Silencing of n-ras gene expression using shRNA decreases transformation efficiency and tumor growth in transformed cells induced by Anti-BPDE

Toxicological Sciences

Volumn 105, Issue 2, 2008, Pages 286-294

  Zhou, Lanlan ^a   Jiang, Yiguo ^a   Tan, Aijun ^b   Greenlee, Anne R ^c   Shen, Yuelan ^a   Liu, Linhua ^a   Yang, Qiaoyuan ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b Center for Disease Control and Prevention of Zhuhai   (China)

^c EASTERN OREGON UNIVERSITY   (United States)

Author keywords

Anti BPDE; H Ras, K Ras, N Ras; Human bronchial epithelial cells; Malignant transformation; RNA interference; Short hairpin RNA

Indexed keywords

BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; K RAS PROTEIN; MESSENGER RNA; RAS PROTEIN; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DRUG TARGETING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR GROWTH; WESTERN BLOTTING;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; BLOTTING, WESTERN; CARCINOGENS; CELL CYCLE; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR STEM CELL ASSAY; UP-REGULATION;

EID: 51849103810     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn122     Document Type: Article

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