Akt signaling regulates actin organization via modulation of MMP-2 activity during chondrogenesis of chick wing limb bud mesenchymal cells

Journal of Cellular Biochemistry

Volumn 102, Issue 1, 2007, Pages 252-261

  Jin, Eun Jung ^a   Kwang, Sook Park ^a   Bang, Ok Sun ^c   Kang, Shin Sung ^a,b  

^a Kyungpook National University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Actin cytoskeleton; Akt; Chondrogenic differentiation; MMP 2

Indexed keywords

ACTIN; GELATINASE A; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL SHAPE; CHICK; CHONDROGENESIS; CONTROLLED STUDY; CYTOSKELETON; ENCHONDRAL OSSIFICATION; ENZYME ACTIVITY; GENE EXPRESSION; GLYCOSAMINOGLYCAN METABOLISM; MESENCHYME CELL; NONHUMAN; PRIORITY JOURNAL;

ACTINS; ANIMALS; CELLS, CULTURED; CHICK EMBRYO; CHONDROCYTES; CHONDROGENESIS; MATRIX METALLOPROTEINASE 2; MESENCHYMAL STEM CELLS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; WING;

EID: 34548478537     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21430     Document Type: Article

References (42)

1. Daniels K, Solursh M. 1991. Modulation of chondrogenesis by the cytoskeleton and extracellular matrix. J Cell Sci 100:249-254.
2. Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK, Steck PA. 1999. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 59:2551-2556.
3. DeLise AM, Fischer L, Tuan RS. 2000. Cellular interactions and signaling in cartilage development. Osteoarthritis Cartilage 8:309-334.
4. Downward J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267.
5. Fichter M, Korner U, Schomburg J, Jennings L, Cole AA, Mollenhauer J. 2006. Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes. J Orthop Res 24:63-70.
6. Franke TF, Kaplan DR, Cantley LC. 1997. PI3K: Downstream AKTion blocks apoptosis. Cell 88:435-437.
7. Hay E, Lemonnier J, Fromigue O, Marie PJ. 2001. Bone morphogenetic protein-2 promotes osteoblast apoptosis through a madindependent, protein kinase C-dependent signaling pathway. J Biol Chem 276:29028-29036.
8. Hayakawa J, Ohmichi M, Kurachi H, Kanda Y, Hisamoto K, Nishio Y, Adachi K, Tasaka K, Kanzaki T, Murata Y. 2000. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res 60: 5988-5994.
9. Hemmings BA. 1997. Akt signaling: Linking membrane events to life and death decisions. Science 275:628-630.
10. Idowu BD, Knight MM, Bader DL, Lee DA. 2000. Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochem J 32:165-174.
11. Izumi M, Fujio Y, Kunisada K, Negoro S, Tone E, Funamoto M, Osugi T, Oshima Y, Nakaoka Y, Kishimoto T, Yamauchi-akihara K, Hirota H. 2001. Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway. J Biol Chem 276:31133-31141.
12. Jin EJ, Lee SY, Choi YA, Jung JC, Bang OS, Kang SS. 2006. BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol Cells 22:353-359.
13. Karsenty G, Wagner EF. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2:389-406.
14. Kim D, Kim S, Koh H, Yoon SO, Chung AS, Cho KS, Chung J. 2001. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15:1953-1962.
15. Kim SJ, Hwang SG, Kim IC, Chun JS. 2003. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways. J Biol Chem 278:42448-42456.
16. Klippel A, Kavanaugh WM, Pot D, Williams LT. 1997. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol 17:338-344.
17. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK. 2001. Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. Oncogene 20:6669-6678.
18. Kubiatowski T, Jang T, Lachyankar MB, Salmonsen R, Nabi RR, Quesenberry PJ, Litofsky NS, Ross AH, Recht LD. 2001. Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas. J Neurosurg 95:480-488.
19. Langelier E, Suetterlin R, Hoemann CD, Aebi U, Buschmann MD. 2000. The chondrocyte cytoskeleton in mature articular cartilage: Structure and distribution of actin, tubulin, and vimentin filaments. J Histochem Cytochem 48:1307-1320.
20. Lawlor MA, Alessi DR. 2001. PKB/Akt: A key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114:2903-2910.
21. Lee MY, Kim WJ, Kang YJ, Jung YM, Kang YM, Suk K, Park JE, Choi EM, Choi BK, Kwon BS, Lee WH. 2006. Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis. J Leukoc Biol 80:922-928.
22. Levkau B, Kenagy RD, Karsan A, Weitkamp B, Clowes AW, Ross R, Raines EW. 2002. Activation of metalloproteinases and their association with integrins: An auxiliary apoptotic pathway in human endothelial cells. Cell Death Differ 9:1360-1367.
23. Lim YB, Kang SS, Park TK, Lee YS, Chun JS, Sonn JK. 2000. Disruption of actin cytoskeleton induces chondrogenesis of mesenchymal cells by activating protein kinase C-alpha signaling. Biochem Biophys Res Commun 273: 609-613.
24. Madsen K, Moskalewski S, Thyberg J, Friberg U. 1979. Comparison of the in vitro effects of colchicine and its derivative colchiceine on chondrocyte morphology and function. Experientia 35:1572-1573.
25. +-ATPases. Biochem J 373:19-24.
26. Margulis A, Zhang W, Alt-Holland A, Crawford HC, Fusenig NE, Gar lick JA. 2005. E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res 65:1783-1791.
27. Milner JM, Rowan AD, Cawston TE, Young DA. 2006. Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis. Arthritis Res Ther 8: R142.
28. Mitra A, Chakrabarti J, Banerji A, Chatterjee A. 2004. Binding of alpha2 monoclonal antibody to human cervical tumor cell (SiHa) surface alpha2betal integrin modulates MMP-2 activity. Gynecol Oncol 94:33-39.
29. Oh CD, Chang SH, Yoon YM, Lee SJ, Lee YS, Kang SS, Chun JS. 2000. Opposing role of mitogen-activated protein kinase subtypes, erk-1/2 and p38, in the regulation of chondrogenesis of mesenchymes. J Biol Chem 275: 5613-5619.
30. Parikka V, Vaananen A, Risteli J, Salo T, Sorsa T, Vaananen HK, Lehenkari P. 2005. Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases. Matrix Biol 24:438-447.
31. Park MJ, Kim MS, Park IC, Kang HS, Yoo H, Park SH, Rhee CH, Hong SI, Lee SH. 2002. PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation. Cancer Res 626318-626322.
32. Reinhardt RA, Lee HM, Schmid M, Payne JB, Golub L. 2005. Relationship between gelatinases and bone turnover in the healing bone defect. J Oral Maxillofac Surg 3:1455-1460.
33. Sandell LJ, Aigner T. 2001. Articular cartilage and changes in arthritis. An introduction: Cell biology of osteoarthritis. Arthritis Res 3:107-113.
34. Schnabel M, Marlovits S, Eckhoff G, Fichtel I, Gotzen L, Vecsei V, Schlegel J. 2002. Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthritis Cartilage 10:62-70.
35. Shen J, O'Brien D, Xu Y. 2006. Matrix metalloproteinase-2 contributes to tumor necrosis factor alpha induced apoptosis in cultured rat cardiac myocytes. Biochem Biophys Res Commun 347:1011-1020.
36. Soder S, Roach HI, Oehler S, Bau B, Haag J, Aigner T. 2006. MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage. Clin Exp Rheumatol 24:302-304.
37. Takigawa M, Takano T, Shirai E, Suzuki F. 1984. Cytoskeleton and differentiation: Effects of cytochalasin B and colchicine on expression of the differentiated phenotype of rabbit costal chondrocytes in culture. Cell Differ 14:197-204.
38. Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M. 2005. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem 280:19185-19195.
39. Testa JR, Bellacosa A. 2001. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98:10983-10985.
40. von der Mark K, von der Mark H. 1977. The role of three genetically distinct collagen types in endochondral ossification and calcification of cartilage. J Bone Joint Surg Br 59-B:458-464.
41. Yoon YM, Oh CD, Kim DY, Lee YS, Park JW, Huh TL, Kang SS, Chun JS. 2000. Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways. J Biol Chem 275:12353-12359.
42. Zigrino P, Drescher C, Mauch C. 2001. Collagen-induced proMMP-2 activation by MT1-MMP in human dermal fibroblasts and the possible role of alpha2betal integrins. Eur J Cell Biol 80:68-77.