Integrity of the cortical actin ring is required for activation of the PI3K/Akt and p38 MAPK signaling pathways in redifferentiation of chondrocytes on chitosan

Cell Biology International

Volumn 32, Issue 10, 2008, Pages 1272-1278

  Park, Eun Hee ^a   Kang, Shin Sung ^a   Lee, Young Sup ^a   Kim, Song Ja ^b   Jin, Eun Jung ^c   Tak, Eun Nam ^a   Sonn, Jong Kyung ^a  

^a Kyungpook National University   (South Korea)

^b Kongju National University   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

Akt; Chondrogenesis; Citosan; Cytoskeleton; p38 MAPK; Redifferentiation

Indexed keywords

CHITOSAN; CYTOCHALASIN D; F ACTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IMMUNOFLUORESCENCE; MESENCHYME CELL; NONHUMAN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; ANIMALS; CELL DIFFERENTIATION; CELL SHAPE; CELLS, CULTURED; CHICK EMBRYO; CHITOSAN; CHONDROCYTES; CYTOCHALASIN D; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INHIBITORS; MAP KINASE SIGNALING SYSTEM; NUCLEIC ACID SYNTHESIS INHIBITORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 52949101333     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2008.07.013     Document Type: Article

References (37)

1. Archer C.W., McDowell J., Bayliss M.T., Stephens M.D., and Bentley G. Phenotypic modulation in sub-populations of human articular chondrocytes in vitro. J Cell Sci 97 (1990) 361-371
2. Benya P.D., and Shaffer J.D. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30 (1982) 215-224
3. Benya P.D., Padilla S.R., and Nimni M.E. The progeny of rabbit articular chondrocytes synthesize collagen types I and III and type I trimer, but not type II. Verifications by cyanogen bromide peptide analysis. Biochemistry 16 (1977) 865-872
4. Benya P.D., Padilla S.R., and Nimni M.E. Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture. Cell 15 (1978) 1313-1321
5. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
6. Chia S.H., Homicz M.R., Schumacher B.L., Thonar E.J., Masuda K., Sah R.L., et al. Characterization of human nasal septal chondrocytes cultured in alginate. J Am Coll Surg 200 (2005) 691-704
7. Dalby M.J., Riehle M.O., Sutherland D.S., Agheli H., and Curtis A.S. Morphological and microarray analysis of human fibroblasts cultured on nanocolumns produced by colloidal lithography. Eur Cell Mater 9 (2005) 1-8
8. Eyster C.A., Duggins Q.S., and Olson A.L. Expression of constitutively active Akt/protein kinase B signals GLUT4 translocation in the absence of an intact actin cytoskeleton. J Biol Chem 280 (2005) 17978-17985
9. Fujita T., Fukuyama R., Enomoto H., and Komori T. Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2. J Cell Biochem 93 (2004) 374-383
10. Hauselmann H.J., Aydelotte M.B., Schumacher B.L., Kuettner K.E., Gitelis S.H., and Thonar E.J. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads. Matrix 12 (1992) 116-129
11. Heyland J., Wiegandt K., Goepfert C., Nagel-Heyer S., Ilinich E., Schumacher U., et al. Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure. Biotechnol Lett 28 (2006) 1641-1648
12. Hidaka K., Kanematsu T., Takeuchi H., Nakata M., Kikkawa U., and Hirata M. Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5. Int J Biochem Cell Biol 33 (2001) 1094-1103
13. Hirsch M.S., Lunsford L.E., Trinkaus-Randall V., and Svoboda K.K. Chondrocyte survival and differentiation in situ are integrin mediated. Dev Dyn 210 (1997) 249-263
14. Hong Y., Song H., Gong Y., Mao Z., Gao C., and Shen J. Covalently crosslinked chitosan hydrogel: properties of in vitro degradation and chondrocyte encapsulation. Acta Biomater 3 (2007) 23-31
15. Huang S., and Ingber D.E. Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp Cell Res 261 (2000) 91-103
16. Hwang S.G., Ryu J.H., Kim I.C., Jho E.H., Jung H.C., Kim K., et al. Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms. J Biol Chem 279 (2004) 26597-26604
17. Idowu B.D., Knight M.M., Bader D.L., and Lee D.A. Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochem J 32 (2000) 165-174
18. Jin E.J., Park K.S., Bang O.S., and Kang S.S. Akt signaling regulates actin organization via modulation of MMP-2 activity during chondrogenesis of chick wing limb bud mesenchymal cells. J Cell Biochem (2007)
19. Kim R.D., Darling C.E., Roth T.P., Ricciardi R., and Chari R.S. Activator protein 1 activation following hypoosmotic stress in HepG2 cells is actin cytoskeleton dependent. J Surg Res 100 (2001) 176-182
20. Krasilnikov M.A. Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry (Mosc.) 65 (2000) 59-67
21. Lahiji A., Sohrabi A., Hungerford D.S., and Frondoza C.G. Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes. J Biomed Mater Res 51 (2000) 586-595
22. Langelier E., Suetterlin R., Hoemann C.D., Aebi U., and Buschmann M.D. The chondrocyte cytoskeleton in mature articular cartilage: structure and distribution of actin, tubulin, and vimentin filaments. J Histochem Cytochem 48 (2000) 1307-1320
23. Lee Y.A., Kang S.S., Baek S.H., Jung J.C., Jin E.J., Tak E.N., et al. Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCα and p38 MAP kinase. Mol Cells (2007)
24. Lefebvre V., Peeters-Joris C., and Vaes G. Production of collagens, collagenase and collagenase inhibitor during the dedifferentiation of articular chondrocytes by serial subcultures. Biochim Biophys Acta 1051 (1990) 266-275
25. Liu H., Lee Y.W., and Dean M.F. Re-expression of differentiated proteoglycan phenotype by dedifferentiated human chondrocytes during culture in alginate beads. Biochim Biophys Acta 1425 (1998) 505-515
26. Mayne R., Vail M.S., Mayne P.M., and Miller E.J. Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity. Proc Natl Acad Sci USA 73 (1976) 1674-1678
27. Oh C.D., and Chun J.S. Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1. J Biol Chem 278 (2003) 36563-36571
28. Peyrollier K., Hajduch E., Gray A., Litherland G.J., Prescott A.R., Leslie N.R., et al. A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B. Biochem J 352 (2000) 617-622
29. Rodriguez-Viciana P., Warne P.H., Khwaja A., Marte B.M., Pappin D., Das P., et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89 (1997) 457-467
30. Schnabel M., Marlovits S., Eckhoff G., Fichtel I., Gotzen L., Vécsei V., et al. Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthr Cart 10 (2002) 62-70
31. Solursh M., Linsenmayer T.F., and Jensen K.L. Chondrogenesis from single limb mesenchyme cells. Dev Biol 94 (1982) 259-264
32. Stokoe D., Stephens L.R., Copeland T., Gaffney P.R., Reese C.B., Painter G.F., et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277 (1997) 567-570
33. Subramanian A., and Lin H.Y. Crosslinked chitosan: its physical properties and the effects of matrix stiffness on chondrocyte cell morphology and proliferation. J Biomed Mater Res A 75 (2005) 742-753
34. Suh J.K., and Matthew H.W. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials 21 (2000) 2589-2598
35. Toker A., and Newton A.C. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 275 (2000) 8271-8274
36. Vinall R.L., Lo S.H., and Reddi A.H. Regulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton. Exp Cell Res 272 (2002) 32-44
37. Zhang Z., Messana J., Hwang N.S., and Elisseeff J.H. Reorganization of actin filaments enhances chondrogenic differentiation of cells derived from murine embryonic stem cells. Biochem Biophys Res Commun 348 (2006) 421-427