TNF-α-mediated inflammation in cerebral aneurysms: A potential link to growth and rupture

Vascular Health and Risk Management

Volumn 4, Issue 4, 2008, Pages 805-817

  Jayaraman, Thottala ^a,b   Paget, Andrew ^a   Shin, Yang Sam ^a   Li, Xiaguai ^a   Mayer, Jillina ^a   Chaudhry, Hina W ^b   Niimi, Yasunari ^a   Silane, Michael ^c   Berenstein, Alejandro ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^b Columbia University ^*  (United States)

^c BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

Inflammation; Innate immunity; Intracranial aneurysm growth; TNF

Indexed keywords

CALCIUM; CYTOKINE; LIPOXYGENASE; RYANODINE RECEPTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ANEURYSM CLIP; ANEURYSM RUPTURE; APOPTOSIS; BRAIN ARTERY ANEURYSM; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL TYPE; CEREBROVASCULAR ACCIDENT; CIGARETTE SMOKING; CORRELATION ANALYSIS; DNA POLYMORPHISM; DRUG MECHANISM; DRUG TARGETING; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME ACTIVITY; HEMODYNAMIC STRESS; HUMAN; HYPERTENSION; INCIDENTAL FINDING; INFLAMMATION; INFLAMMATORY CELL; INNATE IMMUNITY; INTRACRANIAL ANEURYSM; LYMPHOCYTIC INFILTRATION; MACROPHAGE ACTIVATION; MOLECULAR MECHANICS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RISK FACTOR; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UNITED STATES; VASCULAR ENDOTHELIUM;

ANIMALS; APOPTOSIS; ENDOTHELIUM, VASCULAR; HEMODYNAMICS; HUMANS; HYPERTENSION; INFLAMMATION; INFLAMMATION MEDIATORS; INTRACRANIAL ANEURYSM; LIPID METABOLISM; POLYMORPHISM, GENETIC; PROTEINS; RISK FACTORS; RUPTURE; SEX FACTORS; SMOKING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 52249104863     PISSN: 11766344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (95)

1. Aderem A, Ulevitch RJ. 2000. Toll-like receptors in the induction of innate immune responses. Nature, 406:782-7.
2. Aggarwal BB, Takada Y. 2005. Cytokines and Cancer. In: Platanias LC (ed). Chicago, IL: Springer, p. 103.
3. Andrews RJ, Spiegel PK. 1979. Intracranial aneurysms. Age, sex, blood pressure, and multiplicity in an unselected series of patients. J Neurosurg, 51:27-32.
4. Anto RJ, Mukhopadhyay A, Shishodia S, et al. 2002. Cigarette smoke condensate activates nuclear transcription factor-kappa B through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis, 23:1511-18.
5. Bazzoni F, Beutler B. 1996. Tumor necrosis factor ligand and receptor family. N Engl J Med, 334:1717-23.
6. Benelli R, Lorusso G, Albini A, et al. 2006. Cytokines and chemokines as regulators of angiogenesis in health and disease. Curr Pharm Des, 12:3101-15.
7. Berenstein A, Flamm ES, Kupersmith MJ. 1999. Unruptured intracranial aneurysms. N Engl J Med, 340:1439-40.
8. Byrd-Leifer CA, Block EF, Takeda K, et al. 2001. The role of MyD88 and TLR4 in the LPS-mimetic activity of taxol. Eur J Immunol, 31:2448-57.
9. Cao Y, Zhao J, Wang S, et al. 2002. Monocyte chemoattractant protein-1 mRNA in human intracranial aneurysm walls. Zhonghua Yu Fang Yi Xue Za Zhi, 36:519-21.
10. Chen ZK, Lv HS. 2006. Quantification of expression of leukotriene B4 inducing tumor necrosis factor-alpha and interleukin-1 beta at mRNA level in synovial membrane cells of rheumatoid arthritis by real-time quantitative PCR. Beijing Da Xue Xue Bao, 38:533-6.
11. Chyatte D, Bruno G, Desai S, et al. 1999. Inflammation and intracranial aneurysms. Neurosurgery, 45:1137-55.
12. Ferreri NR. 2007. Estrogen-TNF interactions and vascular inflammation. Am J Physiol Heart Circ Physiol, 292:H2566-9.
13. Fontanella M, Rainero I, Gallone S, et al. 2007. Tumor necrosis factor-alpha gene and cerebral aneurysms. Neurosurg, 60:668-72.
14. Gonzalez CF, Cho YI, Ortega HV, et al. 1992. Intracranial aneurysms: flow analysis of their origin and progression. AJNR Am J Neuroradiol, 13:181-8.
15. Gregersen R, Lambertsen K, Finsen B. 2000. Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab, 20:53-65.
16. Grell M, Zimmermann G, Hulser D, et al. 1994. TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signaling pathways. J Immunol, 153:1963-72.
17. Hajeer AH, Hutchinson IV. 2001. Influence of TNF alpha gene polymorphisms on TNF alpha production and disease. Hum Immunol, 62:1191-9.
18. Härtel C, Adam N, Strunk T, et al. 2005. Cytokine responses correlate differentially with age in infancy and early childhood. Clin Exp Immunol, 142:446-53.
19. Hashimoto T, Meng H, Young WL. 2006. Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling. Neurol Res, 28:372-80.
20. Henneke P, Goldenbock DT. 2002. Innate immune recognition of lipopolysaccharide by endothelial cells. Crit Care Med, 30:207-13.
21. Henry PD, Chen CH. 1993. Inflammatory mechanisms of atheroma formation: Influence of fluid mechanics and lipid-derived inflammatory mediators. Am J Hypertens, 6:328S-34S.
22. Higuchi T, Seki N, Kamizono S, et al. 1998. Polymorphism of the 5′ -flanking region of the human necrosis factor (TNF) - alpha gene in Japanese. Tissue Antigens, 51:605-12.
23. Hoi Y, Meng H, Woodward SH, et al. 2004. Effects of arterial geometry on aneurysm growth: three-dimensional computational fluid dynamics study. J Neurosurg, 101:676-81.
24. Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature, 444:860-7.
25. Huang Y, Cao S, Nagamani M, et al. 2005. Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy containing isoflavones. J Clin Endocrinol Metab, 90:3956-62.
26. Hübschle T, Mütze J, Mühlradt PF, et al. 2006. Pyrexia, anorexia, adiposia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1. Am J Physiol Regul Integr Comp Physiol, 290:R180-7.
27. Jang IK, Lassila R, Fuster V. 1993. Atherogenesis and inflammation. Eur J Heart, 14(Suppl K):2-6.
28. Jayaraman T, Berenstein V, Li X, et al. 2005. Tumor necrosis factor alpha in cerebral aneurysms: A key modulator in inflammation. Neurosurgery, 57:558-64.
29. Jou LD, Wong G, Dispensa B, et al. 2005. Correlation between luminal geometry changes and hemodynamics in fusiform intracranial aneurysms. AJNR Am J Neuroradiol, 26:2357-63.
30. Juvela S, Hillbom M, Numminen H, et al. 1993. Cigarette smoking and alcohol consumption as risk factors for aneurismal subarachnoid hemorrhage. Stroke, 24:639-46.
31. Juvela S, Porras M, Poussa K. 2000. Natural history of unruptured intracranial aneurysms: probability and risk factors for aneurysm rupture. Neurosurg Focus, 93:379-87.
32. Juvela S. 2002. Natural history of unruptured intracranial aneurysms: risks for aneurysm formation, growth, and rupture. Acta Neurochir Suppl, 82:27-30.
33. Kapadia SR, Yakoob K, Nader S, et al. 2000. Elevated circulating levels of serum tumor necrosis factor-alpha in patients with hemodynamically significant pressure and volume overload. J Am Coll Cardiol, 36:208-12.
34. Karikó K, Weissman D, Welsh FA. 2004. Inhibition of toll-like receptor and cytokine signaling - a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab, 24:1288-304.
35. Kataoka K, Taneda M, Asai T, et al. 1999. Structural fragility and inflammatory response of ruptured cerebral aneurysm. A comparative study between ruptured and unruptured cerebral aneurysms. Stroke, 30:1396-401.
36. Kirwan JP, Krishnan RK, Weaver JA, et al. 2001. Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia. Am J Physiol Endocrinol Metab, 281:E1137-43.
37. Kongable GL, Lanzino G, Germanson TP, et al. 1996. Gender-related differences in aneurysmal subarachnoid hemorrhage. J Neurosurg, 84:43-8.
38. Krex D, Rohl H, Koing IR, et al. 2003. Tissue inhibitor of metalloproteinases- 1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. Stroke, 34:2817-21.
39. Krings T, Piske RL, Lasjaunias PL. 2005. Intracranial arterial aneurysm vasculopathies: targeting the outer vessel wall, 47:931-7.
40. Kuldo JM, Westra J, Asgeirsdottir SA, et al. 2005. Differential roles of NFκB inhibitors and combinations thereofon TNF-α and IL-1β induced pro-inflammatory status of endothelial cells in vitro. Am J Physiol Cell Physiol, 89:C1229-39.
41. Laflamme N, Rivest S. 2001. Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J, 15:155-63.
42. Lambertsen KL Gregersen R, Finsen B. 2002. Microglial-macrophage synthesis of tumor necrosis factor after focal cerebral ischemia in mice is strain dependent. J Cereb Blood Flow Metab, 22:785-97.
43. Lanzke N, Kleinwächter R, Kerschischnik S, et al. 2007. Differential effects of ethanol on IFN-gamma- and TNF-alpha-producing splenic T lymphocytes in a murine model of Gram-negative pneumonia. Addict Biol, 12:59-68.
44. Longstreth WT Jr, Nelson LM, Koepsell TD, et al. 1992. Cigarette smoking, alcohol use, and subarachnoid hemorrhage. Stroke, 23:1242-9.
45. Luedemann C, Bord E, Qin G, et al. 2005. Ethanol modulation of TNF-alpha biosynthesis and signaling in endothelial cells: synergistic augmentation of TNF-alpha mediated endothelial cell dysfunctions by chronic ethanol. Alcohol Clin Exp Res, 29:930-8.
46. Magder S, Neculcea J, Neculcea V, et al. 2006. Lipopolysaccharide and TNF-alpha produce very similar changes in gene expression in human endothelial cells. J Vasc Res, 43:447-61.
47. Maini RN, Elliott MJ, Brennan FM, et al. 1995. Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease. Immunol Rev, 144:195-223.
48. Meng H, Heng Y, Woodward SH, et al. 2005. Mathematical model of the rupture mechanism of intracranial saccular aneurysms through daughter aneurysm formation and growth. Neurol Res, 27:459-65.
49. Morgan L, Hawe E, Palmen J, et al. 2005. Polymorphism of the heme oxygenase-1 gene and cerebral aneurysms. Br J Neurosurg, 19:317-21.
50. Morgan L, Cooper J, Montgomery H, et al. 2006. The interleukin-6 gene-174G>C promoter polymorphisms are related to cerebral aneurysms. J Neural Neurosurg Psychiatry, 77:915-17.
51. Moriwaki T, Takagi Y, Sadamasa N, et al. 2006. Impaired progression of cerebral aneurysms in interleukin-1 beta deficient mice. Stroke, 37:900-5.
52. Mosca L, Appel LJ, Benjamin EJ, et al. 2004. Evidence based guide-lines for cardiovascular disease prevention in women. Circulation, 109:672-93.
53. Muñoz J, Albillos A, Pérez-Páramo M, et al. 1999. Factors mediating the hemodynamic effects of tumor necrosis factor-alpha in portal hypertensive rats. Am J Physiol, 276:G687-93.
54. Nagel T, Resnick N, Dewey CF Jr, et al. 1999. Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterioscler Thromb Vasc Biol, 19:1825-34.
55. Nahed BV, Bydon M, Ozturk AK, et al. 2007. Genetics of intracranial aneurysms. Neurosurgery, 60:213-25.
56. Norwak M, Gaines GC, Rosenberg J, et al. 2000. LPS-induced liver injury in D-galactosamine-sensitized requires secretion of TNF-alpha and the TNF-p55 receptor. Am J Physiol Regul Intergr Comp Physiol, 278: R1202-9.
57. Ostergaard JR. 1989. Risk factors in intracranial aneurysms: aspects on the formation and rupture of aneurysms, and development of cerebral vasospasm. Acta Neurol Scand, 80:81-98.
58. Paolisso G, Rizzo MR, Mazziotti G, et al. 1998. Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha. Am J Physiol, 275:E294-9.
59. Parker CW, Aykent S. 1982. Calcium stimulation of the 5-lipoxygenase from RBL-1 cells. Biochem Biophys Res Comm, 109:1011-16.
60. Paul-Clark M, McMaster SK, Belcher E, et al. 2006. Differential effects of gram positive versus gram negative bacteria on NOSII and TNFα in macrophages: role of TLR's in synergy between the two. Br J Pharmacol, 148:1067-75.
61. Pavic M, Debourdeau P, Teixeira L, et al. 2001. Bacterial cerebral aneurysms without infectious endocarditis: analysis of a case and review of the literature. Rev Med Interne, 22:867-71.
62. Peschon JJ, Torrance DS, Stocking KL, et al. 1998. TNF deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol, 160:943-52.
63. Peters DG, Kassam AB, Feingold E, et al. 2001. Molecular anatomy of an intracranial aneurysm coordinated expression of genes involves in wound healing and tissue remodeling. Stroke, 32:1036-42.
64. Pimentel-Muinos FX, Seed B. 1999. Regulated commitment of TNF receptor signaling: a molecular switch for death or activation. Immunity, 11:783-93.
65. Polavarapu R, Gongora MC, Winkles JA, et al. 2005. Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation. J Neurosci, 25:10094-100.
66. Puder A Freda PU, Goland RS, et al. 2001. Estrogen modulates the hypothalamic-pituitary-adrenal and inflammatory cytokine responses to endotoxin in women. J Clin Endocrinol Metab, 86:2403-8.
67. Raveedran M, Senthil D, Utama B, et al. 2004. Cigarette suppresses the expression of P4Hα and vascular collagen production. Biochem Biophys Res Comm, 323:592-8.
68. Ruetzler CA, Furuya K, Takeda H, et al. 2001. Brain vessels normally undergo cyclic activation and inactivation: evidence from tumor necrosis factor-alpha, heme oxygenase-1, and manganese superoxide dismutase immunostaining of vessels and perivascular brain cells. J Cereb Blood Flow Metab, 21:244-52.
69. Ruigrok YM, Rinkel GJE, Wimjenga C, 2005. Genetics of intracranial aneurysms. Lancet Neurol, 4:179-89.
70. Schurman L, Sedlinsky C, Mangano A, et al. 2001. Estrogenic status influences nitric oxide-regulated TNF-alpha release from human peripheral blood monocytes. Exp Clin Endocrinol Diabetes, 109:340-4.
71. Sirén AL, McCarron R, Wang L, et al. 2001. Proinflammatory cytokine expression contributes to brain injury provoked by chronic monocyte activation. Mol Med, 7:219-29.
72. Slifka MK, Whitton JL. 2000. Clinical implications of dysregulated cytokine production. J Mol Med, 78:74-80.
73. Srivastava S, Weitzmann MN, Cenci S, et al. 1999. Estrogen decreases TNFoc gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J Clin Invest, 104:503-13.
74. Sun SH, Tang WX, Liu C, et al. 2007. Effects of tumor necrosis factor alpha on proteolysis ofrespiratory muscles in rats with chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Za Zhi, 30:186-91.
75. Takada Y, Aggarwal BB. 2003. Genetic deletion ofthe tumor necrosis factor receptor p60 or p8O sensitizes macrophages to lipopolysaccharide- induced nuclear factor-kappa B, mitogen-activated protein kinases, and apoptosis. J Biol Chem, 278:23390-7.
76. Takeda K, Akira S. 2003. Toll receptors and pathogen resistance. Cell Microbiol, 5:143-53.
77. Takeuchi O, Hoshino K, Kawai T, et al. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-positive and gram-negative bacterial cell wall components. Immunity, 11:443-51.
78. Tang V, Dhirapong A, Yabes AP, et al. 2005. TNF-α-mediated apoptosis in vascular smooth muscle cells requires p73. Am J Physiol Cell Physiol, 289:199-206.
79. Toder RD, Lewis I, Bruno G, et al. 1998. Identification ofa serum gelatinase associated with the occurrence of cerebral aneurysms as pro-matrix metalloproteinase-2. Stroke, 29:1580-3.
80. Tracy KJ, Cerami A. 1993. Tumor necrosis factor, other cytokines and disease. Ann Rev Cell Biol, 9:317-43.
81. Van den Berg JSP, Pals G, Arwert F, et al. 1999. Type III collagen deficiency in saccular intracranial aneurysms: defect in gene regulation? Stroke, 30:1628-31.
82. Vestweber D. 2007. Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium. Immunol Rev, 218:178-96.
83. Wang Z, Rao PJ, Castresana MR, et al. 2005. TNF-alpha induces proliferation or apoptosis in human saphenous vein smooth muscle cells depending on phenotype. Am J Physiol Heart Circ Physiol, 288: H293-301.
84. Weir BK, Kongable GL, Kassell NF, et al. 1998. Cigarette smoking as a cause of aneurismal subarachnoid hemorrhage and risk for vasospasm: a report of the Cooperative Aneurysm Study. J Neurosurgery, 89:405-11.
85. Weiss T, Grell G, Siemienski K, et al. 1998. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60. J Immunol, 161:3136-42.
86. Whitfield PC, Bullock R. 1991. Infected intracranial aneurysm in an infant: case report. Neurosurgery, 28:623-5.
87. Wilson AG, di Giovine FS, Blakemore Al, et al. 1992. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA, 94:3195-9.
88. Wilson AG, deVries N, Pociot F, et al. 1993. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8 and DR3 alleles. J Exp Med, 177:557-60.
89. Wright JL, Tai H, Wang R, et al. 2007. Cigarette smoke upregulates vascular matrix metalloproteinases via TNF-alpha signaling. Am J Physiol Lung Cell Mol Physiol, 292:L125-33.
90. Xing D, Feng W, Miller AP, et al. 2007. Estrogen modulates TNF-α induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-β activation. Am J Physiol Heart Circ Physiol, 292: H2607-12.
91. Xing Z, Gauldie J, Cox G, et al. 1998. IL-6 an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest, 101:311-20.
92. Yanbaeva DG, Dentener MA, Creutzberg EC, et al. 2007. Systemic effects of smoking. Chest, 131:1557-66.
93. Yoneyama T, Kasuya H, Onda H, et al. 2004. Collagen type 1 α2 (Coll A2) is the susceptible gene for intracranial aneurysms. Stroke, 35:443-8.
94. Zhang B, Dhillon S, Geary I, et al. 2001. Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 in relation to subarachnoid hemorrhage. Stroke, 32:2198-202.
95. Zhao L, Moos MP, Grabner R et al. 2004. The 5-lipoxygenase pathways promote pathogenesis of hyperlipiderma-dependent aortic aneurysm. Nat Med, 10:966-73.