Leptin: A possible link between food intake, energy expenditure, and reproductive function

Regulatory Peptides

Volumn 92, Issue 1-3, 2000, Pages 51-56

  Magni, Paolo ^a   Motta, Marcella ^a   Martini, Luciano ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ARTICLE; BODY WEIGHT; ENERGY EXPENDITURE; FERTILITY; FOOD INTAKE; HORMONE RESISTANCE; HUMAN; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRODUCTION;

ANIMAL; EATING; ENERGY METABOLISM; HUMAN; LEPTIN; MICE; REPRODUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0034714043     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(00)00149-X     Document Type: Article

References (50)

1. Wade G.N., Schneider J.E. Metabolic fuels and reproduction in female mammals. Neurosci. Biobehav. Rev. 16:1992;235-272.
2. Woods S.C., Seeley R.J., Jr D.P., Schwartz M.W. Signals that regulate food intake and energy homeostasis. Science. 280:1998;1378.
3. Lane P., Dickie M. Fertile, obese male mice. J Hered. 45:1954;56-58.
4. Coleman D. Diabetes-obesity syndromes in mice. Diabetes. 31:1982;1-6.
5. Stewart D.E. Reproductive function in eating disorders. Ann Med. 24:1992;287-291.
6. Mounzih K., Lu R., Chehab F.F. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 138:1997;1190-1193.
7. Norman R.J., Clark A.M. Obesity and reproductive disorders: a review. Reprod Fertil Devel. 10:1998;55-63.
8. Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrine Rev. 20:1999;68-100.
9. Kalra S., Kalra P. Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Frontiers Neuroendocrinol. 17:1996;371-401.
10. Zhang Y., Proenca R., Maffei M., Baroni M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
11. Kennedy G.C. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Med. 140:1953;578-592.
12. Frisch R., Revelle R. Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science. 169:1970;397-399.
13. Frisch R., Revelle R., Cook S. Components of weight at menarche and the initiation of the adolescent growth spurt in girls: estimated total body water, lean body weight, and fat. Hum Biol. 45:1973;469-483.
14. Frisch R.E., McArthur J. Menstrual cycles: fatness as a determinant of minimum weight or height necessary for maintenance or onset. Science. 185:1974;949-951.
15. Frisch R.E. Pubertal adipose tissue: is it necessary for normal sexual maturation? Evidence from the rat and human female. Feder. Proc. 39:1980;2395-2400.
16. Neel J. Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am J Human Genet. 14:1962;353-362.
17. Rosenbaum M., Leibel R. A molecules integrating somatic energy stores, energy expenditure and fertility. Trends Endocrinol. Metab. 9:1998;117-124.
18. Simpson E.R., Mahendroo M.S., Means G.D., Kilgore M.W. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocrine Rev. 15:1994;342-355.
19. Caro J., Sinha M., Kolaczynski J., Zhang P., Considine R. Leptin: the tale of an obesity gene. Diabetes. 45:1996;1455-1462.
20. Ohtake M., Bray G., Azukizawa M. Studies on hypothermia and thyroid function in the obese (ob/ob) mouse. Am. J Physiol. 233:1977;R110-R115.
21. Collins S., Kuhn C., Petro A. Role of leptin in fat regulation. Nature. 380:1996;677-681.
22. Tartaglia L.A., Demski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolf E.A., Monroe C.A., Tepper R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271.
23. Aubert R., Herzog J., Camus M., Guenet J., Lemonnier D. Description of a new model of genetic obesity: the dbPas mouse. J Nutr. 115:1985;327-333.
24. Leibel R.L., Chung W.K., Chua S.C. The molecular genetics of rodent single gene obesities. J Biol Chem. 272:1997;31937-31940.
25. Barash I.A., Cheung C.C., Weigle D.S., Ren H., Kabigting E.B., Kuijper J.L., Clifton D.K., Steiner R.A. Leptin is a metabolic signal to the reproductive system. Endocrinology. 137:1996;3144-3147.
26. Chehab F., Lim M., Ronghua L. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 12:1996;318-320.
27. Chehab F.F., Mounzih K., Lu R., Lim M.E. Early onset of reproductive function in normal female mice treated with leptin. Science. 275:1997;88-90.
28. Ahima R., Dushay J., Flier S., Prabakaran K., Flier J. Leptin accelerates the timing of puberty in normal female mice. J Clin Invest. 99:1997;391-395.
29. Cheung C.C., Thornton J.E., Kuiyper J.L., Weigle D.S., Clifton D.K., Steiner R.A. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology. 138:1997;855-858.
30. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS. 387:1996;113-116.
31. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol. 8:1996;733-735.
32. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J Clin Invest. 98:1996;1101-1106.
33. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte D.J., Woods S.C., Seeley R.J., Weigle D.S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:1996;531-535.
34. Erickson J.C., Hollopeter G., Palmiter R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science. 274:1996;1704-1707.
35. Magni P., Maggi R., Pimpinelli F., Motta M. Cholinergic muscarinic mechanisms regulate neuropeptide Y gene expression via protein kinase C in human neuroblastoma cells. Brain Res. 798:1998;75-82.
36. Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology. 139:1998;795-798.
37. Yu W.H., Walczewska A., Karanth S., McCann S.M. Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced L.H. release from the pituitary gland. Endocrinology. 138:1997;5055-5058.
38. Magni P., Vettor R., Pagano C., Calcagno A., Beretta E., Messi E., Zanisi M., Martini L., Motta M. Expression of a leptin receptor in immortalized GnRH-secreting neurons. Endocrinology. 140:1999;1581-1585.
39. Yu W.H., Kimura M., Walczewska A., Karanth S., McCann S.M. Role of leptin in hypothalamic-pituitary function. Proc. Nat. Acad. Sci. USA. 94:1997;1023-1028.
40. Tartaglia L.A. The leptin receptor. J Biol. Chem. 272:1997;6093-6096.
41. Masuzaki H., Ogawa Y., Sagawa N., et al. Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nat Med. 3:1997;1029-1033.
42. Lollmann B., Gruninger S., Stricker-Krongrad A., Chiesi M. Detection and quantification of the leptin receptor mRNA splice variants Ob-Ra, b, and, e in different mouse tissues. Biochem. Biophys. Res. Commun. 238:1997;648-652.
43. Kutoh E., Boss O., Levasseur F., Giacobino J.P. Quantification of the full length leptin receptor (Ob-Rb) in human brown and white adipose tissue. Life Sci. 62:1997;445-451.
44. Hoggard N., Hunter L., Duncan J.S., Williams L.M., Trayhurn P., Mercer J.G. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc. Nat. Acad. Sci. USA. 94:1997;11073-11078.
45. Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H., Lynn R.B., Zhang P.L., Sinha M.K., Considine R.V. Decreased cerebrospinal-fluid/serum leptin ratio obesity: a possible mechanism for leptin resistance. Lancet. 348:1996;159-161.
46. Montague C., Prins J., Sanders L., Digby J., O'Rahilly S. Depot- and sex-specific differences in human leptin mRNA expression. Diabetes. 46:1996;342-347.
47. Strobel A., Issad T., Camoin M., Ozata M., Strosberg A.D. A leptin mutation associated with hypogonadism and morbid obesity. Nature Genet. 18:1998;213-215.
48. Mantzoros C., Flier J., Rogol A. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V: Rising leptin levels may signal the onset of puberty. J Clin. Endocrinol. Metab. 1982:1997;1065-1070.
49. Rosenbaum M., Nicolson M., Hirsch J., Heymsfield S.B., Gallagher D., Chu F., Leibel R.L. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin. Endocrinol. Metab. 81:1996;3424-3427.
50. Wiesner G., Vaz M., Collier G., Seals D., Kaye D., Jennings G., Lambert G., Wilkinson D., Esler M. Leptin is released from the human brain: influence of adiposity and gender. J Clin. Endocrinol. Metab. 84:1999;2270-2274.