimulates glucose metabolism and inhibits lipolysis in rat adipocytes in vitro. J Nutr. 2002;132:1141-8.
29. Rodbell M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem. 1964;239:375-80.
30. Van Harmelen V, Reynisdottir S, Cianflone K, Degerman E, Hoffstedt J, Nilsell K, Sniderman A, Arner P. Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin. J Biol Chem. 1999;274:18243-51.
31. MacKenzie SJ, Yarwood SJ, Peden AH, Bolger GB, Vernon RG, Houslay MD. Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes. Proc Natl Acad Sci U S A. 1998;95:3549-54.
32. Li TSC, Mazza G, Cottrell AC, Gao L. Ginsenosides in roots and leaves of American ginseng. J Agric Food Chem. 1996;44:717-20.
33. Issad T, Combettes M, Ferre P. Isoproterenol inhibits insulin-stimulated tyrosine phosphorylation of the insulin receptor without increasing its serine/threonine phosphorylation. Eur J Biochem. 1995;234:108-15.
34. Campbell PJ, Carlson MG, Hill JO, Nurjhan N. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol. 1992;263:E1063-9.
35. Edens NK, Reaves LA, Henry DE. Extract of ginseng (Panax ginseng) stimulates glucose transport and inhibits lipolysis in vitro [abstract]. Diabetes. 2001;50:Suppl 2:A413.
36. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58:1685-93.
37. Shakur Y, Holst LS, Landstrom TR, Movsesian M, Degerman E, Manganiello V. Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog Nucleic Acid Res Mol Biol. 2001;66:241-77.
38. Snyder PB, Esselstyn JM, Loughney K, Wolda SL, Florio VA. The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis. J Lipid Res. 2004;46:494-503.
39. Kim SH, Park KS. Effects of Panax ginseng extract on lipid metabolism in humans. Pharmacol Res. 2003;48:511-3.