메뉴 건너뛰기




Volumn 6, Issue 8, 2006, Pages 496-507

Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; ANTIRETROVIRUS AGENT; DARUNAVIR; ENFUVIRTIDE; ETRAVIRINE; HYDROXYUREA; INDINAVIR; INTEGRASE INHIBITOR; LAMIVUDINE; LOPINAVIR; MK 0158; NELFINAVIR; PLACEBO; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; TIPRANAVIR; UNCLASSIFIED DRUG; VIRUS RNA;

EID: 33746266719     PISSN: 14733099     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1473-3099(06)70550-3     Document Type: Review
Times cited : (22)

References (146)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella Jr. F., Delaney K., Moorman A., et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 338 (1998) 853-860
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.1    Delaney, K.2    Moorman, A.3
  • 2
    • 0343742642 scopus 로고    scopus 로고
    • Decline in deaths from AIDS due to new antiretrovirals
    • Hogg R., O'Shaughnessy M., Gataric N., et al. Decline in deaths from AIDS due to new antiretrovirals. Lancet 349 (1997) 1294
    • (1997) Lancet , vol.349 , pp. 1294
    • Hogg, R.1    O'Shaughnessy, M.2    Gataric, N.3
  • 3
    • 3042848853 scopus 로고    scopus 로고
    • Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviralnaïve patients: a 3-year randomized trial
    • Gallant J., Staszewski S., Pozniak A., et al. Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviralnaïve patients: a 3-year randomized trial. JAMA 292 (2004) 191-201
    • (2004) JAMA , vol.292 , pp. 191-201
    • Gallant, J.1    Staszewski, S.2    Pozniak, A.3
  • 4
    • 3342924014 scopus 로고    scopus 로고
    • Comparison of once-daily atazanavir with efavirenz, each in combination with fixed-dose zidovudine and lamivudine, as initial therapy for patients infected with HIV
    • Squires K., Lazzarin A., Gatell J., et al. Comparison of once-daily atazanavir with efavirenz, each in combination with fixed-dose zidovudine and lamivudine, as initial therapy for patients infected with HIV. J Acquir Immune Defic Syndr 36 (2004) 1011-1019
    • (2004) J Acquir Immune Defic Syndr , vol.36 , pp. 1011-1019
    • Squires, K.1    Lazzarin, A.2    Gatell, J.3
  • 5
    • 0037182766 scopus 로고    scopus 로고
    • Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
    • Walmsley S., Bernstein B., King M., et al. Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med 346 (2002) 2039-2046
    • (2002) N Engl J Med , vol.346 , pp. 2039-2046
    • Walmsley, S.1    Bernstein, B.2    King, M.3
  • 6
    • 0033033234 scopus 로고    scopus 로고
    • HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy
    • Deeks S., Hecht F., Swanson M., et al. HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy. AIDS 13 (1999) F35-F43
    • (1999) AIDS , vol.13
    • Deeks, S.1    Hecht, F.2    Swanson, M.3
  • 7
    • 0344015847 scopus 로고    scopus 로고
    • Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients
    • Fatkenheuer G., Theisen A., Rockstroh J., et al. Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients. AIDS 11 (1997) F113-F116
    • (1997) AIDS , vol.11
    • Fatkenheuer, G.1    Theisen, A.2    Rockstroh, J.3
  • 8
    • 0037119026 scopus 로고    scopus 로고
    • Durability and predictors of success of highly active antiretroviral therapy for ambulatory HIV-infected patients
    • the HIV Outpatient Study Investigators
    • Palella F., Chmiel J., Mooreman A., Holmberg S., and the HIV Outpatient Study Investigators. Durability and predictors of success of highly active antiretroviral therapy for ambulatory HIV-infected patients. AIDS 16 (2002) 1617-1626
    • (2002) AIDS , vol.16 , pp. 1617-1626
    • Palella, F.1    Chmiel, J.2    Mooreman, A.3    Holmberg, S.4
  • 9
    • 0033587510 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions
    • Lucas G., Chaisson R., and Moore R. Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions. Ann Intern Med 131 (1999) 81-87
    • (1999) Ann Intern Med , vol.131 , pp. 81-87
    • Lucas, G.1    Chaisson, R.2    Moore, R.3
  • 10
    • 0036523833 scopus 로고    scopus 로고
    • Response to antiretroviral therapy among patients exposed to three classes of antiretrovirals: results from the EuroSIDA study
    • Mocroft A., Phillips A., Friis-Moller N., et al. Response to antiretroviral therapy among patients exposed to three classes of antiretrovirals: results from the EuroSIDA study. Antivir Ther 7 (2002) 21-30
    • (2002) Antivir Ther , vol.7 , pp. 21-30
    • Mocroft, A.1    Phillips, A.2    Friis-Moller, N.3
  • 11
    • 3142660152 scopus 로고    scopus 로고
    • The prevalence of antiretroviral drug resistance in the United States
    • Richman D., Morton S., Wrin T., et al. The prevalence of antiretroviral drug resistance in the United States. AIDS 18 (2004) 1393-1401
    • (2004) AIDS , vol.18 , pp. 1393-1401
    • Richman, D.1    Morton, S.2    Wrin, T.3
  • 12
    • 21844462147 scopus 로고    scopus 로고
    • Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients
    • Zaccarelli M., Tozzi V., Lorenzini P., et al. Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients. AIDS 19 (2005) 1081-1089
    • (2005) AIDS , vol.19 , pp. 1081-1089
    • Zaccarelli, M.1    Tozzi, V.2    Lorenzini, P.3
  • 13
    • 33746229390 scopus 로고    scopus 로고
    • Predictors of death, and response to therapy in patients with multi(three)-class drug resistant HIV in the UK
    • Grover D., Allen L., Pillay D., et al. Predictors of death, and response to therapy in patients with multi(three)-class drug resistant HIV in the UK. Antivir Ther 10 suppl 1 (2005) S7
    • (2005) Antivir Ther , vol.10 , Issue.SUPPL. 1
    • Grover, D.1    Allen, L.2    Pillay, D.3
  • 14
    • 33746229423 scopus 로고    scopus 로고
    • Hogg RS, Bangsberg D, Alexander C, et al. Drug resistance is associated with an increased risk of death in patients first starting HAART. 12th Conference on Retroviruses and Opportunistic Infections; Boston, MA, USA; Feb 22-25, 2005. Abstract 712.
  • 15
    • 3042726798 scopus 로고    scopus 로고
    • Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel
    • Yeni P., Hammer S., Hirsch S., et al. Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel. JAMA 292 (2004) 251-265
    • (2004) JAMA , vol.292 , pp. 251-265
    • Yeni, P.1    Hammer, S.2    Hirsch, S.3
  • 16
    • 33750454570 scopus 로고    scopus 로고
    • Department of Health and Human Services (DHHS) Panel on Clinical Practices for Treatment of HIV Infection (accessed June 14, 2006)
    • Department of Health and Human Services (DHHS) Panel on Clinical Practices for Treatment of HIV Infection. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents (May 4, 2006). http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf (accessed June 14, 2006)
    • (2006) Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents
  • 18
    • 0033037358 scopus 로고    scopus 로고
    • Worldwide evaluation of DNA sequencing approaches for identification of drug resistance mutations in the human immunodeficiency virus type 1 reverse transcriptase
    • Schuurman R., Demeter L., Reichelderfer P., et al. Worldwide evaluation of DNA sequencing approaches for identification of drug resistance mutations in the human immunodeficiency virus type 1 reverse transcriptase. J Clin Microbiol 37 (1999) 2291-2296
    • (1999) J Clin Microbiol , vol.37 , pp. 2291-2296
    • Schuurman, R.1    Demeter, L.2    Reichelderfer, P.3
  • 19
    • 12144255316 scopus 로고    scopus 로고
    • Pre-existing L74V is a risk factor for virological non-response and development of K65R in patients taking tenofovir DF (TDF)
    • Bae A., Waters J., Margot N., Borroto-Esoda K., and Miller M. Pre-existing L74V is a risk factor for virological non-response and development of K65R in patients taking tenofovir DF (TDF). Antivir Ther 9 suppl (2004) S174
    • (2004) Antivir Ther , vol.9 , Issue.SUPPL
    • Bae, A.1    Waters, J.2    Margot, N.3    Borroto-Esoda, K.4    Miller, M.5
  • 20
    • 33746182512 scopus 로고    scopus 로고
    • Marcelin AG, Roquebert B, Malet I, Wirden M, Katlama C, Calvez V. Role of HIV-1 minority populations on resistance mutational patterns evolution after nelfinavir failure and susceptibility to protease inhibitors. 12th Conference on Retroviruses and Opportunistic Infections; Boston, MA, USA; Feb 22-25, 2005. Abstract 683.
  • 21
    • 33746229430 scopus 로고    scopus 로고
    • Ceccherini-Silberstein, F, Gori C, Santoro M, et al. Dynamics of protease inhibitor-resistance mutations during treatment interruptions. 12th Conference on Retroviruses and Opportunistic Infections; Boston, MA, USA; Feb 22-25, 2005. Abstract 681.
  • 22
    • 33746229429 scopus 로고    scopus 로고
    • Mellors J, Palmer S, Nissley D, et al. Low-frequency NNRTI-resistant variants contribute to failure of efavirenz-containing regimens. 11th Conference on Retroviruses and Opportunistic Infections; San Francisco, CA, USA; Feb 8-11, 2004. Abstract 39.
  • 23
    • 33746221821 scopus 로고    scopus 로고
    • Wind-Rotolo M, Haggerty C, Siliciano J, et al. Archived NNRTI-resistant HIV-1 in the resting CD4+ T cell reservoir of patients with a previous history of K103N or Y181C mutations. 13th Conference on Retroviruses and Opportunistic Infections; Denver, CO, USA; Feb 5-8, 2005. Abstract 616.
  • 24
    • 0035282512 scopus 로고    scopus 로고
    • Clinical use of genotypic and phenotypic drug resistance testing to monitor antiretroviral chemotherapy
    • Hanna G., and D'Aquila R. Clinical use of genotypic and phenotypic drug resistance testing to monitor antiretroviral chemotherapy. Clin Infect Dis 32 (2001) 774-782
    • (2001) Clin Infect Dis , vol.32 , pp. 774-782
    • Hanna, G.1    D'Aquila, R.2
  • 25
    • 0028333887 scopus 로고
    • Susceptibilities of human immundeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reverse transcriptase inhibitors
    • Byrnes V., Emini E., Schleif W., et al. Susceptibilities of human immundeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reverse transcriptase inhibitors. Antimicrob Agents Chemother 38 (1994) 1404-1407
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1404-1407
    • Byrnes, V.1    Emini, E.2    Schleif, W.3
  • 26
    • 0026454435 scopus 로고
    • 3′-Azido-3′-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors
    • Larder B. 3′-Azido-3′-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 36 (1992) 2664-2669
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2664-2669
    • Larder, B.1
  • 27
    • 0035970694 scopus 로고    scopus 로고
    • Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype
    • van Laethem K., Witvrouw M., Pannecouque C., et al. Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype. AIDS 15 (2001) 553-561
    • (2001) AIDS , vol.15 , pp. 553-561
    • van Laethem, K.1    Witvrouw, M.2    Pannecouque, C.3
  • 28
    • 0027285372 scopus 로고
    • Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
    • Tisdale M., Kemp S., Parry N., and Larder B. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad USA 90 (1993) 5653-5656
    • (1993) Proc Natl Acad USA , vol.90 , pp. 5653-5656
    • Tisdale, M.1    Kemp, S.2    Parry, N.3    Larder, B.4
  • 29
    • 0025950055 scopus 로고
    • Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase
    • St Clair M., Martin J., Tudor-Williams G., et al. Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 253 (1991) 1557-1559
    • (1991) Science , vol.253 , pp. 1557-1559
    • St Clair, M.1    Martin, J.2    Tudor-Williams, G.3
  • 30
    • 0037131303 scopus 로고    scopus 로고
    • Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates
    • Whitcomb J., Huang W., Limoli K., et al. Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates. AIDS 16 (2002) F417
    • (2002) AIDS , vol.16
    • Whitcomb, J.1    Huang, W.2    Limoli, K.3
  • 31
    • 18344409610 scopus 로고    scopus 로고
    • The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis
    • Haubrich R., Kemper C., Hellmann N., et al. The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis. AIDS 16 (2002) F3340
    • (2002) AIDS , vol.16
    • Haubrich, R.1    Kemper, C.2    Hellmann, N.3
  • 32
    • 2442657656 scopus 로고    scopus 로고
    • Identification of I50L as the signature atazanavir (ATV)-resistance mutation in treatment-naive HIV-1-infected patients receiving ATV-containing regimens
    • Colonno R., Rose R., McLaren C., Thiry A., Parkin N., and Friborg J. Identification of I50L as the signature atazanavir (ATV)-resistance mutation in treatment-naive HIV-1-infected patients receiving ATV-containing regimens. J Infect Dis 189 (2004) 1802-1810
    • (2004) J Infect Dis , vol.189 , pp. 1802-1810
    • Colonno, R.1    Rose, R.2    McLaren, C.3    Thiry, A.4    Parkin, N.5    Friborg, J.6
  • 33
    • 0036337934 scopus 로고    scopus 로고
    • Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the gag polyprotein precursor aberrantly
    • Resch W., Ziermann R., Parkin N., Gamarnik A., and Swanstrom R. Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the gag polyprotein precursor aberrantly. J Virol 76 (2002) 8659-8666
    • (2002) J Virol , vol.76 , pp. 8659-8666
    • Resch, W.1    Ziermann, R.2    Parkin, N.3    Gamarnik, A.4    Swanstrom, R.5
  • 34
    • 0034002883 scopus 로고    scopus 로고
    • A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir
    • Ziermann R., Limoli K., Das K., Arnold E., Petropoulos C., and Parkin N. A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir. J Virol 74 (2000) 4414-4419
    • (2000) J Virol , vol.74 , pp. 4414-4419
    • Ziermann, R.1    Limoli, K.2    Das, K.3    Arnold, E.4    Petropoulos, C.5    Parkin, N.6
  • 35
    • 2442419529 scopus 로고    scopus 로고
    • Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort
    • Tozzi V., Zaccarelli M., Narciso P., et al. Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort. J Infect Dis 189 (2004) 1688-1695
    • (2004) J Infect Dis , vol.189 , pp. 1688-1695
    • Tozzi, V.1    Zaccarelli, M.2    Narciso, P.3
  • 36
    • 0035876456 scopus 로고    scopus 로고
    • Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy
    • Shulman N., Zolopa A., Passaro D., et al. Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy. AIDS 15 (2001) 1125-1132
    • (2001) AIDS , vol.15 , pp. 1125-1132
    • Shulman, N.1    Zolopa, A.2    Passaro, D.3
  • 37
    • 0037626084 scopus 로고    scopus 로고
    • Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs
    • Katzenstein D., Bosch R., Hellmann N., Wang N., Bacheler L., and Albrecht M. Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs. AIDS 17 (2003) 821-830
    • (2003) AIDS , vol.17 , pp. 821-830
    • Katzenstein, D.1    Bosch, R.2    Hellmann, N.3    Wang, N.4    Bacheler, L.5    Albrecht, M.6
  • 38
    • 0036337934 scopus 로고    scopus 로고
    • Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly
    • Resch W., Ziermann R., Parkin N., Gamarnik A., and Swanstrom R. Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly. J Virol 76 (2002) 8659-8666
    • (2002) J Virol , vol.76 , pp. 8659-8666
    • Resch, W.1    Ziermann, R.2    Parkin, N.3    Gamarnik, A.4    Swanstrom, R.5
  • 39
    • 0035893128 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 hypersusceptibility to amprenavir in vitro can be associated with virus load response to treatment in vivo
    • Zachary K., Hanna G., and D'Aquila R. Human immunodeficiency virus type 1 hypersusceptibility to amprenavir in vitro can be associated with virus load response to treatment in vivo. Clin Infect Dis 33 (2001) 2075-2077
    • (2001) Clin Infect Dis , vol.33 , pp. 2075-2077
    • Zachary, K.1    Hanna, G.2    D'Aquila, R.3
  • 40
    • 33746258658 scopus 로고    scopus 로고
    • Gomes P, Diogo I, Goncalves MF, et al. Different pathways to nelfinavir genotypic resistance in HIV-1 subtypes B and G. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, WA, USA; Feb 24-28, 2002. Abstract 46.
  • 41
    • 0037415062 scopus 로고    scopus 로고
    • A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to nonnucleoside reverse transcriptase inhibitors
    • Brenner B., Turner D., Oliveira M., et al. A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to nonnucleoside reverse transcriptase inhibitors. AIDS 17 (2003) F1-F5
    • (2003) AIDS , vol.17
    • Brenner, B.1    Turner, D.2    Oliveira, M.3
  • 42
    • 21144431829 scopus 로고    scopus 로고
    • Analysis of discrepancies in the interpretation of antiretroviral drug resistance results in HIV-1 infected patients of Basque country, Spain
    • Munoz M., Carmona R., Perez-Alvarez L., et al. Analysis of discrepancies in the interpretation of antiretroviral drug resistance results in HIV-1 infected patients of Basque country, Spain. J Clin Virol 33 (2005) 224-229
    • (2005) J Clin Virol , vol.33 , pp. 224-229
    • Munoz, M.1    Carmona, R.2    Perez-Alvarez, L.3
  • 43
    • 0037541210 scopus 로고    scopus 로고
    • Genotype-phenotype discordance: the evolution in our understanding HIV-1 drug resistance
    • Zolopa A. Genotype-phenotype discordance: the evolution in our understanding HIV-1 drug resistance. AIDS 17 (2003) 1077-1078
    • (2003) AIDS , vol.17 , pp. 1077-1078
    • Zolopa, A.1
  • 44
    • 0038555736 scopus 로고    scopus 로고
    • Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance
    • Parkin N., Chappey C., and Petropoulos C. Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance. AIDS 17 (2003) 955-961
    • (2003) AIDS , vol.17 , pp. 955-961
    • Parkin, N.1    Chappey, C.2    Petropoulos, C.3
  • 45
    • 0035923671 scopus 로고    scopus 로고
    • Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons
    • Garcia-Lerma J., Nidtha S., Blumoff K., Weinstock H., and Heneine W. Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons. Proc Natl Acad Sci USA 98 (2001) 13907-13912
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13907-13912
    • Garcia-Lerma, J.1    Nidtha, S.2    Blumoff, K.3    Weinstock, H.4    Heneine, W.5
  • 46
    • 0037271788 scopus 로고    scopus 로고
    • Discrepant results in the interpretation of HIV-1 drug-resistance genotypic data among widely used algorithms
    • Kijak G., Rubio A., Pampuro S., et al. Discrepant results in the interpretation of HIV-1 drug-resistance genotypic data among widely used algorithms. HIV Med 4 (2003) 72-78
    • (2003) HIV Med , vol.4 , pp. 72-78
    • Kijak, G.1    Rubio, A.2    Pampuro, S.3
  • 47
    • 0041314116 scopus 로고    scopus 로고
    • Comparison between rules-based human immunodeficiency virus type 1 genotype interpretations and real or virtual phenotype: concordance analysis and correlation with clinical outcome in heavily treated patients
    • Torti C., Quiros-Roldan E., Keulen W., et al. Comparison between rules-based human immunodeficiency virus type 1 genotype interpretations and real or virtual phenotype: concordance analysis and correlation with clinical outcome in heavily treated patients. J Infect Dis 188 (2003) 194-201
    • (2003) J Infect Dis , vol.188 , pp. 194-201
    • Torti, C.1    Quiros-Roldan, E.2    Keulen, W.3
  • 48
    • 0002508891 scopus 로고    scopus 로고
    • Predicting HIV-1 phenotypic resistance from genotype using a large phenotype-genotype relational database
    • Larder B., De Vroey V., Dehertogh P., Kemp S., Bloor S., and Hertogs K. Predicting HIV-1 phenotypic resistance from genotype using a large phenotype-genotype relational database. Antivir Ther 4 suppl 1 (1999) 41
    • (1999) Antivir Ther , vol.4 , Issue.SUPPL. 1 , pp. 41
    • Larder, B.1    De Vroey, V.2    Dehertogh, P.3    Kemp, S.4    Bloor, S.5    Hertogs, K.6
  • 49
    • 0033606540 scopus 로고    scopus 로고
    • Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial
    • Durant J., Clevenbergh P., Halfon P., et al. Drug-resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial. Lancet 353 (1999) 2195-2199
    • (1999) Lancet , vol.353 , pp. 2195-2199
    • Durant, J.1    Clevenbergh, P.2    Halfon, P.3
  • 50
    • 0033920318 scopus 로고    scopus 로고
    • A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy
    • Baxter J., Mayers D., Wentworth D., et al. A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. AIDS 14 (2000) F83-F93
    • (2000) AIDS , vol.14
    • Baxter, J.1    Mayers, D.2    Wentworth, D.3
  • 51
    • 0037169170 scopus 로고    scopus 로고
    • Clinical utility of HIV-1 genotyping and expert advice: the Havana trial
    • Tural C., Ruiz L., Holtzer C., et al. Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS 16 (2002) 209-218
    • (2002) AIDS , vol.16 , pp. 209-218
    • Tural, C.1    Ruiz, L.2    Holtzer, C.3
  • 52
    • 0037083803 scopus 로고    scopus 로고
    • Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: a randomized study (ARGENTA)
    • Cingolani A., Antinori A., Rizzo M., et al. Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: a randomized study (ARGENTA). AIDS 16 (2002) 369-379
    • (2002) AIDS , vol.16 , pp. 369-379
    • Cingolani, A.1    Antinori, A.2    Rizzo, M.3
  • 53
    • 0037040360 scopus 로고    scopus 로고
    • A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy
    • Cohen C., Hunt S., Sension M., et al. A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy. AIDS 16 (2002) 579-588
    • (2002) AIDS , vol.16 , pp. 579-588
    • Cohen, C.1    Hunt, S.2    Sension, M.3
  • 54
    • 0037159936 scopus 로고    scopus 로고
    • PharmAdapt: a randomized prospective study to evaluate the benefit of therapeutic monitoring of protease inhibitors: 12 week results
    • Clevenbergh P., Garraffo R., Durant J., and Dellamonica P. PharmAdapt: a randomized prospective study to evaluate the benefit of therapeutic monitoring of protease inhibitors: 12 week results. AIDS 16 (2002) 2311-2315
    • (2002) AIDS , vol.16 , pp. 2311-2315
    • Clevenbergh, P.1    Garraffo, R.2    Durant, J.3    Dellamonica, P.4
  • 55
    • 0242331663 scopus 로고    scopus 로고
    • Predictors of the virological response to a change in the antiretroviral treatment regimen in HIV-1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (Narval trial, ANRS 088)
    • Vray M., Meynard J., Dalban C., et al. Predictors of the virological response to a change in the antiretroviral treatment regimen in HIV-1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (Narval trial, ANRS 088). Antivir Ther 8 (2003) 427-434
    • (2003) Antivir Ther , vol.8 , pp. 427-434
    • Vray, M.1    Meynard, J.2    Dalban, C.3
  • 56
    • 0037340710 scopus 로고    scopus 로고
    • Real versus virtual phenotype to guide treatment in heavily pretreated patients: 48-week follow-up of the Genotipo-Fenotipo di Resistenza (GenPheRex) trial
    • Mazzotta F., Lo Caputo S., Torti C., et al. Real versus virtual phenotype to guide treatment in heavily pretreated patients: 48-week follow-up of the Genotipo-Fenotipo di Resistenza (GenPheRex) trial. J Acquir Immune Defic Syndr 32 (2003) 268-280
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 268-280
    • Mazzotta, F.1    Lo Caputo, S.2    Torti, C.3
  • 57
    • 9144233519 scopus 로고    scopus 로고
    • Phenotype or virtual phenotype for choosing antiretroviral therapy after failure: a prospective, randomized study
    • Perez-Elias M., Garcia-Arota I., Munoz V., et al. Phenotype or virtual phenotype for choosing antiretroviral therapy after failure: a prospective, randomized study. Antivir Ther 8 (2003) 577-584
    • (2003) Antivir Ther , vol.8 , pp. 577-584
    • Perez-Elias, M.1    Garcia-Arota, I.2    Munoz, V.3
  • 58
    • 10744233410 scopus 로고    scopus 로고
    • Impact of genotypic resistance testing on selection of salvage regimen in clinical practice
    • Haupts S., Ledergerber B., Boni J., et al. Impact of genotypic resistance testing on selection of salvage regimen in clinical practice. Antivir Ther 8 (2003) 443-454
    • (2003) Antivir Ther , vol.8 , pp. 443-454
    • Haupts, S.1    Ledergerber, B.2    Boni, J.3
  • 59
    • 10644231092 scopus 로고    scopus 로고
    • Selection of antiretroviral therapy guided by genotypic or phenotypic resistance testing: an open-label, randomized, multicenter study (PhenGen)
    • Saracino A., Monno L., Locaputo S., et al. Selection of antiretroviral therapy guided by genotypic or phenotypic resistance testing: an open-label, randomized, multicenter study (PhenGen). J Acquir Immune Defic Syndr 37 (2004) 1587-1598
    • (2004) J Acquir Immune Defic Syndr , vol.37 , pp. 1587-1598
    • Saracino, A.1    Monno, L.2    Locaputo, S.3
  • 60
    • 10744227842 scopus 로고    scopus 로고
    • Long-term efficacy of routine access to antiretroviral-resistance testing in HIV type 1-infected patients: results of the clinical efficacy of resistance testing trial
    • Wegner S., Wallace M., Aronson N., et al. Long-term efficacy of routine access to antiretroviral-resistance testing in HIV type 1-infected patients: results of the clinical efficacy of resistance testing trial. Clin Infect Dis 38 (2004) 723-730
    • (2004) Clin Infect Dis , vol.38 , pp. 723-730
    • Wegner, S.1    Wallace, M.2    Aronson, N.3
  • 61
    • 4644356397 scopus 로고    scopus 로고
    • GENOPHAR: a randomized study of plasma drug measurements in association with genotypic resistance testing and expert advice to optimize therapy in patients failing antiretroviral therapy
    • Bossi P., Peytavin G., Ait-Mohand H., et al. GENOPHAR: a randomized study of plasma drug measurements in association with genotypic resistance testing and expert advice to optimize therapy in patients failing antiretroviral therapy. HIV Med 5 (2004) 352-359
    • (2004) HIV Med , vol.5 , pp. 352-359
    • Bossi, P.1    Peytavin, G.2    Ait-Mohand, H.3
  • 62
    • 33746229860 scopus 로고    scopus 로고
    • Blanco J, Guelar A, Domingo P, et al. Genotypic vs real phenotypic tests to guide salvage antiretroviral therapy in heavily pretreated patients with virological failure: a 48 weeks prospective, randomized study (VIHRES Study). 11th Conference on Retroviruses and Opportunistic Infections; San Francisco, CA, USA; Feb 8-11, 2004. Abstract 675.
  • 63
    • 20144376467 scopus 로고    scopus 로고
    • A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575
    • Haubrich R., Kemper C., Hellmann N., et al. A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575. AIDS 19 (2005) 295-302
    • (2005) AIDS , vol.19 , pp. 295-302
    • Haubrich, R.1    Kemper, C.2    Hellmann, N.3
  • 64
    • 27744442318 scopus 로고    scopus 로고
    • A randomized controlled trial of the clinical utility of genotypic resistance testing in patients with limited prior exposure to antiretroviral drugs
    • Evaluation of Resistance Assays (ERA) Trial Investigators
    • Evaluation of Resistance Assays (ERA) Trial Investigators. A randomized controlled trial of the clinical utility of genotypic resistance testing in patients with limited prior exposure to antiretroviral drugs. HIV Clin Trials 6 (2005) 183-186
    • (2005) HIV Clin Trials , vol.6 , pp. 183-186
  • 65
    • 17144391149 scopus 로고    scopus 로고
    • A randomized controlled trial of the value of phenotypic testing in addition to genotypic testing for HIV drug resistance: evaluation of resistance assays (ERA) trial investigators
    • Dunn D., Green H., Loveday C., et al. A randomized controlled trial of the value of phenotypic testing in addition to genotypic testing for HIV drug resistance: evaluation of resistance assays (ERA) trial investigators. J Acquir Immune Defic Syndr 38 (2005) 553-559
    • (2005) J Acquir Immune Defic Syndr , vol.38 , pp. 553-559
    • Dunn, D.1    Green, H.2    Loveday, C.3
  • 66
    • 7744231500 scopus 로고    scopus 로고
    • Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis
    • Panidou E., Trikalinos T., and Ioannidis J. Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis. AIDS 18 (2004) 2153-2161
    • (2004) AIDS , vol.18 , pp. 2153-2161
    • Panidou, E.1    Trikalinos, T.2    Ioannidis, J.3
  • 67
    • 17044402473 scopus 로고    scopus 로고
    • HIV-1 drug resistance: degree of underestimation by a cross-sectional versus a longitudinal testing approach
    • Harrigan P., Wynhoven B., Brumme Z., et al. HIV-1 drug resistance: degree of underestimation by a cross-sectional versus a longitudinal testing approach. J Infect Dis 191 (2005) 1325-1330
    • (2005) J Infect Dis , vol.191 , pp. 1325-1330
    • Harrigan, P.1    Wynhoven, B.2    Brumme, Z.3
  • 68
    • 33746268285 scopus 로고    scopus 로고
    • Palella F, Armon C, Chmiel J, et al. Enhanced survival associated with use of HIV susceptibility testing among HAART-experienced patients in the HIV Outpatient Study (HOPS). 13th Conference on Retroviruses and Opportunistic Infections; Denver, CO, USA; Feb 5-8, 2006. Abstract 654.
  • 69
    • 20644445015 scopus 로고    scopus 로고
    • HIV-1 pol replication capacity predicts disease progression
    • Daar E., Kesler K., Wrin T., et al. HIV-1 pol replication capacity predicts disease progression. AIDS 19 (2005) 871-877
    • (2005) AIDS , vol.19 , pp. 871-877
    • Daar, E.1    Kesler, K.2    Wrin, T.3
  • 70
    • 0033803642 scopus 로고    scopus 로고
    • A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression
    • Quinones-Mateu M., Ball S., Marozsan A., et al. A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression. J Virol 74 (2000) 9222-9233
    • (2000) J Virol , vol.74 , pp. 9222-9233
    • Quinones-Mateu, M.1    Ball, S.2    Marozsan, A.3
  • 71
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1
    • Martinez-Picado J., Savara A., Sutton L., and D'Aquila R. Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J Virol 73 (1999) 3744-3752
    • (1999) J Virol , vol.73 , pp. 3744-3752
    • Martinez-Picado, J.1    Savara, A.2    Sutton, L.3    D'Aquila, R.4
  • 72
    • 0001818434 scopus 로고    scopus 로고
    • Drug resistance is associated with impaired protease and reverse transcriptase function and reduced replication capacity: characterization of recombinant viruses derived from 150 HIV-1 infected patients
    • Gamarnik A., Wrin T., Ziermann R., et al. Drug resistance is associated with impaired protease and reverse transcriptase function and reduced replication capacity: characterization of recombinant viruses derived from 150 HIV-1 infected patients. Antivir Ther 5 suppl 3 (2000) 92
    • (2000) Antivir Ther , vol.5 , Issue.SUPPL. 3 , pp. 92
    • Gamarnik, A.1    Wrin, T.2    Ziermann, R.3
  • 73
    • 0035141001 scopus 로고    scopus 로고
    • Implications of antiretroviral resistance on viral fitness
    • Nijhuis M., Deeks S., and Boucher C. Implications of antiretroviral resistance on viral fitness. Curr Opin Infect Dis 14 (2001) 23-28
    • (2001) Curr Opin Infect Dis , vol.14 , pp. 23-28
    • Nijhuis, M.1    Deeks, S.2    Boucher, C.3
  • 74
    • 0037012979 scopus 로고    scopus 로고
    • Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity
    • Prado J., Wrin T., Beauchaine J., et al. Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity. AIDS 16 (2002) 1009-1017
    • (2002) AIDS , vol.16 , pp. 1009-1017
    • Prado, J.1    Wrin, T.2    Beauchaine, J.3
  • 75
    • 0347052875 scopus 로고    scopus 로고
    • Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations
    • Deval J., White K., Miller M., et al. Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations. J Biol Chem 279 (2004) 509-516
    • (2004) J Biol Chem , vol.279 , pp. 509-516
    • Deval, J.1    White, K.2    Miller, M.3
  • 76
    • 0034070773 scopus 로고    scopus 로고
    • Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection
    • Deeks S., Barbour J., Martin J., Swanson M., and Grant R. Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection. J Infect Dis 181 (2000) 946-953
    • (2000) J Infect Dis , vol.181 , pp. 946-953
    • Deeks, S.1    Barbour, J.2    Martin, J.3    Swanson, M.4    Grant, R.5
  • 77
    • 0035341522 scopus 로고    scopus 로고
    • Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen
    • Piketty C., Weiss L., Thomas F., Mohamed A., Belec L., and Kazatchkine M. Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen. J Infect Dis 183 (2001) 1328-1335
    • (2001) J Infect Dis , vol.183 , pp. 1328-1335
    • Piketty, C.1    Weiss, L.2    Thomas, F.3    Mohamed, A.4    Belec, L.5    Kazatchkine, M.6
  • 78
    • 0035864943 scopus 로고    scopus 로고
    • Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
    • Deeks S., Wrin T., Liegler T., et al. Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. N Engl J Med 344 (2001) 472-480
    • (2001) N Engl J Med , vol.344 , pp. 472-480
    • Deeks, S.1    Wrin, T.2    Liegler, T.3
  • 79
    • 0034523865 scopus 로고    scopus 로고
    • Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure
    • Miller V., Sabin C., Hertogs K., et al. Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure. AIDS 14 (2000) 2857-2867
    • (2000) AIDS , vol.14 , pp. 2857-2867
    • Miller, V.1    Sabin, C.2    Hertogs, K.3
  • 80
    • 33746268287 scopus 로고    scopus 로고
    • Castagna A, Danise A, Menzo S, et al. E-184V study: lamivudine monotherapy vs treatment interruption in failing HIV-1 infected subjects, harboring the M184V mutation: 48-week final results. 3rd IAS Conference on HIV Pathogenesis and Treatment; Rio de Janeiro, Brazil; July 24-27, 2005. Abstract WeFo0205.
  • 81
    • 10644246071 scopus 로고    scopus 로고
    • Persistent antiretroviral activity of nucleoside analogues after prolonged zidovudine and lamivudine therapy as demonstrated by rapid loss of activity after discontinuation
    • Eron Jr. J., Bartlett J., Santana J., et al. Persistent antiretroviral activity of nucleoside analogues after prolonged zidovudine and lamivudine therapy as demonstrated by rapid loss of activity after discontinuation. J Acquir Immune Defic Syndr 37 (2004) 1581-1583
    • (2004) J Acquir Immune Defic Syndr , vol.37 , pp. 1581-1583
    • Eron Jr., J.1    Bartlett, J.2    Santana, J.3
  • 82
    • 0034687071 scopus 로고    scopus 로고
    • Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy
    • Grabar S., Le Moing V., Goujard C., et al. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy. Ann Intern Med 133 (2000) 401-410
    • (2000) Ann Intern Med , vol.133 , pp. 401-410
    • Grabar, S.1    Le Moing, V.2    Goujard, C.3
  • 83
    • 0345701518 scopus 로고    scopus 로고
    • Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control
    • Sufka S., Ferrari G., Gryszowka V., et al. Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control. J Infect Dis 187 (2003) 1027-1037
    • (2003) J Infect Dis , vol.187 , pp. 1027-1037
    • Sufka, S.1    Ferrari, G.2    Gryszowka, V.3
  • 84
    • 33746221815 scopus 로고    scopus 로고
    • Deeks SG, Lu J, Hoh R, et al. Interruption of enfuvirtide in patients with enfuvirtide resistance. 12th Conference on Retroviruses and Opportunistic Infections; Boston, MA, USA; Feb 22-25, 2005. Abstract 680.
  • 85
    • 29244472063 scopus 로고    scopus 로고
    • In vivo dynamics of the K103N mutation following the withdrawal of non-nucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected patients
    • Gianotti N., Galli L., Boeri E., et al. In vivo dynamics of the K103N mutation following the withdrawal of non-nucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected patients. New Microbiol 28 (2005) 319-326
    • (2005) New Microbiol , vol.28 , pp. 319-326
    • Gianotti, N.1    Galli, L.2    Boeri, E.3
  • 86
    • 3142674798 scopus 로고    scopus 로고
    • Virological and immunological impact of non-nucleoside reverse transcriptase inhibitor withdrawal in HIV-infected patients with multiple treatment failures
    • Piketty C., Gerard L., Chazallon C., et al. Virological and immunological impact of non-nucleoside reverse transcriptase inhibitor withdrawal in HIV-infected patients with multiple treatment failures. AIDS 18 (2004) 1469-1471
    • (2004) AIDS , vol.18 , pp. 1469-1471
    • Piketty, C.1    Gerard, L.2    Chazallon, C.3
  • 87
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    • Lalezari J., Henry K., O'Hearn M., et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. N Engl J Med 348 (2003) 2175-2185
    • (2003) N Engl J Med , vol.348 , pp. 2175-2185
    • Lalezari, J.1    Henry, K.2    O'Hearn, M.3
  • 88
    • 0037849954 scopus 로고    scopus 로고
    • Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia
    • Lazzarin A., Clotet B., Cooper D., et al. Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N Engl J Med 348 (2003) 2186-2195
    • (2003) N Engl J Med , vol.348 , pp. 2186-2195
    • Lazzarin, A.1    Clotet, B.2    Cooper, D.3
  • 89
    • 33746229855 scopus 로고    scopus 로고
    • Lazzarin A, Mukwaya G, Clumeck N, et al. Tipranavir/ritonavir (TPV/r) demonstrates superior treatment response to lopinavir/r (LPV/r), amprenavir/r (APV/r) or saquinavir/r (SQV/r) in PI-experienced patients from the TPV RESIST-1 and RESIST-2 trials. 3rd IAS Conference on HIV Pathogenesis and Treatment; Rio de Janeiro, Brazil; July 24-27, 2005. Abstract WePe6.3C07.
  • 90
    • 33746258651 scopus 로고    scopus 로고
    • Cooper D, Hicks C, Cahn P, et al. 24-week RESIST study analyses: the efficacy of tipranavir/ritonavir is superior to lopinavir/ritonavir, and the TPV/r treatment response is enhanced by inclusion of genotypically active antiretrovirals in the optimized background regimen. 12th Conference on retroviruses and Opportunistic Infections; Boston, MA, USA; Feb 22-25, 2005. Abstract 560.
  • 91
    • 33746229856 scopus 로고    scopus 로고
    • Thommes JA, Demasi R, Haubrich R. Improved virologic response in three-class experienced patients when an active boosted protease inhibitor is combined with enfuvirtide (ENF). 43rd Annual Meeting of the Infectious Diseases Society of America; San Francisco, CA, USA; Oct 6-9, 2005. Abstract 785.
  • 92
    • 33746258650 scopus 로고    scopus 로고
    • Grossman HA, Hicks C, Nadler J, et al. Efficacy and tolerability of Tmc125 in HIV patients with NNRTI and PI resistance at 24 weeks: Tmc125-c223. 45th Interscience Conference of Antimicrobial Agents and Chemotherapy; Washington, DC, USA: Dec 16-19, 2005. Abstract H-416c.
  • 93
    • 33746229857 scopus 로고    scopus 로고
    • Katlama C, Berger D, Bellos N, et al. Efficacy of TMC114/r in 3-class experienced patients with limited treatment options: 24-week planned interim analysis of 2 96-week multinational dose-finding trials. 12th Conference on Retroviruses and Opportunistic Infections; Boston, MA, USA; Feb 22-25, 2005. Abstract 164LB.
  • 94
    • 33746229444 scopus 로고    scopus 로고
    • Grinsztejn B, Nguyen BY, Katlama C, et al. Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 13th Conference on Retroviruses and Opportunistic Infections; Denver, CO, USA; Feb 5-8, 2006. Abstract 159LB.
  • 95
    • 0035198762 scopus 로고    scopus 로고
    • Principles and practice of HIV-protease inhibitor pharmacoenhancement
    • Moyle G., and Back D. Principles and practice of HIV-protease inhibitor pharmacoenhancement. HIV Med 2 (2001) 105-113
    • (2001) HIV Med , vol.2 , pp. 105-113
    • Moyle, G.1    Back, D.2
  • 96
    • 0034128937 scopus 로고    scopus 로고
    • Dual protease inhibitor therapy in HIV-infected patients: pharmacological rationale and clinical benefit
    • Flexner C. Dual protease inhibitor therapy in HIV-infected patients: pharmacological rationale and clinical benefit. Ann Rev Pharmacol Toxicol 40 (2000) 649-674
    • (2000) Ann Rev Pharmacol Toxicol , vol.40 , pp. 649-674
    • Flexner, C.1
  • 97
    • 0037224471 scopus 로고    scopus 로고
    • Overcoming resistance: virologic response to a salvage regimen with the combination of ritonavir plus indinavir
    • Casado J., Moreno A., Marti-Belda P., et al. Overcoming resistance: virologic response to a salvage regimen with the combination of ritonavir plus indinavir. HIV Clin Trials 4 (2003) 21-28
    • (2003) HIV Clin Trials , vol.4 , pp. 21-28
    • Casado, J.1    Moreno, A.2    Marti-Belda, P.3
  • 98
    • 0036499067 scopus 로고    scopus 로고
    • Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients
    • Benson C., Deeks S., Brun S., et al. Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients. J Infect Dis 185 (2002) 599-607
    • (2002) J Infect Dis , vol.185 , pp. 599-607
    • Benson, C.1    Deeks, S.2    Brun, S.3
  • 99
    • 0141612910 scopus 로고    scopus 로고
    • Randomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 trial
    • Dragsted U., Gerstoft J., Pedersen C., et al. Randomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 trial. Clin Infect Dis 188 (2003) 635-642
    • (2003) Clin Infect Dis , vol.188 , pp. 635-642
    • Dragsted, U.1    Gerstoft, J.2    Pedersen, C.3
  • 100
    • 25444471854 scopus 로고    scopus 로고
    • A randomized trial to evaluate lopinavir/ritonavir versus saquinavir/ritonavir in HIV-1-infected patients: the MaxCmin2 trial
    • Ulrik B., Jan G., Mike Y., et al. A randomized trial to evaluate lopinavir/ritonavir versus saquinavir/ritonavir in HIV-1-infected patients: the MaxCmin2 trial. Antivir Ther 10 (2005) 735-743
    • (2005) Antivir Ther , vol.10 , pp. 735-743
    • Ulrik, B.1    Jan, G.2    Mike, Y.3
  • 101
    • 0037114877 scopus 로고    scopus 로고
    • Open-label study of a twice-daily indinavir 800-mg/ritonavir 200-mg regimen in HIV-infected adults failing a protease inhibitor regimen
    • Katner H., Paar D., Nadler J., et al. Open-label study of a twice-daily indinavir 800-mg/ritonavir 200-mg regimen in HIV-infected adults failing a protease inhibitor regimen. J Acquir Immune Defic Syndr 31 (2002) 483-487
    • (2002) J Acquir Immune Defic Syndr , vol.31 , pp. 483-487
    • Katner, H.1    Paar, D.2    Nadler, J.3
  • 102
    • 0036097178 scopus 로고    scopus 로고
    • Salvage therapy with amprenavir and ritonavir: prospective study in 17 heavily pretreated patients
    • Arvieux C., Tattevin P., Souala F., et al. Salvage therapy with amprenavir and ritonavir: prospective study in 17 heavily pretreated patients. HIV Clin Trials 3 (2002) 125-132
    • (2002) HIV Clin Trials , vol.3 , pp. 125-132
    • Arvieux, C.1    Tattevin, P.2    Souala, F.3
  • 103
    • 33746258243 scopus 로고    scopus 로고
    • Badaro R, DeJesus E, Lazzarin A, et al. Efficacy and safety of atazanavir (ATV) with ritonavir (RTV) or saquinavir (SQV) versus lopinavir/ritonavir (LPV/RTV) in combination with tenofovir (TFV) and one NRTI in patients who have experienced virologic failure to multiple HAART regimens: 16-week results from BMS AI424-045. 2nd IAS Conference on HIV Pathogenesis and Treatment; Paris, France; July 13-16, 2003. Abstract 118.
  • 104
    • 33746258652 scopus 로고    scopus 로고
    • DeJesus E, LaMarca A, Sension M, et al. The Context study: efficacy and safety of GW433908/RTV in PI-experienced subjects with virological failure (24 week results). 10th Conference on Retroviruses and Opportunistic Infections; Boston, MA, USA; Feb 10-14, 2003. Abstract 178.
  • 105
    • 33746268284 scopus 로고    scopus 로고
    • Patterson P, Zala C, Coll P, et al. Virological response and safety at 48 weeks of double boosted protease inhibitors with lopinavir/r plus either saquinavir or amprenavir in heavily pretreated HIV infected patients. 14th International AIDS Conference; Barcelona, Spain; July 7-12, 2002. Abstract TuPeB4492.
  • 106
    • 33746268283 scopus 로고    scopus 로고
    • Staszewski S, Dauer B, von Hentig N, et al. The LOPSAQ study: 24 week analysis of the double protease inhibitor salvage regimen containing lopinavir (LPV/r) plus saquinavir without any additional antiretroviral therapy. 2nd IAS Conference on HIV Pathogenesis and Treatment; Paris, France; July 13-16, 2003. Abstract 583.
  • 107
    • 33746221402 scopus 로고    scopus 로고
    • Corbett AH, Eron JJ, Diebold M, et al. A triple protease inhibitor (PI) salvage regimen of amprenavir (APV) + saquinavir (SQV) + mini dose ritonavir (r): steady state (SS) pharmacokinetics (PK) and initial RNA and CD4 response. 14th International AIDS Conference; Barcelona, Spain; July 7-12, 2002. Abstract TuPeB4464.
  • 108
    • 33746229447 scopus 로고    scopus 로고
    • Dauer B, Von Hentig N, Müller A, et al. The CRIXILOP cohort study: preliminary results from a salvage study of the boosted double protease inhibitor (PI) regimen containing indinavir (IDV) plus lopinavir/ritonavir (LPV/r) without the addition of reverse transcriptase inhibitors (RTI) in heavily therapy-experienced HIV+ patients. 9th European AIDS Conference; Warsaw, Poland; Oct 25-29, 2004. Abstract 7.4/4.
  • 109
    • 33746258240 scopus 로고    scopus 로고
    • Raguin G, Chene G, Morand-Joubert L, et al. Salvage therapy with lopinavir/ritonavir, amprenavir + an additional boost with ritonavir: 1-year results of Puzzle 1-ANRS 104 study. 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment; Paris, France; July 13-16, 2003. Abstract 585.
  • 110
    • 33746258239 scopus 로고    scopus 로고
    • Ruiz L, Ribera E, Bonjoch A, et al. Virological and immunological benefit of a salvage therapy that includes kaletra plus fortovase preceded or not by antiretroviral therapy interruption (TI) in advanced HIV-infected patients (6-month-follow-up). 9th Conference on Retroviruses and Opportunistic Infections; Seattle, WA, USA; Feb 24-28, 2002. Abstract 421-W.
  • 111
    • 33746258238 scopus 로고    scopus 로고
    • Baldini F, RizzoMG, Hoetelmans R, et al. A prospective study of deep salvage therapy with lopinavir/r, amprenavir, and NRTIs: final 24-week data, pharmacokinetics, and association of drug levels/drug susceptibility with virologic response. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, WA, USA; Feb 24-28, 2002. Abstract 423-W.
  • 112
    • 0033762620 scopus 로고    scopus 로고
    • Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen
    • Izopet J., Massip P., Souyris C., et al. Shift in HIV resistance genotype after treatment interruption and short-term antiviral effect following a new salvage regimen. AIDS 14 (2000) 2247-2255
    • (2000) AIDS , vol.14 , pp. 2247-2255
    • Izopet, J.1    Massip, P.2    Souyris, C.3
  • 113
    • 0034523865 scopus 로고    scopus 로고
    • Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure
    • Miller V., Sabin C., Hertogs K., et al. Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure. AIDS 14 (2000) 2857-2867
    • (2000) AIDS , vol.14 , pp. 2857-2867
    • Miller, V.1    Sabin, C.2    Hertogs, K.3
  • 114
    • 0037661201 scopus 로고    scopus 로고
    • Kinetics of disappearance of resistance mutations and reappearance of wild-type during structured treatment interruptions
    • Halfon P., Durant J., Clevenbergh P., et al. Kinetics of disappearance of resistance mutations and reappearance of wild-type during structured treatment interruptions. AIDS 17 (2003) 1351-1361
    • (2003) AIDS , vol.17 , pp. 1351-1361
    • Halfon, P.1    Durant, J.2    Clevenbergh, P.3
  • 115
    • 0142074332 scopus 로고    scopus 로고
    • Role of structued treatment interruption before a 5-drug salvage antiretroviral regimen: the Retrogene Study
    • Ruiz L., Ribera E., Bonjoch A., et al. Role of structued treatment interruption before a 5-drug salvage antiretroviral regimen: the Retrogene Study. J Infect Dis 188 (2003) 977-985
    • (2003) J Infect Dis , vol.188 , pp. 977-985
    • Ruiz, L.1    Ribera, E.2    Bonjoch, A.3
  • 116
    • 0042431969 scopus 로고    scopus 로고
    • Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus
    • Lawrence J., Mayers D., Hullseik K., et al. Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus. N Engl J Med 349 (2003) 837-846
    • (2003) N Engl J Med , vol.349 , pp. 837-846
    • Lawrence, J.1    Mayers, D.2    Hullseik, K.3
  • 117
    • 27144521249 scopus 로고    scopus 로고
    • No benefit of a structured treatment interruption based on genotypic resistance in heavily pretreated HIV-infected patients
    • Ghosn J., Wirden M., Ktorza N., et al. No benefit of a structured treatment interruption based on genotypic resistance in heavily pretreated HIV-infected patients. AIDS 19 (2005) 1643-1647
    • (2005) AIDS , vol.19 , pp. 1643-1647
    • Ghosn, J.1    Wirden, M.2    Ktorza, N.3
  • 118
    • 10744223335 scopus 로고    scopus 로고
    • Benefit of treatment interruption in HIV-infected patients with multiple therapeutic failures: a randomized controlled trial (ANRS 097)
    • Katlama C., Dominguez S., Gourlain K., et al. Benefit of treatment interruption in HIV-infected patients with multiple therapeutic failures: a randomized controlled trial (ANRS 097). AIDS 18 (2004) 217-226
    • (2004) AIDS , vol.18 , pp. 217-226
    • Katlama, C.1    Dominguez, S.2    Gourlain, K.3
  • 119
    • 0035808534 scopus 로고    scopus 로고
    • Multiple therapy rescue therapy for HIV-infected individuals with prior virologic failure to multiple regimens
    • Montaner J., Harrigan P., Jahnke N., et al. Multiple therapy rescue therapy for HIV-infected individuals with prior virologic failure to multiple regimens. AIDS 15 (2001) 61-69
    • (2001) AIDS , vol.15 , pp. 61-69
    • Montaner, J.1    Harrigan, P.2    Jahnke, N.3
  • 120
    • 0036153694 scopus 로고    scopus 로고
    • Brief report: two-year outcome of a multidrug regimen in patients who did not respond to a protease inhibitor regimen
    • Youle M., Tyrer M., Fisher M., et al. Brief report: two-year outcome of a multidrug regimen in patients who did not respond to a protease inhibitor regimen. J Acquir Immune Defic Syndr 29 (2002) 58-61
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 58-61
    • Youle, M.1    Tyrer, M.2    Fisher, M.3
  • 121
    • 0001873555 scopus 로고    scopus 로고
    • Virological and immunological response to mega-HAART salvage therapy after failure of multiple antiretroviral regimens
    • Staszewski S., Gute P., Carlebach A., et al. Virological and immunological response to mega-HAART salvage therapy after failure of multiple antiretroviral regimens. AIDS 12 suppl 4 (1998) S40
    • (1998) AIDS , vol.12 , Issue.SUPPL. 4
    • Staszewski, S.1    Gute, P.2    Carlebach, A.3
  • 122
    • 0006734904 scopus 로고    scopus 로고
    • Surrogate marker responses to multidrug combinations comprising hydroxyurea, efavirenz, double protease inhibitors and nucleoside analogues in protease inhibitor failures
    • Youle M., Mocroft A., Johnson M., et al. Surrogate marker responses to multidrug combinations comprising hydroxyurea, efavirenz, double protease inhibitors and nucleoside analogues in protease inhibitor failures. Antiviral Ther 4 suppl 1 (1999) 18-19
    • (1999) Antiviral Ther , vol.4 , Issue.SUPPL. 1 , pp. 18-19
    • Youle, M.1    Mocroft, A.2    Johnson, M.3
  • 123
    • 0035663699 scopus 로고    scopus 로고
    • Therapeutic drug monitoring as a tool in treating HIV infection
    • Khoo S., Gibbons S., and Back D. Therapeutic drug monitoring as a tool in treating HIV infection. AIDS 15 suppl (2001) S171-S181
    • (2001) AIDS , vol.15 , Issue.SUPPL
    • Khoo, S.1    Gibbons, S.2    Back, D.3
  • 124
    • 0038101663 scopus 로고    scopus 로고
    • Pharmaocinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients
    • Burger D., Boyd M., Duncombe C., et al. Pharmaocinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients. J Antimicrob Chemother 51 (2003) 1231-1238
    • (2003) J Antimicrob Chemother , vol.51 , pp. 1231-1238
    • Burger, D.1    Boyd, M.2    Duncombe, C.3
  • 125
    • 33746229448 scopus 로고    scopus 로고
    • Garraffo R, Lavrut T, Pierre B, et al. Efavirenz and nevirapine concentration-effect retlationships in HIV-infected patients pharmacologically followed by routine therapetuc drug monitoring (TDM). 4th International Workshop on Clinical Pharmacology of HIV Therapy; Cannes, France; March 27-29, 2003. Abstract 26.
  • 126
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
    • Haas D., Ribaudo H., Kim R., et al. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS 18 (2004) 2391-2400
    • (2004) AIDS , vol.18 , pp. 2391-2400
    • Haas, D.1    Ribaudo, H.2    Kim, R.3
  • 127
    • 33746245367 scopus 로고    scopus 로고
    • La Porte C, van der Ende M, Gyssens I, et al. Gender differences in nevirapine and efavirenz pharmacokinetics. 4th International Workshop on Clinical Pharmacology of HIV Therapy; Cannes, France; March 27-29, 2003. Abstract 10.
  • 128
    • 0035808574 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1 infected patients
    • Marzolini C., Telenti, Decostered L., Greub G., Biollaz J., and Buclin T. Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1 infected patients. AIDS 15 (2001) 71-75
    • (2001) AIDS , vol.15 , pp. 71-75
    • Marzolini, C.1    Telenti2    Decostered, L.3    Greub, G.4    Biollaz, J.5    Buclin, T.6
  • 129
    • 0033967796 scopus 로고    scopus 로고
    • Toxicity and drug exposure in a quadruple drug regimen in HIV-1 infected patients participating in the ADAM study
    • Reijers M., Weigel H., Hart A., et al. Toxicity and drug exposure in a quadruple drug regimen in HIV-1 infected patients participating in the ADAM study. AIDS 14 (2000) 59-67
    • (2000) AIDS , vol.14 , pp. 59-67
    • Reijers, M.1    Weigel, H.2    Hart, A.3
  • 130
    • 0035461510 scopus 로고    scopus 로고
    • Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatine capsules) administration
    • Buss N., Snell P., Bock J., Hsu A., and Jorga K. Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatine capsules) administration. Br J Clin Pharmacol 52 (2001) 255-264
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 255-264
    • Buss, N.1    Snell, P.2    Bock, J.3    Hsu, A.4    Jorga, K.5
  • 131
    • 0037867653 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naive HIV-1-infected individuals
    • Burger D., Hugen P., Reiss P., et al. Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naive HIV-1-infected individuals. AIDS 17 (2003) 1157-1165
    • (2003) AIDS , vol.17 , pp. 1157-1165
    • Burger, D.1    Hugen, P.2    Reiss, P.3
  • 132
    • 0041941506 scopus 로고    scopus 로고
    • Antiretroviral concentrations in untimed plasma samples predict therapy outcome in a population with advanced disease
    • Alexander C., Asselin J., Ting L., et al. Antiretroviral concentrations in untimed plasma samples predict therapy outcome in a population with advanced disease. J Infect Dis 188 (2003) 541-548
    • (2003) J Infect Dis , vol.188 , pp. 541-548
    • Alexander, C.1    Asselin, J.2    Ting, L.3
  • 133
    • 33645096370 scopus 로고    scopus 로고
    • Clinical pharmacodynamics of HIV-1 protease inhibitors: use of inhibitory quotients to optimise pharmacotherapy
    • Morse G., Catanzaro L., and Acosta E. Clinical pharmacodynamics of HIV-1 protease inhibitors: use of inhibitory quotients to optimise pharmacotherapy. Lancet Infect Dis 6 (2006) 215-225
    • (2006) Lancet Infect Dis , vol.6 , pp. 215-225
    • Morse, G.1    Catanzaro, L.2    Acosta, E.3
  • 134
    • 0036148608 scopus 로고    scopus 로고
    • Amprenavir inhibitory quotient and virological response in human immunodeficiency virus-infected patients on an amprenavir-containing salvage regimen without or with ritonavir
    • Duval X., Lamotte C., Race E., et al. Amprenavir inhibitory quotient and virological response in human immunodeficiency virus-infected patients on an amprenavir-containing salvage regimen without or with ritonavir. Antimicrob Agents Chemother 46 (2002) 570-574
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 570-574
    • Duval, X.1    Lamotte, C.2    Race, E.3
  • 135
    • 0037308542 scopus 로고    scopus 로고
    • Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients
    • Marcelin A., Lamotte C., Delaugerre C., et al. Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients. Antimicrob Agents Chemother 47 (2003) 594-600
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 594-600
    • Marcelin, A.1    Lamotte, C.2    Delaugerre, C.3
  • 136
    • 1542723603 scopus 로고    scopus 로고
    • Deep salvage with amprenavir and lopinavir/ritonavir: correlation of pharmacokinetics and drug resistance with pharmacodynamics
    • De Luca A., Baldini F., Cingolani A., Di Giambenedetto S., Hoetelmans R., and Cauda R. Deep salvage with amprenavir and lopinavir/ritonavir: correlation of pharmacokinetics and drug resistance with pharmacodynamics. J Acquir Immune Defic Syndr 35 (2004) 359-366
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 359-366
    • De Luca, A.1    Baldini, F.2    Cingolani, A.3    Di Giambenedetto, S.4    Hoetelmans, R.5    Cauda, R.6
  • 137
    • 3042689560 scopus 로고    scopus 로고
    • Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR study)
    • Breilh D., Pellegrin I., Rouzes A., et al. Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR study). AIDS 18 (2004) 1305-1310
    • (2004) AIDS , vol.18 , pp. 1305-1310
    • Breilh, D.1    Pellegrin, I.2    Rouzes, A.3
  • 138
    • 20944446492 scopus 로고    scopus 로고
    • Virological and pharmacological parameters predicting the response to lopinavirritonavir in heavily protease inhibitor-experienced patients
    • Marcelin A., Cohen-Codar I., King M., et al. Virological and pharmacological parameters predicting the response to lopinavirritonavir in heavily protease inhibitor-experienced patients. Antimicrob Agents Chemother 49 (2005) 1720-1726
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1720-1726
    • Marcelin, A.1    Cohen-Codar, I.2    King, M.3
  • 140
    • 4344707647 scopus 로고    scopus 로고
    • The NIQ of lopinavir is predictive of a 48-week virological response in highly treatment experienced HIV-1-infected subjects treated with a lopinavir/ritonavir-containing regimen
    • Castagna A., Gianotti N., Galli L., et al. The NIQ of lopinavir is predictive of a 48-week virological response in highly treatment experienced HIV-1-infected subjects treated with a lopinavir/ritonavir-containing regimen. Antivir Ther 9 (2004) 537-543
    • (2004) Antivir Ther , vol.9 , pp. 537-543
    • Castagna, A.1    Gianotti, N.2    Galli, L.3
  • 141
    • 12244262297 scopus 로고    scopus 로고
    • Pharmacokinetic pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients
    • Hsu A., Isaacson J., Brun S., et al. Pharmacokinetic pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 47 (2003) 350-359
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 350-359
    • Hsu, A.1    Isaacson, J.2    Brun, S.3
  • 142
    • 21244448394 scopus 로고    scopus 로고
    • Evaluation of atazanavir trough, atazanavir genotypic inhibitory quotient, and baseline HIV genotype as predictors of a 24-week virological response in highly drug-experienced, HIV-infected patients treated with unboosted atazanavir
    • Gianotti N., Seminari E., Guffanti M., et al. Evaluation of atazanavir trough, atazanavir genotypic inhibitory quotient, and baseline HIV genotype as predictors of a 24-week virological response in highly drug-experienced, HIV-infected patients treated with unboosted atazanavir. New Microbiol 28 (2005) 119-125
    • (2005) New Microbiol , vol.28 , pp. 119-125
    • Gianotti, N.1    Seminari, E.2    Guffanti, M.3
  • 143
    • 7944228403 scopus 로고    scopus 로고
    • Predictors of virological response to atazanavir in protease inhibitor-experienced patients
    • Barrios A., Rendon A., Gallego O., et al. Predictors of virological response to atazanavir in protease inhibitor-experienced patients. HIV Clin Trials 5 (2004) 201-205
    • (2004) HIV Clin Trials , vol.5 , pp. 201-205
    • Barrios, A.1    Rendon, A.2    Gallego, O.3
  • 144
    • 9644272512 scopus 로고    scopus 로고
    • Clinically relevant interpretation of genotype and relationship to plasma drug concentrations for resistance to saquinavir-ritonavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients
    • Marcelin A., Dalban C., Peytavin G., et al. Clinically relevant interpretation of genotype and relationship to plasma drug concentrations for resistance to saquinavir-ritonavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients. Antimicrob Agents Chemother 48 (2004) 4687-4692
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4687-4692
    • Marcelin, A.1    Dalban, C.2    Peytavin, G.3
  • 145
    • 0036895440 scopus 로고    scopus 로고
    • Virtual inhibitory quotient predicts response to ritonavir boosting of indinavir-based therapy in human immunodeficiency virus-infected patients with ongoing viremia
    • Shulman N., Zolopa A., Havlir D., et al. Virtual inhibitory quotient predicts response to ritonavir boosting of indinavir-based therapy in human immunodeficiency virus-infected patients with ongoing viremia. Antimicrob Agents Chemother 46 (2002) 3907-3916
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3907-3916
    • Shulman, N.1    Zolopa, A.2    Havlir, D.3
  • 146
    • 33746245365 scopus 로고    scopus 로고
    • Hatano H, Hunt P, Weidler J, et al. Rate of viral evolution and risk of losing future drug options in heavily pre-treated patients remaining on a stable partially suppressive regimen. 13th Conference on Retroviruses and Opportunistic Infections; Denver, CO, USA; Feb 5-8, 2006. Abstract 615.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.