Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme a and acylglucuronic conjugates of ketoprofen

Biochemical Pharmacology

Volumn 68, Issue 10, 2004, Pages 1957-1969

  Levoin, Nicolas ^a   Blondeau, Céline ^a   Guillaume, Cécile ^a   Grandcolas, Line ^a   Chretien, Franoise ^b   Jouzeau, Jean Yves ^a   Benoit, Etienne ^c   Chapleur, Yves ^b   Netter, Patrick ^a   Lapicque, Franoise ^a  

^a Physiopathol Pharmacologie A   (France)

^b NANCY UNIVERSITÉ   (France)

^c Groupement Hospitalier Edouard Herriot   (France)

Author keywords

Acylglucuronide; Chiral nonsteroidal anti inflammatory drugs; Coenzyme A; COX inhibition; Metabolite

Indexed keywords

COENZYME A; COENZYME A THIOESTER; COENZYME A1; COENZYME A2; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DRUG ANTIBODY; DRUG METABOLITE; KETOPROFEN ACYLGLUCURONIDE; KETOPROFEN COENZYME A; KETOPROFEN DERIVATIVE; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; CATTLE; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CONJUGATION; DRUG INTERACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; IMMUNOPRECIPITATION; INCUBATION TIME; MEMBRANE BINDING; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; PULMONARY ARTERY; STEREOCHEMISTRY;

ACYL COENZYME A; ACYLATION; ANIMALS; CATTLE; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ISOENZYMES; KETOPROFEN; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 5144227936     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.07.015     Document Type: Article

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