Induction of cell death by TiO2 nanoparticles: Studies on a human monoblastoid cell line

Toxicology in Vitro

Volumn 22, Issue 7, 2008, Pages 1689-1696

  Vamanu, Carmen I ^a   Cimpan, Mihaela R ^a   Høl, Paul J ^a,b   Sørnes, Steinar ^a   Lie, Stein A ^c   Gjerdet, Nils R ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c Unifob Health   (Norway)

Author keywords

Apoptosis; Cell viability; Cytotoxicity; Nanoparticle; Titanium oxide

Indexed keywords

NANOPARTICLE; TITANIUM DIOXIDE;

APOPTOSIS; ARTICLE; BLOOD; CELL DEATH; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMPLANT; MONOCYTE; PLASMA; SUSPENSION; TRANSMISSION ELECTRON MICROSCOPY;

APOPTOSIS; BIOCOMPATIBLE MATERIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NECROSIS; PARTICLE SIZE; PROSTHESES AND IMPLANTS; TIME FACTORS; TITANIUM; U937 CELLS;

EID: 51749089010     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.07.002     Document Type: Article

References (45)

1. Agins H.J., Alcock N.W., Bansal M., Salvati E.A., Wilson P.D., Pellicci P.M., and Bullough P.G. Metallic wear in failed titanium-alloy total hip replacements - a histological and quantitative-analysis. The Journal of Bone and Joint Surgery American 70A (1988) 347-356
2. Arys A., Philippart C., Dourov N., He Y., Le Q.T., and Pireaux J.J. Analysis of titanium dental implants after failure of osseointegration: combined histological, electron microscopy, and X-ray photoelectron spectroscopy approach. Journal of Biomedical Materials Research 43 (1998) 300-312
3. Balbus J.M., Maynard A.D., Colvin V.L., Castranova V., Daston G.P., Denison R.A., Dreher K.L., Goering P.L., Goldberg A.M., Kulinowski K.M., Monteiro-Riviere N.A., Oberdörster G., Omenn G.S., Pinkerton K.E., Ramos K.S., Rest K.M., Sass J.B., Silbergeld E.K., and Wong B.A. Meeting report: hazard assessment for nanoparticles - report from an interdisciplinary workshop. Environmental Health Perspectives 115 (2007) 1654-1659
4. Borm P.J., Robbins D., Haubold S., Kuhlbusch T., Fissan H., Donaldson K., Schins R., Stone V., Kreyling W., Lademann J., Krutmann J., Warheit D., and Oberdorster E. The potential risks of nanomaterials: a review carried out for ECETOC. Particle and Fibre Toxicology 3 (2006) 11
5. Brien W.W., Salvati E.A., Betts F., Bullough P., Wright T., Rimnac C., Buly R., and Garvin K. Metal levels in cemented total hip arthroplasty. A comparison of well-fixed and loose implants. Clinical Orthopaedics and Related Research (1992) 66-74
6. Buly R.L., Huo M.H., Salvati E., Brien W., and Bansal M. Titanium wear debris in failed cemented total hip arthroplasty. An analysis of 71 cases. The Journal of Arthroplasty 7 (1992) 315-323
7. Chen H.W., Su S.F., Chien C.T., Lin W.H., Yu S.L., Chou C.C., Chen J.J., and Yang P.C. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. The FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 20 (2006) 2393-2935
8. Cimpan M.R., Cressey L.I., Skaug N., Halstensen A., Lie S.A., Gjertsen B.T., and Matre R. Patterns of cell death induced by eluates from denture base acrylic resins in U-937 human monoblastoid cells. European Journal of Oral Sciences 108 (2000) 59-69
9. Clarke P.G. Developmental cell death: morphological diversity and multiple mechanisms. Anatomy and Embryology 181 (1990) 195-213
10. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M., Strober, W., ßCoico, R., 1995. Flow cytometry for DNA analysis. In: Current Protocols in Immunology, pp. 1-6.
11. Cunningham B.W., Orbegoso C.M., Dmitriev A.E., Hallab N.J., Sefter J.C., and McAfee P.C. The effect of titanium particulate on development and maintenance of a posterolateral spinal arthrodesis: an in vivo rabbit model. Spine 27 (2002) 1971-1981
12. Darzynkiewicz Z., Juan G., Li X., Gorczyca W., Murakami T., and Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 27 (1997) 1-20
13. Desai M.P., Labhasetwar V., Walter E., Levy R.J., and Amidon G.L. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharmaceutical Research 14 (1997) 1568-1573
14. Donaldson K., Brown D., Clouter A., Duffin R., MacNee W., Renwick L., Tran L., and Stone V. The pulmonary toxicology of ultrafine particles. Journal of Aerosol Medicine: The Official Journal of the International Society for Aerosols in Medicine 15 (2002) 213-220
15. Galea-Lauri J., Richardson A.J., Latchman D.S., and Katz D.R. Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology. Journal of Immunology (Baltimore, Md.: 1950) 157 (1996) 4109-4118
16. Geiser M., Rothen-Rutishauser B., Kapp N., Schurch S., Kreyling W., Schulz H., Semmler M., Im Hof V., Heyder J., and Gehr P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environmental Health Perspectives 113 (2005) 1555-1560
17. Gjertsen B.T., Cressey L.I., Ruchaud S., Houge G., Lanotte M., and Doskeland S.O. Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. Journal of Cell Science 107 Part 12 (1994) 3363-3377
18. Gong J., Traganos F., and Darzynkiewicz Z. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Analytical Biochemistry 218 (1994) 314-319
19. Haberzettl P., Duffin R., Kramer U., Hohr D., Schins R.P., Borm P.J., and Albrecht C. Actin plays a crucial role in the phagocytosis and biological response to respirable quartz particles in macrophages. Archives of Toxicology 81 (2007) 459-470
20. Hallab N.J., Skipor A., and Jacobs J.J. Interfacial kinetics of titanium- and cobalt-based implant alloys in human serum: metal release and biofilm formation. Journal of Biomedical Materials Research 65 (2003) 311-318
21. Hockenbery D.M., Oltvai Z.N., Yin X.M., Milliman C.L., and Korsmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75 (1993) 241-251
22. Jacobs J.J., Skipor A.K., Campbell P.A., Hallab N.J., Urban R.M., and Amstutz H.C. Can metal levels be used to monitor metal-on-metal hip arthroplasties?. The Journal of Arthroplasty 19 (2004) 59-65
23. Jensen P.H., Cressey L.I., Gjertsen B.T., Madsen P., Mellgren G., Hokland P., Gliemann J., Doskeland S.O., Lanotte M., and Vintermyr O.K. Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis. British Journal of Cancer 70 (1994) 834-840
24. Leopold S.S., Berger R.A., Patterson L., Skipor A.K., Urban R.M., and Jacobs J.J. Serum titanium level for diagnosis of a failed, metal-backed patellar component. The Journal of Arthroplasty 15 (2000) 938-943
25. Limbach L.K., Li Y.C., Grass R.N., Brunner T.J., Hintermann M.A., Muller M., Gunther D., and Stark W.J. Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations. Environmental Science and Technology 39 (2005) 9370-9376
26. Long T.C., Saleh N., Tilton R.D., Lowry G.V., and Veronesi B. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environmental Science and Technology 40 (2006) 4346-4352
27. Long T.C., Tajuba J., Sama P., Saleh N., Swartz C., Parker J., Hester S., Lowry G.V., and Veronesi B. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environmental Health Perspectives 115 (2007) 1631-1637
28. Loro L., Vintermyr O.K., and Johannessen A.C. Apoptosis in normal and diseased oral tissues. Oral Diseases 11 (2005) 274-287
29. Lynch I., Dawson K.A., and Linse S. Detecting cryptic epitopes created by nanoparticles. Science's STKE Signal Transduction Knowledge Environment (2006) 14
30. Moss O.R., and Wong V.A. When nanoparticles get in the way: impact of projected area on in vivo and in vitro macrophage function. Inhalation Toxicology 18 (2006) 711-716
31. Murdock R.C., Braydich-Stolle L., Schrand A.M., Schlager J.J., and Hussain S.M. Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. Toxicological Sciences: An Official Journal of the Society of Toxicology 101 (2008) 239-253
32. Nel A., Xia T., Madler L., and Li N. Toxic potential of materials at the nanolevel. Science 311 (2006) 622-627
33. Nilsson C., Johansson U., Johansson A.C., Kagedal K., and Ollinger K. Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cells. Apoptosis: An International Journal on Programmed Cell Death 11 (2006) 1149-1159
34. Oberdörster G., Maynard A., Donaldson K., Castranova V., Fitzpatrick J., Ausman K., Carter J., Karn B., Kreyling W., Lai D., Olin S., Monteiro-Riviere N., Warheit D., and Yang H. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle and Fibre Toxicology 2 (2005) 8
35. Osano E., Kishi J., and Takahashi Y. Phagocytosis of titanium particles and necrosis in TNF-alpha-resistant mouse sarcoma L929 cells. Toxicology in Vitro: An International Journal Published in Association with BIBRA 17 (2003) 41-47
36. Otsuki Y., Li Z., and Shibata M.A. Apoptotic detection methods - from morphology to gene. Progress in Histochemistry and Cytochemistry 38 (2003) 275-339
37. Panyam J., Sahoo S.K., Prabha S., Bargar T., and Labhasetwar V. Fluorescence and electron microscopy probes for cellular and tissue uptake of poly(d, l-lactide-co-glycolide) nanoparticles. International Journal of Pharmaceutics 262 (2003) 1-11
38. Pioletti D.P., Takei H., Kwon S.Y., Wood D., and Sung K.L. The cytotoxic effect of titanium particles phagocytosed by osteoblasts. Journal of Biomedical Materials Research 46 (1999) 399-407
39. Rahman Q., Lohani M., Dopp E., Pemsel H., Jonas L., Weiss D.G., and Schiffmann D. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environmental Health Perspectives 110 (2002) 797-800
40. Sayes C.M., Wahi R., Kurian P.A., Liu Y., West J.L., Ausman K.D., Warheit D.B., and Colvin V.L. Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicological Sciences: An Official Journal of the Society of Toxicology 92 (2006) 174-185
41. Stringer B., Imrich A., and Kobzik L. Flow cytometric assay of lung macrophage uptake of environmental particulates. Cytometry 20 (1995) 23-32
42. Teeguarden J.G., Hinderliter P.M., Orr G., Thrall B.D., and Pounds J.G. Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicological Sciences: An Official Journal of the Society of Toxicology 95 (2007) 300-312
43. 2 particles in cultured human lymphoblastoid cells. Mutation Research 628 (2007) 99-106
44. Wang M.L., Tuli R., Manner P.A., Sharkey P.F., Hall D.J., and Tuan R.S. Direct and indirect induction of apoptosis in human mesenchymal stem cells in response to titanium particles. Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society 21 (2003) 697-707
45. Zhang Q., Kusaka Y., Sato K., Nakakuki K., Kohyama N., and Donaldson K. Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: role of free radicals. Journal of Toxicology and Environmental Health Part A 53 (1998) 423-438