Inulin results in increased levels of β-catenin and cyclin D1 as the adenomas increase in size from small to large in the Min/+ mouse

British Journal of Nutrition

Volumn 99, Issue 5, 2008, Pages 963-970

  Misikangas, Marjo ^a   Tanayama, Heidi ^a   Rajakangas, Johanna ^a   Lindén, Jere ^a   Pajari, Anne Maria ^a   Mutanen, Marja ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Adenoma growth; Adenomatous polyposis coli; Colon cancer; E cadherin; Intestinal tumorigenesis

Indexed keywords

BETA CATENIN; CYCLIN D1; GELATINASE B; INULIN; NUCLEAR PROTEIN; UVOMORULIN;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON ADENOMA; COLON CARCINOGENESIS; COLON POLYPOSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; FEEDING BEHAVIOR; GROWTH RATE; LIPID DIET; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VOLUME;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; BETA CATENIN; CADHERINS; CYCLIN D1; DIET; DIETARY FATS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; INULIN; MICE; MICE, INBRED C57BL; NEOPLASM PROTEINS; SIGNAL TRANSDUCTION;

MUS;

EID: 53049093860     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507853414     Document Type: Article

References (39)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J & Thun MJ (2007) Cancer statistics, 2007. CA Cancer J Clin 57, 43-66.
2. Kinzler KW & Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87, 159-170.
3. Corpet DE & Pierre F (2003) Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 12 1391-400.
4. Misikangas M, Pajari AM, Paivarinta E & Mutanen M (2005) Promotion of adenoma growth by dietary inulin is associated with increase in cyclin D1 and decrease in adhesion proteins in Min/+ mice mucosa. J Nutr Biochem 16, 402-409.
5. Näthke IS (2004) The adenomatous polyposis coli protein: The Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol 20, 337-366.
6. Cowin P (1994) Unraveling the cytoplasmic interactions of the cadherin superfamily. Proc Natl Acad Sci U S A 91, 10759-10761.
7. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R & Ben-Ze'ev A (1999) The cyclin D1 gene is a target of the beta-catenin/ LEF-1 pathway. Proc Natl Acad Sci U S A 96, 5522-5527.
8. Tetsu O & McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426.
9. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B & Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512.
10. Hao X, Tomlinson I, Ilyas M, Palazzo JP & Talbot IC (1997) Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours. Virchows Arch 431, 167-172.
11. Herter P, Kuhnen C, Muller KM, Wittinghofer A & Muller O (1999) Intracellular distribution of beta-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps. J Cancer Res Clin Oncol 125, 297-304.
12. Brabletz T, Herrmann K, Jung A, Faller G & Kirchner T (2000) Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am J Pathol 156, 865-870.
13. Cavallaro U & Christofori G (2004) Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4, 118-132.
14. Arber N, Hibshoosh H, Moss SF, Sutter T, Zhang Y, Begg M, Wang S, Weinstein IB & Holt PR (1996) Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology 110, 669-674.
15. Kristt D, Turner I, Koren R, Ramadan E & Gal R (2000) Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: An in situ hybridization analysis. Pathol Oncol Res 6, 65-70.
16. Bartkova J, Thullberg M, Slezak P, Jaramillo E, Rubio C, Thomassen LH & Bartek J (2001) Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. Gastroenterology 120, 1680-1688.
17. Utsunomiya T, Doki Y, Takemoto H, Shiozaki H, Yano M, Sekimoto M, Tamura S, Yasuda T, Fujiwara Y & Monden M (2001) Correlation of beta-catenin and cyclin D1 expression in colon cancers. Oncology 61, 226-233.
18. Bahnassy AA, Zekri AR, El-Houssini S, El-Shehaby AM, Mahmoud MR, Abdallah S & El-Serafi M (2004) Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroenterology 4, 22.
19. Mermelshtein A, Gerson A, Walfisch S, Delgado B, Shechter-Maor G, Delgado J, Fich A & Gheber L (2005) Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas. Br J Cancer 93, 338-345.
20. Zucker S & Vacirca J (2004) Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev 23, 101-117.
21. Mook OR, Frederiks WM & Van Noorden CJ (2004) The role of gelatinases in colorectal cancer progression and metastasis. Biochim Biophys Acta 1705, 69-89.
22. Reeves PG, Nielsen FH & Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939-1951.
23. Luebeck EG & Moolgavkar SH (2002) Multistage carcinogenesis and the incidence of colorectal cancer. Proc Natl Acad Sci U S A 99, 15095-15100.
24. Pool-Zobel BL (2005) Inulin-type fructans and reduction in colon cancer risk: Review of experimental and human data. Br J Nutr 93, Suppl. 1, S73-S90.
25. Takahashi M & Wakabayashi K (2004) Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci 95, 475-480.
26. Song J, Medline A, Mason JB, Gallinger S & Kim Y-I (2000) Effects of dietary folate on intestinal tumorigenesis in the ApcMin Mouse. Cancer Res 60, 5434-5440.
27. O'Shaughnessy JA, Kelloff GJ, Gordon GB, et al. (2002) Treatment and prevention of intraepithelial neoplasia: An important target for accelerated new agent development. Clin Cancer Res 8, 314-346.
28. Rafter J, Bennett M, Caderni G, et al. (2007) Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85, 488-496.
29. Behrens J (2005) The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem Soc Trans 33, 672-675.
30. Zhang T, Nanney LB, Luongo C, Lamps L, Heppner KJ, DuBois RN & Beauchamp RD (1997) Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res 57, 169-175.
31. Sansom OJ, Reed KR, van de Wetering M, Muncan V, Winton DJ, Clevers H & Clarke AR (2005) Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine. J Biol Chem 280, 28463-28467.
32. Wilding J, Straub J, Bee J, Churchman M, Bodmer W, Dickson C, Tomlinson I & Ilyas M (2002) Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice. Cancer Res 62, 4562-4565.
33. Hulit J, Wang C, Li Z, et al. (2004) Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol 24, 7598-7611.
34. Smits R, Ruiz P, Diaz-Cano S, Luz A, Jagmohan-Changur S, Breukel C, Birchmeier C, Birchmeier W & Fodde R (2000) E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology 119, 1045-1053.
35. Gottardi CJ, Wong E & Gumbiner BM (2001) E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol 153, 1049-1060.
36. Gottardi CJ & Gumbiner BM (2004) Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol 167, 339-349.
37. Carothers AM, Melstrom KA Jr, Mueller JD, Weyant MJ & Bertagnolli MM (2001) Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice. J Biol Chem 276, 39094-39102.
38. Ju J, Hong J, Zhou JN, et al. (2005) Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. Cancer Res 65, 10623-10631.
39. Hinck L, Nelson WJ & Papkoff J (1994) Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin. J Cell Biol 124, 729-741.