Possible allosteric interactions of monoindazole-substituted P2 cyclic urea analogues with wild-type and mutant HIV-1 protease

Journal of Computer-Aided Molecular Design

Volumn 22, Issue 10, 2008, Pages 737-745

  Garg, Rajni ^a,b   Bhhatarai, Barun ^b  

^a CALIFORNIA STATE UNIVERSITY   (United States)

^b CLARKSON UNIVERSITY   (United States)

Author keywords

Allosteric interaction; HIV 1; Monoindazole cyclic urea; Mutant HIV 1 protease; Protease inhibitor; QSAR; Wild type HIV 1 protease

Indexed keywords

AMINO ACIDS; BIOACTIVITY; COMPUTATIONAL CHEMISTRY; METABOLISM; PATIENT TREATMENT; UREA; VIRUSES;

ALLOSTERIC INTERACTION; CYCLIC UREAS; HIV-1; HIV-1 PROTEASE; MONOINDAZOLE CYCLIC UREA; MUTANT HIV-1 PROTEASE; PROTEASE INHIBITOR; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; WILD TYPES; WILD-TYPE HIV-1 PROTEASE;

MOLECULES;

AMINO ACID; CYCLIC UREA DERIVATIVE; INDAZOLE DERIVATIVE; LIGAND; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL INTERACTION; DRUG STRUCTURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VIRUS ISOLATION; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

EID: 52249124316     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/s10822-008-9210-y     Document Type: Article

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