Suppressed expression of non-DSB repair genes inhibits gamma-radiation-induced cytogenetic repair and cell cycle arrest

DNA Repair

Volumn 7, Issue 11, 2008, Pages 1835-1845

  Zhang, Ye ^a,b   Rohde, Larry H ^b   Emami, Kamal ^a,c   Hammond, Dianne ^a,d   Casey, Rachael ^a,e   Mehta, Satish K ^a,d   Jeevarajan, Antony S ^a   Pierson, Duane L ^a   Wu, Honglu ^a  

^a NASA JOHNSON SPACE CENTER   (United States)

^b UNIVERSITY OF HOUSTON CLEAR LAKE   (United States)

^c WYLE LABORATORIES   (United States)

^d Enterprise Advisory Services Inc   (United States)

^e UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

Author keywords

Cell cycle; DNA repair; Gamma radiation; Gene expression; siRNA

Indexed keywords

SMALL INTERFERING RNA;

ARTICLE; ATM GENE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CHEK1 GENE; CHEK2 GENE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EXCISION REPAIR; FIBROBLAST; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN GENOME; IHPK3 GENE; IONIZING RADIATION; MICRONUCLEUS; MLH1 GENE; MRE11A GENE; NUCLEOTIDE SEQUENCE; PDCD8 GENE; PRIORITY JOURNAL; RAD1 GENE; RAD17 GENE; RAD50 GENE; RAD51 GENE; RBBP8 GENE; SESN GENE; SUMO1 GENE; XPA GENE; XPC GENE; XRCC2 GENE;

CELL CYCLE; CELL LINE; CHROMOSOME ABERRATIONS; CHROMOSOMES; CYTOGENETICS; DNA DAMAGE; DNA REPAIR; GAMMA RAYS; GENE EXPRESSION PROFILING; HUMANS; KINETICS; RADIATION, IONIZING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC;

EID: 53149123597     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.07.009     Document Type: Article

References (47)

1. Slupphaug G., Kavli B., and Krokan H.E. The interacting pathways for prevention and repair of oxidative DNA damage. Mutat Res. 531 (2003) 231-251
2. Norbury C.J., and Hickson I.D. Cellular responses to DNA damage. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 367-401
3. Bartek J., and Lukas J. Mammalian G1-S-phase checkpoints in response to DNA damage. Curr. Opin. Cell Biol. 13 (2001) 738-747
4. Falck J., Mailand N., Syljuasen R.G., Bartek J., and Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410 (2001) 842-847
5. Heinloth A.N., Shackelford R.E., Innes C.L., Bennett L., Li L., and Amin. R.P. ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation. Radiat. Res. 160 (2003) 273-290
6. Zhao R., Gish K., Murphy M., Yin Y., Notterman D., Hoffman W.H., Tom E., Mack D.H., and Levine A.J. Analysis of P53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 14 (2000) 981-993
7. Adimoolam S., and Ford. J.M. P53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 12985-12990
8. Snyder A.R., and Morgan W.F. Gene expression profiling after irradiation: clues to understanding acute and persistent responses?. Cancer Metastasis Rev. 23 (2004) 259-268
9. Zhou T., Chou J.W., Simpson D.A., Zhou Y., Mullen T.E., Medeiros M., Bushel P.R., Paules R.S., Yang X., Hurban P., Lobenhofer E.K., and Kaufmann W.K. Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence. Environ. Health Perspect. 114 (2006) 553-559
10. Bishay K., Ory K., Lebeau J., Levalois C., Olivier M.F., and Chevillard S. DNA damage-related gene expression as biomarkers to assess cellular response after gamma irradiation of a human lymphoblastoid cell line. Oncogene 19 (2000) 916-923
11. Ding L., Shingyoji M., Chen F., Hwang J., Burma S., Lee C., Cheng J., and Chen. D.J. Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat. Res. 164 (2005) 17-26
12. Daino K., Ichimura S., and Nenoi M. Early induction of CDKN1A (p21) and GADD45 mRNA by a low dose of ionizing radiation is due to their dose-dependent post-transcriptional regulation. Radiat. Res. 157 (2002) 478-482
13. Fornace A.J., Amundson S.A., Do K.T., Meltzer P., Trent J., and Bittner M. Stress-gene induction by low-dose gamma irradiation. Mil Mede. 167 (2002) 13-15
14. Campbell M.R., Wang Y., Andrew S.E., and Liu. Y. Msh2 deficiency leads to chromosomal abnormalities, centrosome amplification, and telomere capping defect. Oncogene 25 (2006) 2531-2536
15. Burr K.L., van Duyn-Goedhart A., Hickenbotham P., Monger K., van Buul P.P., and Dubrova Y.E. The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline. Mutat. Res. 617 (2007) 147-151
16. Rahman N., and Scott R.H. Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. Hum. Mol. Genet. 16 (2007) 60-66
17. Perrault R., Cheong N., Wang H., Wang H., and Iliakis G. RPA facilitates rejoining of DNA double-strand breaks in an in vitro assay utilizing genomic DNA as substrate. Int. J. Radiat. Biol. 77 (2001) 593-607
18. Wu H., Hada M., Meador J., Hu X., Rusek A., and Cucinotta F.A. Induction of micronuclei in human fibroblasts across the bragg curve of energetic heavy ions. Radiat. Res. 166 (2006) 583-589
19. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
20. Fenech M., and Morley A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161 (1986) 193-198
21. Desai N., Davis E., O'Neill P., Durante M., Cucinotta F.A., and Wu. H. Immunofluorescent detection of DNA double strand breaks induced by high-LET irradiation. Radiat. Res. 164 (2005) 518-522
22. Patino-Garcia B., Hoegel J., Varga D., Hoehne M., Michel I., Jainta S., Kreienberg R., Maier C., and Vogel W. Scoring variability of micronuclei in binucleated human lymphocytes in a case-control study. Mutagenesis 21 (2006) 191-197
23. Fenech M., Chang W.P., Kirsch-Volders M., Holland N., Bonassi S., and Zeiger E. Human Micronucleus project HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat. Res. 534 (2003) 65-75
24. Kawata T., Ito H., George K., Wu H., and Cucinotta F.A. Chromosome aberrations induced by high-LET radiations. Biol. Sci. Space. 18 (2004) 216-223
25. Wu H., Durante M., Furusawa Y., George K., Kawata T., and Cucinotta F.A. Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions. Radiat. Res. 160 (2003) 418-424
26. Gorbunova V., Seluanov A., Mao Z., and Hine. C. Changes in DNA repair during aging. Nucleic Acids Res. 35 (2007) 7466-7474
27. Robins P., Harris A.L., Goldsmith I., and Lindahl T. Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6 methylguanine-DNA methyltransferase. Nucleic Acids Res. 11 (1983) 7743-7758
28. Trujillo K.M., Yuan S.S., Lee E.Y., and Sung. P. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273 (1998) 21447-21450
29. Prasad T.K., Yeykal C.C., and Greene E.C. Visualizing the assembly of human Rad51 filaments on double-stranded DNA. J. Mol. Biol. 363 (2006) 713-728
30. Myers J.S., and Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J. Biol. Chem. 281 (2006) 9346-9350
31. Biard D.S.D. Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones. Nucleic Acids Res. 35 (2007) 3535-3550
32. Jasin M. Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene 21 (2002) 8981-8993
33. Abaji C., Cousineau I., and Belmaaza A. BRCA2 regulates homologous recombination in response to DNA damage: implications for genome stability and carcinogenesis. Cancer Res. 65 (2005) 4117-4125
34. Sargent R.G., Branneman M.A., and Wilson J.H. Repair of site-specific double-strand breaks in mammalian chromosome by homologous and illegitimate recombination. Mol. Cell Biol. 17 (1997) 267-277
35. Bomgarden R.D., Lupardus P.J., Soni D.V., Yee M., Ford J.M., and Cimprich K.A. Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling. EMBO J. 25 (2006) 2605-2614
36. Raptis S., Mrkonjic M., Green R.C., Pethe V.V., Monga N., Chan Y.M., Daftary D., Dicks E., Younghusband B.H., Parfrey P.S., Gallinger S.S., McLaughlin J.R., Knight J.A., and Bapat B. MLH1-93G > A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer. J. Natl. Cancer Inst. 99 (2007) 463-474
37. Davis T.E., Wilson-Can Patten C., Meyers M., Kunugi K.A., Cuthill S., Reznikoff C., Garces C., Boland C.R., Kinsella T.J., Fishel R., and Boothman D.A. Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res. 58 (1998) 767-778
38. Anantha R.W., Vassin V.M., and Borowiec J.A. Sequential and synergistic modification of human replication factor A stimulates chromosomal DNA repair. J. Biol. Chem. 282 (2007) 35910-35923
39. Sacher M., Pfander B., Hoege C., and Jentsch S. Control of Rad52 recombination activity by double-strand break-induced SUMO modification. Nat. Cell Biol. 8 (2006) 1284-1290
40. Wang Q.E., Zhu Q., Wani G., El-Mahdy M.A., Li J., and Wani. A.A. DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation. Nucleic Acids Res. 33 (2005) 4023-4034
41. Kopnin P.B., Agapova L.S., Kopnin B.P., and Chumakov P.M. Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. Cancer Res. 67 (2007) 4671-4678
42. Tusher V.G., Tibshirani R., and Chu. G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 5116-5121
43. Antone L.B. Paradigm shifts in radiation biology: their impact on intervention for radiation-induced disease. Radiat. Res. 164 (2005) 454-461
44. Olivieri G., Bodycote J., and Wolff S. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 223 (1984) 594-597
45. Stoilov L.M., Mullenders H.F., Darroudi F., and Natarajan A.T. Adaptive response to DNA and chromosomal damage induced by X-rays in human blood lymphocytes. Mutagenesis 22 (2007) 117-122
46. Wang Z., Saigusa S., and Sasaki M.S. Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays. Mutat. Res. 246 (1991) 179-186
47. Domingues I., Panneerselvam N., Escalza P., Natarajan A.T., and Cortes F. Adaptive response to radiation damage in human lymphocytes conditioned with hydrogen peroxide as measured by the cytokinesis-block micronucleus technique. Mutat. Res. 301 (1993) 135-141