Recent success stories leading to commercializable bioactive compounds with the aid of traditional QSAR procedures

Quantitative Structure-Activity Relationships

Volumn 16, Issue 2, 1997, Pages 107-112

  Fujita, Toshio ^a,b  

^a FUJITSU LABORATORIES LTD   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Agrochemicals; Antiinflammatory agent; Antimigraine agent; Drug design; Fungicide; Molecular modelling; Pharmaceuticals; QSAR

Indexed keywords

COMPUTATIONAL CHEMISTRY; FUNGICIDES; MOLECULAR MODELING; STRUCTURAL OPTIMIZATION;

ANTI-INFLAMMATORY AGENTS; ANTIMIGRAINE; ANTIMIGRAINE AGENT; AZOLE FUNGICIDES; BIOACTIVE COMPOUNDS; DRUG DESIGN; METABOLIC FATE; MOLECULAR MODELING STUDIES; QSAR; STRUCTURAL OPTIMISATIONS;

AGRICULTURAL CHEMICALS;

ANTIINFLAMMATORY AGENT; ANTIMIGRAINE AGENT; BENZHYDRYL DERIVATIVE; FLOBUFEN; FUNGICIDE; IPCONAZOLE; LOMERIZINE; METCONAZOLE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; MOLECULAR MODEL; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0030934103     PISSN: 09318771     EISSN: None     Source Type: Journal    
DOI: 10.1002/qsar.19970160202     Document Type: Article

References (27)

1. (a) Hansch, C., Sammes, P.G., Taylor, J.B. and Ramsden, C.A. (Eds.), "Comprehensive Medicinal Chemistry, Vol. 4: Quantitative Drug Design", Pergamon Press, Oxford, 1990.
2. (b) Fujita, T. (Ed.), "QSAR and Drug Design, New Developments and Applications", Elsevier, Amsterdam, 1995.
3. Hansch, C. and Fujita, T., J. Amer. Chem. Soc. 86, 1616-1626 (1964).
4. Naito, S., Osumi, S., Sekishiro, K. and Hirose, M., Chem. Pharm. Bull. 20, 682-688 (1972).
5. Toda, N., Usui, H., Osumi, S., Kanda, M. and Kitao, K., Arch. Int. Pharmacodyn. Ther. 260, 230-243 (1982).
6. Ohtaka, H., Kanazawa, T., Ito, K. and Tsukamoto, G., Chem. Pharm. Bull. 35, 3270-3275 (1987).
7. Ohtaka, H. and Tsukamoto, G., Chem. Pharm. Bull. 35 4117-4123 (1987).
8. Fujita, T. and Nishioka, T., Prog. Phys. Org. Chem. 12, 49-89 (1976).
9. Verloop, A., Hoogenstraaten, W. and Tipker, J., Drug Design 7, 165-207 (1976).
10. Todd, P.A. and Benfield, P., Drugs 38, 482-499 (1989).
11. Hara, H., Morita, T., Sukamoto, T. and Culter, F.M., CNS Drug Reviews 1, 204-226 (1995).
12. Krämer, W., In Haug, G. and Hoffmann, H. (Eds.), "Chemistry of Plant Protection, Vol. 1", Springer-Verlag, Heidelberg, 1986, p. 25.
13. Köller, W., In Köller, W. (Ed.) "Target Sites of Fungicide Action", CRC Press, Boca Raton, FL, 1992, p. 119.
14. Lyr, H., In Frehse, H. (Ed.), "Pesticide Chemistry", VCH, Weinheim, 1991, p. 161.
15. Kumazawa, S., Ito, A., Saishoji, T. and Chuman, H., Japan Chemistry Program Exchange Newsletter, Vol. 6, No. 4, 1995, p. 3.
16. Chuman, H., Ito, A., Saishoji, T. and Kumazawa, S., In Hansch, C. and Fujita, T. (Eds.), "Classical and Three-Dimensional QSAR in Agrochemistry", ACS Symp. Ser. No. 606, American Chemical Society, Washington, D.C., 1995, p. 171.
17. Sampson, A.J., Cazenave, A., Laffranque, J.-P., Jones, R.G., Kumazawa, S. and Chida, T., Proc. 1992 Brighton Crop Prot. Conf. - Pests and Diseases, Vol. 1, 1992, p. 419.
18. Panajotova, V., Anderova, E., Jandera, A. and Kuchar, M., Arzneim.-Forsch. 46 in press (1996).
19. Sloboda, A.E., Tolman, E.L., Osterberg, A.C. and Panagides, J., Arzneim.-Forsch. 30, 716-721 (1980).
20. Kuchar, M., Maturova, E., Brunova, B., Grimova, J., Tomkova, H. and Holubek, K.J., Coll. Czech. Chem. Comm. 53, 1862-1872 (1988).
21. Chiccarelli, F.S., Eisner, H.J. and Van Lear, G.E., Arzneim-Forsch. 30, 707-715 (1980).
22. Chiccarelli, P.S., Eisner, H.J. and Van Lear, G.E., Arzneim.-Forsch. 30, 728-735 (1980).
23. Fujita, T., Acta. Pharm. Jugosl. 37, 43-51 (1987).
24. Fujita, T., In Ref. 1(a), p. 540.
25. Hansch, C. and Leo, A., "Exploring QSAR", American Chemical Society, Washington, D.C., 1995, p. 223.
26. Fujita, T., In Jolles, G. and Wooldridge, K.R.H. (Eds.) "Drug Design: Fact or Fantasy?" Academic Press, London, 1984, p. 19.
27. Plummer, E.L., In Magee, P.S., Kohn, G.K. and Menn, J.J. (Eds.), "Pesticide Synthesis Through Rational Approaches", ACS Symp. Ser. No. 255, American Chemical Society, Washington, D.C., 1984, p. 295.