메뉴 건너뛰기




Volumn 13, Issue 18, 2008, Pages 7022-7031

The use of genetically engineered model systems for research on human aging

Author keywords

Aging; Cell Death; Gerontogenes; Review; RNA Microarray; Senescence

Indexed keywords

DROSOPHILA MELANOGASTER; EUKARYOTA;

EID: 52049108897     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3207     Document Type: Article
Times cited : (9)

References (49)
  • 1
    • 0037052454 scopus 로고    scopus 로고
    • Demography: Broken limits to life expectancy
    • DOI 10.1126/science.1069675
    • Oeppen, J. & J. W. Vaupel: Demography. Broken limits to life expectancy. Science, 296, 1029-31 (2002) (Pubitemid 34517101)
    • (2002) Science , vol.296 , Issue.5570 , pp. 1029-1031
    • Oeppen, J.1    Vaupel, J.W.2
  • 4
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • DOI 10.1101/gad.1381406
    • Powers, R. W., 3rd, M. Kaeberlein, S. D. Caldwell, B. K. Kennedy & S. Fields: Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev, 20, 174-84 (2006) (Pubitemid 43112936)
    • (2006) Genes and Development , vol.20 , Issue.2 , pp. 174-184
    • Powers III, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 5
    • 33645472504 scopus 로고    scopus 로고
    • New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
    • Hansen, M., A. L. Hsu, A. Dillin & C. Kenyon: New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet, 1, 119-28 (2005)
    • (2005) PLoS Genet , vol.1 , pp. 119-128
    • Hansen, M.1    Hsu, A.L.2    Dillin, A.3    Kenyon, C.4
  • 6
    • 11144314912 scopus 로고    scopus 로고
    • Yeast longevity and aging - The mitochondrial connection
    • DOI 10.1016/j.mad.2004.08.016, PII S0047637404001964, The Voyage to Old Age: Searching for Human Longevity Genes
    • Jazwinski, S. M.: Yeast longevity and aging-the mitochondrial connection. Mech Ageing Dev, 126, 243-8 (2005) (Pubitemid 40038344)
    • (2005) Mechanisms of Ageing and Development , vol.126 , Issue.2 , pp. 243-248
    • Jazwinski, S.M.1
  • 7
    • 0030820491 scopus 로고    scopus 로고
    • Accelerated aging and nucleolar fragmentation in yeast SGS1 mutants
    • DOI 10.1126/science.277.5330.1313
    • Sinclair, D. A., K. Mills & L. Guarente: Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science, 277, 1313-6 (1997) (Pubitemid 27449085)
    • (1997) Science , vol.277 , Issue.5330 , pp. 1313-1316
    • Sinclair, D.A.1    Mills, K.2    Guarente, L.3
  • 8
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins - Emerging roles in physiology, aging, and calorie restriction
    • DOI 10.1101/gad.1467506
    • Haigis, M. C. & L. P. Guarente: Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev, 20, 2913-21 (2006) (Pubitemid 44771725)
    • (2006) Genes and Development , vol.20 , Issue.21 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 9
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: Insights into their biological function
    • DOI 10.1042/BJ20070140
    • Michan, S. & D. Sinclair: Sirtuins in mammals: insights into their biological function. Biochem J, 404, 1-13 (2007) (Pubitemid 46788079)
    • (2007) Biochemical Journal , vol.404 , Issue.1 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 12
    • 0034894667 scopus 로고    scopus 로고
    • Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
    • DOI 10.1016/S0531-5565(01)00105-X, PII S053155650100105X
    • Wagner, M., B. Hampel, D. Bernhard, M. Hala, W. Zwerschke & P. Jansen-Durr: Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis. Exp Gerontol, 36, 1327-47. (2001) (Pubitemid 32707871)
    • (2001) Experimental Gerontology , vol.36 , Issue.8 , pp. 1327-1347
    • Wagner, M.1    Hampel, B.2    Bernhard, D.3    Hala, M.4    Zwerschke, W.5    Jansen-Durr, P.6
  • 13
    • 9644310524 scopus 로고    scopus 로고
    • Differential regulation of apoptotic cell death in senescent human cells
    • DOI 10.1016/j.exger.2004.05.010, PII S0531556504002864
    • Hampel, B., F. Malisan, H. Niederegger, R. Testi & P. Jansen-Durr: Differential regulation of apoptotic cell death in senescent human cells. Exp Gerontol, 39, 1713-21 (2004) (Pubitemid 39576141)
    • (2004) Experimental Gerontology , vol.39 , Issue.11-12 SPEC. ISSUE , pp. 1713-1721
    • Hampel, B.1    Malisan, F.2    Niederegger, H.3    Testi, R.4    Jansen-Durr, P.5
  • 15
    • 33645972267 scopus 로고    scopus 로고
    • Molecular regulation of apoptosis in fast plantaris muscles of aged rats
    • Pistilli, E. E., P. M. Siu & S. E. Alway: Molecular regulation of apoptosis in fast plantaris muscles of aged rats. J Gerontol A Biol Sci Med Sci, 61, 245-55 (2006)
    • (2006) J Gerontol A Biol Sci Med Sci , vol.61 , pp. 245-255
    • Pistilli, E.E.1    Siu, P.M.2    Always, S.E.3
  • 16
    • 33646259974 scopus 로고    scopus 로고
    • Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart
    • DOI 10.1096/fj.05-5116fje
    • Kwak, H. B., W. Song & J. M. Lawler: Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart. Faseb J, 20, 791-3 (2006) (Pubitemid 46671217)
    • (2006) FASEB Journal , vol.20 , Issue.6 , pp. 791-793
    • Kwak, H.-B.1    Song, W.2    Lawler, J.M.3
  • 21
    • 0034080896 scopus 로고    scopus 로고
    • Subtractive hybridization of mRNA from early passage and senescent endothelial cells
    • DOI 10.1016/S0531-5565(00)00080-2, PII S0531556500000802
    • Grillari, J., O. Hohenwarter, R. M. Grabherr & H. Katinger: Subtractive hybridization of mRNA from early passage and senescent endothelial cells. Exp Gerontol, 35, 187-97 (2000) (Pubitemid 30190084)
    • (2000) Experimental Gerontology , vol.35 , Issue.2 , pp. 187-197
    • Grillari, J.1    Hohenwarter, O.2    Grabherr, R.M.3    Katinger, H.4
  • 22
    • 0034715941 scopus 로고    scopus 로고
    • HNMP 200: Anovel human common nuclear matrix protein combining structural and regulatory functions
    • Gotzmann, J., C. Gerner, M. Meissner, K. Holzmann, R. Grimm, W. Mikulits & G. Sauermann: hNMP 200: Anovel human common nuclear matrix protein combining structural and regulatory functions. Exp Cell Res, 261, 166-79. (2000)
    • (2000) Exp Cell Res , vol.261 , pp. 166-179
    • Gotzmann, J.1    Gerner, C.2    Meissner, M.3    Holzmann, K.4    Grimm, R.5    Mikulits, W.6    Sauermann, G.7
  • 25
    • 0027491331 scopus 로고
    • Yeast precursor mRNA processing protein PRP19 associates with the spliceosome concomitant with or just after dissociation of U4 small nuclear RNA
    • Tarn, W. Y., K. R. Lee & S. C. Cheng: Yeast precursor mRNA processing protein PRP19 associates with the spliceosome concomitant with or just after dissociation of U4 small nuclear RNA. Proc Natl Acad Sci U S A, 90,10821-5 (1993)
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10821-11085
    • Tarn, W.Y.1    Lee, K.R.2    Cheng, S.C.3
  • 28
    • 0034405427 scopus 로고    scopus 로고
    • Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
    • Ajuh, P., B. Kuster, K. Panov, J. C. Zomerdijk, M. Mann & A. I. Lamond: Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. Embo J, 19, 6569-81. (2000)
    • (2000) Embo J , vol.19 , pp. 6569-6581
    • Ajuh, P.1    Kuster, B.2    Panov, K.3    Zomerdijk, J.C.4    Mann, M.5    Lamond, A.I.6
  • 30
    • 0037073946 scopus 로고    scopus 로고
    • Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
    • DOI 10.1126/science.1077783
    • Makarov, E. M., O. V. Makarova, H. Urlaub, M. Gentzel, C. L. Will, M. Wilm & R. Luhrmann: Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science, 298, 2205-8. (2002) (Pubitemid 35471248)
    • (2002) Science , vol.298 , Issue.5601 , pp. 2205-2208
    • Makarov, E.M.1    Makarova, O.V.2    Urlaub, H.3    Gentzel, M.4    Will, C.L.5    Wilm, M.6    Luhrmann, R.7
  • 31
    • 3242737496 scopus 로고    scopus 로고
    • A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing
    • DOI 10.1038/sj.emboj.7600241
    • Makarova, O. V., E. M. Makarov, H. Urlaub, C. L. Will, M. Gentzel, M. Wilm & R. Luhrmann: A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. Embo J, 23, 2381-91. Epub 2004 Jun 03. (2004) (Pubitemid 38954845)
    • (2004) EMBO Journal , vol.23 , Issue.12 , pp. 2381-2391
    • Makarova, O.V.1    Makarov, E.M.2    Urlaub, H.3    Will, C.L.4    Gentzel, M.5    Wilm, M.6    Luhrmann, R.7
  • 32
    • 33745860086 scopus 로고    scopus 로고
    • Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions
    • DOI 10.1128/MCB.00582-06
    • Deckert, J., K. Hartmuth, D. Boehringer, N. Behzadnia, C. L. Will, B. Kastner, H. Stark, H. Urlaub & R. Luhrmann: Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. MolCell Biol, 26, 5528-43 (2006) (Pubitemid 44036218)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.14 , pp. 5528-5543
    • Deckert, J.1    Hartmuth, K.2    Boehringer, D.3    Behzadnia, N.4    Will, C.L.5    Kastner, B.6    Stark, H.7    Urlaub, H.8    Luhrmann, R.9
  • 34
    • 33947118612 scopus 로고    scopus 로고
    • Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome
    • DOI 10.1016/j.bbrc.2007.02.134, PII S0006291X0700407X
    • Sihn, C. R., S. Y. Cho, J. H. Lee, T. R. Lee & S. H. Kim: Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome. Biochem Biophys Res Commun, 356, 175-80 (2007) (Pubitemid 46413146)
    • (2007) Biochemical and Biophysical Research Communications , vol.356 , Issue.1 , pp. 175-180
    • Sihn, C.-R.1    Cho, S.Y.2    Lee, J.H.3    Lee, T.R.4    Kim, S.H.5
  • 35
    • 33846829798 scopus 로고    scopus 로고
    • The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage
    • DOI 10.1016/j.bbrc.2007.01.097, PII S0006291X07001222
    • Lu, X. & R. J. Legerski: The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage. Biochem Biophys Res Commun, 354, 968-74 (2007) (Pubitemid 46216227)
    • (2007) Biochemical and Biophysical Research Communications , vol.354 , Issue.4 , pp. 968-974
    • Lu, X.1    Legerski, R.J.2
  • 36
    • 0042346327 scopus 로고    scopus 로고
    • Central role of the proteasome in senescence and survival of human fibroblasts. Induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation
    • DOI 10.1074/jbc.M301048200
    • Chondrogianni, N., F. L. Stratford, I. P. Trougakos, B. Friguet, A. J. Rivett & E. S. Gonos: Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem, 278, 28026-37 (2003) (Pubitemid 36899999)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.30 , pp. 28026-28037
    • Chondrogianni, N.1    Stratford, F.L.L.2    Trougakos, I.P.3    Friguet, B.4    Rivett, A.J.5    Gonos, E.S.6
  • 38
    • 33751413608 scopus 로고    scopus 로고
    • Aging and the ubiquitinome: Traditional and non-traditional functions of ubiquitin in aging cells and tissues
    • DOI 10.1016/j.exger.2006.07.003, PII S0531556506002464
    • Grillari, J., H. Katinger & R. Voglauer: Aging and the ubiquitinome: Traditional and non-traditional functions ofubiquitin in aging cells and tissues. Exp Gerontol, 41, 1067-1079 (2006) (Pubitemid 44820714)
    • (2006) Experimental Gerontology , vol.41 , Issue.11 , pp. 1067-1079
    • Grillari, J.1    Katinger, H.2    Voglauer, R.3
  • 40
    • 84860316630 scopus 로고    scopus 로고
    • Purification and identification of proteins binding to the hereditary persistence fetal hemoglobin (HPFH) -198 mutation in the gamma -globin gene promoter
    • Olave, I. A., C. Doneanu, X. Fang, G. Stamatoyannopoulos & Q. Li: Purification and identification of proteins binding to the hereditary persistence fetal hemoglobin (HPFH) -198 mutation in the gamma -globin gene promoter. J Biol Chem, (2006)
    • (2006) J Biol Chem
    • Olave, I.A.1    Doneanu, C.2    Fang, X.3    Stamatoyannopoulos, G.4    Li, Q.5
  • 41
    • 28844509443 scopus 로고    scopus 로고
    • The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links
    • DOI 10.1074/jbc.M508453200
    • Zhang, N., R. Kaur, X. Lu, X. Shen, L. Li & R. J. Legerski: The PSO4 MRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. J Biol Chem, 280, 40559-67 (2005) (Pubitemid 41780545)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.49 , pp. 40559-40567
    • Zhang, N.1    Kaur, R.2    Lu, X.3    Shen, X.4    Li, L.5    Legerski, R.J.6
  • 43
    • 0033151822 scopus 로고    scopus 로고
    • Werner syndrome helicase contains a 5'→3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding
    • DOI 10.1093/nar/27.11.2361
    • Suzuki, N., M. Shiratori & Y. F. Makoto Goto: Werner syndrome helicase contains a 5 (prime)->3 (prime) exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding. Nucleic Acids Res. 27, 2361-2368 (1999) (Pubitemid 29245656)
    • (1999) Nucleic Acids Research , vol.27 , Issue.11 , pp. 2361-2368
    • Suzuki, N.1    Shiratori, M.2    Goto, M.3    Furuichi, Y.4
  • 45
    • 0014816132 scopus 로고
    • Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype
    • Martin, G. M., C. A. Sprague & C. J. Epstein: Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest, 23, 86-92 (1970)
    • (1970) Lab Invest , vol.23 , pp. 86-92
    • Martin, G.M.1    Sprague, C.A.2    Epstein, C.J.3
  • 46
    • 38049034465 scopus 로고    scopus 로고
    • Contributions of DNA interstrand cross-links to aging of cells and organisms
    • Grillari, J., H. Katinger & R. Voglauer: Contributions of DNA interstrand cross-links to aging of cells and organisms. Nucleic Acids Res, (2007)
    • (2007) Nucleic Acids Res
    • Grillari, J.1    Katinger, H.2    Voglauer, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.