Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin

Protein Science

Volumn 8, Issue 11, 1999, Pages 2347-2354

  Gigoux, Véronique ^a   Maigret, Bernard ^b   Escrieut, Chantal ^a   Silvente Poirot, Sandrine ^a   Bouisson, Michèle ^a   Fehrentz, Jean Alain ^c   Moroder, Luis ^d   Gully, Danielle ^e   Martinez, Jean ^c   Vaysse, Nicole ^a   Fourmy, Daniel ^a  

^a CHU RANGUEIL   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c CNRS   (France)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e SANOFI   (France)

Author keywords

Cholecystokinin; Modeling; Mutagenesis; Receptor; Site; Sulfate

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; ARGININE DERIVATIVE; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; JMV 179; LINTITRIPT; N TERT BUTYLOXYCARBONYLCHOLECYSTOKININ[27-32][28,31 NORLEUCINE] PHENETHYL ESTER; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG RECEPTOR BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

EID: 0032696904     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.8.11.2347     Document Type: Article

References (32)

1. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y. 1997. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94:10455-10460.
2. Campagne F, Jestin R, Reversat JL, Bernassau JM, Maigret B. 1999. Visualisation and integration of G-protein-coupled receptor related information help the modelling: Description and application of the viseur program. J Comput Aid Model Design. Forthcoming.
3. Clerc P, Dufresne M, Saillan C, Chastre E, Andre T, Escrieut C, Kennedy K, Vaysse N, Gespach C, Fourmy D. 1997. Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach and colon. Int J Cancer 72:931-936.
4. de Weerth A, Pisegna JR, Huppi K, Wank SA. 1993. Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. Biochem Biophys Res Commun 194:811-818.
5. Folsch UR. 1984. Regulation of pancreatic growth. Clin Gastroenterol 13:679-699.
6. Fourmy D, Lopez P, Poirot S, Jimenez J, Dufresne M, Moroder L, Powers SP, Vaysse N. 1989. A new probe for affinity labelling pancreatic cholecystokinin receptor with minor modification of its structure. Eur J Biochem 185:397-403.
7. Gigoux V, Escrieut C, Silvente-Poirot S, Maigret B, Gouilleux L, Fehrentz JA, Gully D, Moroder L, Vaysse N, Fourmy D. 1998. Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state. J Biol Chem 273:14380-14386.
8. Gully D, Frehel D, Marcy C, Spinazze A, Lespy L, Neliat G, Maffrand JP, Le Fur G. 1993. Peripheral biological activity of SR 27897: A new potent non-peptide antagonist of CCKA receptors. Eur J Pharmacol 232:13-19.
9. Henderson R, Baldwin JM, Ceska TA, Zemlin F, Beckmann E, Downing KH. 1990. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J Mol Biol 213:899-929.
10. Horn F, Weare J, Beukers MW, Horsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G. 1998. GPCRDB: An information system for G protein-coupled receptors. Nucl Acids Res 26:275-279.
11. Huang SC, Fortune KP, Wank SA, Kopin AS, Gardner JD. 1994. Multiple affinity states of different cholecystokinin receptors. J Biol Chem 269: 26121-26126.
12. Innis RB, Snyder SH. 1980. Distinct cholecystokinin receptors in brain and pancreas. Proc Natl Acad Sci USA 77:6917-6921.
13. Jensen RT, Lemp GF, Gardner JD. 1982. Interactions of COOH-terminal fragments of cholecystokinin with receptors on dispersed acini from guinea pig pancreas. J Biol Chem 257:5554-5559.
14. Ji Z, Hadac EM, Henne RM, Patel SA, Lybrand TP, Miller LJ. 1997. Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling. J Biol Chem 272:24393-401.
15. Kenakin T. 1995. Pharmacological proteus? Trends Pharmacol Sci 16:256-258.
16. Kennedy K, Gigoux V, Escrieut C, Maigret B, Martinez J, Moroder L, Frehel D, Gully D, Vaysse N, Fourmy D. 1997. Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin. J Biol Chem 272:2920-2926.
17. Lefkowitz RJ, Cotecchia S, Samama P, Costa T. 1993. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol Sci 14:303-307.
18. Mutt V, Jorpes E. 1971. Hormonal polypeptides of the upper intestine. Biochem J 125:57P-58P.
19. Rehfeld JF, van Solinge WW. 1994. The tumor biology of gastrin and cholecystokinin. Adv Cancer Res 63:295-347.
20. Schwartz TW, Rosenkilde MM. 1996. Is there a "lock" for all agonist "keys" in 7TM receptors? [see Comments]. Trends Pharmacol Sci 17:213-216.
21. Silvente-Poirot S, Dufresne M, Vaysse N, Fourmy D. 1993. The peripheral cholecystokinin receptors. Eur J Biochem 215:513-529.
22. Silvente-Poirot S, Escrieut C, Galès C, Fehrentz JA, Escherich A, Wank SA, Martinez J, Moroder L, Maigret B, Bouisson M, et al. 1999. Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor. J Biol Chem 274:23191-23197.
23. Silvente-Poirot S, Escrieut C, Wank SA. 1998. Role of the extracellular domains of the cholecystokinin receptor in agonist binding [In Process Citation]. Mol Pharmacol 54:364-371.
24. Silvente-Poirot S, Wank SA. 1996. A segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity of the peptide agonist gastrin. J Biol Chem 271:14698-14706.
25. Steigerwalt RW, Williams JA. 1981. Characterization of cholecystokinin receptors on rat pancreatic membranes. Endocrinology 109:1746-1753.
26. Strader CD, Fong TM, Graziano MP, Tota MR. 1995. The family of G-protein-coupled receptors. FASEB J 9:745-54.
27. Talkad VD, Fortune KP, Pollo DA, Shah GN, Wank SA, Gardner JD. 1994. Direct demonstration of three different states of the pancreatic cholecystokinin receptor. Proc Natl Acad Sci USA 91:1868-1872.
28. Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Miller LJ. 1993. Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor. Biochem Biophys Res Commun 193:204-211.
29. Unger VM, Hargrave PA, Baldwin JM, Schertler GF. 1997. Arrangement of rhodopsin transmembrane alpha-helices. Nature 389:203-206.
30. Wank SA. 1998. G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: An exemplary family [In Process Citation]. Am J Physiol 274:G607-G613.
31. Weinberg DS, Ruggeri B, Barber MT, Biswas S, Miknyocki S, Waldman SA. 1997. Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma. J Clin Invest 100:597-603.
32. Williams JA, Blevins GT Jr. 1993. Cholecystokinin and regulation of pancreatic acinar cell function. Physiol Rev 73:701-723.