Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 2, 2008, Pages 531-538

  Koljonen, Maija ^a   Rousu, Katja ^b   Cierny, Jakub ^a   Kaukonen, Ann Marie ^a   Hirvonen, Jouni ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b ORION CORPORATION   (Finland)

Author keywords

Anionic compounds; Caco 2; PAMPA; pH dependency; Transport mechanisms

Indexed keywords

2 HYDROXY 1 NAPHTHOIC ACID; 5 HYDROXYISOPHTHALIC ACID; EDETIC ACID; GENTISIC ACID; NAPHTHALENE DERIVATIVE; PHTHALIC ACID DERIVATIVE; SALICYLIC ACID; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; ARTICLE; ARTIFICIAL MEMBRANE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSPORT; HUMAN; HUMAN CELL; KINETICS; LIPID MEMBRANE; MEMBRANE PERMEABILITY; PASSIVE TRANSPORT;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; EDETIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL; PERMEABILITY; PHOSPHOLIPIDS; SALICYLIC ACID;

EID: 52949107287     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.05.017     Document Type: Article

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