메뉴 건너뛰기




Volumn 157, Issue 1, 1996, Pages 297-304

Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-κB activation

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DNA FRAGMENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR;

EID: 0029952514     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (87)

References (54)
  • 7
    • 0025098536 scopus 로고
    • Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor
    • Espevik, T., M. Brockhaus, H. Loetscher, U. Nostad, and R. Shalaby. 1990. Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor. J. Exp. Med. 171:415.
    • (1990) J. Exp. Med. , vol.171 , pp. 415
    • Espevik, T.1    Brockhaus, M.2    Loetscher, H.3    Nostad, U.4    Shalaby, R.5
  • 9
    • 0025107818 scopus 로고
    • Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses
    • Thoma, B., M. Grell, K. Pfizenmaier, and P. Scheurich. 1990. Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses. J. Exp. Med. 172:1019.
    • (1990) J. Exp. Med. , vol.172 , pp. 1019
    • Thoma, B.1    Grell, M.2    Pfizenmaier, K.3    Scheurich, P.4
  • 11
    • 0026474991 scopus 로고
    • Antiviral activity of tumor necrosis factor (TNF) is signaled through the 55-kDa receptor, type I TNF
    • Wong, G. H. W., L. A. Tartaglia, M. S. Lee, and D. V. Goeddel. 1992. Antiviral activity of tumor necrosis factor (TNF) is signaled through the 55-kDa receptor, type I TNF. J. Immunol. 149:3350.
    • (1992) J. Immunol. , vol.149 , pp. 3350
    • Wong, G.H.W.1    Tartaglia, L.A.2    Lee, M.S.3    Goeddel, D.V.4
  • 13
    • 0027429199 scopus 로고
    • P80 form of the human tumor necrosis factor receptor is involved in DNA fragmentation
    • Higuchi, M., and B. B. Aggarwal. 1993. P80 form of the human tumor necrosis factor receptor is involved in DNA fragmentation. FEBS Lett. 331:252.
    • (1993) FEBS Lett. , vol.331 , pp. 252
    • Higuchi, M.1    Aggarwal, B.B.2
  • 14
    • 0026751717 scopus 로고
    • The p70 tumor necrosis factor receptor mediates cytotoxicity
    • Heller, R., K. Song, N. Fan, and D. J. Chang. 1992. The p70 tumor necrosis factor receptor mediates cytotoxicity. Cell 70:47.
    • (1992) Cell , vol.70 , pp. 47
    • Heller, R.1    Song, K.2    Fan, N.3    Chang, D.J.4
  • 15
    • 0028295054 scopus 로고
    • Differential roles of two forms of TNF receptor on TNF-induced cytotoxicity: DNA fragmentation and differentiation
    • Higuchi, M., and B. B. Aggarwal. 1994. Differential roles of two forms of TNF receptor on TNF-induced cytotoxicity: DNA fragmentation and differentiation. J. Immunol. 152:4017.
    • (1994) J. Immunol. , vol.152 , pp. 4017
    • Higuchi, M.1    Aggarwal, B.B.2
  • 16
    • 0023616299 scopus 로고
    • Tumor cell killing by tumor necrosis factor: Inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism
    • Matthews, N., M. L. Neale, S. K. Jackson, and J. M. Stark. 1987. Tumor cell killing by tumor necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism. Immunology 62:153.
    • (1987) Immunology , vol.62 , pp. 153
    • Matthews, N.1    Neale, M.L.2    Jackson, S.K.3    Stark, J.M.4
  • 19
    • 0027328056 scopus 로고
    • Depletion of mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
    • Schulze-Osthoff, K., R. Beyaert, V. Vandevoorde, G. Haegeman, and W. Fiers. 1993. Depletion of mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J. 12:3095.
    • (1993) EMBO J. , vol.12 , pp. 3095
    • Schulze-Osthoff, K.1    Beyaert, R.2    Vandevoorde, V.3    Haegeman, G.4    Fiers, W.5
  • 20
    • 0018348253 scopus 로고
    • Activation of membrane phospholipase A by guinea pig lymphotoxin (GLT)
    • Kobayashi, Y., J. Sawada, and T. Osawa. 1979. Activation of membrane phospholipase A by guinea pig lymphotoxin (GLT). J. Immunol. 122:791.
    • (1979) J. Immunol. , vol.122 , pp. 791
    • Kobayashi, Y.1    Sawada, J.2    Osawa, T.3
  • 21
  • 23
    • 0023272405 scopus 로고
    • Protection from tumor necrosis factor cytotoxicity by protease inhibitors
    • Ruggiero, V., S. E. Johnson, and C. Baglioni. 1987. Protection from tumor necrosis factor cytotoxicity by protease inhibitors. Cell. Immunol. 107:317.
    • (1987) Cell. Immunol. , vol.107 , pp. 317
    • Ruggiero, V.1    Johnson, S.E.2    Baglioni, C.3
  • 24
    • 0024208544 scopus 로고
    • Involvement of a serine protease in tumor-necrosis-factor-mediated cytotoxicily
    • Suffys, P., R. Beyaert, F. Van Roy, and W. Fiers. 1988. Involvement of a serine protease in tumor-necrosis-factor-mediated cytotoxicily. Eur. J. Biochem. 178: 257.
    • (1988) Eur. J. Biochem. , vol.178 , pp. 257
    • Suffys, P.1    Beyaert, R.2    Van Roy, F.3    Fiers, W.4
  • 25
    • 0023690115 scopus 로고
    • Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation
    • Agarwal, S., B.-E. Drysdale, and H. S. Shin. 1988. Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation. J. Immunol. 140:4187.
    • (1988) J. Immunol. , vol.140 , pp. 4187
    • Agarwal, S.1    Drysdale, B.-E.2    Shin, H.S.3
  • 26
    • 0025865236 scopus 로고
    • Inhibitors of ADP-ribose polymerase decrease the resistance of HER2/neu-expressing cancer cells to the cytotoxic effects of tumor necrosis factor
    • Lichtenstein, A., J. F. Gera, J. Andrew, J. Berenson, and C. F. Ware. 1991. Inhibitors of ADP-ribose polymerase decrease the resistance of HER2/neu-expressing cancer cells to the cytotoxic effects of tumor necrosis factor. J. Immunol. 146:2052.
    • (1991) J. Immunol. , vol.146 , pp. 2052
    • Lichtenstein, A.1    Gera, J.F.2    Andrew, J.3    Berenson, J.4    Ware, C.F.5
  • 29
    • 0026007737 scopus 로고
    • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma interferon: Specific role in cell differentiation
    • Kim, M.-Y., C. Linardic, L., Obeid, and Y. Hannun. 1991. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma interferon: specific role in cell differentiation. J. Biol. Chem. 266:484.
    • (1991) J. Biol. Chem. , vol.266 , pp. 484
    • Kim, M.-Y.1    Linardic, C.2    Obeid, L.3    Hannun, Y.4
  • 30
    • 0026458406 scopus 로고
    • TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown
    • Schutze, S., K. Potthof, T. Machleidt, and M. Kronke. 1992. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71:765.
    • (1992) Cell , vol.71 , pp. 765
    • Schutze, S.1    Potthof, K.2    Machleidt, T.3    Kronke, M.4
  • 31
    • 0027183695 scopus 로고
    • Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor-kappa B translocation in intact HL-60 cells
    • Yang, Z., M. Costanzo, D. W. Golde, and R. N. Kolesnick. 1993. Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor-kappa B translocation in intact HL-60 cells. J. Biol. Chem. 268:20520.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20520
    • Yang, Z.1    Costanzo, M.2    Golde, D.W.3    Kolesnick, R.N.4
  • 32
    • 0027327212 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide: Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B
    • Dbaido, G. S., L. M. Obeid, and Y. A. Hannun. 1993. Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide: dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J. Biol. Chem. 268:17762.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17762
    • Dbaido, G.S.1    Obeid, L.M.2    Hannun, Y.A.3
  • 33
    • 0028292774 scopus 로고
    • Dissociation of endogenous cellular ceramide from NF-kappa B activation
    • Betts, J. C., A. B. Agranoff, G. J. Nabel, and J. A. Shayman. 1994. Dissociation of endogenous cellular ceramide from NF-kappa B activation. J. Biol. Chem. 269:8455.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8455
    • Betts, J.C.1    Agranoff, A.B.2    Nabel, G.J.3    Shayman, J.A.4
  • 34
    • 0028204240 scopus 로고
    • Ceramide does not mediate the effect of tumor necrosis factor alpha on the superoxide radical generation in human neutrophils
    • Yanaga, F., and S. P. Watson. 1994. Ceramide does not mediate the effect of tumor necrosis factor alpha on the superoxide radical generation in human neutrophils. Biochem. J. 298:733.
    • (1994) Biochem. J. , vol.298 , pp. 733
    • Yanaga, F.1    Watson, S.P.2
  • 35
    • 0027973628 scopus 로고
    • A possible role of sphingosine in induction of apoptosis by tumor necrosis factor alpha in human neutrophils
    • Ohta, H., Y. Yatomi, E. A. Sweeney, S. Hakomori, and Y. Igarashi. 1994. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor alpha in human neutrophils. FEBS Lett. 355:267.
    • (1994) FEBS Lett. , vol.355 , pp. 267
    • Ohta, H.1    Yatomi, Y.2    Sweeney, E.A.3    Hakomori, S.4    Igarashi, Y.5
  • 36
    • 0028334693 scopus 로고
    • Inhibition of ceramide pathway does not affect ability of TNF-α to activate nuclear factor-kappa B
    • Johns, L. D., T. Sarr, and G. E. Ranges. 1994. Inhibition of ceramide pathway does not affect ability of TNF-α to activate nuclear factor-kappa B. J. Immunol. 152:5877.
    • (1994) J. Immunol. , vol.152 , pp. 5877
    • Johns, L.D.1    Sarr, T.2    Ranges, G.E.3
  • 37
    • 0027762512 scopus 로고
    • Sphingolipid breakdown products: Anti-proliferative and tumor-suppressor lipids
    • Hannun, Y. A., and C. M. Linardic. 1993. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim. Biophys. Acta 1154:223.
    • (1993) Biochim. Biophys. Acta , vol.1154 , pp. 223
    • Hannun, Y.A.1    Linardic, C.M.2
  • 38
    • 0028108015 scopus 로고
    • Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
    • Wiegmann, K., S. Schutze, T. Machleidt, D. Witte, and M. Kronke. 1994. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78:1005.
    • (1994) Cell , vol.78 , pp. 1005
    • Wiegmann, K.1    Schutze, S.2    Machleidt, T.3    Witte, D.4    Kronke, M.5
  • 39
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose, R., M. Verheij, A. Haimovitz-Friedman, K. Scotto, Z. Fuks, and R. Kolesnick. 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82:405.
    • (1995) Cell , vol.82 , pp. 405
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.6
  • 40
    • 0025934998 scopus 로고
    • Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein
    • Jaffrezou, J-P., J.-M. Herbert, T. Levada, M.-N. Gau, P. Chatelain, and G. Laurent. 1991. Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein. J. Biol. Chem. 266: 19858.
    • (1991) J. Biol. Chem. , vol.266 , pp. 19858
    • Jaffrezou, J.-P.1    Herbert, J.-M.2    Levada, T.3    Gau, M.-N.4    Chatelain, P.5    Laurent, G.6
  • 41
    • 0026498122 scopus 로고
    • Modulation of subcellular distribution of doxorubicin in multidrug resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta-phenethyl)amino]propyloxy)- benzenesulfonyl)) indolizine
    • Jaffrezou, J-P., T. Levada, P. Chatelain, and G. Laurent. 1992. Modulation of subcellular distribution of doxorubicin in multidrug resistant P388/ADR mouse leukemia cells by the chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta-phenethyl)amino]propyloxy)- benzenesulfonyl)) indolizine. Cancer Res. 52:6440.
    • (1992) Cancer Res. , vol.52 , pp. 6440
    • Jaffrezou, J.-P.1    Levada, T.2    Chatelain, P.3    Laurent, G.4
  • 42
    • 0028837149 scopus 로고
    • Characterization of apoptotic effects of human tumor necrosis factor: Development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells
    • Higuchi, M., S. Singh, and B. B. Aggarwal. 1995. Characterization of apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells. J. Immunol. Methods 178:173.
    • (1995) J. Immunol. Methods , vol.178 , pp. 173
    • Higuchi, M.1    Singh, S.2    Aggarwal, B.B.3
  • 43
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells
    • Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucleic Acids Res. 17:6419.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 44
    • 0028275931 scopus 로고
    • Qualitative and quantitative differences between tumor necrosis factor and lymphotoxin for mediation of early and late cellular responses
    • Chaturvedi, M., R. LaPushin, and B. B. Aggarwal. 1994. Qualitative and quantitative differences between tumor necrosis factor and lymphotoxin for mediation of early and late cellular responses. J. Biol. Chem. 269:14575.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14575
    • Chaturvedi, M.1    LaPushin, R.2    Aggarwal, B.B.3
  • 45
    • 0027946050 scopus 로고
    • Reconstitution of NF-κB activation induced by tumor necrosis factor requires membrane-associated components: Comparison with pathway activated by ceramide
    • Reddy, S. A. G., M. M. Chaturvedi, B. G. Darnay, H. Chan, M. Higuchi, and B. B. Aggarwal. 1994. Reconstitution of NF-κB activation induced by tumor necrosis factor requires membrane-associated components: comparison with pathway activated by ceramide. J. Biol. Chem. 269:25369.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25369
    • Reddy, S.A.G.1    Chaturvedi, M.M.2    Darnay, B.G.3    Chan, H.4    Higuchi, M.5    Aggarwal, B.B.6
  • 46
    • 0025866614 scopus 로고
    • Human acid sphingomyelinase from human urine
    • Quintern, L. E., and K. Sandhoff. 1991. Human acid sphingomyelinase from human urine. Methods Enzymol. 197:536.
    • (1991) Methods Enzymol. , vol.197 , pp. 536
    • Quintern, L.E.1    Sandhoff, K.2
  • 47
    • 0029049833 scopus 로고
    • Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation
    • Ito, A., and K. Horigome. 1995. Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation. J. Neurochem. 65:463.
    • (1995) J. Neurochem. , vol.65 , pp. 463
    • Ito, A.1    Horigome, K.2
  • 48
    • 0022974603 scopus 로고
    • Sphingosine inhibition of protein kinase C and of phorbol dibutyrate binding in vitro and in human platelets
    • Hannun, A. Y., C. R. Loomis, A. H. Merrill, Jr., and R. M. Bell. 1986. Sphingosine inhibition of protein kinase C and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 261:12604.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12604
    • Hannun, A.Y.1    Loomis, C.R.2    Merrill Jr., A.H.3    Bell, R.M.4
  • 49
    • 0028321883 scopus 로고
    • Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response
    • Zhang, L., M. Higuchi, K. Totpal, M. M. Chaturvedi, and B. B. Aggarwal. 1994. Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response. J. Biol. Chem. 269:10270.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10270
    • Zhang, L.1    Higuchi, M.2    Totpal, K.3    Chaturvedi, M.M.4    Aggarwal, B.B.5
  • 50
    • 0026683969 scopus 로고
    • Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells
    • Totpal, K., S. Agarwal, and B. B. Aggarwal. 1992. Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells. Cancer Res. 52:2557.
    • (1992) Cancer Res. , vol.52 , pp. 2557
    • Totpal, K.1    Agarwal, S.2    Aggarwal, B.B.3
  • 51
    • 0028964674 scopus 로고
    • Protein tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-κB
    • Singh, S., and B. B. Aggarwal. 1995. Protein tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-κB. J. Biol. Chem. 270:10631.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10631
    • Singh, S.1    Aggarwal, B.B.2
  • 52
    • 0026723048 scopus 로고
    • Ceramide stimulates a cytosolic protein phosphatase
    • Doborowsky, R. T., and Y. A. Hannun. 1992. Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Chem. 267:5048.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5048
    • Doborowsky, R.T.1    Hannun, Y.A.2
  • 53
    • 0029003788 scopus 로고
    • PKC zeta is a molecular switch in signal transduction of TNF-α, bi-functionally regulated by ceramide and arachidonic acid
    • Muller, G., M. Ayoub, P. Storz, J. Rennecke, D. Fabbro, and K. Pfizenmaier. 1995. PKC zeta is a molecular switch in signal transduction of TNF-α, bi-functionally regulated by ceramide and arachidonic acid. EMBO J. 14:1961.
    • (1995) EMBO J. , vol.14 , pp. 1961
    • Muller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, D.5    Pfizenmaier, K.6
  • 54
    • 0024475227 scopus 로고
    • NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
    • Lenardo, M. J., and D. Baltimore. 1989. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227.
    • (1989) Cell , vol.58 , pp. 227
    • Lenardo, M.J.1    Baltimore, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.