Allosteric interactions and QSAR: On the role of ligand hydrophobicity

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 9, 2003, Pages 2075-2084

  Hansch, Corwin ^a   Garg, Rajni ^b   Kurup, Alka ^a   Mekapati, Suresh Babu ^a  

^a POMONA COLLEGE   (United States)

^b CLARKSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; AMINE OXIDASE (FLAVIN CONTAINING); HEMOGLOBIN; HEMOGLOBIN CHAIN; LIGAND; RECEPTOR; RECEPTOR PROTEIN; XANTHINE OXIDASE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN MITOCHONDRION; CARCINOMA CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA BASE; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HUMAN CELL; HYDROPHOBICITY; MATHEMATICAL COMPUTING; MEMBRANE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OXIDATION; PARTITION COEFFICIENT; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RAT STRAIN; RECEPTOR AFFINITY; REDUCTION;

EID: 0037401941     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00056-7     Document Type: Article

References (30)

1. Koshland D.E. Jr. Proc. Natl. Acad. Sci. U.S.A. 44:1958;98.
2. Monod J., Changeux J.-P., Jacob J. Mol. Biol. 6:1963;306.
3. Koshland, D. E. Jr., In The Enzymes; Boyer, P.D., Ed.; Academic: New York, 1970; Vol 1, p 342.
4. Changeux J.-P., Edelstein S.J. Neuron. 21:1998;959.
5. Perutz M.G. Mechanisms of Cooperativity and Allosteric Regulation in Proteins. 1990;Cambridge University, Cambridge.
6. Royer W.E. Jr., Knapp J.E., Strand K., Heaslet H.A. Trends Biochem. Sci. 26:2001;297.
7. Kurup A., Garg R., Hansch C. Chem. Rev. 101:2001;2573.
8. Hansch C., Garg R., Kurup A. Bioorg. Med. Chem. 9:2001;283.
9. Mekapati S.B., Hansch C. Bioorg. Med. Chem. 9:2001;2885.
10. Garg R., Kurup A., Hansch C. Bioorg. Med. Chem. 9:2001;3164.
11. Reisberg P.I., Olson J.S. J. Biol. Chem. 255:1980;4144.
12. Hansch C., Leo A. Exploring QSAR: Fundamentals and Applications in Chemistry and Biology. 1995;American Chemical Society, Washington DC
13. (b) Gao H., Hansch C. Drug Metab. Rev. 18:1996;513.
14. Kiehs K., Hansch C., Moore L. Biochemistry. 5:1966;2602.
15. Sabbioni G. Chem. Res. Toxicol. 7:1994;267.
16. Selassie C.D., Garg R., Kapur S., Kurup A., Verma R.P., Mekapati S.B., Hansch C. Chem. Rev. 102:2002;2585.
17. Jagannadham V., Steenken S. J. Am. Chem. Soc. 106:1984;6542.
18. Tatsumi K., Kitamura S., Yoshimura H., Kawazoe Y. Chem. Pharm. Bull. 26:1978;1713.
19. Lang P.-Z., Ma X.-F., Lu G.-H., Wang Y., Bian Y. Chemosphere. 32:1996;1547.
20. Vijalyalakshmi, Sundaram E.V. Indian J. Chem. 17A:1979;495.
21. Hansch C., Gao H. Chem. Rev. 97:1997;2995.
22. Gross S.S., Lane P. Proc. Natl. Acad. Sci. U.S.A. 96:1999;9967.
23. Kuroda S., Akahane A., Itani H., Nishimura S., Durkin K., Tenda Y., Sakane K. Bioorg. Med. Chem. 8:2000;55.
24. Sami S.M., Dorr R.T., Alberts D.S., Solyom A.M., Remers W.A. J. Med. Chem. 43:2000;3067.
25. Pozdnev V.F., Kirkel A.Z., Kamyshanskaya N.S., Axenova L.N., Medvedev A.E. J. Neural Transm. Suppl. 52:1998;351.
26. Naeff H.S.D., Van der Plas H.C., Tramper J., Muller F. Quant. Struct.-Act. Rel. 4:1985;161.
27. Ueeda M., Thompson R.D., Arroyo L.H., Olsson R.A. J. Med. Chem. 34:1991;1334.
28. Koshland D.E. Jr., Neet K.E. Annu. Rev. Biochem. 37:1968;359.
29. Jencks W.P. Catalysis in Chemistry and Enzymology. 1969;Dover, New York. p 289.
30. Christopoulos A. Nature Rev. Drug Disc. 1:2002;198.