Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling

Journal of Biological Chemistry

Volumn 282, Issue 43, 2007, Pages 31688-31702

  Bendz, Henriette ^a,b   Ruhland, Sibylle C ^a,b   Pandya, Maya J ^c,e   Hainzl, Otmar ^c   Riegelsberger, Stefan ^a   Bräuchle, Christoph ^a   Mayer, Matthias P ^d   Buchner, Johannes ^c   Issels, Rolf D ^a,b   Noessner, Elfriede ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EXOGENOUS ANTIGENS; HEAT SHOCK PROTEIN 70; MATURATION; RECOMBINANT GENERATION; T CELL STIMULATION;

ANTIGENS; BYPRODUCTS; DENDRIMERS; IMMUNOLOGY; OPTIMIZATION; TUMORS;

PROTEINS;

EXOTOXIN; EXOTOXIN A; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; MELAN A; MEMBRANE PROTEIN; MONOPHENOL MONOOXYGENASE; NUCLEOTIDE DERIVATIVE; PEPTIDE DERIVATIVE; RECOMBINANT HEAT SHOCK PROTEIN 70; RECOMBINANT PROTEIN; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING; UNCLASSIFIED DRUG;

ACIDIFICATION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; CROSS PRESENTATION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG MECHANISM; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOMODULATION; INNATE IMMUNITY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PINOCYTOSIS; PRIORITY JOURNAL;

ANTIGEN PRESENTATION; ANTIGENS, NEOPLASM; B-LYMPHOCYTES; CALCIUM; CELL LINE, TUMOR; CROSS-PRIMING; DENDRITIC CELLS; ENDOSOMES; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY, NATURAL; MICROSCOPY, CONFOCAL; MODELS, IMMUNOLOGICAL; PINOCYTOSIS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 35748934798     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704129200     Document Type: Article

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