Oxidation of Cofilin Mediates T Cell Hyporesponsiveness under Oxidative Stress Conditions

Immunity

Volumn 29, Issue 3, 2008, Pages 404-413

  Klemke, Martin ^a   Wabnitz, Guido H ^a   Funke, Faustina ^a   Funk, Beate ^a   Kirchgessner, Henning ^a   Samstag, Yvonne ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

COFILIN; DISULFIDE; F ACTIN;

ARTICLE; CELL STIMULATION; CHEMOTAXIS; CONTROLLED STUDY; DEPHOSPHORYLATION; DEPOLYMERIZATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STEADY STATE; T LYMPHOCYTE;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANTIGENS, CD28; ANTIGENS, CD3; CHEMOTAXIS, LEUKOCYTE; HUMANS; HYDROGEN PEROXIDE; LIM KINASES; LYMPHOCYTE ACTIVATION; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; T-LYMPHOCYTES;

EID: 51349166966     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.06.016     Document Type: Article

References (34)

1. Billadeau D.D., Nolz J.C., and Gomez T.S. Regulation of T-cell activation by the cytoskeleton. Nat. Rev. Immunol. 7 (2007) 131-143
2. Burkhardt J.K., Carrizosa E., and Shaffer M.H. The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26 (2008) 233-259
3. Bowman G.D., Nodelman I.M., Hong Y., Chua N.H., Lindberg U., and Schutt C.E. A comparative structural analysis of the ADF/cofilin family. Proteins 41 (2000) 374-384
4. Condeelis J. How is actin polymerization nucleated in vivo?. Trends Cell Biol. 11 (2001) 288-293
5. Dustin M.L. Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses. Curr. Opin. Cell Biol. 19 (2007) 529-533
6. Eibert S.M., Lee K.H., Pipkorn R., Sester U., Wabnitz G.H., Giese T., Meuer S.C., and Samstag Y. Cofilin peptide homologs interfere with immunological synapse formation and T cell activation. Proc. Natl. Acad. Sci. USA 101 (2004) 1957-1962
7. Gelderman K.A., Hultqvist M., Holmberg J., Olofsson P., and Holmdahl R. T cell surface redox levels determine T cell reactivity and arthritis susceptibility. Proc. Natl. Acad. Sci. USA 103 (2006) 12831-12836
8. Gelderman K.A., Hultqvist M., Pizzolla A., Zhao M., Nandakumar K.S., Mattsson R., and Holmdahl R. Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. J. Clin. Invest. 117 (2007) 3020-3028
9. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., and Dustin M.L. The immunological synapse: a molecular machine controlling T cell activation. Science 285 (1999) 221-227
10. Hultqvist M., Olofsson P., Holmberg J., Backstrom B.T., Tordsson J., and Holmdahl R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc. Natl. Acad. Sci. USA 101 (2004) 12646-12651
11. Ikebe C., Ohashi K., Fujimori T., Bernard O., Noda T., Robertson E.J., and Mizuno K. Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively initiated transcripts. Genomics 46 (1997) 504-508
12. Jackson S.H., Devadas S., Kwon J., Pinto L.A., and Williams M.S. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat. Immunol. 5 (2004) 818-827
13. Lee K.H., Meuer S.C., and Samstag Y. Cofilin: A missing link between T cell co-stimulation and rearrangement of the actin cytoskeleton. Eur. J. Immunol. 30 (2000) 892-899
14. Mizuno K., Okano I., Ohashi K., Nunoue K., Kuma K., Miyata T., and Nakamura T. Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. Oncogene 9 (1994) 1605-1612
15. Moriyama K., Iida K., and Yahara I. Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1 (1996) 73-86
16. Nebl G., Fischer S., Penzel R., and Samstag Y. Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K. Cell. Signal. 16 (2004) 235-243
17. Olofsson P., Holmberg J., Tordsson J., Lu S., Akerstrom B., and Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat. Genet. 33 (2003) 25-32
18. Otsuji M., Kimura Y., Aoe T., Okamoto Y., and Saito T. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. Proc. Natl. Acad. Sci. USA 93 (1996) 13119-13124
19. Pirzer U.C., Schurmann G., Post S., Betzler M., and Meuer S.C. Differential responsiveness to CD3-Ti vs. CD2-dependent activation of human intestinal T lymphocytes. Eur. J. Immunol. 20 (1990) 2339-2342
20. Qiao L., Schurmann G., Autschbach F., Wallich R., and Meuer S.C. Human intestinal mucosa alters T-cell reactivities. Gastroenterology 105 (1993) 814-819
21. Rabilloud T., Heller M., Gasnier F., Luche S., Rey C., Aebersold R., Benahmed M., Louisot P., and Lunardi J. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. J. Biol. Chem. 277 (2002) 19396-19401
22. Samstag Y., Bader A., and Meuer S.C. A serine phosphatase is involved in CD2-mediated activation of human T lymphocytes and natural killer cells. J. Immunol. 147 (1991) 788-794
23. Samstag Y., Henning S.W., Bader A., and Meuer S.C. Dephosphorylation of pp19: A common second signal for human T cell activation mediated through different accessory molecules. Int. Immunol. 4 (1992) 1255-1262
24. Samstag Y., Eckerskorn C., Wesselborg S., Henning S., Wallich R., and Meuer S.C. Costimulatory signals for human T-cell activation induce nuclear translocation of pp19/cofilin. Proc. Natl. Acad. Sci. USA 91 (1994) 4494-4498
25. Samstag Y., Eibert S.M., Klemke M., and Wabnitz G.H. Actin cytoskeletal dynamics in T lymphocyte activation and migration. J. Leukoc. Biol. 73 (2003) 30-48
26. Schmielau J., and Finn O.J. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res. 61 (2001) 4756-4760
27. Schmielau J., Nalesnik M.A., and Finn O.J. Suppressed T-cell receptor zeta chain expression and cytokine production in pancreatic cancer patients. Clin. Cancer Res. 7 (2001) 933s-939s
28. Sido B., Braunstein J., Breitkreutz R., Herfarth C., and Meuer S.C. Thiol-mediated redox regulation of intestinal lamina propria T lymphocytes. J. Exp. Med. 192 (2000) 907-912
29. Sido B., Lasitschka F., Giese T., Gassler N., Funke B., Schroder-Braunstein J., Brunnemer U., Meuer S.C., and Autschbach F. A prominent role for mucosal cystine/cysteine metabolism in intestinal immunoregulation. Gastroenterology 134 (2008) 179-191
30. Wabnitz G.H., Nebl G., Klemke M., Schroder A.J., and Samstag Y. Phosphatidylinositol 3-kinase functions as a Ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after costimulation of untransformed human T lymphocytes. J. Immunol. 176 (2006) 1668-1674
31. Wabnitz G.H., Kocher T., Lohneis P., Stober C., Konstandin M.H., Funk B., Sester U., Wilm M., Klemke M., and Samstag Y. Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25. Eur. J. Immunol. 37 (2007) 649-662
32. Yang K.S., Kang S.W., Woo H.A., Hwang S.C., Chae H.Z., Kim K., and Rhee S.G. Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid. J. Biol. Chem. 277 (2002) 38029-38036
33. Yonezawa N., Nishida E., and Sakai H. pH control of actin polymerization by cofilin. J. Biol. Chem. 260 (1985) 14410-14412
34. Yonezawa N., Nishida E., Iida K., Yahara I., and Sakai H. Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides. J. Biol. Chem. 265 (1990) 8382-8386