Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 8818-8823

  Zhang, Chaowei ^a   Zink, Deborah L ^a   Ushio, Misti ^a   Burgess, Bruce ^a   Onishi, Russell ^a   Masurekar, Prakash ^a   Barrett, John F ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibiotic; Natural products; Protein synthesis inhibitor; Thizolyl peptides

Indexed keywords

OXAZOLIDINE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; THIAZOLE DERIVATIVE; THIAZOMYCIN A; UNCLASSIFIED DRUG;

AMYCOLATOPSIS FASTIDIOSA; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; GRAM POSITIVE BACTERIUM; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; SCREENING TEST; SOIL MICROFLORA;

ACTINOMYCETALES; ANTI-BACTERIAL AGENTS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; OXAZOLES; PEPTIDES, CYCLIC; STAPHYLOCOCCUS AUREUS; THIAZOLES;

AMYCOLATOPSIS FASTIDIOSA; POSIBACTERIA;

EID: 52949132998     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.079     Document Type: Article

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