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Volumn 2, Issue 3, 2008, Pages 217-227

Raltegravir: Opening the road for integrase inhibitors in clinical practice

Author keywords

HAART; HIV 1 infection therapy; Integrase inhibitors; MK 0518; Raltegravir

Indexed keywords

ANTIRETROVIRUS AGENT; ATAZANAVIR; COMPLEMENTARY DNA; DARUNAVIR; EFAVIRENZ; ENFUVIRTIDE; ETRAVIRINE; INTEGRASE; INTEGRASE INHIBITOR; L 870812; LAMIVUDINE; MARAVIROC; MIDAZOLAM; N (4 FLUOROBENZYL) 8 HYDROXY 5 (TETRAHYDRO 2H 1,2 THIAZIN 2 YL) 1,6 NAPHTHYRIDINE 7 CARBOXAMIDE S,S DIOXIDE; ORAL CONTRACEPTIVE AGENT; PLACEBO; RALTEGRAVIR; RIFAMPICIN; RITONAVIR; TENOFOVIR; TIPRANAVIR; UNCLASSIFIED DRUG;

EID: 52349083875     PISSN: 17469600     EISSN: None     Source Type: Journal    
DOI: 10.2217/17469600.2.3.217     Document Type: Article
Times cited : (3)

References (38)
  • 1
    • 33746266719 scopus 로고    scopus 로고
    • Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults
    • Temesgen Z, Cainelli F, Poeschla EM, Vlahakis SA, Vento S: Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults. Lancet Infect Dis. 6(8), 496-507(2006).
    • (2006) Lancet Infect Dis , vol.6 , Issue.8 , pp. 496-507
    • Temesgen, Z.1    Cainelli, F.2    Poeschla, E.M.3    Vlahakis, S.A.4    Vento, S.5
  • 3
    • 0032601402 scopus 로고    scopus 로고
    • HIV integrase structure and function
    • Esposito D, Craigie R: HIV integrase structure and function. Adv. Virus Res. 52, 319-333 (1999).
    • (1999) Adv. Virus Res , vol.52 , pp. 319-333
    • Esposito, D.1    Craigie, R.2
  • 4
    • 2942553781 scopus 로고    scopus 로고
    • Structure and function of HIV-1 integrase
    • Chiu TK, Davies DR: Structure and function of HIV-1 integrase. Curr. Top. Med. Chem. 4(9), 965-977 (2004).
    • (2004) Curr. Top. Med. Chem , vol.4 , Issue.9 , pp. 965-977
    • Chiu, T.K.1    Davies, D.R.2
  • 6
    • 34447548922 scopus 로고    scopus 로고
    • HIV integrase inhibitors as therapeutic agents in AIDS
    • Nair V, Chi G: HIV integrase inhibitors as therapeutic agents in AIDS. Rev. Med. Virol. 17(4), 277-295 (2007).
    • (2007) Rev. Med. Virol , vol.17 , Issue.4 , pp. 277-295
    • Nair, V.1    Chi, G.2
  • 7
    • 13044295993 scopus 로고    scopus 로고
    • Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
    • Goldgur Y, Craigie R, Cohen GH et al.: Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design. Proc. Natl Acad. Sci. USA 96(23), 13040-13043 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.23 , pp. 13040-13043
    • Goldgur, Y.1    Craigie, R.2    Cohen, G.H.3
  • 8
    • 3843108916 scopus 로고    scopus 로고
    • A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
    • Hazuda DJ, Anthony NJ, Gomez RP et al.: A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc. Natl Acad. Sci. USA 101(31), 11233-11238 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.31 , pp. 11233-11238
    • Hazuda, D.J.1    Anthony, N.J.2    Gomez, R.P.3
  • 9
    • 0034723439 scopus 로고    scopus 로고
    • Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
    • Hazuda DJ, Felock P, Witmer M et al.: Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 287(5453), 646-650 (2000).
    • (2000) Science , vol.287 , Issue.5453 , pp. 646-650
    • Hazuda, D.J.1    Felock, P.2    Witmer, M.3
  • 10
    • 3242769788 scopus 로고    scopus 로고
    • Integrase inhibitors and cellular immunity suppress retroviral replication in Rhesus macaques
    • Hazuda DJ, Young SD, Guare JP et al.: Integrase inhibitors and cellular immunity suppress retroviral replication in Rhesus macaques. Science 305(5683), 528-532 (2004).
    • (2004) Science , vol.305 , Issue.5683 , pp. 528-532
    • Hazuda, D.J.1    Young, S.D.2    Guare, J.P.3
  • 12
    • 33947715164 scopus 로고    scopus 로고
    • Role of integrase inhibitors in the treatment of HIV disease
    • Palmisano L. Role of integrase inhibitors in the treatment of HIV disease. Expert Rev. And. Infect. Ther. 5(1), 67-75 (2007).
    • (2007) Expert Rev. And. Infect. Ther , vol.5 , Issue.1 , pp. 67-75
    • Palmisano, L.1
  • 13
    • 38349194563 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects
    • Iwamoto M, Wenning LA, Perry AS et al.: Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects. Clin. Pharmacol. Ther. 83(2), 293-299 (2007).
    • (2007) Clin. Pharmacol. Ther , vol.83 , Issue.2 , pp. 293-299
    • Iwamoto, M.1    Wenning, L.A.2    Perry, A.S.3
  • 15
    • 34548065793 scopus 로고    scopus 로고
    • Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme
    • Kassahun K, McIntosh I, Cui D et al.: Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme. Drug Metab. Dispos. 35(9), 1657-1663 (2007).
    • (2007) Drug Metab. Dispos , vol.35 , Issue.9 , pp. 1657-1663
    • Kassahun, K.1    McIntosh, I.2    Cui, D.3
  • 18
    • 78650279086 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of raltegravir (MK-0518) in experienced HIV-infected patients
    • Madrid, Spain , Abstract ABS021
    • Long K, Soulié C, Schneider L et al.: Therapeutic drug monitoring of raltegravir (MK-0518) in experienced HIV-infected patients. 11th European AIDS Conference. Madrid, Spain (2007) (Abstract ABS021).
    • (2007) 11th European AIDS Conference
    • Long, K.1    Soulié, C.2    Schneider, L.3
  • 20
    • 38549106905 scopus 로고    scopus 로고
    • Efficacy of raltegravir, an HIV integrase inhibitor, in combination with regimens containing enfuvirtide, darunavir, or tipranavir in patients with triple-class resistant virus: Combined results from Benchmrk-1 and Benchmrk-2
    • Madrid, Spain , Abstract 151
    • Kumar P, Cooper D, Steigbigel R, Zhao J, Teppler H, Nguyen BY: Efficacy of raltegravir, an HIV integrase inhibitor, in combination with regimens containing enfuvirtide, darunavir, or tipranavir in patients with triple-class resistant virus: combined results from Benchmrk-1 and Benchmrk-2. 11th European AIDS Conference. Madrid, Spain (2007) (Abstract 151).
    • (2007) 11th European AIDS Conference
    • Kumar, P.1    Cooper, D.2    Steigbigel, R.3    Zhao, J.4    Teppler, H.5    Nguyen, B.Y.6
  • 22
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A Phase II randomised controlled trial
    • Grinsztejn B, Nguyen BY, Katlama C et al.: Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a Phase II randomised controlled trial. Lancet 369(9569), 1261-1269 (2007).
    • (2007) Lancet , vol.369 , Issue.9569 , pp. 1261-1269
    • Grinsztejn, B.1    Nguyen, B.Y.2    Katlama, C.3
  • 27
    • 33845366857 scopus 로고    scopus 로고
    • Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
    • Markowitz M, Morales-Ramirez JO, Nguyen BY et al.: Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J. Acquir. Immune Defic. Syndr. 43(5), 509-515 (2006).
    • (2006) J. Acquir. Immune Defic. Syndr , vol.43 , Issue.5 , pp. 509-515
    • Markowitz, M.1    Morales-Ramirez, J.O.2    Nguyen, B.Y.3
  • 28
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
    • Markowitz M, Nguyen BY, Gotuzzo E et al.: Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J. Acquir. Immune Defic. Syndr. 46(2), 125-133 (2007)
    • (2007) J. Acquir. Immune Defic. Syndr , vol.46 , Issue.2 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3
  • 29
    • 37349120701 scopus 로고    scopus 로고
    • Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase
    • Murray JM, Emery S, Kelleher AD et al.: Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS 21(17), 2315-2321 (2007).
    • (2007) AIDS , vol.21 , Issue.17 , pp. 2315-2321
    • Murray, J.M.1    Emery, S.2    Kelleher, A.D.3
  • 30
    • 52349108864 scopus 로고    scopus 로고
    • 48 weeks efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple class resistant virus
    • Chicago, IL, USA , Abstract H-713
    • Grinsztejn B, Nguyen BY, Katlama C et al.: 48 weeks efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple class resistant virus. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, USA (2007) (Abstract H-713).
    • (2007) 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Grinsztejn, B.1    Nguyen, B.Y.2    Katlama, C.3
  • 33
    • 43749098454 scopus 로고    scopus 로고
    • 48-week results from BENCHMRK-1, a Phase III study of raltegravir in patients failing antiretroviral therapy with triple class resistant HIV-1
    • Presented at:, Boston, USA, 3-6 February
    • Cooper D, Gatell J, Rockstroh J et al.: 48-week results from BENCHMRK-1, a Phase III study of raltegravir in patients failing antiretroviral therapy with triple class resistant HIV-1. Presented at: 15th Conference on Retroviruses and Opportunities Infections. Boston, USA, 3-6 February, 2008.
    • (2008) 15th Conference on Retroviruses and Opportunities Infections
    • Cooper, D.1    Gatell, J.2    Rockstroh, J.3
  • 34
    • 43749084994 scopus 로고    scopus 로고
    • 48-week results from BENCHMRK-2, a Phase III study of raltegravir in patients failing antiretroviral therapy with triple class resistant HIV-1
    • Presented at:, Boston, USA, 3-6 February
    • Steigbigel R, Kumar P, Eron J et al.: 48-week results from BENCHMRK-2, a Phase III study of raltegravir in patients failing antiretroviral therapy with triple class resistant HIV-1. Presented at: 15th Conference on Retroviruses and Opportunities Infections. Boston, USA, 3-6 February, 2008.
    • (2008) 15th Conference on Retroviruses and Opportunities Infections
    • Steigbigel, R.1    Kumar, P.2    Eron, J.3
  • 35
    • 35648950291 scopus 로고    scopus 로고
    • Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection
    • Presented at:, Barbados, 12-16 June
    • Hazuda D, Miller MD, Nguyen BY, Zhao J: Resistance to the HIV-integrase inhibitor raltegravir: analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection. Presented at: XVI International HIV Drug Resistance Workshop. Barbados, 12-16 June, 2007.
    • (2007) XVI International HIV Drug Resistance Workshop
    • Hazuda, D.1    Miller, M.D.2    Nguyen, B.Y.3    Zhao, J.4
  • 36
    • 52349096822 scopus 로고    scopus 로고
    • Resistance analysis of a Phase 2 study of the integrase inhibitor elvitegravir (GS-9137)
    • Madrid, Spain , Abstract ABS014
    • McColl D, Fransen S, Gupta S et al.: Resistance analysis of a Phase 2 study of the integrase inhibitor elvitegravir (GS-9137). 11th European AIDS Conference. Madrid, Spain (2007) (Abstract ABS014 5).
    • (2007) 11th European AIDS Conference , pp. 5
    • McColl, D.1    Fransen, S.2    Gupta, S.3
  • 37
    • 52349089088 scopus 로고    scopus 로고
    • Clinical experience with raltegravir (MK-0518), with an optimised background regimen in highly treatment-experienced patients
    • Madrid, Spain , Abstract ABS0155
    • Teague A, Scott C, Bower M, Gazzard B, Nelson M: Clinical experience with raltegravir (MK-0518), with an optimised background regimen in highly treatment-experienced patients. 11th European AIDS conference. Madrid, Spain (2007) (Abstract ABS0155).
    • (2007) 11th European AIDS conference
    • Teague, A.1    Scott, C.2    Bower, M.3    Gazzard, B.4    Nelson, M.5
  • 38
    • 48949088324 scopus 로고    scopus 로고
    • Outcomes of patients switched from enfuvirtide to raltegravir within a virological supressive regimen
    • Boston, USA, 3-6 February, Poster 799
    • Harris M, Larsen G, Montaner J: Outcomes of patients switched from enfuvirtide to raltegravir within a virological supressive regimen. 15th Conference on Retroviruses and Opportunistics Infections. Boston, USA, 3-6 February, 2008 (Poster 799).
    • (2008) 15th Conference on Retroviruses and Opportunistics Infections
    • Harris, M.1    Larsen, G.2    Montaner, J.3


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