Hypolipidemic effect in cholesterol-fed rats of a soluble fiber-rich product obtained from cocoa husks

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 16, 2008, Pages 6985-6993

  Ramos, Sonia ^a   Moulay, Leila ^b   Granado Serrano, Ana Belén ^a   Vilanova, Olga ^b   Muguerza, Begoña ^b   Goya, Luis ^a   Bravo, Laura ^a  

^a INSTITUTO DEL FRÍO CSIC   (Spain)

^b Natraceutical Group ^*  (Spain)

Author keywords

Body weight; Hypercholesterolemia; Lipid peroxidation; Polyphenols; Soluble cocoa fiber

Indexed keywords

ANTILIPEMIC AGENT; ANTIOXIDANT; FLAVONOID; LIPID; MALONALDEHYDE;

ANIMAL; ARTICLE; BLOOD; CACAO; CHEMISTRY; CHOLESTEROL INTAKE; DIETARY FIBER; MALE; PLANT SEED; RAT; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTILIPEMIC AGENTS; ANTIOXIDANTS; CACAO; CHOLESTEROL, DIETARY; DIETARY FIBER; FLAVONOIDS; LIPIDS; MALE; MALONDIALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; SEEDS; SOLUBILITY;

ANIMALIA; RATTUS; THEOBROMA CACAO;

EID: 51649120909     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf8009816     Document Type: Article

References (35)

1. Kris-Etherton, P. M.; Hecker, K. D.; Bonanome, A.; Coval, S. M.; Binkoski, A. E.; Hilpert, K. F.; Griel, A. E.; Etherton, T. D. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002, 113, 71S-88S.
2. Bazzano, L. A.; Song, Y.; Bubes, V.; Good, C. K.; Manson, J. E.; Liu, S. Dietary intake of whole and refined breakfast cereals and weight gain in men. Obes. Res. 2005, 13, 1952-1960.
3. McKeown, N. M.; Meigs, J. B.; Liu, S.; Wilson, P. W. F.; Jacques, P. F. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am. J. Clin. Nutr. 2002, 76, 390-398.
4. Artiss, J. D.; Brogan, K.; Brucal, M.; Moghaddam, M.; Jen, K-L.C. The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats. Metab. Clin. Experim. 2006, 55, 195-292.
5. Brown, L.; Rosner, B.; Willett, W. W.; Sacks, F. M. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am. J. Clin. Nutr. 1999, 69, 30-42.
6. Chen, H. L.; Haack, V. S.; Janecky, C. W.; Vollendorf, N. W.; Marlett, J. A. Mechanisms by which wheat bran and oat bran increase stool weight in humans. Am. J. Clin. Nutr. 1998, 68, 711-719.
7. Slavin, J. L. Dietary Fiber and Colon Cancer. In Handbook of Dietary Fiber; Chen, S. S., Dreher M. L.; Marcel Dekker: New York, 2001; pp 31-45.
8. Marlett, J. M.; Yang, E. J.; Slavin, J. L. Position of the American Dietetic Association: health implications of dietary fiber. J. Am. Diet. Assoc. 2002, 102, 993-1000.
9. Jenkins, D. J.; Marchie, A.; Augustin, L. S. A.; Ros, E.; Kendall, C. W. C. Viscous dietary fibre and metabolic effects. Clin. Nutr. Suppl. 2004, 1, 39-49.
10. Davidson, T. L.; Swithers, S. E. Food viscosity influences caloric intake composition and body weight in rats. Obes. Res. 2005, 13, 537-544.
11. Anderson, J. W.; Allgood, L. D.; Lawrence, A.; Altringer, L. A.; Jerdack, G. R.; Hengehold, D. A.; Morel, J. G. Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am. J. Clin. Nutr. 2000, 71, 472-479.
12. Jenkins, D. J.; Kendall, C. W.; Vuksan, V.; Vidgen, E.; Parker, T.; Faulkner, D.; Mehling, C. C.; Garsetti, M.; Testolin, G.; Cunnane, S. C.; Ryan, M. A.; Corey, P. N. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am. J. Clin. Nutr. 2002, 75, 834-839.
13. Lecumberri, E.; Mateos, R.; Izquierdo-Pulido, M.; Ruperez, P.; Goya, L.; Bravo, L. Dietary fibre composition and antioxidant and physico-chemical properties of a fibre-rich product from cocoa (Theobroma cacao L.). Food Chem. 2007, 104, 948-954.
14. Yoon, K. Y.; Cha, M.; Shin, S. R.; Kim, K. S. Enzymatic production of a soluble-fibre hydrolyzate from carrots pomace and its sugar composition. Food Chem. 2005, 92, 151-157.
15. AOAC. Official Methods of Analysis, 17th ed.; AOAC International: Arlington, VA, 2000.
16. Lecumberri, E.; Goya, L.; Mateos, R.; Alia, M.; Ramos, S.; Izquierdo-Pulido, M.; Bravo, L. A diet rich in dietary fibre from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats. Nutrition 2007, 23, 332-341.
17. Calvo, L.; Muguerza, B.; Cienfuegos-Jovellanos, E. Microbial inactivation and butter extraction in a cocoa derivative. J. Supercrit. Fluids 2007, 42, 80-87.
18. Pulido, R.; Bravo, L.; Saura-Calixto, F. Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. J. Agric. Food Chem. 2000, 48, 3396-3402.
19. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237.
20. Wu, X.; Beecher, G. R.; Holden, J. M.; Haytowitz, D. B.; Gebhardt, S. E.; Prior, R. L. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J. Agric. Food Chem. 2004, 52, 4026-4037.
21. Guide for the care and use of laboratory animals; NIH Publication No. 18-23; U.S. Institutes of Health: Bethesda, MD, revised 1985.
22. Mateos, R.; Goya, L.; Bravo, L. Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J. Chromatogr., B 2005, 827, 76-82.
23. Pérez-Jiménez, J.; Arranz, S.; Tabernero, M.; Díaz-Rubio, M. E.; Serrano, J.; Goñi, I.; Saura-Calixto, F. Updated methodology to determine antioxidant capacity in plant foods, oils and beverages: extraction, measurement and expression of results. Food Res. Int. 2008, 41, 274-285.
24. Gu, L.; House, S. E.; Wu, X.; Ou, B.; Prior, R. L. Procyanidin and catechin contents and antioxidant capacity of cocoa and chocolate products. J. Agric. Food Chem. 2006, 50, 4057-4061.
25. Adams, K. F.; Schatzkin, A.; Harris, T. B.; Kipnis, V.; Mouw, T. Ballard-Barbasj, R.; Hollenbeck, A.; Leitzmann, M. F. Overweight, obesity and mortality in a large prospective cohort of persons 50 to 71 years old. N. Engl. J. Med 2006, 355, 763-778.
26. Fernandez, M. L.; Sun, D. M.; Tosca, M. A.; McNamara, D. J. Citrus pectin and cholesterol interact to regulate hepatic cholesterol homeostasis and lipoprotein metabolism: a dose-response study in guinea pigs. Am. J. Clin. Nutr. 1994, 59, 869-878.
27. Delzenne, N. M.; Cani, P. D.; Daubioul, C.; Neyrinck, A. M. Impact of inulin and oligofructose on gastrointestinal peptides. Br. J. Nutr. 2005, 93 (1), S157-S161.
28. Gaysinskaya, V. A.; Karatayev, O.; Chang, G. Q.; Leibowitz, S. F. Increased caloric intake after a high-fat preload: relation to circulating triglycerides and orexigenic peptides. Physiol. Behav. 2007, 91, 142-153.
29. Chau, C.-F.; Huang, Y.-L. Effects of the insoluble fiber derived from Passiflora edulis seed on plasma and hepatic lipids and fecal output. Mol. Nutr. Food Res. 2005, 49, 786-790.
30. Fernandez, M. L. Distinct mechanisms of plasma LDL lowering by dietary fiber in the guinea pig: specific effects of pectin, guar gum, and psyllium. J. Lipid Res. 1995, 36, 2394-2404.
31. Yang, J. L.; Kim, Y. H.; Lee, H. S.; Lee, M. S.; Moon, Y. K. Barley beta-glucan lowers serum cholesterol based on the upregulation of cholesterol 7alpha-hydroxylase activity and mRNA abundance in cholesterol-fed rats. J. Nutr. Sci. Vitaminol. 2003, 49, 381-387.
32. Chai, Y. M.; Lim, B. K.; Lee, J. Y.; Kim, M. N.; Park, M. R.; Rhee, S. J. Effects of manufactured soluble dietary fiber from Quercus mongolica on hepatic HMG-CoA reductase and lipoprotein and lipoprotein lipase activities in epididymal adipose tissue of rats fed high cholesterol diets. J. Med. Food 2003, 6, 329-336.
33. Delzenne, N.; Kok, N. Effect of non-digestible fermentable carbohydrates on hepatic fatty acid metabolism. Biochem. Soc. Trans. 1998, 26, 228-230.
34. Mursu, J.; Voutilainen, S.; Nurmi, T.; Rissanen, T. H.; Virtanen, J. K.; Kaikkonen, J.; Nyyssönen, K.; Salonen, J. T. Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radical Biol. Med. 2004, 37, 1351-1359.
35. Kurosawa, T.; Itoh, F.; Nozaki, A.; Nakano, Y.; Katsuda, S.; Osakabe, N.; Tsubone, H.; Kondo, K.; Itakura, H. Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. Atherosclerosis 2005, 179, 237-246.