Synthesis, screening for antitubercular activity and 3D-QSAR studies of substituted N-phenyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxamides

European Journal of Medicinal Chemistry

Volumn 43, Issue 10, 2008, Pages 2103-2115

  Virsodia, Vijay ^a   Pissurlenkar, Raghuvir R S ^b   Manvar, Dinesh ^c   Dholakia, Chintan ^d   Adlakha, Priti ^e   Shah, Anamik ^a   Coutinho, Evans C ^b  

^a SAURASHTRA UNIVERSITY   (India)

^b BOMBAY COLLEGE OF PHARMACY   (India)

^c Calyx Chemicals and Pharmaceuticals Ltd   (India)

^d Unimark Remedies Ltd   (India)

^e VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Antitubercular activity; CoMFA; CoMSIA; Tetrahydropyrimidines

Indexed keywords

ACETANILIDE DERIVATIVE; ALDEHYDE; AMIDE; N (2,3 DIMETHYLPHENYL) 6 METHYL 2 OXO 4 (3 PHENOXYPHENYL) 1,2,3,4 TETRAHYDRO PYRIMIDINE 5 CARBOXAMIDE; N PHENYL 6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE DERIVATIVE; PHENYL GROUP; PYRIMIDINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UREA;

ANTIBACTERIAL ACTIVITY; ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; ANTITUBERCULAR AGENTS; DRUG EVALUATION, PRECLINICAL; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53149115626     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.08.004     Document Type: Article

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