Remarkable effect of 2α-modification on the VDR antagonistic activity of 1α-hydroxyvitamin D3-26,23-lactones

Organic and Biomolecular Chemistry

Volumn 1, Issue 24, 2003, Pages 4396-4402

  Saito, Nozomi ^a   Matsunaga, Toshihiro ^a   Fujishima, Toshie ^a   Anzai, Miyuki ^b   Saito, Hiroshi ^b   Takenouchi, Kazuya ^b   Miura, Daishiro ^b   Ishizuka, Seiichi ^b   Takayama, Hiroaki ^a   Kittaka, Atsushi ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TEIJIN LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; DERIVATIVES; GENES; HORMONES; MOLECULAR STRUCTURE; SYNTHESIS (CHEMICAL);

ALLYLATION; GENE EXPRESSION; VITAMIN D RECEPTORS (VDR);

VITAMINS;

1,25-DIHYDROXYVITAMIN D3-26,23-LACTONE; CALCITRIOL; CALCITRIOL 26,23 LACTONE; CALCITRIOL RECEPTOR; CALCIUM; DRUG DERIVATIVE;

ANIMAL; ARTICLE; BINDING COMPETITION; CELL DIFFERENTIATION; CELL STRAIN HL 60; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IC 50; METABOLISM; RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; BINDING, COMPETITIVE; CALCITRIOL; CALCIUM; CELL DIFFERENTIATION; CELL LINE, TUMOR; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; RATS; RECEPTORS, CALCITRIOL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1542472173     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b311107e     Document Type: Article

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