Non-opioid induction of morphine-6-glucuronide synthesis is elicited by prolonged exposure of rat hepatocytes to heroin

Drug and Alcohol Dependence

Volumn 98, Issue 3, 2008, Pages 179-184

  Graziani, Manuela ^a   Antonilli, Letizia ^a   Togna, Anna Rita ^a   Brusadin, Valentina ^b   Viola, Stefania ^a   Togna, Giuseppina ^a   Badiani, Aldo ^a   Nencini, Paolo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Biotransformation; Glucuronidation; Hepatocytes; Liver; Metabolism; Methadone; Morphine; Morphine 3 glucuronide; Morphine 6 glucuronide; Naltrexone; Rat

Indexed keywords

DIAMORPHINE; METHADONE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; NALTREXONE;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIVER CELL; LIVER CELL CULTURE; LIVER METABOLISM; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ANALGESICS, OPIOID; ANIMALS; CELL SEPARATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HALF-LIFE; HEPATOCYTES; HEROIN; MALE; MORPHINE DERIVATIVES; NALTREXONE; NARCOTIC ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 53049087864     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2008.05.008     Document Type: Article

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