The TGFβ inducible early gene plays a central role in the anti-proliferative response to TGFβ

Signal Transduction

Volumn 4, Issue 1-2, 2004, Pages 29-35

  Johnsen, Steven A ^a,b   Subramaniam, Malayannan ^b   Effenberger, Katharina E ^a   Spelsberg, Thomas C ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Breast cancer; Cellular proliferation; Smad; TGF beta; TIEG; Transcription factors

Indexed keywords

SMAD PROTEIN; SMAD7 PROTEIN; TETRACYCLINE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; BREAST CANCER; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; EARLY RESPONSE GENE; FIBROBLAST; GENE; GENE INDUCTION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TIEG GENE;

ANIMALIA;

EID: 4444298193     PISSN: 16154053     EISSN: None     Source Type: Journal    
DOI: 10.1002/sita.200400032     Document Type: Article

References (31)

1. Hartsough, M. T. and Mulder, K. M. (1995) Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells. J. Biol. Chem. 270: 7117-24
2. Hocevar, B. A., Brown, T. L., and Howe, P. H. (1999) TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18: 1345-56
3. Hanafusa, H., Ninomiya-Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J., Shibuya, H., Matsumoto, K., and Nishida, E. (1999) Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J. Biol. Chem. 274: 27161-7
4. Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A., Moses, H. L., and Arteaga, C. L. (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem. 275: 36803-10
5. Derynck, R. and Zhang, Y. E. (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584
6. Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-3
7. Kim, S. K., Fan, Y., Papadimitrakopoulou, V., dayman, G., Hittelman, W. N., Hong, W. K., Lotan, R., and Mao, L. (1996) DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. Cancer Res. 56: 2519-21
8. Schutte, M., Hruban, R. H., Hedrick, L., Cho, K. R., Nadasdy, G. M., Weinstein, C. L., Bova, G. S., Isaacs, W. B., Cairns, P., Nawroz, H., Sidransky, D., Casero, R. A., Meltzer, P. S., Hahn, S. A., and Kern, S. E. (1996) DPC4 gene in various tumor types. Cancer Res. 56: 2527-30
9. Takagi, Y., Kohmura, H., Futamura, M., Kida, H., Tanemura, H., Shimokawa, K., and Saji, S. (1996) Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology 111: 1369-72
10. Kleeff, J., Ishiwata, T., Maruyama, H., Friess, H., Truong, P., Buchler, M. W., Falb, D., and Korc, M. (1999) The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Oncogene 18: 5363-72
11. Kleeff, J., Maruyama, H., Friess, H., Buchler, M. W., Falb, D., and Korc, M. (1999) Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer. Biochem. Biophys. Res. Commun. 255: 268-73
12. Colmenares, C. and Stavnezer, E. (1989) The ski oncogene induces muscle differentiation in quail embryo cells. Cell 59: 293-303
13. Boyer, P. L., Colmenares, C., Stavnezer, E., and Hughes, S. H. (1993) Sequence and biological activity of chicken snoN cDNA clones. Oncogene 8: 457-66
14. Koli, K. M. and Arteaga, C. L. (1996) Complex role of tumor cell transforming growth factor (TGF)-beta s on breast carcinoma progression. J. Mammary. Gland. Biol. Neoplasia. 1: 373-380
15. Johnsen, S. A., Subramaniam, M., Janknecht, R., and Spelsberg, T. C. (2002) TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene 21: 5783-5790
16. Subramaniam, M., Harris, S. A., Oursler, M. J., Rasmussen, K., Riggs, B. L., and Spelsberg, T. C. (1995) Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res. 23: 4907-12
17. Hefferan, T. E., Reinholz, G. G., Rickard, D. J., Johnsen, S. A., Waters, K. M., Subramaniam, M., and Spelsberg, T. C. (2000) Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. J. Biol. Chem. 275: 20255-9
18. Bender, H., Wang, Z., Schuster, N., and Krieglstein, K. (2004) TIEG1 facilitates transforming growth factor-beta-mediated apoptosis in the oligodendroglial cell line OLI-neu. J. Neurosci. Res. 75: 344-352
19. Johnsen, S. A., Subramaniam, M., Katagiri, T., Janknecht, R., and Spelsberg, T. C. (2002) Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. J. Cell Biochem. 87: 233-241
20. Johnsen, S. A., Subramaniam, M., Monroe, D. G., Janknecht, R., and Spelsberg, T. C. (2002) Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. J. Biol. Chem. 277: 30754-30759
21. Subramaniam, M., Hefferan, T. E., Tau, K., Peus, D., Pittelkow, M., Jalal, S., Riggs, B. L., Roche, P., and Spelsberg, T. C. (1998) Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene. J. Cell. Biochem. 68: 226-36
22. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17: 3091-100
23. Chalaux, E., Lopez-Rovira, T., Rosa, J. L., Pons, G., Boxer, L. M., Bartrons, R., and Ventura, F. (1999) A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cells. FEBS Lett. 457: 478-82
24. Tachibana, I., Imoto, M., Adjei, P. N., Gores, G. J., Subramaniam, M., Spelsberg, T. C., and Urrutia, R. (1997) Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J. Clin. Invest. 99: 2365-74
25. Arteaga, C. L., Tandon, A. K., Von Hoff, D. D., and Osborne, C. K. (1988) Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res. 48: 3898-3904
26. Burel, S. A., Harakawa, N., Zhou, L., Pabst, T., Tenen, D. G., and Zhang, D. E. (2001) Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol. Cell Biol. 21: 5577-5590
27. Miyamoto, H., Rahman, M., Takatera, H., Kang, H. Y., Yen, S., Chang, H. C., Nishimura, K., Fujimoto, N., and Chang, C. (2002) A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth. J. Biol. Chem. 277: 4609-4617
28. Moustakas, A., Pardali, K., Gaal, A., and Heldin, C. H. (2002) Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. Immunol. Lett. 82: 85-91
29. Moustakas, A. and Kardassis, D. (1998) Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. USA 95: 6733-8
30. Blok, L. J., Grossmann, M. E., Perry, J. E., and Tindall, D. J. (1995) Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. Mol. Endocrinol. 9: 1610-20
31. Noti, J. D., Johnson, A. K., and Dillon, J. D. (2004) The zinc-finger transcription factor TIEG1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter. J. Biol. Chem. 279: 26948-26958.