Self-administration of heroin produces alterations in the expression of inducible nitric oxide synthase

Drug and Alcohol Dependence

Volumn 66, Issue 3, 2002, Pages 225-233

  Lanier, Ryan K ^a   Ijames, Stephanie G ^a   Carrigan, Kelly A ^a   Carelli, Regina M ^a   Lysle, Donald T ^a  

^a Program In Biological Psychology   (United States)

Author keywords

Heroin; Immunobiology; Neuroimmunomodulation; Nitric oxide synthase; Opioid; Self administration

Indexed keywords

DIAMORPHINE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE;

ANIMAL BEHAVIOR; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DEGRADATION; INFUSION; LIVER; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPLEEN; WESTERN BLOTTING;

ANIMALS; CONDITIONING, OPERANT; HEROIN; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; LIPOPOLYSACCHARIDES; LIVER; LUNG; MALE; NARCOTICS; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RATS, INBRED LEW; RNA, MESSENGER; SELF ADMINISTRATION; SPLEEN;

ANIMALIA;

EID: 0036568571     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(01)00203-4     Document Type: Article

References (46)

1. Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway
2. Immunosuppression induced by nitric oxide and its inhibition by interleukin-4
3. Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism
4. Intravenous self-administration of heroin in the rat: Experimental technique and computer analysis
5. Differential regulation of μ-opiate receptors in heroin- and morphine-dependent rats
6. Morphine pellet-induced immunomodulation in mice: Temporal relationships
7. Morphine-induced immunomodulation is not related to serum morphine concentrations
8. Intravenous drug self-administration in animals
9. Single-step method of RNA isolation by acide guanidinium thiocyanate-phenol-chloroform extraction
10. Response-dependent versus response-independent presentation of cocaine: Differences in the lethal effects of drug
11. Macrophage nitric oxide mediates immunosuppression in infectious inflammation
12. Evidence for beta adrenergic receptor involvement in the immunomodulatory effects of morphine
13. Macrophage-derived nitric oxide is involved in the depressed Con A-responsiveness of splenic lymphocytes from rats administered morphine in-vivo
14. Macrophage-derived nitric oxide is involved in the depressed Con A-responsiveness of splenic lymphocytes from rats administered morphine in-vivo
15. Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats
16. Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats
17. Phenotypic and functional assessments of immune status in the rat spleen following acute heroin treatment
18. Alterations of immune functions in heroin addicts and heroin withdrawal subjects
19. Antimicrobial and immunopathologic effect of cytokine-induced nitric oxide synthesis
20. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
21. Interferon inhibition by narcotic analgesics
22. Infections resulting from narcotic addiction: Report of 102 cases
23. Opioids inhibit the induction of nitric oxide synthase in J774 macrophages
24. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates
25. Absence of cross-tolerance to heroin in morphine-tolerant mice
26. Effects of certain abused drugs on hemolysin forming cells
27. Morphine-induced decreases in in vivo antibody responses
28. The major medical complication of heroin addiction
29. Endocarditis in 'main line' opium addicts
30. Endogenous opioids regulate the expression of inducible nitric oxide synthase by splenocytes
31. Heroin modulates the expression of inducible nitric oxide synthase
32. Morphine-induced alterations of immune status: Dose-dependency, compartment specificity and antagonism by naltrexone
33. A comparative study of physiological and subjective effects of heroin and morphine administered intravenously in postaddicts
34. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
35. Decreased natural and antibody-dependent cellular cytotoxic activities in intravenous drug users
36. Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells
37. Nitric oxide mediates immune dysfunction in the spontaneously hypertensive rat
38. A study of the analgesia, subjective depression, and euphoria produced by morphine, heroine, dilaudid and codeine in the normal human subject
39. Involvement of brain opiate receptors in the immune-suppressive effect of morphine
40. Neurotransmitter turnover in rat striatum is correlated with morphine self-administration
41. Brain neurotransmitter turnover correlated with morphine-seeking behavior of rats
42. Limbic acetylcholine turnover rates correlated with rat morphine-seeking behaviors
43. Heroin and morphine: Aversive and analgesic effects in rats
44. Direct cellular immunomodulation produced by diacetylmorphine (heroin) or methadone
45. Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei
46. Altered immune responses in mice lacking inducible nitric oxide synthase