Toll-like receptor signaling in the ischemic heart

Frontiers in Bioscience

Volumn 13, Issue 15, 2008, Pages 5772-5779

  Frantz, Stefan ^a   Ertl, Georg ^a   Bauersachs, Johann ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Heart Failure; Innate Immunity; Ischemic Injury; Myocardium; Review; TLR

Indexed keywords

TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL; CARDIOMEGALY; DISEASE MODEL; HEART FAILURE; HEART MUSCLE ISCHEMIA; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOMEGALY; DISEASE MODELS, ANIMAL; HEART FAILURE; HUMANS; MYOCARDIAL ISCHEMIA; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 52049106096     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3114     Document Type: Review

References (50)

1. Akira, S., S. Uematsu & O. Takeuchi: Pathogen recognition and innate immunity. Cell, 124, 783-801 (2006) (Pubitemid 43261452)
2. Janeway, C. A., Jr.: Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol, 54 Pt 1, 1-13 (1989) (Pubitemid 20177564)
3. Janeway, C. A., Jr. & R. Medzhitov: Introduction: the role of innate immunity in the adaptive immune response. Semin Immunol, 10, 349-50 (1998) (Pubitemid 28499547)
4. Medzhitov, R. & C. A. Janeway, Jr.: Innate immunity: the virtues of a nonclonal system of recognition. Cell, 91, 295-8 (1997) (Pubitemid 27467959)
5. Medzhitov, R. & C. A. Janeway, Jr.: Innate immunity: impact on the adaptive immune response. Curr Opin Immunol, 9, 4-9 (1997) (Pubitemid 27095892)
6. Medzhitov, R. & C. A. Janeway, Jr.: An ancient system of host defense. Curr Opin Immunol, 10, 12-5 (1998) (Pubitemid 28112072)
7. Vabulas, R. M., P. Ahmad-Nejad, C. da Costa, T. Miethke, C. J. Kirschning, H. Hacker & H. Wagner: Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem, 276, 31332-9 (2001) (Pubitemid 37385004)
8. Okamura, Y., M. Watari, E. S. Jerud, D. W. Young, S. T. Ishizaka, J. Rose, J. C. Chow & J. F. Strauss, 3rd: The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem, 276, 10229-33 (2001)
9. Scheibner, K. A., M. A. Lutz, S. Boodoo, M. J. Fenton, J. D. Powell & M. R. Horton: Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol, 177, 1272-81 (2006) (Pubitemid 44036633)
10. Kaisho, T. & S. Akira: Toll-like receptor function and signaling. J Allergy Clin Immunol, 117, 979-87; quiz 988 (2006)
11. Medzhitov, R., P. Preston-Hurlburt, E. Kopp, A. Stadlen, C. Chen, S. Ghosh & C. A. Janeway, Jr.: MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell, 2, 253-8 (1998) (Pubitemid 128373651)
12. Frantz, S., L. Kobzik, Y. D. Kim, R. Fukazawa, R. Medzhitov, R. T. Lee & R. A. Kelly: Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest, 104, 271-80 (1999)
13. Re, F. & J. L. Strominger: Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem, 276, 37692-9 (2001)
14. Frantz, S., G. Ertl & J. Bauersachs: Mechanisms of Disease: Toll-like receptors in cardiovascular disease. Nat Clin Pract Cardiovasc Med, 4, 444-54 (2007) (Pubitemid 47180328)
15. Michelsen, K. S. & M. Arditi: Toll-like receptor signaling and atherosclerosis. Curr Opin Hematol, 13, 163-8 (2006)
16. Methe, H., J. O. Kim, S. Kofler, M. Weis, M. Nabauer & J. Koglin: Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Circulation, 111, 2654-61 (2005) (Pubitemid 40740866)
17. Foldes, G., S. von Haehling, D. O. Okonko, E. A. Jankowska, P. A. Poole-Wilson & S. D. Anker: Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure. Int J Cardiol (2007)
18. Satoh, M., Y. Shimoda, C. Maesawa, T. Akatsu, Y. Ishikawa, Y. Minami, K. Hiramori & M. Nakamura: Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction. Int J Cardiol, 109, 226-34 (2006)
19. Frantz, S., R. A. Kelly & T. Bourcier: Role of TLR-2 in the activation of nuclear factor-kappa B by oxidative stress in cardiac myocytes. J Biol Chem, 276, 5197-5203 (2001)
20. Boyd, J. H., S. Mathur, Y. Wang, R. M. Bateman & K. R. Walley: Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. Cardiovasc Res, 72, 384-93 (2006) (Pubitemid 44665856)
21. Zhu, X., H. Zhao, A. R. Graveline, E. S. Buys, U. Schmidt, K. D. Bloch, A. Rosenzweig & W. Chao: MyD88 and NOS2 are essential for Toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol, 291, H1900-9 (2006) (Pubitemid 44497698)
22. Chong, A. J., A. Shimamoto, C. R. Hampton, H. Takayama, D. J. Spring, C. L. Rothnie, M. Yada, T. H. Pohlman & E. D. Verrier: Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardiovasc Surg, 128, 170-9 (2004) (Pubitemid 38969797)
23. Oyama, J., C. Blais, Jr., X. Liu, M. Pu, L. Kobzik, R. A. Kelly & T. Bourcier: Reduced myocardial ischemiareperfusion injury in toll-like receptor 4-deficient mice. Circulation, 109, 784-9 (2004) (Pubitemid 38222900)
24. Hua, F., T. Ha, J. Ma, Y. Li, J. Kelley, X. Gao, I. W. Browder, R. L. Kao, D. L. Williams & C. Li: Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J Immunol, 178, 7317-24 (2007) (Pubitemid 46847459)
25. Favre, J., P. Musette, V. Douin-Echinard, K. Laude, J. P. Henry, J. F. Arnal, C. Thuillez & V. Richard: Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol, 27, 1064-71 (2007) (Pubitemid 46641958)
26. Hua, F., T. Ha, J. Ma, X. Gao, J. Kelley, D. L. Williams, I. W. Browder, R. L. Kao & C. Li: Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts. Biochem Biophys Res Commun, 338, 1118-25 (2005) (Pubitemid 41597753)
27. Hall, G., J. D. Hasday & T. B. Rogers: Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol, 41, 580-91 (2006) (Pubitemid 44374539)
28. Morgan, E. N., E. M. Boyle, Jr., W. Yun, J. M. Griscavage-Ennis, A. L. Farr, T. G. Canty, Jr., T. H. Pohlman & E. D. Verrier: An essential role for NF-kappaB in the cardioadaptive response to ischemia. Ann Thorac Surg, 68, 377-82 (1999) (Pubitemid 29521080)
29. Chandrasekar, B. & G. L. Freeman: Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium. FEBS Lett, 401, 30-4 (1997) (Pubitemid 27051252)
30. Morishita, R., T. Sugimoto, M. Aoki, I. Kida, N. Tomita, A. Moriguchi, K. Maeda, Y. Sawa, Y. Kaneda, J. Higaki & T. Ogihara: In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction. Nat Med, 3, 894-9 (1997) (Pubitemid 27353450)
31. Brown, M., M. McGuinness, T. Wright, X. Ren, Y. Wang, G. P. Boivin, H. Hahn, A. M. Feldman & W. K. Jones: Cardiac-specific blockade of NF-kappaB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo. Am J Physiol Heart Circ Physiol, 289, H466-76 (2005) (Pubitemid 40934134)
32. Onai, Y., J. Suzuki, T. Kakuta, Y. Maejima, G. Haraguchi, H. Fukasawa, S. Muto, A. Itai & M. Isobe: Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc Res, 63, 51-9 (2004) (Pubitemid 38759809)
33. Ertl, G. & S. Frantz: Healing after myocardial infarction. Cardiovasc Res, 66, 22-32 (2005) (Pubitemid 40360705)
34. Frantz, S., J. Bauersachs & R. A. Kelly: Innate immunity and the heart. Curr Pharm Des, 11, 1279-90 (2005) (Pubitemid 40458273)
35. Birks, E. J., L. E. Felkin, N. R. Banner, A. Khaghani, P. J. Barton & M. H. Yacoub: Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices. J Heart Lung Transplant, 23, 228-35 (2004) (Pubitemid 38175301)
36. Frantz, S., K. Hu, B. Bayer, S. Gerondakis, J. Strotmann, A. Adamek, G. Ertl & J. Bauersachs: Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction. FASEB J, 20, 1918-20 (2006)
37. Tillmanns, J., H. Carlsen, R. Blomhoff, G. Valen, L. Calvillo, G. Ertl, J. Bauersachs & S. Frantz: Caught in the act: In vivo molecular imaging of the transcription factor NF-kappaB after myocardial infarction. Biochem Biophys Res Commun, 342, 773-4 (2006) (Pubitemid 43320465)
38. Chao, W., Y. Shen, L. Li & A. Rosenzweig: Importance of FADD signaling in serum deprivation-and hypoxiainduced cardiomyocyte apoptosis. J Biol Chem, 277, 31639-45 (2002) (Pubitemid 34968967)
39. Frantz, S., S. Stoerk, S. Ok, H. Wagner, C. E. Angermann, G. Ertl & J. Bauersachs: Effect of chronic heart failure on nuclear factor kappa B in peripheral leukocytes. Am J Cardiol, 94, 671-3 (2004) (Pubitemid 39165855)
40. Shishido, T., N. Nozaki, S. Yamaguchi, Y. Shibata, J. Nitobe, T. Miyamoto, H. Takahashi, T. Arimoto, K. Maeda, M. Yamakawa, O. Takeuchi, S. Akira, Y. Takeishi & I. Kubota: Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation, 108, 2905-10 (2003) (Pubitemid 37517819)
41. Timmers, L., J. P. Sluijter, J. K. van Keulen, I. E. Hoefer, M. G. Nederhoff, M. J. Goumans, P. A. Doevendans, C. J. van Echteld, J. A. Joles, P. H. Quax, J. J. Piek, G. Pasterkamp & D. P. de Kleijn: Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function Following Myocardial Infarction. Circ Res (2007)
42. Seki, E., S. De Minicis, C. H. Osterreicher, J. Kluwe, Y. Osawa, D. A. Brenner & R. F. Schwabe: TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med, 13, 1324-32 (2007) (Pubitemid 350073596)
43. Ha, T., Y. Li, F. Hua, J. Ma, X. Gao, J. Kelley, A. Zhao, G. E. Haddad, D. L. Williams, I. William Browder, R. L. Kao & C. Li: Reduced cardiac hypertrophy in tolllike receptor 4-deficient mice following pressure overload. Cardiovasc Res, 68, 224-34 (2005) (Pubitemid 41428419)
44. Zhang, D., V. Gaussin, G. E. Taffet, N. S. Belaguli, M. Yamada, R. J. Schwartz, L. H. Michael, P. A. Overbeek & M. D. Schneider: TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nat Med, 6, 556-63 (2000) (Pubitemid 30305906)
45. Ha, T., F. Hua, Y. Li, J. Ma, X. Gao, J. Kelley, A. Zhao, G. E. Haddad, D. L. Williams, I. W. Browder, R. L. Kao & C. Li: Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol, 290, H985-94 (2006)
46. Purcell, N. H., G. Tang, C. Yu, F. Mercurio, J. A. DiDonato & A. Lin: Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci U S A, 98, 6668-73 (2001) (Pubitemid 32538274)
47. Hirotani, S., K. Otsu, K. Nishida, Y. Higuchi, T. Morita, H. Nakayama, O. Yamaguchi, T. Mano, Y. Matsumura, H. Ueno, M. Tada & M. Hori: Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation, 105, 509-15 (2002) (Pubitemid 34141710)
48. Kawano, S., T. Kubota, Y. Monden, N. Kawamura, H. Tsutsui, A. Takeshita & K. Sunagawa: Blockade of NFkappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II. Cardiovasc Res, 67, 689-98 (2005) (Pubitemid 41033364)
49. Freund, C., R. Schmidt-Ullrich, A. Baurand, S. Dunger, W. Schneider, P. Loser, A. El-Jamali, R. Dietz, C. Scheidereit & M. W. Bergmann: Requirement of nuclear factor-kappaB in angiotensin II-and isoproterenol-induced cardiac hypertrophy in vivo. Circulation, 111, 2319-25 (2005) (Pubitemid 40647067)
50. Frantz, S., D. Fraccarollo, H. Wagner, T. M. Behr, P. Jung, C. E. Angermann, G. Ertl & J. Bauersachs: Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure. Cardiovasc Res, 57, 749-56 (2003) (Pubitemid 36254868)