The Case for Shifting Borderline Personality Disorder to Axis I

Biological Psychiatry

Volumn 64, Issue 8, 2008, Pages 653-659

  New, Antonia S ^a,b   Triebwasser, Joseph ^a,b   Charney, Dennis S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Axis I; Axis II; borderline personality disorder; nosology; specificity; validity

Indexed keywords

ACETYLCHOLINE; ANTIDEPRESSANT AGENT; DOPAMINE; LITHIUM; MOOD STABILIZER; NEUROLEPTIC AGENT;

BIPOLAR DISORDER; BORDERLINE STATE; CINGULATE GYRUS; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISABILITY; DISEASE COURSE; FAMILIAL DISEASE; HERITABILITY; HUMAN; MAJOR DEPRESSION; NEUROBIOLOGY; NEUROIMAGING; ORBITAL CORTEX; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROGNOSIS; PSYCHIATRIC DIAGNOSIS; PSYCHOLOGIC ASSESSMENT; REVIEW; SCHIZOPHRENIA; STIGMA;

BORDERLINE PERSONALITY DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; HUMANS;

EID: 52949119549     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.04.020     Document Type: Review

References (100)

1. Paris J. Recent advances in the treatment of borderline personality disorder. Can J Psychiatry 50 (2005) 435-441
2. Akiskal H.S., Chen S.E., Davis G.C., Puzantian V.R., Kahgarian M., and Bolinger J.M. Borderline: An adjective in search of a noun. J Clin Psychiatry 46 (1985) 41-48
3. Robins E., and Guze S.B. Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. Am J Psychiatry 126 (1970) 983-987
4. Schulz S.C., and Goldberg S.C. Is borderline personality disorder an illness?. Psychopharmacol Bull 20 (1984) 554-560
5. Sanislow C.A., Grilo C.M., and McGlashan T.H. Factor analysis of the DSM-III-R borderline personality disorder criteria in psychiatric inpatients. Am J Psychiatry 157 (2000) 1629-1633
6. Sanislow C.A., Grilo C.M., Morey L.C., Bender D.S., Skodol A.E., Gunderson J.G., et al. Confirmatory factor analysis of DSM-IV criteria for borderline personality disorder: Findings from the collaborative longitudinal personality disorders study. Am J Psychiatry 159 (2002) 284-290
7. Johansen M., Karterud S., Pedersen G., Gude T., and Falkum E. An investigation of the prototype validity of the borderline DSM-IV construct. Acta Psychiatr Scand 109 (2004) 289-298
8. Fossati A., Maffei C., Bagnato M., Donati D., Namia C., and Novella L. Latent structure analysis of DSM-IV borderline personality disorder criteria. Compr Psychiatry 40 (1999) 72-79
9. Clifton A., and Pilkonis P.A. Evidence for a single latent class of Diagnostic and Statistical Manual of Mental Disorders borderline personality pathology. Compr Psychiatry 48 (2007) 70-78
10. McGlashan T.H., Grilo C.M., Skodol A.E., Gunderson J.G., Shea M.T., Morey L.C., et al. The Collaborative Longitudinal Personality Disorders Study: Baseline Axis I/II and II/II diagnostic co-occurrence. Acta Psychiatr Scand 102 (2000) 256-264
11. Shea M.T., Stout R.L., Yen S., Pagano M.E., Skodol A.E., Morey L.C., et al. Associations in the course of personality disorders and Axis I disorders over time. J Abnorm Psychol 113 (2004) 499-508
12. Fyer M.R., Frances A.J., Sullivan T., Hurt S.W., and Clarkin J. Comorbidity of borderline personality disorder. Arch Gen Psychiatry 45 (1988) 348-352
13. Zanarini M.C., Frankenburg F.R., Hennen J., Reich D.B., and Silk K.R. Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission. Am J Psychiatry 161 (2004) 2108-2114
14. Links P.S., Heslegrave R.J., Mitton J.E., Van Reekum R., and Patrick J. Borderline psychopathology and recurrences of clinical disorders. J Nerv Ment Dis 183 (1995) 582-586
15. Gunderson J.G., Weinberg I., Daversa M.T., Kueppenbender K.D., Zanarini M.C., Shea M.T., et al. Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder. Am J Psychiatry 163 (2006) 1173-1178
16. Kelsoe J.R. Arguments for the genetic basis of the bipolar spectrum. J Affect Disord 73 (2003) 183-197
17. Silverman J.M., Pinkham L., Horvath T.B., Coccaro E.F., Klar H., Schear S., et al. Affective and impulsive personality disorder traits in the relatives of patients with borderline personality disorder. Am J Psychiatry 148 (1991) 1378-1385
18. Coccaro E.F., and Kavoussi R.J. Fluoxetine and impulsive aggressive behavior in personality disordered subjects. Arch Gen Psychiatry 54 (1997) 1081-1088
19. Coid J., Yang M., Tyrer P., Roberts A., and Ullrich S. Prevalence and correlates of personality disorder in Great Britain. Br J Psychiatry 188 (2006) 423-431
20. Lenzenweger M.F., Lane M.C., Loranger A.W., and Kessler R.C. DSM-IV personality disorders in the National Comorbidity Survey Replication. Biol Psychiatry 62 (2007) 553-564
21. Zimmerman M., Rothschild L., and Chelminski I. The prevalence of DSM-IV personality disorders in psychiatric outpatients. Am J Psychiatry 162 (2005) 1911-1918
22. Comtois K.A., Russo J., Snowden M., Srebnik D., Ries R., and Roy-Byrne P. Factors associated with high use of public mental health services by persons with borderline personality disorder. Psychiatr Serv 54 (2003) 1149-1154
23. Bender D., Dolan R., Skodol A., Sanislow C.A., Dyck I.R., McGlashan T.H., et al. Treatment utilization by patients with personality disorders. Am J Psychiatry 158 (2001) 295-302
24. Frankenburg F.R., and Zanarini M.C. The association between borderline personality disorder and chronic medical illnesses, poor health-related lifestyle choices, and costly forms of health care utilization. J Clin Psychiatry 65 (2004) 1660-1665
25. Lieb K., Zanarini M.C., Schmahl C., Linehan M.M., and Bohus M. Borderline personality disorder. Lancet 364 (2004) 453-461
26. Black D.W., Blum N., Pfohl B., and Hale N. Suicidal behavior in borderline personality disorder: Prevalence, risk factors, prediction, and prevention. J Personal Disord 18 (2004) 226-239
27. Skodol A.E., Gunderson J., McGlashan T., Dyck I.R., Stout R.L., Bender D.S., et al. Functional impairment in patients with schizotypal, borderline, avoidant, and obsessive compulsive personality disorders. Am J Psychiatry 159 (2002) 276-283
28. Zanarini M.C., Frankenburg F.R., Hennen J., Reich D.B., and Silk K.R. The McLean Study of Adult Development (MSAD): Overview and implications of the first six years of prospective follow-up. J Personal Disord 19 (2005) 505-523
29. Paris J., and Zweig-Frank H. A 27-year follow-up of patients with borderline personality disorder. Compr Psychiatry 42 (2001) 482-487
30. Zanarini M.C., Frankenburg F.R., Hennen J., Reich D.B., and Silk K.R. Prediction of the 10-year course of borderline personality disorder. Am J Psychiatry 163 (2006) 827-832
31. Paris J (2003): Personality Disorder Over Time: Precursors, Course and Outcome. Washington DC: American Psychiatric Press.
32. Loranger A.W., Oldham J.M., and Tulis E.H. Familial transmission of DSM-III borderline personality disorder. Arch Gen Psychiatry 39 (1982) 795-799
33. Zanarini M.C., Frankenburg F.R., Yong L., Raviola G., Bradford Reich D., Hennen J., et al. Borderline psychopathology in the first-degree relatives of borderline and axis II comparison probands. J Personal Disord 18 (2004) 439-447
34. Riso L.P., Klein D.N., Anderson R.L., and Ouimette P.C. A family study of outpatients with borderline personality disorder and no history of mood disorder. J Personal Disord 14 (2000) 208-217
35. Torgersen S. Genetics of patients with borderline personality disorder. Psychiatr Clin North Am 23 (2000) 1-9
36. Ji W.Y., Hu Y.H., Huang Y.Q., Cao W.H., Lv J., Qin Y., et al. A twin study of personality disorder heritability. [Article in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi 27 (2006) 137-141
37. Coolidge F.L., Thede L.L., and Jang K.L. Heritability of personality disorders in childhood: A preliminary investigation. J Personal Disord 15 (2001) 33-40
38. Moskowitz D.S., Pinard G., Zuroff D.C., Annable L., and Young S.N. The effect of tryptophan on social interaction in everyday life: A placebo-controlled study. Neuropsychopharmacology 25 (2001) 277-289
39. Russell J.J., Moskowitz D.S., Zuroff D.C., Sookman D., and Paris J. Stability and variability of affective experience and interpersonal behavior in borderline personality disorder. J Abnorm Psychol 116 (2007) 578-588
40. Bohus M., Schmahl C., and Lieb K. New developments in the neurobiology of borderline personality disorder. Curr Psychiatry Rep 6 (2004) 43-50
41. New A.S., Goodman M., Treibwasser J., and Siever L.J. Recent advances in the biological study of personality disorders. Psych Clin North Am 31 (2008)
42. Coccaro E.F., Siever L.J., Klar H.M., Maurer G., Cochrane K., Cooper T.B., et al. Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 46 (1989) 587-599
43. O'Keane V., Maloney E., O'Neil H., O'Connor A., Smith C., and Dinan T.G. Blunted prolactin response to d-fenfluramine in sociopathy: Evidence for subsensitivity of central serotonergic function. Br J Psychiatry 160 (1992) 643-646
44. Siever L., and Trestman R.L. The serotonin system and aggressive personality disorder. Int Clin Psychopharmacology 8 (1993) 33-39
45. Dougherty D.M., Bjork J.M., Huckabee H., Moeller F., and Swann A. Laboratory measures of aggression and impulsivity in women with borderline personality disorder. Psychiatry Res 85 (1999) 315-326
46. Siever L.J., Buchsbaum M.S., New A.S., Spiegel-Cohen J., Wei T., Hazlett E.A., et al. d,l-fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology 20 (1999) 413-423
47. New A., Hazlett E., Buchsbaum M.S., Goodman M., Reynolds D., Mitropoulou V., et al. Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chloropiperazine in impulsive aggression. Arch Gen Psychiatry 59 (2002) 621-629
48. Soloff P.H., Meltzer C.C., Greer P.J., Constantine D., and Kelly T.M. A fenfluramine-activated FDG-PET study of borderline personality disorder. Biol Psychiatry 47 (2000) 540-547
49. Leyton M., Okazawa H., Diksic M., Paris J., Rosa P., Mzengeza S., et al. Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. Am J Psychiatry 158 (2001) 775-782
50. New A.S., Buchsbaum M.S., Hazlett E.A., Goodman M., Koenigsberg H.W., Lo J., et al. Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression. Psychopharmacology (Berl) 176 (2004) 451-458
51. Frankle W.G., Lombardo I., New A.S., Goodman M., Talbot P.S., Huang Y., et al. Brain serotonin transporter distribution in subjects with impulsive aggressivity: A positron emission study with [11C]McN 5652. Am J Psychiatry 162 (2005) 915-923
52. Soloff P.H., Price J.C., Meltzer C.C., Fabio A., Frank G.K., and Kaye W.H. 5HT2A receptor binding is increased in borderline personality disorder. Biol Psychiatry 62 (2007) 580-587
53. Siever L., Torgersen S., Gunderson J., Livesley W., and Kendler K. The borderline diagnosis III: Identifying endophenotypes for genetic studies. Biol Psychiatry 51 (2002) 964-968
54. Friedel R.O. Dopamine dysfunction in borderline personality disorder: A hypothesis. Neuropsychopharmacology 29 (2004) 1029-1039
55. Gurvitz I.G., Koenigsberg H.W., and Siever L.J. Neurotransmitter dysfunction in patients with borderline personality disorder. Psychiatr Clin North Am 23 (2000) 27-40
56. Schmahl C., and Bremner J.D. Neuroimaging in borderline personality disorder. J Psychiatr Res 40 (2006) 419-427
57. Tebartz van Elst L., Hesslinger B., Thiel T., et al. Frontolimbic brain abnormalities in patients with borderline personality disorder: A volumetric magnetic resonance imaging study. Biol Psychiatry 54 (2003) 163-171
58. Hazlett E.A., New A.S., Newmark R., Haznedar M.M., Lo J.N., Speiser L.J., et al. Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biol Psychiatry 58 (2005) 614-623
59. Minzenberg M.J., Fan J., New A.S., Tang C.Y., and Siever L.J. Frontolimbic structural changes in borderline personality disorder. J Psychiatr Res 42 (2008) 727-733
60. Goyer P.F., Andreason P.J., Semple W.E., Clayton A.H., King A.C., Compton-Toth B.A., et al. Positron-emission tomography and personality disorders. Neuropsychopharmacology 10 (1994) 21-28
61. Schmahl C., Bohus M., Esposito F., Treede R.D., Di Salle F., Greffrath W., et al. Neural correlates of antinociception in borderline personality disorder. Arch Gen Psychiatry 63 (2006) 659-667
62. Minzenberg M.J., Fan J., New A.S., Tang C.Y., and Siever L.J. Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: An event-related fMRI study. Psychiatry Res 155 (2007) 231-243
63. Schnell K., Dietrich T., Schnitker R., Daumann J., and Herpertz S.C. Processing of autobiographical memory retrieval cues in borderline personality disorder. J Affect Disord 97 (2007) 253-259
64. Ressler K.J., and Mayberg H.S. Targeting abnormal neural circuits in mood and anxiety disorders: From the laboratory to the clinic. Nat Neurosci 10 (2007) 1116-1124
65. Blumberg H.P., Charney D.S., and Krystal J.H. Frontotemporal neural systems in bipolar disorder. Semin Clin Neuropsychiatry 7 (2002) 243-254
66. Caetano S.C., Kaur S., Brambilla P., Nicoletti M., Hatch J.P., Sassi R.B., et al. Smaller cingulate volumes in unipolar depressed patients. Biol Psychiatry 59 (2006) 702-706
67. Coryell W., Nopoulos P., Drevets W., Wilson T., and Andreasen N.C. Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: Diagnostic specificity and prognostic implications. Am J Psychiatry 162 (2005) 1706-1712
68. Ballmaier M., Toga A.W., Blanton R.E., Sowell E.R., Lavretsky H., Peterson J., et al. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: An MRI-based parcellation of the prefrontal cortex. Am J Psychiatry 161 (2004) 99-108
69. Hajek T., Carrey N., and Alda M. Neuroanatomical abnormalities as risk factors for bipolar disorder. Bipolar Disord 7 (2005) 393-403
70. Sassi R.B., Brambilla P., Hatch J.P., Nicoletti M.A., Mallinger A.G., Frank E., et al. Reduced left anterior cingulate volumes in untreated bipolar patients. Biol Psychiatry 56 (2004) 467-475
71. Davidson R.J., Irwin W., Anderle M.J., and Kalin N.H. The neural substrates of affective processing in depressed patients treated with venlafaxine. Am J Psychiatry 160 (2003) 64-75
72. Blumberg H.P., Leung H.C., Skudlarski P., Lacadie C.M., Fredericks C.A., Harris B.C., et al. A functional magnetic resonance imaging study of bipolar disorder: State- and trait-related dysfunction in ventral prefrontal cortices. Arch Gen Psychiatry 60 (2003) 601-609
73. Shin L.M., McNally R.J., Kosslyn S.M., Thompson W.L., Rauch S.L., Alpert N.M., et al. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. Am J Psychiatry 156 (1999) 575-584
74. Gunderson J.G., and Phillips K.A. A current view of the interface between borderline personality disorder and depression. Am J Psychiatry 148 (1991) 967-975
75. McGlashan T.H., Grilo C.M., Sanislow C.A., Ralevski E., Morey L.C., Gunderson J.G., et al. Two-year prevalence and stability of individual DSM-IV criteria for schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders: Toward a hybrid model of axis II disorders. Am J Psychiatry 162 (2005) 883839
76. Gunderson J.G. Disturbed relationships as a phenotype for borderline personality disorder. Am J Psychiatry 164 (2007) 1637-1640
77. Hill J., Pilkonis P., Morse J., Feske U., Reynolds S., Hope H., et al. Social domain dysfunction and disorganization in borderline personality disorder. Psychol Med 38 (2008) 135-146
78. Jovev M., and Jackson H.J. The relationship of borderline personality disorder, life events and functioning in an Australian psychiatric sample. J Personal Disord 20 (2006) 205-217
79. Brodsky B.S., Groves S.A., Oquendo M.A., Mann J.J., and Stanley B. Interpersonal precipitants and suicide attempts in borderline personality disorder. Suicide Life Threat Behav 36 (2006) 313-322
80. Wagner A.W., and Linehan M.M. Facial expression recognition ability among women with borderline personality disorder: Implications for emotion regulation?. J Personal Disord 13 (1999) 329-344
81. Blair R.J., Colledge E., Murray L., and Mitchell D.G. A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendencies. J Abnorm Child Psychol 29 (2001) 491-498
82. Lynch T.R., Rosenthal M.Z., Kosson D.S., Cheavens J.S., Lejuez C.W., and Blair R.J. Heightened sensitivity to facial expressions of emotion in borderline personality disorder. Emotion 6 (2006) 647-655
83. Donegan N.H., Sanislow C.A., Blumberg H.P., Fulbright R.K., Lacadie C., Skudlarski P., et al. Amygdala hyperreactivity in borderline personality disorder: Implications for emotional dysregulation. Biol Psychiatry 54 (2003) 1284-1293
84. Moriceau S., and Sullivan R.M. Neurobiology of infant attachment. Dev Psychobiol 47 (2005) 230-242
85. Siever L.J., and Davis K. A psychobiological perspective on the personality disorders. Am J Psychiatry 148 (1991) 1647-1658
86. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
87. Paris J. The nature of borderline personality disorder: Multiple dimensions, multiple symptoms, but one category. J Personal Disord 21 (2007) 457-473
88. Paris J. Memories of abuse in borderline patients: True or false?. Harv Rev Psychiatry 3 (1995) 10-17
89. Silverman A.B., Reinherz H.Z., and Giaconia R.M. The long-term sequelae of child and adolescent abuse: A longitudinal community study. Child Abuse Negl 20 (1996) 709-723
90. Paris J. Childhood precursors of borderline personality disorder. Psychiatr Clin North Am 23 (2000) 77-88 vii
91. Bailey J.M., and Shriver A. Does childhood sexual abuse cause borderline personality disorder?. J Sex Marital Ther 25 (1999) 45-57
92. Herman J.L., Perry J.C., and van der Kolk B.A. Childhood trauma in borderline personality disorder. Am J Psychiatry 146 (1989) 490-495
93. Battle C.L., Shea M.T., Johnson D.M., Yen S., Zlotnick C., Zanarini M.C., et al. Childhood maltreatment associated with adult personality disorders: Findings from the Collaborative Longitudinal Personality Disorders Study. J Personal Disord 18 (2004) 193-211
94. Bierer L.M., Yehuda R., Schmeidler J., Mitropoulou V., New A.S., Silverman J.M., and Siever L.J. Abuse and neglect in childhood: Relationship to personality disorder diagnoses. CNS Spectr 8 (2003) 737-754
95. Bandelow B., Krause J., Wedekind D., Broocks A., Hajak G., and Ruther E. Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with borderline personality disorder and healthy controls. Psychiatry Res 134 (2005) 169-179
96. Fossati A., Madeddu F., and Maffei C. Borderline personality disorder and childhood sexual abuse: A meta-analytic study. J Personal Disord 13 (1999) 268-280
97. Goodman M., and Yehuda R. The relationship between psychological trauma and borderline personality disorder. Psychiatric Annals 32 (2002) 337-346
98. Paris J. Does childhood trauma cause personality disorders in adults?. Can J Psychiatry 43 (1998) 148-153
99. McGloin J.M., and Widom C.S. Resilience among abused and neglected children grown up. Dev Psychopathol 13 (2001) 1021-1038
100. Zanarini M.C., and Frankenburg F.R. Pathways to the development of borderline personality disorder. J Personal Disord 11 (1997) 93-104