Heat shock protein-antigen fusions lose their enhanced immunostimulatory capacity after endotoxin depletion

Molecular Immunology

Volumn 46, Issue 1, 2008, Pages 181-191

  Marincek, Boris Christian ^a   Kühnle, Marie Cristine ^a   Srokowski, Cathy ^b   Schild, Hansjörg ^b   Hämmerling, Günter ^a   Momburg, Frank ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Endotoxin; Fusion protein; Heat shock protein 70; TLR ligands; Tumor vaccine

Indexed keywords

ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CPG OLIGODEOXYNUCLEOTIDE 1668; ENDOTOXIN; HEAT SHOCK PROTEIN; HYBRID PROTEIN; IMMUNOLOGICAL ADJUVANT; LIPOPOLYSACCHARIDE; RECOMBINANT ANTIGEN; RECOMBINANT HEAT SHOCK PROTEIN 70 OVALBUMIN FUSION PROTEIN; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL MATURATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ESCHERICHIA COLI; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOSTIMULATION; IN VIVO STUDY; MELANOMA CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; TUMOR IMMUNITY; TUMOR MODEL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CROSS-PRIMING; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; ENDOTOXINS; HSP70 HEAT-SHOCK PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASMS; OLIGODEOXYRIBONUCLEOTIDES; OVALBUMIN; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

MUS;

EID: 52949110165     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.07.039     Document Type: Article

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