Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue- specific expression of two alternatively initiated transcripts

Genomics

Volumn 46, Issue 3, 1997, Pages 504-508

  Ikebe, Chiho ^a   Ohashi, Kazumasa ^a   Fujimori, Toshihiko ^b   Bernard, Ora ^c   Noda, Tetsuo ^d   Robertson, Elizabeth J ^b   Mizuno, Kensaku ^a,e  

^a KYUSHU UNIVERSITY   (Japan)

^b HARVARD UNIVERSITY   (United States)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

^d CANCER INSTITUTE   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Gene structure; LIM domain; LIMK2; Protein kinase

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; MESSENGER RNA; NUCLEOTIDE; PHOSPHOTRANSFERASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; EXON; GENE; GENE STRUCTURE; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESTRICTION MAPPING; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING;

EID: 0031573790     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.5060     Document Type: Article

References (11)

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2. 2. Bernard, O., Ganiatsas, S., Kannourakis, G., and Dringen, R. (1994). Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Cell Growth Differ. 5: 1159-1171.
3. 3. Cheng, A. K., and Robertson, E. J. (1995). The murine LIM-kinase gene (limk) encodes a novel serine threonine kinase expressed predominantly in trophoblast giant cells and the developing nervous system. Mech. Dev. 52: 187-197.
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6. 6. Mizuno, K., Okano, I., Ohashi, K., Nunoue, K., Kuma, K., Miyata, T., and Nakamura, T. (1994). Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. Oncogene 9: 1605-1612.
7. 7. Nunoue, K., Ohashi, K., Okano, I., and Mizuno, K. (1995). LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family. Oncogene 11: 701-710.
8. 8. Ohashi, K., Toshima, J., Tajinda, K., Nakamura, T., and Mizuno, K. (1994). Molecular cloning of a chicken lung cDNA encoding a novel protein kinase with N-terminal two LIM/double zinc finger motifs. J. Biochem. 116: 636-642.
9. 9. Okano, I., Hiraoka, J., Otera, H., Nunoue, K., Ohashi, K., Iwashita, S., Hirai, M., and Mizuno, K. (1995). Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. J. Biol. Chem. 270: 31321-31330.
10. 10. Osada, H., Hasada, K., Inazawa, J., Uchida, K., Ueda, R., Takahashi, T., and Takahashi, T. (1996). Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation. Biochem. Biophys. Res. Commun. 229: 582-589.
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