Wound-healing properties of transforming growth factor β (TGF-β) inducible early gene 1 (TIEG1) knockout mice

Journal of Musculoskeletal Research

Volumn 11, Issue 2, 2008, Pages 63-69

  Taguchi, Manabu ^a   Moran, Steven L ^a   Zobitz, Mark E ^a   Zhao, Chunfeng ^a   Subramaniam, Malayannan ^a   Spelsberg, Thomas C ^a   Amadio, Peter C ^a  

^a MAYO CLINIC   (United States)

Author keywords

Breaking strength; Smad; TGF ; TIEG; Wound healing

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EARLY RESPONSE GENE; EPITHELIZATION; GENE EXPRESSION; GENETIC REGULATION; HISTOPATHOLOGY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; POSTOPERATIVE PERIOD; SKIN INJURY; WESTERN BLOTTING; WILD TYPE; WOUND HEALING;

EID: 52949121805     PISSN: 02189577     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0218957708002012     Document Type: Article

References (24)

1. Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, Roberts AB. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1: 260-266, 1999.
2. Beck LS, DeGuzman L, Lee WP, Xu Y, Siegel MW, Amento EP. One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing. J Clin Invest 92: 2841-2849, 1993.
3. Chalaux E, Lopez-Rovira T, Rosa JL, Pons G, Boxer LM, Bartrons R, Ventura F. A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cells. FEBS Lett 457: 478-482, 1999.
4. Derynck R, Zhang Y, Feng XH. Smads: Transcriptional activators of TGF-beta responses. Cell 95: 737-740, 1998.
5. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003.
6. Hefferan TE, Reinholz GG, Rickard DJ, Johnsen SA, Waters KM, Subramaniam M, Spelsberg TC. Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. J Biol Chem 275: 20255-20259, 2000.
7. Hefferan TE, Subramaniam M, Khosla S, Riggs BL, Spelsberg TC. Cytokine-specific induction of the TGF-beta inducible early gene (TIEG): Regulation by specific members of the TGF-beta family. J Cell Biochem 78: 380-390, 2000.
8. Johnsen SA, Subramaniam M, Effenberger KE, Spelsberg TC. The TGF-beta inducible early gene plays a central role in the anti-proliferative response to TGF-beta. Signal Transduct 4: 29-35, 2004.
9. Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC. TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene 21: 5783-5790, 2002.
10. Johnsen SA, Subramaniam M, Katagiri T, Janknecht R, Spelsberg TC. Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. J Cell Biochem 87: 233-241, 2002.
11. McGrath MH. Peptide growth factors and wound healing. Clin Plast Surg 17: 421-432, 1990.
12. Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci 114: 4359-4369, 2001.
13. Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF. Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science 237: 1333-1336, 1987.
14. O'Kane S, Ferguson MW. Transforming growth factor beta s and wound healing. Int J Biochem Cell Biol 29:63-78, 1997.
15. Ono I. The effects of basic fibroblast growth factor (bFGF) on the breaking strength of acute incisional wounds. J Dermatol Sci 29 104-113, 2002.
16. Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A, Hodivala-Dilke K. Accelerated re-epithelialization in beta3-integrin-deficient-mice is associated with enhanced TGF-beta1 signaling. Nat Med 11: 167-174, 2005.
17. Ribeiro A, Bronk SF, Roberts PJ, Urrutia R, Gores GJ. The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress. Hepatology 30: 1490-1497, 1999.
18. Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol 166: 1405-1418, 2005.
19. Smith PD, Kuhn MA, Franz MG, Wachtel TL, Wright TE, Robson MC. Initiating the inflammatory phase of incisional healing prior to tissue injury. J Surg Res 92: 11-17, 2000.
20. Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol 25: 1191-1199, 2005.
21. Subramaniam M, Harris SA, Oursler MJ, Rasmussen K, Riggs BL, Spelsberg TC. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res 23: 4907-4912, 1995.
22. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Ogawa H. Exogenous Smad3 accelerates wound healing in a rabbit dermal ulcer model. J Invest Dermatol 123: 229-236, 2004.
23. Tachibana I, Imoto M, Adjei PN, Gores GJ, Subramaniam M, Spelsberg TC, Urrutia R. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J Clin Invest 99: 2365-2374, 1997.
24. Wright TE, Hill DP, Ko F, Soler PM, Smith PD, Franz M, Nichols EH, Robson MC. The effect of TGF-beta2 in various vehicles on incisional wound healing. Int J Surg Investig 2: 133-143, 2000.